Sex differences in tuberculosis

Seminars in Immunopathology, Journal Year: 2018, Volume and Issue: 41(2), P. 225 - 237

Published: Oct. 25, 2018

Language: Английский

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Sex and Gender Differences in Lung Disease

Advances in experimental medicine and biology, Journal Year: 2021, Volume and Issue: unknown, P. 227 - 258

Published: Jan. 1, 2021

Language: Английский

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Sex Differences in the Blood Transcriptome Identify Robust Changes in Immune Cell Proportions with Aging and Influenza Infection

Cell Reports, Journal Year: 2019, Volume and Issue: 29(7), P. 1961 - 1973.e4

Published: Nov. 1, 2019

Sex differences in autoimmunity and infection suggest that a better understanding of molecular sex will improve the diagnosis treatment immune-related disease. We identified 144 differentially expressed genes, referred to as immune expression signature (iSEXS), between human males females using an integrated multi-cohort analysis blood transcriptome profiles from six discovery cohorts five continents with 458 healthy individuals. validated iSEXS 11 additional 524 peripheral samples. When we separated into genes located on chromosomes (XY-iSEXS) or autosomes (autosomal-iSEXS), both modules distinguished females. reflects cell proportions, female-associated showing higher by CD4+ T cells male-associated myeloid cells. Autosomal-iSEXS detected increase monocytes age females, reflected sex-differential dynamics during influenza infection, predicted antibody response males, but not

Language: Английский

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Advanced model systems and tools for basic and translational human immunology

Genome Medicine, Journal Year: 2018, Volume and Issue: 10(1)

Published: Sept. 28, 2018

There are fundamental differences between humans and the animals we typically use to study immune system. We have learned much from genetically manipulated inbred animal models, but instances in which these findings been successfully translated human immunity rare. Embracing genetic environmental diversity of can tell us about biology cell types elasticity Although people more immunologically diverse than conventionally housed tools technologies now available that permit high-throughput analysis samples, including both blood tissues, will give deep insights into health disease. As gain a detailed picture system, build sophisticated models better reflect this complexity, enabling discovery new immunological mechanisms facilitating translation clinic.

Language: Английский

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Sex differences in IL-17 contribute to chronicity in male versus female urinary tract infection

JCI Insight, Journal Year: 2019, Volume and Issue: 4(13)

Published: May 30, 2019

Sex-based differences influence incidence and outcome of infectious disease. Women have a significantly greater urinary tract infection (UTI) than men, yet, conversely, male UTI is more persistent with associated morbidity. Mechanisms underlying these sex-based are unknown, in part due to lack experimental models. We optimized model transurethrally infect mice directly compared both sexes. Although sexes were initially equally colonized by uropathogenic E. coli, only testosterone-treated female remained chronically infected for up 4 weeks. Female had robust innate responses, including higher IL-17 expression, increased γδ T cells group 3 lymphoid the bladder following infection. Accordingly, neutralizing abolished resolution mice, identifying cytokine pathway necessary bacterial clearance. Our findings support concept that responses contribute impaired immunity males provide rationale non-antibiotic-based immune targeting improve response UTI.

Language: Английский

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