Workshop report. Circadian rhythm sleep–wake disorders: gaps and opportunities DOI Creative Commons
Jeanne F. Duffy, Sabra M. Abbott, Helen J. Burgess

et al.

SLEEP, Journal Year: 2021, Volume and Issue: 44(5)

Published: Feb. 14, 2021

Abstract This White Paper presents the results from a workshop cosponsored by Sleep Research Society (SRS) and for on Biological Rhythms (SRBR) whose goals were to bring together sleep clinicians circadian rhythm researchers identify existing gaps in diagnosis treatment areas of high-priority research sleep–wake disorders (CRSWD). CRSWD are distinct class caused alterations time-keeping system, its entrainment mechanisms, or misalignment endogenous external environment. In these disorders, timing primary episode is either earlier later than desired, irregular day-to-day, and/or occurs at wrong time. While there incomplete insufficient prevalence data, likely affect least 800,000 perhaps as many 3 million individuals United States, if Shift Work Disorder Jet Lag included, then millions more impacted. The SRS Advocacy Taskforce has identified which additional high-quality could have significant impact improve patient care. Participants selected their expertise assigned one three working groups: Phase Disorders, Entrainment Other. Each group presented summary current state science specific area, followed discussion all participants. outcome those presentations discussions here.

Language: Английский

Chronotype and Social Jetlag: A (Self-) Critical Review DOI Creative Commons
Till Roenneberg, Luísa K. Pilz, Giulia Zerbini

et al.

Biology, Journal Year: 2019, Volume and Issue: 8(3), P. 54 - 54

Published: July 12, 2019

The Munich ChronoType Questionnaire (MCTQ) has now been available for more than 15 years and its original publication cited 1240 times (Google Scholar, May 2019). Additionally, online version, which was until July 2017, produced almost 300,000 entries from all over the world (MCTQ database). MCTQ gone through several versions, translated into 13 languages, validated against other objective measures of daily timing in independent studies. Besides being used as a method to correlate circadian features human biology with factors—ranging health issues geographical factors—the gave rise quantification old wisdoms, like “teenagers are late”, new concepts, social jetlag. Some MCTQ’s simplicity some view it critically. Therefore, is time present self-critical on MCTQ, address misunderstandings, give definitions MCTQ-derived chronotype concept

Language: Английский

Citations

506
Circadian disruption: What do we actually mean? DOI
Céline Vetter

European Journal of Neuroscience, Journal Year: 2018, Volume and Issue: 51(1), P. 531 - 550

Published: Nov. 7, 2018

The circadian system regulates physiology and behavior. Acute challenges to the system, such as those experienced when traveling across time zones, will eventually result in re-synchronization local environmental cues, but this is oftentimes accompanied by adverse short-term consequences. When are chronically, adaptation may not be achieved, for example case of rotating night shift workers. transient chronic disturbance most frequently referred "circadian disruption", many other terms have been proposed used refer similar situations. It now beyond doubt that contributes health disease, emphasizing need clear terminology describing their goal review provide an overview describe disruption discuss quantifications experimental observational settings with a focus on human research, highlight limitations currently available tools. For research advance translational science, clear, operationalizable, scalable key, they enable improved assessment reproducibility results, ideally ranging from mechanistic settings, including animal large-scale randomized clinical trials.

Language: Английский

Citations

246
Impact of Circadian Disruption on Cardiovascular Function and Disease DOI
Sarah L. Chellappa,

Nina Vujović,

Jonathan S. Williams

et al.

Trends in Endocrinology and Metabolism, Journal Year: 2019, Volume and Issue: 30(10), P. 767 - 779

Published: Aug. 16, 2019

Language: Английский

Citations

239
Wearable technologies for developing sleep and circadian biomarkers: a summary of workshop discussions DOI Open Access
Christopher M. Depner, Philip Cheng, Jaime K. Devine

et al.

SLEEP, Journal Year: 2019, Volume and Issue: 43(2)

Published: Oct. 23, 2019

Abstract The “International Biomarkers Workshop on Wearables in Sleep and Circadian Science” was held at the 2018 SLEEP Meeting of Associated Professional Societies. workshop brought together experts consumer sleep technologies medical devices, circadian physiology, clinical translational research, practice. goals were: (1) characterize term “wearable” for use science identify relevant metrics wearables to measure; (2) assess current science; (3) barriers applying (4) opportunities advance science. For purposes biomarker development fields, included terms “wearables,” “nearables,” “ingestibles.” Given state technology, limited validation wearable devices against gold standard measurements is primary factor limiting large-scale research. As such, committee proposed a set best practices studies guidelines regarding how choose device research use. To complement studies, recommends public data repository data. Finally, scientists must actively engage maintain rigor scientific findings health messages based technology.

Language: Английский

Citations

198
Perfect timing: circadian rhythms, sleep, and immunity — an NIH workshop summary DOI Creative Commons
Jeffrey A. Haspel, Ron C. Anafi,

Marishka Brown

et al.

JCI Insight, Journal Year: 2020, Volume and Issue: 5(1)

Published: Jan. 15, 2020

Recent discoveries demonstrate a critical role for circadian rhythms and sleep in immune system homeostasis. Both innate adaptive responses — ranging from leukocyte mobilization, trafficking, chemotaxis to cytokine release T cell differentiation —are mediated time of day–dependent manner. The National Institutes Health (NIH) recently sponsored an interdisciplinary workshop, “Sleep Insufficiency, Circadian Misalignment, the Immune Response,” highlight new research linking biology function identify areas high translational potential. This Review summarizes topics discussed highlights immediate opportunities delineating clinically relevant connections among biological rhythms, sleep, regulation.

Language: Английский

Citations

198
Importance of circadian timing for aging and longevity DOI Creative Commons
Victoria A. Acosta-Rodríguez, Filipa Rijo‐Ferreira, Carla B. Green

et al.

Nature Communications, Journal Year: 2021, Volume and Issue: 12(1)

Published: May 17, 2021

Dietary restriction (DR) decreases body weight, improves health, and extends lifespan. DR can be achieved by controlling how much and/or when food is provided, as well adjusting nutritional composition. Because these factors are often combined during DR, it unclear which necessary for beneficial effects. Several drugs have been utilized that target nutrient-sensing gene pathways, many of change expression throughout the day, suggesting timing drug administration critical. Here, we discuss dietary pharmacological interventions promote a healthy lifespan influencing energy intake circadian rhythms.

Language: Английский

Citations

183
Metabolic and cardiovascular consequences of shift work: The role of circadian disruption and sleep disturbances DOI
Laura Kervezee, Anastasi Kosmadopoulos, Diane B. Boivin

et al.

European Journal of Neuroscience, Journal Year: 2018, Volume and Issue: 51(1), P. 396 - 412

Published: Oct. 25, 2018

Abstract Shift work, defined as work occurring outside typical daytime working hours, is associated with an increased risk of various non‐communicable diseases, including diabetes and cardiovascular disease. Disruption the internal circadian timing system concomitant sleep disturbances thought to play a critical role in development these health problems. Indeed, controlled laboratory studies have shown that short‐term misalignment restriction independently impair physiological processes, insulin sensitivity, energy expenditure, immune function, blood pressure cardiac modulation by autonomous nervous system. If allowed persist, acute effects may lead cardiometabolic diseases long term. Here, we discuss evidence for contributions disruption metabolic problems shift workers. Improving understanding mechanisms affected disturbance will contribute implementation strategies prevent or mitigate impact work.

Language: Английский

Citations

174
Circadian rhythms and disorders of the timing of sleep DOI
Nicholas Meyer, Allison G. Harvey, Steven W. Lockley

et al.

The Lancet, Journal Year: 2022, Volume and Issue: 400(10357), P. 1061 - 1078

Published: Sept. 1, 2022

Language: Английский

Citations

172
Melatonin Effects on Glucose Metabolism: Time To Unlock the Controversy DOI
Marta Garaulet, Jingyi Qian, José C. Florez

et al.

Trends in Endocrinology and Metabolism, Journal Year: 2020, Volume and Issue: 31(3), P. 192 - 204

Published: Jan. 1, 2020

Language: Английский

Citations

145
Foundations of circadian medicine DOI Creative Commons
Achim Kramer, Tanja Lange, Claudia Spies

et al.

PLoS Biology, Journal Year: 2022, Volume and Issue: 20(3), P. e3001567 - e3001567

Published: March 24, 2022

The circadian clock is an evolutionarily highly conserved endogenous timing program that structures physiology and behavior according to the time of day. Disruption rhythms associated with many common pathologies. emerging field medicine aims exploit mechanisms clock–disease interaction for clinical diagnosis, treatment, prevention. In this Essay, we outline principle approaches medicine, highlight development in selected areas, point out open questions challenges. Circadian has unambiguous health benefits over standard care but rarely utilized. It biology become integrated part translational research.

Language: Английский

Citations

70