International Journal of Molecular Sciences,
Journal Year:
2017,
Volume and Issue:
18(10), P. 2168 - 2168
Published: Oct. 17, 2017
The
circadian
timing
system
(CTS)
controls
various
biological
functions
in
mammals
including
xenobiotic
metabolism
and
detoxification,
immune
functions,
cell
cycle
events,
apoptosis
angiogenesis.
Although
the
importance
of
CTS
is
well
known
pharmacology
drugs,
it
less
appreciated
at
clinical
level.
Genome-wide
studies
highlighted
that
majority
drug
target
genes
are
controlled
by
CTS.
This
suggests
chronotherapeutic
approaches
should
be
taken
for
many
drugs
to
enhance
their
effectiveness.
Currently
successfully
applied
treatment
different
types
cancers.
chronotherapy
approach
has
improved
tolerability
antitumor
efficacy
anticancer
both
experimental
animals
cancer
patients.
Thus,
chronobiological
have
been
determining
most
appropriate
time
administration
agents
minimize
side
effects
or
toxicity
efficacy,
so
as
optimize
therapeutic
ratio.
review
focuses
on
underlying
mechanisms
i.e.,
chronopharmacokinetics
chronopharmacodynamics
with
molecular
aspects,
provides
an
overview
some
recent
advances
development
chronopharmaceutics.
Genome Medicine,
Journal Year:
2019,
Volume and Issue:
11(1)
Published: Dec. 1, 2019
Abstract
Circadian
clocks
are
endogenous
oscillators
that
control
24-h
physiological
and
behavioral
processes.
The
central
circadian
clock
exerts
over
myriad
aspects
of
mammalian
physiology,
including
the
regulation
sleep,
metabolism,
immune
system.
Here,
we
review
advances
in
understanding
genetic
sleep
through
system,
as
well
impact
dysregulated
gene
expression
on
metabolic
function.
We
also
recent
studies
have
begun
to
unravel
clock’s
role
controlling
cardiovascular
nervous
systems,
gut
microbiota,
cancer,
aging.
Such
these
systems
relies,
part,
transcriptional
regulation,
with
evidence
for
genome-wide
chromosome
organization.
These
novel
insights
into
genomic
human
physiology
provide
opportunities
discovery
improved
treatment
strategies
new
biological
underpinnings
disease.
Journal of Clinical Investigation,
Journal Year:
2018,
Volume and Issue:
128(9), P. 3826 - 3839
Published: June 28, 2018
BACKGROUND.
The
circadian
clock
is
a
fundamental
and
pervasive
biological
program
that
coordinates
24-hour
rhythms
in
physiology,
metabolism,
behavior,
it
essential
to
health.
Whereas
therapy
adapted
time
of
day
increasingly
reported
be
highly
successful,
needs
personalized,
since
internal
different
for
each
individual.
In
addition,
not
stable
trait,
but
influenced
by
many
factors,
including
genetic
predisposition,
age,
sex,
environmental
light
levels,
season.
An
easy
convenient
diagnostic
tool
currently
missing.
JCI Insight,
Journal Year:
2020,
Volume and Issue:
5(1)
Published: Jan. 15, 2020
Recent
discoveries
demonstrate
a
critical
role
for
circadian
rhythms
and
sleep
in
immune
system
homeostasis.
Both
innate
adaptive
responses
—
ranging
from
leukocyte
mobilization,
trafficking,
chemotaxis
to
cytokine
release
T
cell
differentiation
—are
mediated
time
of
day–dependent
manner.
The
National
Institutes
Health
(NIH)
recently
sponsored
an
interdisciplinary
workshop,
“Sleep
Insufficiency,
Circadian
Misalignment,
the
Immune
Response,”
highlight
new
research
linking
biology
function
identify
areas
high
translational
potential.
This
Review
summarizes
topics
discussed
highlights
immediate
opportunities
delineating
clinically
relevant
connections
among
biological
rhythms,
sleep,
regulation.
