Role of baicalin as a potential therapeutic agent in hepatobiliary and gastrointestinal disorders: A review DOI Creative Commons

Risha Ganguly,

Ashutosh Gupta, Abhay K. Pandey

et al.

World Journal of Gastroenterology, Journal Year: 2022, Volume and Issue: 28(26), P. 3047 - 3062

Published: July 7, 2022

Baicalin is a natural bioactive compound derived from Scutellaria baicalensis, which extensively used in traditional Chinese medicine. A literature survey demonstrated the broad spectrum of health benefits baicalin such as antioxidant, anticancer, anti-inflammatory, antimicrobial, cardio-protective, hepatoprotective, renal protective, and neuroprotective properties. hydrolyzed to its metabolite baicalein by action gut microbiota, further reconverted via phase 2 metabolism liver. Many studies have suggested that exhibits therapeutic potential against several types hepatic disorders including fibrosis, xenobiotic-induced liver injury, fatty disease, viral hepatitis, cholestasis, ulcerative colitis, hepatocellular colorectal cancer. During vitro vivo examinations, it has been observed showed protective role gut-associated abnormalities modifying signaling pathways nuclear factor-kappa B, transforming growth factor beta 1/SMAD3, sirtuin 1, p38/mitogen-activated protein kinase/Janus kinase, calcium/calmodulin-dependent kinase kinaseβ/adenosine monophosphate-activated kinase/acetyl-coenzyme carboxylase pathways. Furthermore, also regulates expression fibrotic genes smooth muscle actin, connective tissue factor, β-catenin, inflammatory cytokines interferon gamma, interleukin-6 (IL-6), tumor necrosis factor-alpha, IL-1β, attenuates production apoptotic proteins caspase-3, caspase-9 B-cell lymphoma 2. However, due low solubility poor bioavailability, widespread applications still remain challenge. This review summarized gastrointestinal attributes with an emphasis on molecular mechanisms regulate interaction microbiota.

Language: Английский

Pharmacological basis and new insights of quercetin action in respect to its anti-cancer effects DOI Creative Commons
Simin Tang, Xueting Deng, Jian Zhou

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2019, Volume and Issue: 121, P. 109604 - 109604

Published: Nov. 13, 2019

Quercetin is a kind of flavonoid compounds that comes from nature and widely existed in the daily diet. Previous studies have found quercetin has many effects such as anti-inflammatory, anti-oxidation anti-cancer. Both vivo vitro experiments demonstrated can exert anti-tumor by altering cell cycle progression, inhibiting proliferation, promoting apoptosis, angiogenesis metastasis affecting autophagy. This review summarizes evidence for pharmacological potential inhibition on cancers, supporting viewpoint should be adequately considered therapeutic agent against various cancers.

Language: Английский

Citations

506
New opportunities and challenges of natural products research: When target identification meets single-cell multiomics DOI
Yuyu Zhu, Zijun Ouyang, Haojie Du

et al.

Acta Pharmaceutica Sinica B, Journal Year: 2022, Volume and Issue: 12(11), P. 4011 - 4039

Published: Aug. 27, 2022

Language: Английский

Citations

247
Applications of multi‐omics analysis in human diseases DOI Creative Commons

Chongyang Chen,

Jing Wang,

Donghui Pan

et al.

MedComm, Journal Year: 2023, Volume and Issue: 4(4)

Published: July 31, 2023

Multi-omics usually refers to the crossover application of multiple high-throughput screening technologies represented by genomics, transcriptomics, single-cell proteomics and metabolomics, spatial so on, which play a great role in promoting study human diseases. Most current reviews focus on describing development multi-omics technologies, data integration, particular disease; however, few them provide comprehensive systematic introduction multi-omics. This review outlines existing technical categories multi-omics, cautions for experimental design, focuses integrated analysis methods especially approach machine learning deep integration corresponding tools, medical researches (e.g., cancer, neurodegenerative diseases, aging, drug target discovery) as well open-source tools databases, finally, discusses challenges future directions precision medicine. With algorithms, important disease research, also provided detailed introduction. will guidance researchers, who are just entering into research.

Language: Английский

Citations

182
Baicalin Alleviates Oxidative Stress and Inflammation in Diabetic Nephropathy via Nrf2 and MAPK Signaling Pathway DOI Creative Commons

Leyi Ma,

Fan Wu,

Qingqing Shao

et al.

Drug Design Development and Therapy, Journal Year: 2021, Volume and Issue: Volume 15, P. 3207 - 3221

Published: July 1, 2021

Oxidative stress and inflammation play essential roles in the development progression of diabetic nephropathy (DN). Baicalin (BAI), a natural flavonoid, has been showed to have renoprotective effect various renal diseases. However, its underlying mechanisms DN remain unclear. In this study, we explored potential effects BAI on using spontaneous model.The protective evaluated by detecting DN-related biochemical indicators, kidney histopathology cell apoptosis. After that, examined level oxidative explain BAI's effects. Then, Nrf2 pathway was tested clarify antioxidant activity, transcriptomics conducted elucidate anti-inflammatory activity. Finally, Western blot applied for final mechanism verification.Our results found that effectively ameliorated conditions, proteinuria, histopathological changes apoptosis DN. significantly improved levels glutathione peroxidase (GSH-PX), superoxide dismutase (SOD) catalase (CAT), reduced malondialdehyde (MDA) level. Meanwhile, infiltration inflammatory cells including T-lymphocytes, T-helper cells, neutrophils macrophages, mRNA pro-inflammatory cytokines (IL-1β, IL-6, MCP-1 TNFα) were also obviously inhibited BAI. Afterward, activated signaling increased expression downstream enzymes (HO-1, NQO-1). Kidney revealed inhibition MAPK may contribute which verified later experiment. treatment did inhibit activation canonical family, such as Erk1/2, JNK P38.In summary, our data demonstrated can treat alleviating inflammation, associated with Nrf2-mediated MAPK-mediated pathway.

Language: Английский

Citations

139
Mitochondrial morphology controls fatty acid utilization by changing CPT1 sensitivity to malonyl‐CoA DOI Creative Commons
Jennifer Ngo, Dong Wook Choi,

Illana A. Stanley

et al.

The EMBO Journal, Journal Year: 2023, Volume and Issue: 42(11)

Published: March 14, 2023

Changes in mitochondrial morphology are associated with nutrient utilization, but the precise causalities and underlying mechanisms remain unknown. Here, using cellular models representing a wide variety of shapes, we show strong linear correlation between fragmentation increased fatty acid oxidation (FAO) rates. Forced elongation following MFN2 over-expression or DRP1 depletion diminishes FAO, while forced upon knockdown knockout augments FAO as evident from respirometry metabolic tracing. Remarkably, genetic induction phenocopies distinct cell type-specific biological functions enhanced FAO. These include stimulation gluconeogenesis hepatocytes, insulin secretion islet β-cells exposed to acids, survival FAO-dependent lymphoma subtypes. We find that increases long-chain not short-chain identifying carnitine O-palmitoyltransferase 1 (CPT1) downstream effector regulation Mechanistically, determined reduces malonyl-CoA inhibition CPT1, CPT1 sensitivity inhibition. Overall, these findings underscore physiologic role for mechanism whereby fuel preference capacity determined.

Language: Английский

Citations

95
The Pharmacological Efficacy of Baicalin in Inflammatory Diseases DOI Open Access
Yongqiang Wen, Shaobin Wang, Chenxu Zhao

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(11), P. 9317 - 9317

Published: May 26, 2023

Baicalin is one of the most abundant flavonoids found in dried roots Scutellaria baicalensis Georgi (SBG) belonging to genus Scutellaria. While baicalin demonstrated have anti-inflammatory, antiviral, antitumor, antibacterial, anticonvulsant, antioxidant, hepatoprotective, and neuroprotective effects, its low hydrophilicity lipophilicity limit bioavailability pharmacological functions. Therefore, an in-depth study baicalin’s pharmacokinetics contributes laying theoretical foundation for applied research disease treatment. In this view, physicochemical properties anti-inflammatory activity are summarized terms bioavailability, drug interaction, inflammatory conditions.

Language: Английский

Citations

64
Flavonoids for gastrointestinal tract local and associated systemic effects: A review of clinical trials and future perspectives DOI Creative Commons
Xiaopeng Li, Enjun Xie,

Shumin Sun

et al.

Journal of Advanced Research, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Flavonoids are naturally occurring dietary phytochemicals with significant antioxidant effects aside from several health benefits. People often consume them in combination other food components. Compiling data establishes a link between bioactive flavonoids and prevention of diseases animal models, including cardiovascular diseases, diabetes, gut dysbiosis, metabolic dysfunction-associated steatotic liver disease (MASLD). However, numerous clinical studies have demonstrated the ineffectiveness contradicting rodent thereby challenging validity using as supplements. This review provides perspective to emphasize effective roles well summarize their specific mechanisms animals briefly. First, this offers an in-depth elucidation processes within human, encompassing small, large intestine, liver. Furthermore, comprehensive overview various functions gastrointestinal tract, hindering breakdown assimilation macronutrients, such polysaccharides lipids, regulating hormone secretion inhibition mineral iron absorption. In unabsorbed major portion interact flora leading biotransformation. Once absorbed circulated bloodstream, or metabolites exert beneficial systemic effects. Lastly, we examine protective disorders, endothelial dysfunction, MASLD, disease, obesity, hyperlipidemia, insulin resistance. conclusion, outlines safety future prospects field health, especially syndrome (MetS).

Language: Английский

Citations

4
Botanical Flavonoids: Efficacy, Absorption, Metabolism and Advanced Pharmaceutical Technology for Improving Bioavailability DOI Creative Commons
Lei Hu, Yongming Luo, Jiaxin Yang

et al.

Molecules, Journal Year: 2025, Volume and Issue: 30(5), P. 1184 - 1184

Published: March 6, 2025

Flavonoids represent a class of natural plant secondary metabolites with multiple activities including antioxidant, antitumor, anti-inflammatory, and antimicrobial properties. However, due to their structural characteristics, they often exhibit low bioavailability in vivo. In this review, we focus on the vivo study flavonoids, particularly effects gut microbiome common modifications such as methylation, acetylation, dehydroxylation, etc. These aim change characteristics original substances enhance absorption bioavailability. order improve discuss two feasible methods, namely dosage form modification chemical modification, hope that these approaches will offer new insights into application flavonoids for human health. article, also introduce types, sources, efficacy flavonoids. conclusion, is comprehensive review how

Language: Английский

Citations

2
Diosgenin ameliorates palmitic acid-induced lipid accumulation via AMPK/ACC/CPT-1A and SREBP-1c/FAS signaling pathways in LO2 cells DOI Creative Commons
Ke Fang, Fan Wu,

Guang Chen

et al.

BMC Complementary and Alternative Medicine, Journal Year: 2019, Volume and Issue: 19(1)

Published: Sept. 13, 2019

Non-alcoholic fatty liver disease (NAFLD) is the most common chronic and characterized by excessive hepatic lipid accumulation. Many studies have suggested that overload key initial factor contributes to steatosis. Our previous study indicated diosgenin (DSG) has a beneficial effect on energy metabolism, but underlying mechanism remains unclear.Human normal hepatocytes (LO2 cells) were incubated with palmitic acid establish cell model of nonalcoholic liver. The effects DSG glucose uptake mitochondrial function evaluated. Furthermore, oxidative stress, consumption synthesis in LO2 cells was investigated.The results induced obvious accumulation treatment significantly reduced intracellular content. upregulated expression lipolysis proteins, including phospho-AMP activated protein kinase (p-AMPK), phospho-acetyl-coA carboxylase (p-ACC) carnitine acyl transferase 1A (CPT-1A), inhibited synthesis-related sterol regulatory element-binding 1c (SREBP-1c) synthase (FAS). Additionally, DSG-treated displayed marked improvement function, less production reactive oxygen species higher membrane potential compared group.This suggests can reduce may be related improving increasing β-oxidation decreasing synthesis. above changes might mediated activation AMPK/ACC/CPT-1A pathway inhibition SREBP-1c/FAS pathway.

Language: Английский

Citations

144
Where Metabolism Meets Senescence: Focus on Endothelial Cells DOI Creative Commons
Jacopo Sabbatinelli, Francesco Prattichizzo, Fabiola Olivieri

et al.

Frontiers in Physiology, Journal Year: 2019, Volume and Issue: 10

Published: Dec. 17, 2019

Despite the decline in their proliferative potential, senescent cells display a high metabolic activity. Senescent have been shown to acquire more glycolytic state even presence of oxygen levels, way similar cancer cells. The diversion pyruvate, final product glycolysis, away from oxidative phosphorylation results an altered bioenergetic and may occur as response enhanced stress caused by accumulation dysfunctional mitochondria. This shift leads increased AMP/ATP ADP/ATP ratios, subsequent AMPK activation, ultimately p53-mediated growth arrest. Mounting evidences suggest that reprogramming is critical direct considerable amounts energy toward specific activities related state, including senescence-associated secretory phenotype (SASP) modulation immune responses within cell tissue microenvironment. Interestingly, despite relative abundance vascular compartment, healthy endothelial (ECs) produce most ATP content anaerobic conversion glucose lactate. Their rate further increases during senescence. Alterations EC metabolism identified age-related diseases (ARDs) associated with vasculature, atherosclerosis, type 2 diabetes cardiovascular diseases. In particular, higher production reactive species deriving variety enzymatic sources, uncoupled nitric oxide synthase electron transport chain, causes DNA damage activates NAD+-consuming enzymes polyADP-ribose polymerase 1 (PARP1). These non-physiological mechanisms drive impairment flux intermediates into many pathological pathways. Of note, ECs has reported context ARDs. Through pro-oxidant, pro-inflammatory, vasoconstrictor, prothrombotic activities, they negatively impact on physiology, promoting both onset development Here, we review current knowledge cellular senescence-related changes contribution underlying pathogenesis ARDs, particular focus ECs. Moreover, potential interventions aimed at modulating metabolism, order prevent or delay ARD onset, will be discussed.

Language: Английский

Citations

127