Biocompatible Material‐Based Flexible Biosensors: From Materials Design to Wearable/Implantable Devices and Integrated Sensing Systems

Small, Journal Year: 2023, Volume and Issue: 19(27)

Published: April 3, 2023

Abstract Human beings have a greater need to pursue life and manage personal or family health in the context of rapid growth artificial intelligence, big data, Internet Things, 5G/6G technologies. The application micro biosensing devices is crucial connecting technology personalized medicine. Here, progress current status from biocompatible inorganic materials organic composites are reviewed material‐to‐device processing described. Next, operating principles pressure, chemical, optical, temperature sensors dissected these flexible biosensors wearable/implantable discussed. Different systems acting vivo vitro, including signal communication energy supply then illustrated. potential in‐sensor computing for applications sensing also Finally, some essential needs commercial translation highlighted future opportunities considered.

Language: Английский

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Implantable intracortical microelectrodes: reviewing the present with a focus on the future

Microsystems & Nanoengineering, Journal Year: 2023, Volume and Issue: 9(1)

Published: Jan. 5, 2023

Abstract Implantable intracortical microelectrodes can record a neuron’s rapidly changing action potentials (spikes). In vivo neural activity recording methods often have either high temporal or spatial resolution, but not both. There is an increasing need to more neurons over longer duration in vivo. However, there remain many challenges overcome before achieving long-term, stable, high-quality recordings and realizing comprehensive, accurate brain analysis. Based on the vision of idealized implantable microelectrode device, performance requirements for are divided into four aspects, including quality, stability, throughput, multifunctionality, which presented order importance. The current possible solutions given from perspective each aspect. developments technology analyzed summarized.

Language: Английский

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Bioresorbable shape-adaptive structures for ultrasonic monitoring of deep-tissue homeostasis

Science, Journal Year: 2024, Volume and Issue: 383(6687), P. 1096 - 1103

Published: March 7, 2024

Monitoring homeostasis is an essential aspect of obtaining pathophysiological insights for treating patients. Accurate, timely assessments homeostatic dysregulation in deep tissues typically require expensive imaging techniques or invasive biopsies. We introduce a bioresorbable shape-adaptive materials structure that enables real-time monitoring deep-tissue using conventional ultrasound instruments. Collections small metal disks distributed within thin, pH-responsive hydrogels, deployed by surgical implantation syringe injection, allow ultrasound-based measurements spatiotemporal changes pH early anastomotic leaks after gastrointestinal surgeries, and their bioresorption recovery period eliminates the need extraction. Demonstrations large animal models illustrate capabilities leakage from intestine, stomach, pancreas.

Language: Английский

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Recent Development of Implantable Chemical Sensors Utilizing Flexible and Biodegradable Materials for Biomedical Applications

ACS Nano, Journal Year: 2024, Volume and Issue: 18(5), P. 3969 - 3995

Published: Jan. 25, 2024

Implantable chemical sensors built with flexible and biodegradable materials exhibit immense potential for seamless integration biological systems by matching the mechanical properties of soft tissues eliminating device retraction procedures. Compared conventional hospital-based blood tests, implantable have capability to achieve real-time monitoring high accuracy important biomarkers such as metabolites, neurotransmitters, proteins, offering valuable insights clinical applications. These innovative could provide essential information preventive diagnosis effective intervention. To date, despite extensive research on bioresorbable electronics, development has faced several challenges related design, resulting in only a limited number successful accomplishments. This review highlights recent advancements based materials, encompassing their sensing strategies, geometric configurations. The following discussions focus demonstrated detection various objects including ions, small molecules, few examples macromolecules using and/or sensors. Finally, we will present current explore future directions.

Language: Английский

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Wireless Battery-free and Fully Implantable Organ Interfaces

Chemical Reviews, Journal Year: 2024, Volume and Issue: 124(5), P. 2205 - 2280

Published: Feb. 21, 2024

Advances in soft materials, miniaturized electronics, sensors, stimulators, radios, and battery-free power supplies are resulting a new generation of fully implantable organ interfaces that leverage volumetric reduction mechanics by eliminating electrochemical storage. This device class offers the ability to provide high-fidelity readouts physiological processes, enables stimulation, allows control over organs realize therapeutic diagnostic paradigms. Driven seamless integration with connected infrastructure, these devices enable personalized digital medicine. Key advances carefully designed material, electrophysical, electrochemical, electromagnetic systems form implantables mechanical properties closely matched target deliver functionality supports sensors stimulators. The elimination operation, anywhere from acute, lifetimes matching subject physical dimensions imperceptible operation. review provides comprehensive overview basic building blocks related topics such as implantation, delivery, sterilization, user acceptance. State art examples categorized system an outlook interconnection advanced strategies for computation leveraging consistent influx elevate this current battery-powered is highlighted.

Language: Английский

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An ultraflexible organic differential amplifier for recording electrocardiograms

Nature Electronics, Journal Year: 2019, Volume and Issue: 2(8), P. 351 - 360

Published: Aug. 15, 2019

Language: Английский

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Depth-resolved fiber photometry with a single tapered optical fiber implant

Nature Methods, Journal Year: 2019, Volume and Issue: 16(11), P. 1185 - 1192

Published: Oct. 7, 2019

Language: Английский

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Battery-free, lightweight, injectable microsystem for in vivo wireless pharmacology and optogenetics

Proceedings of the National Academy of Sciences, Journal Year: 2019, Volume and Issue: 116(43), P. 21427 - 21437

Published: Oct. 10, 2019

Significance Neuroscience studies using optogenetics have greatly improved our understanding of brain circuits. Advances in the combined use and pharmacology to further probe important neurochemical signals has lagged, however, large part due inconvenience conventional cannulated approaches, as well difficulty controlling, powering, manufacturing optofluidic devices that are reliable scalable for distribution neuroscience community. Here, we present a battery-free, wireless, lightweight device allows adjustable infusion rates, hands-free operation, unlimited power supply, is compatible with existing near-field communication (NFC) technology. We show this not only reproduces optogenetic pharmacological experiments vivo but, additionally, far greater freedom movement small animal models compared existing, comparable platforms.

Language: Английский

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Biointegrated and Wirelessly Powered Implantable Brain Devices: A Review

IEEE Transactions on Biomedical Circuits and Systems, Journal Year: 2020, Volume and Issue: 14(2), P. 343 - 358

Published: Jan. 15, 2020

Implantable neural interfacing devices have added significantly to engineering by introducing the low-frequency oscillations of small populations neurons known as local field potential well high-frequency action potentials individual neurons. Regardless astounding progression late, conventional modulating system is still incapable achieve desired chronic in vivo implantation. The real constraint emerges from mechanical and physical differences between implants brain tissue that initiates an inflammatory reaction glial scar formation reduces recording stimulation quality. Furthermore, traditional strategies consisting rigid tethered cause substantial damage impede natural behavior animal, thus hindering measurements. Therefore, enabling fully implantable requires biocompatibility, wireless power/data capability, biointegration using thin flexible electronics, properties. This article reviews biocompatibility design approaches for developing biointegrated wirelessly powered animals aimed at long-term outlines current challenges toward next generation devices.

Language: Английский

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Stretchable conductive nanocomposite based on alginate hydrogel and silver nanowires for wearable electronics

APL Materials, Journal Year: 2018, Volume and Issue: 7(3)

Published: Dec. 20, 2018

Wearable electronic devices are used to perform various functions on the human skin, and their mechanical softness while maintaining high performances is critical. Therefore, there a need develop novel materials with outstanding electrical ionic conductivity for wearable electronics. Here, we present an intrinsically stretchable conductive nanocomposite based alginate hydrogels silver nanowires (AgNWs). The developed was applied highly soft electrodes that can be in devices. electrode prepared by cross-linking molecules presence of AgNWs, exhibiting higher electrical, conductivity, stretchability, lower modulus than conventional conducting rubbers. By forming bilayer structure ultrasoft hydrogel layer, properties device could matched skin. We fabricating key components electronics, such as antenna skin-mountable supercapacitor. Such demonstrations successfully proved effectiveness proposed material

Language: Английский

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