Frontiers in Endocrinology,
Journal Year:
2022,
Volume and Issue:
13
Published: June 9, 2022
In
aging
society,
osteoporotic
fractures
have
become
one
major
social
problem
threatening
the
health
of
elderly
population
in
China.
Compared
with
conventional
fractures,
low
bone
mass,
defect
and
retarded
healing
issues
lead
to
great
difficulties
treatment
rehabilitation.
Addressing
concerns
clinical
settings,
we
proposed
“three
one”
repair
strategy
focusing
on
anti-osteoporosis
therapies,
appropriate
grafting
fracture
accelerating.
We
summarize
misconceptions
strategies
for
management,
expecting
improvement
prognosis
outcomes
further
improve
therapeutic
effect
living
quality
patients.
Advanced Materials,
Journal Year:
2023,
Volume and Issue:
35(42)
Published: July 12, 2023
Neural-vascular
networks
are
densely
distributed
through
periosteum,
cortical
bone,
and
cancellous
which
is
of
great
significance
for
bone
regeneration
remodeling.
Although
significant
progress
has
been
made
in
tissue
engineering,
ineffective
regeneration,
delayed
osteointegration
still
remains
an
issue
due
to
the
ignorance
intrabony
nerves
blood
vessels.
Herein,
inspired
by
space-filling
polyhedra
with
open
architectures,
polyhedron-like
scaffolds
spatial
topologies
prepared
via
3D-printing
technology
mimic
meshwork
structure
bone.
Benefiting
from
its
topologies,
greatly
promoted
osteogenic
differentiation
mesenchymal
stem
cells
(BMSCs)
activating
PI3K-Akt
signals,
exhibiting
satisfactory
performance
on
angiogenesis
neurogenesis.
Computational
fluid
dynamic
(CFD)
simulation
elucidates
that
have
a
relatively
lower
area-weighted
average
static
pressure,
beneficial
osteogenesis.
Furthermore,
vivo
experiments
further
demonstrate
obviously
promote
formation
osteointegration,
as
well
inducing
vascularization
ingrowth
nerves,
leading
innervated
vascularized
regeneration.
Taken
together,
this
work
offers
promising
approach
fabricating
multifunctional
without
additional
exogenous
seeding
growth
factors,
holds
potential
functional
clinical
translation.
Frontiers in Pain Research,
Journal Year:
2023,
Volume and Issue:
3
Published: Jan. 4, 2023
Personalised
and
targeted
interventions
have
revolutionised
cancer
treatment
dramatically
improved
survival
rates
in
recent
decades.
Nonetheless,
effective
pain
management
remains
a
problem
for
patients
diagnosed
with
cancer,
who
continue
to
suffer
from
the
painful
side
effects
of
itself,
as
well
treatments
disease.
This
will
grow
an
ageing
population
rapid
advent
more
therapeutics
treat
Current
guidelines
World
Health
Organisation
are
generalised
different
severities,
but
fail
address
heterogeneity
mechanisms
varying
types,
stages
disease
plans.
Pain
is
most
common
complaint
leading
emergency
unit
visits
by
over
one-third
that
been
experience
under-treated
pain.
review
summarises
preclinical
models
states,
particular
focus
on
cancer-induced
bone
chemotherapy-associated
We
provide
overview
how
can
recapitulate
aspects
sensory
dysfunction
observed
persistent
or
neuropathic
following
chemotherapy.
Peripheral
central
nervous
system
discussed,
along
key
cellular
molecular
mediators
highlighted
animal
These
include
interactions
between
neuronal
cells,
cells
non-neuronal
tumour
microenvironment.
Therapeutic
targets
beyond
opioid-based
reviewed
International Journal of Oral Science,
Journal Year:
2024,
Volume and Issue:
16(1)
Published: Jan. 19, 2024
Abstract
Bone
formation
and
deposition
are
initiated
by
sensory
nerve
infiltration
in
adaptive
bone
remodeling.
Here,
we
focused
on
the
role
of
Semaphorin
3A
(Sema3A),
expressed
nerves,
mechanical
loads-induced
withdrawal
using
orthodontic
tooth
movement
(OTM)
model.
Firstly,
was
activated
after
3rd
day
OTM,
coinciding
with
a
decrease
nerves
an
increase
pain
threshold.
Sema3A,
rather
than
growth
factor
(NGF),
highly
both
trigeminal
ganglion
axons
periodontal
ligament
following
OTM.
Moreover,
vitro
loads
upregulated
Sema3A
neurons
instead
human
cells
(hPDLCs)
within
24
hours.
Furthermore,
exogenous
restored
suppressed
alveolar
osteogenic
differentiation
hPDLCs
induced
overload.
Mechanistically,
prevented
overstretching
F-actin
overload
through
ROCK2
pathway,
maintaining
mitochondrial
dynamics
as
fusion.
Therefore,
exhibits
dual
therapeutic
effects
formation,
pain-sensitive
analgesic
positive
regulator
for
formation.
Journal of Nanobiotechnology,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: May 15, 2024
The
complexity
of
repairing
large
segment
defects
and
eradicating
residual
tumor
cell
puts
the
osteosarcoma
clinical
management
challenging.
Current
biomaterial
design
often
overlooks
crucial
role
precisely
regulating
innervation
in
bone
regeneration.
Here,
we
develop
a
Germanium
Selenium
(GeSe)
co-doped
polylactic
acid
(PLA)
nanofiber
membrane-coated
tricalcium
phosphate
bioceramic
scaffold
(TCP-PLA/GeSe)
that
mimics
bone-periosteum
structure.
This
biomimetic
offers
dual
functionality,
combining
piezoelectric
photothermal
conversion
capabilities
while
remaining
biodegradable.
When
subjected
to
ultrasound
irradiation,
US-electric
stimulation
TCP-PLA/GeSe
enables
spatiotemporal
control
neurogenic
differentiation.
feature
supports
early
during
formation,
promoting
differentiation
Schwann
cells
(SCs)
by
increasing
intracellular
Ca
Pain,
Journal Year:
2019,
Volume and Issue:
160(10), P. 2210 - 2220
Published: May 22, 2019
Abstract
Chronic
pain
continues
to
be
a
significant
global
burden
despite
the
availability
of
variety
nonpharmacologic
and
pharmacologic
treatment
options.
Thus,
there
is
need
for
new
analgesics
with
novel
mechanisms
action.
In
this
regard,
antibodies
directed
against
nerve
growth
factor
(NGF-Abs)
are
class
agents
in
development
chronic
conditions
such
as
osteoarthritis
low-back
pain.
This
comprehensive
narrative
review
summarizes
evidence
supporting
pronociceptive
functions
NGF
that
include
contributing
peripheral
central
sensitization
through
tropomyosin
receptor
kinase
A
activation
stimulation
local
neuronal
sprouting.
The
potential
role
signaling
also
examined
provide
mechanistic
basis
observed
efficacy
NGF-Abs
clinical
trials
these
particular
states.
Finally,
safety
profile
terms
common
adverse
events,
joint
safety,
structure/function
discussed.
Nature Communications,
Journal Year:
2020,
Volume and Issue:
11(1)
Published: Feb. 26, 2020
Abstract
Denervation
of
skeletal
muscles
induces
severe
muscle
atrophy,
which
is
preceded
by
cellular
alterations
such
as
increased
plasma
membrane
permeability,
reduced
resting
potential
and
accelerated
protein
catabolism.
The
factors
that
induce
these
changes
remain
unknown.
Conversely,
functional
recovery
following
denervation
depends
on
successful
reinnervation.
Here,
we
show
activation
nicotinic
acetylcholine
receptors
(nAChRs)
quantal
release
(ACh)
from
motoneurons
sufficient
to
prevent
induced
denervation.
Using
in
vitro
assays,
ACh
non-hydrolysable
analogs
repressed
the
expression
connexin43
connexin45
hemichannels,
promote
atrophy.
In
co-culture
studies,
connexin43/45
hemichannel
knockout
or
knockdown
innervation
fibers
dorsal
root
ganglion
neurons.
Our
results
released
exerts
a
hitherto
unknown
function
independent
myofiber
contraction.
nAChRs
connexin
hemichannels
are
molecular
targets
for
therapeutic
intervention
variety
pathological
conditions
with
synaptic
neuromuscular
transmission.
Nature Communications,
Journal Year:
2021,
Volume and Issue:
12(1)
Published: Aug. 16, 2021
Abstract
Pain
is
a
central
feature
of
soft
tissue
trauma,
which
under
certain
contexts,
results
in
aberrant
osteochondral
differentiation
tissue-specific
stem
cells.
Here,
the
role
sensory
nerve
fibers
this
abnormal
cell
fate
decision
investigated
using
severe
extremity
injury
model
mice.
Soft
trauma
NGF
(Nerve
growth
factor)
expression,
particularly
within
perivascular
types.
Consequently,
NGF-responsive
axonal
invasion
occurs
precedes
osteocartilaginous
differentiation.
Surgical
denervation
impedes
ingrowth,
with
significant
delays
cartilage
and
bone
formation.
Likewise,
either
deletion
Ngf
or
two
complementary
methods
to
inhibit
its
receptor
TrkA
(Tropomyosin
kinase
A)
lead
similar
Mechanistically,
single-cell
sequencing
suggests
shift
from
TGFβ
FGF
signaling
activation
among
pre-chondrogenic
cells
after
denervation.
Finally,
analysis
human
pathologic
specimens
databases
confirms
relevance
NGF-TrkA
disease.
In
sum,
NGF-mediated
TrkA-expressing
ingrowth
drives
trauma.
inhibition
may
have
dual
therapeutic
use
both
as
an
analgesic
negative
regulator
