Wireless multi-lateral optofluidic microsystems for real-time programmable optogenetics and photopharmacology DOI Creative Commons
Yixin Wu, Mingzheng Wu, Abraham Vázquez‐Guardado

et al.

Nature Communications, Journal Year: 2022, Volume and Issue: 13(1)

Published: Sept. 22, 2022

Abstract In vivo optogenetics and photopharmacology are two techniques for controlling neuronal activity that have immense potential in neuroscience research. Their applications tether-free groups of animals been limited part due to tools availability. Here, we present a wireless, battery-free, programable multilateral optofluidic platform with user-selected modalities optogenetics, pharmacology photopharmacology. This system features mechanically compliant microfluidic electronic interconnects, capabilities dynamic control over the rates drug delivery real-time programmability, simultaneously up 256 separate devices single cage environment. Our behavioral experiments demonstrate motor behaviors grouped mice through co-located gene controlled photolysis caged glutamate. These systems may expand scope wireless study neural processing animal models.

Language: Английский

Emerging Implantable Energy Harvesters and Self-Powered Implantable Medical Electronics DOI
Dongjie Jiang, Bojing Shi, Han Ouyang

et al.

ACS Nano, Journal Year: 2020, Volume and Issue: 14(6), P. 6436 - 6448

Published: May 27, 2020

Implantable energy harvesters (IEHs) are the crucial component for self-powered devices. By harvesting from organisms such as heartbeat, respiration, and chemical redox reaction of glucose, IEHs utilized power source implantable medical electronics. In this review, we summarize electronics (SIMEs). The typical nanogenerators, biofuel cells, electromagnetic generators, transcutaneous devices that based on ultrasonic or optical energy. A benefit these technologies in vivo, SIMEs emerged, including cardiac pacemakers, nerve/muscle stimulators, physiological sensors. We provide perspectives challenges potential solutions associated with SIMEs. Beyond issue, highlight implanted show therapeutic function vivo.

Language: Английский

Citations

290
Wireless and battery-free technologies for neuroengineering DOI Open Access
Sang Min Won, Le Cai, Philipp Gutruf

et al.

Nature Biomedical Engineering, Journal Year: 2021, Volume and Issue: 7(4), P. 405 - 423

Published: March 8, 2021

Language: Английский

Citations

259
Emerging Modalities and Implantable Technologies for Neuromodulation DOI Creative Commons
Sang Min Won, Enming Song, Jonathan T. Reeder

et al.

Cell, Journal Year: 2020, Volume and Issue: 181(1), P. 115 - 135

Published: March 26, 2020

Language: Английский

Citations

219
Evolution of 3D Printing Methods and Materials for Electrochemical Energy Storage DOI
Vladimir Egorov, Umair Gulzar, Yan Zhang

et al.

Advanced Materials, Journal Year: 2020, Volume and Issue: 32(29)

Published: June 8, 2020

Additive manufacturing has revolutionized the building of materials direct from design, allowing high resolution rapid prototyping in complex 3D designs with many materials. printing hasenabled strength damage-tolerant structures, bioprinted artificial organs and tissues, ultralight metals, medicine, education, prosthetics, architecture, consumer electronics,and as a tool for engineers hobbyists alike. emerged useful electrode material assembly method batteries supercapacitors recent years. The field initially grew extrusion-based methods such fused deposition modelling, evolved to photopolymerization intricate composites, while supercapacitor technologies less sensitive solvents more often involved jetting processes. Underpinning every part printable battery other devices is nature feed material. Material purity, fidelity, accuracy, complexity, ability form conductive, ceramic, glassy, or solvent-stable plastics relies on composite an extent, that future electrochemical energy storage will depend are co-operatively informed by requirements device how it fabricated. In this Perspective, we address outline linking existing performance limitations materials, casing electrodes electrolytes. We also look taking inspiration additive manufacturing, posit links between allow new factor cells.

Language: Английский

Citations

192
Photocurable bioresorbable adhesives as functional interfaces between flexible bioelectronic devices and soft biological tissues DOI
Quansan Yang, Tong Wei, Rose T. Yin

et al.

Nature Materials, Journal Year: 2021, Volume and Issue: 20(11), P. 1559 - 1570

Published: July 29, 2021

Language: Английский

Citations

178
Recent advances in neurotechnologies with broad potential for neuroscience research DOI
Abraham Vázquez‐Guardado, Yiyuan Yang, Amay J. Bandodkar

et al.

Nature Neuroscience, Journal Year: 2020, Volume and Issue: 23(12), P. 1522 - 1536

Published: Nov. 16, 2020

Language: Английский

Citations

173
Soft implantable drug delivery device integrated wirelessly with wearable devices to treat fatal seizures DOI Creative Commons
Hyun‐Woo Joo, Youngsik Lee, Jaemin Kim

et al.

Science Advances, Journal Year: 2021, Volume and Issue: 7(1)

Published: Jan. 1, 2021

Personalized biomedical devices have enormous potential to solve clinical challenges in urgent medical situations. Despite this potential, a device for situ treatment of fatal seizures using pharmaceutical methods has not been developed yet. Here, we present novel system neurological emergencies, such as status epilepticus, epileptic condition that requires immediate treatment, soft implantable drug delivery (SID). The SID is integrated wirelessly with wearable monitoring electroencephalography signals and triggering subcutaneous release through wireless voltage induction. Because the integration, bulky rigid components sensors, batteries, electronic circuits can be moved from wearables, thus, mechanical softness miniaturization are achieved. efficacy prompt could demonstrated animal experiments vivo, which brain damages were reduced survival rates increased.

Language: Английский

Citations

151
Biocompatible Material‐Based Flexible Biosensors: From Materials Design to Wearable/Implantable Devices and Integrated Sensing Systems DOI
Gang Liu, Ziyu Lv, Saima Batool

et al.

Small, Journal Year: 2023, Volume and Issue: 19(27)

Published: April 3, 2023

Abstract Human beings have a greater need to pursue life and manage personal or family health in the context of rapid growth artificial intelligence, big data, Internet Things, 5G/6G technologies. The application micro biosensing devices is crucial connecting technology personalized medicine. Here, progress current status from biocompatible inorganic materials organic composites are reviewed material‐to‐device processing described. Next, operating principles pressure, chemical, optical, temperature sensors dissected these flexible biosensors wearable/implantable discussed. Different systems acting vivo vitro, including signal communication energy supply then illustrated. potential in‐sensor computing for applications sensing also Finally, some essential needs commercial translation highlighted future opportunities considered.

Language: Английский

Citations

87
Optophysiology: Illuminating cell physiology with optogenetics DOI Creative Commons
Peng Tan, Lian He, Yun Huang

et al.

Physiological Reviews, Journal Year: 2022, Volume and Issue: 102(3), P. 1263 - 1325

Published: Jan. 24, 2022

Optogenetics combines light and genetics to enable precise control of living cells, tissues, organisms with tailored functions. has the advantages noninvasiveness, rapid responsiveness, tunable reversibility, superior spatiotemporal resolution. Following initial discovery microbial opsins as light-actuated ion channels, a plethora naturally occurring or engineered photoreceptors photosensitive domains that respond at varying wavelengths ushered in next chapter optogenetics. Through protein engineering synthetic biology approaches, genetically encoded photoswitches can be modularly into scaffolds host cells myriad biological processes, well behavioral disease intervention vivo. Here, we summarize these optogenetic tools on basis their fundamental photochemical properties better inform chemical design principles. We also highlight exemplary applications opsin-free optogenetics dissecting cellular physiology (designated "optophysiology") describe current progress, future trends, wireless optogenetics, which enables remote interrogation physiological processes minimal invasiveness. This review is anticipated spark novel thoughts next-generation devices promise accelerate both basic translational studies.

Language: Английский

Citations

82
Miniature battery-free bioelectronics DOI
Vishnu Nair, Ashley N Dalrymple, Zhanghao Yu

et al.

Science, Journal Year: 2023, Volume and Issue: 382(6671)

Published: Nov. 9, 2023

Miniature wireless bioelectronic implants that can operate for extended periods of time transform how we treat disorders by acting rapidly on precise nerves and organs in a way drugs cannot. To reach this goal, materials methods are needed to wirelessly transfer energy through the body or harvest from itself. We review some capabilities emerging identify performance envelope existing technology discover where opportunities lie improve much-and efficiently-we deliver tiny support medical technologies.

Language: Английский

Citations

58