Temporal variations in the pattern of breathing: techniques, sources, and applications to translational sciences DOI Creative Commons
Yoshitaka Oku

The Journal of Physiological Sciences, Journal Year: 2022, Volume and Issue: 72(1)

Published: Aug. 29, 2022

Abstract The breathing process possesses a complex variability caused in part by the respiratory central pattern generator brainstem; however, it also arises from chemical and mechanical feedback control loops, network reorganization sharing with nonrespiratory motor acts, as well inputs cortical subcortical systems. notion that fluctuations contain hidden information has prompted scientists to decipher signals better understand fundamental mechanisms of generation, interactions emotion, influences on neuronal networks associated cognition, changes healthy disease-carrying individuals. Respiration can be used express emotion. Furthermore, respiration appears organize brain-wide oscillations via cross-frequency coupling, optimizing cognitive performance. With aid theory-based techniques machine learning, translated into form usable clinical practice for diagnosis, emotion recognition, mental conditioning.

Language: Английский

The Retrotrapezoid Nucleus: Central Chemoreceptor and Regulator of Breathing Automaticity DOI
Patrice G. Guyenet, Ruth L. Stornetta, George M. P. R. Souza

et al.

Trends in Neurosciences, Journal Year: 2019, Volume and Issue: 42(11), P. 807 - 824

Published: Oct. 18, 2019

Language: Английский

Citations

160
The integrated brain network that controls respiration DOI Creative Commons
Friedrich Krohn, Manuele Novello, Ruben S. van der Giessen

et al.

eLife, Journal Year: 2023, Volume and Issue: 12

Published: March 8, 2023

Respiration is a brain function on which our lives essentially depend. Control of respiration ensures that the frequency and depth breathing adapt continuously to metabolic needs. In addition, respiratory control network has organize muscular synergies integrate ventilation with posture body movement. Finally, coupled cardiovascular emotion. Here, we argue can handle this all by integrating brainstem central pattern generator circuit in larger also comprises cerebellum. Although currently not generally recognized as center, cerebellum well known for its coordinating modulating role motor behavior, autonomic nervous system. review, discuss regions involved respiration, their anatomical functional interactions. We how sensory feedback result adaptation these mechanisms be compromised various neurological psychological disorders. demonstrate generators are part integrated regions.

Language: Английский

Citations

80
Emergent Elements of Inspiratory Rhythmogenesis: Network Synchronization and Synchrony Propagation DOI Creative Commons
Sufyan Ashhad, Jack L. Feldman

Neuron, Journal Year: 2020, Volume and Issue: 106(3), P. 482 - 497.e4

Published: March 3, 2020

Language: Английский

Citations

86
Neuronal mechanisms underlying opioid-induced respiratory depression: our current understanding DOI
Jan‐Marino Ramirez, Nicholas Burgraff, Aguan Wei

et al.

Journal of Neurophysiology, Journal Year: 2021, Volume and Issue: 125(5), P. 1899 - 1919

Published: April 7, 2021

Opioid-induced respiratory depression (OIRD) represents the primary cause of death associated with therapeutic and recreational opioid use. Within United States, rate from abuse since early 1990s has grown disproportionally, prompting classification as a nationwide “epidemic.” Since this time, we have begun to unravel many fundamental cellular systems-level mechanisms opioid-related death. However, factors such individual vulnerability, neuromodulatory compensation, redundancy effects across central peripheral nervous systems created barrier concise, integrative view OIRD. review, bring together multiple perspectives in field OIRD create an overarching viewpoint what know, where essential topic research going forward into future.

Language: Английский

Citations

74
PreBötzinger complex neurons drive respiratory modulation of blood pressure and heart rate DOI Creative Commons
Clément Menuet, Angela A. Connelly, Jaspreet K. Bassi

et al.

eLife, Journal Year: 2020, Volume and Issue: 9

Published: June 15, 2020

Heart rate and blood pressure oscillate in phase with respiratory activity. A component of these oscillations is generated centrally, neurons entraining the activity pre-sympathetic parasympathetic cardiovascular neurons. Using a combination optogenetic inhibition excitation vivo situ rats, as well neuronal tracing, we demonstrate that preBötzinger Complex (preBötC) neurons, which form kernel for inspiratory rhythm generation, directly modulate Specifically, inhibitory preBötC cardiac neuron whilst excitatory sympathetic vasomotor activity, generating heart respiration. Our data reveal yet more functions entrained to preBötC, role cardiorespiratory oscillations. The findings have implications pathologies, such hypertension failure, where entrainment diminished exaggerated.

Language: Английский

Citations

71
Understanding and countering opioid‐induced respiratory depression DOI Open Access
Jordan T. Bateman, Sandy E. Saunders, Erica S. Levitt

et al.

British Journal of Pharmacology, Journal Year: 2021, Volume and Issue: 180(7), P. 813 - 828

Published: June 5, 2021

Respiratory depression is the proximal cause of death in opioid overdose, yet mechanisms underlying this potentially fatal outcome are not well understood. The goal review to provide a comprehensive understanding pharmacological opioid‐induced respiratory depression, which could lead improved therapeutic options counter as other detrimental effects opioids on breathing. development tolerance system also discussed, differences degree caused by various agonists. Finally, potential future agents aimed at reversing or avoiding through non‐opioid receptor targets and certain advantages over naloxone. By providing an overview network, will benefit research countering depression. LINKED ARTICLES This article part themed issue Advances Opioid Pharmacology Time Epidemic. To view articles section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v180.7/issuetoc

Language: Английский

Citations

66
Latent neural population dynamics underlying breathing, opioid-induced respiratory depression and gasping DOI Creative Commons
Nicholas E. Bush, Jan‐Marino Ramirez

Nature Neuroscience, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 5, 2024

Abstract Breathing is vital and must be concurrently robust flexible. This rhythmic behavior generated maintained within a rostrocaudally aligned set of medullary nuclei called the ventral respiratory column (VRC). The properties individual VRC are well known, yet technical challenges have limited interrogation entire population simultaneously. Here we characterize over 15,000 units using high-density electrophysiology, opto-tagging histological reconstruction. Population dynamics analysis reveals consistent rotational trajectories through low-dimensional neural manifold. These rotations even during opioid-induced depression. During severe hypoxia-induced gasping, reconfigure from to all-or-none, ballistic efforts. Thus, latent provide unifying lens onto activities large, heterogeneous populations neurons involved in simple, vital, breathing, describe how these respond variety perturbations.

Language: Английский

Citations

11
Dual mechanisms of opioid-induced respiratory depression in the inspiratory rhythm-generating network DOI Creative Commons
Nathan A. Baertsch, Nicholas E. Bush, Nicholas Burgraff

et al.

eLife, Journal Year: 2021, Volume and Issue: 10

Published: Aug. 17, 2021

The analgesic utility of opioid-based drugs is limited by the life-threatening risk respiratory depression. Opioid-induced depression (OIRD), mediated μ-opioid receptor (MOR), characterized a pronounced decrease in frequency and regularity inspiratory rhythm, which originates from medullary preBötzinger Complex (preBötC). To unravel cellular- network-level consequences MOR activation preBötC, MOR-expressing neurons were optogenetically identified manipulated transgenic mice vitro vivo. Based on these results, model OIRD was developed silico. We conclude that hyperpolarization - expressing preBötC alone does not phenocopy OIRD. Instead, effects are twofold: (1) pre-inspiratory spiking reduced (2) excitatory synaptic transmission suppressed, thereby disrupting network-driven rhythmogenesis. These dual mechanisms opioid action act synergistically to make normally robust rhythm-generating network particularly prone collapse when challenged with exogenous opioids.

Language: Английский

Citations

48
Multi-Level Regulation of Opioid-Induced Respiratory Depression DOI
Barbara Palković, Vitaliy Marchenko, Edward J. Zuperku

et al.

Physiology, Journal Year: 2020, Volume and Issue: 35(6), P. 391 - 404

Published: Oct. 14, 2020

Opioids depress minute ventilation primarily by reducing respiratory rate. This results from direct effects on the preBötzinger Complex as well depression of Parabrachial/Kölliker-Fuse Complex, which provides excitatory drive to neurons mediating phase-switch. also awake forebrain and chemodrive.

Language: Английский

Citations

45
Respiratory disorders of Parkinson’s disease DOI
Yasmin C. Aquino, Laís M. Cabral, Nicole C. Miranda

et al.

Journal of Neurophysiology, Journal Year: 2021, Volume and Issue: 127(1), P. 1 - 15

Published: Nov. 24, 2021

Parkinson's disease (PD) is characterized by the progressive loss of dopaminergic neurons in substantia nigra, mainly affecting people over 60 yr age. Patients develop both classic symptoms (tremors, muscle rigidity, bradykinesia, and postural instability) nonclassical (orthostatic hypotension, neuropsychiatric deficiency, sleep disturbances, respiratory disorders). Thus, patients with PD can have a significantly impaired quality life, especially when they do not multimodality therapeutic follow-up. The alterations associated this syndrome are main cause mortality PD. They be classified as peripheral caused disorders upper airways or muscles involved breathing central triggered functional deficits important located brainstem control. Currently, there little research describing these disorders, therefore, no well-established knowledge about subject, making treatment difficult. In review, history pathology data changes obtained thus far will addressed.

Language: Английский

Citations

38