Circadian misalignment increases mood vulnerability in simulated shift work DOI Creative Commons
Sarah L. Chellappa, Christopher J. Morris, Frank A. J. L. Scheer

et al.

Scientific Reports, Journal Year: 2020, Volume and Issue: 10(1)

Published: Oct. 29, 2020

Abstract Night shift work can associate with an increased risk for depression. As night workers experience a ‘misalignment’ between their circadian system and daily sleep–wake behaviors, negative health consequences, we investigated whether exposure to misalignment underpins mood vulnerability in simulated work. We performed randomized within-subject crossover laboratory studies non-shift workers. Simulated shifts were used induce the endogenous pacemaker sleep/wake cycles (circadian misalignment), while environmental conditions food intake controlled. Circadian adversely impacted emotional state, such that well-being levels significantly decreased throughout 4 days of continuous workers, as compared when they under alignment (interaction “circadian condition” vs. “day”, mood: p < 0.001; well-being: adjusted -values). Similarly, reduced misalignment, = 0.002; Our findings indicate is important biological component vulnerability, individuals who engage are susceptible its deleterious effects.

Language: Английский

Recommendations for daytime, evening, and nighttime indoor light exposure to best support physiology, sleep, and wakefulness in healthy adults DOI Creative Commons
Timothy M. Brown, George C. Brainard, Christian Cajochen

et al.

PLoS Biology, Journal Year: 2022, Volume and Issue: 20(3), P. e3001571 - e3001571

Published: March 17, 2022

Ocular light exposure has important influences on human health and well-being through modulation of circadian rhythms sleep, as well neuroendocrine cognitive functions. Prevailing patterns do not optimally engage these actions for many individuals, but advances in our understanding the underpinning mechanisms emerging lighting technologies now present opportunities to adjust promote optimal physical mental performance. A newly developed, international standard provides a SI-compliant way quantifying influence intrinsically photosensitive, melanopsin-expressing, retinal neurons that mediate effects. The report recommendations lighting, based an expert scientific consensus expressed easily measured quantity (melanopic equivalent daylight illuminance (melaponic EDI)) defined within this standard. are supported by detailed analysis sensitivity circadian, neuroendocrine, alerting responses ocular provide straightforward framework inform design practice.

Language: Английский

Citations

328
Smartphone addiction and depression, anxiety: The role of bedtime procrastination and self-control DOI
Yaoguo Geng, Jingjing Gu, Jing Wang

et al.

Journal of Affective Disorders, Journal Year: 2021, Volume and Issue: 293, P. 415 - 421

Published: July 1, 2021

Language: Английский

Citations

202
Melanopic illuminance defines the magnitude of human circadian light responses under a wide range of conditions DOI Creative Commons
Timothy M. Brown

Journal of Pineal Research, Journal Year: 2020, Volume and Issue: 69(1)

Published: April 5, 2020

Abstract Ocular light drives a range of nonvisual responses in humans including suppression melatonin secretion and circadian phase resetting. These are driven by intrinsically photosensitive retinal ganglion cells (ipRGCs) which combine intrinsic, melanopsin‐based, phototransduction with extrinsic rod/cone‐mediated signals. As result this arrangement, it has remained unclear how best to quantify predict its effects. To address this, we analysed data from nineteen different laboratory studies that measured suppression, resetting and/or alerting wide array stimulus types, intensities durations or without pupil dilation. Using newly established SI‐compliant metrics ipRGC‐influenced light, show melanopic illuminance consistently provides the available predictor for human system. In almost all cases, is able fully account differences sensitivity stimuli varying spectral composition, acting drive track variations illumination characteristic those encountered over civil twilight (~1‐1000 lux equivalent daylight illuminance). Collectively, our demonstrate widespread utility as metric predicting impact environmental illumination. therefore provide strong support use basis guidelines seek regulate exposure benefit health inform future lighting design.

Language: Английский

Citations

188
Light Pollution, Circadian Photoreception, and Melatonin in Vertebrates DOI Open Access
Maja Grubisić, Abraham Haim, Pramod Bhusal

et al.

Sustainability, Journal Year: 2019, Volume and Issue: 11(22), P. 6400 - 6400

Published: Nov. 14, 2019

Artificial light at night (ALAN) is increasing exponentially worldwide, accelerated by the transition to new efficient lighting technologies. However, ALAN and resulting pollution can cause unintended physiological consequences. In vertebrates, production of melatonin—the “hormone darkness” a key player in circadian regulation—can be suppressed ALAN. this paper, we provide an overview research on melatonin vertebrates. We discuss how disrupts natural photic environments, its effect rhythms, different photoreceptor systems across vertebrate taxa. then present results systematic review which identified studies under typical light-polluted conditions fishes, amphibians, reptiles, birds, mammals, including humans. Melatonin extremely low intensities many ranging from 0.01–0.03 lx for fishes rodents 6 sensitive Even lower, wavelength-dependent are implied some require rigorous testing ecological contexts. studies, suppression occurs minimum levels tested, and, better-studied groups, reported occur lower levels. identify major gaps conclude that, most crucial information lacking. No were amphibians reptiles long-term impacts low-level exposure unknown. Given high sensitivity paucity available information, it further order inform effective mitigation strategies human health wellbeing fitness vertebrates ecosystems.

Language: Английский

Citations

172
Circadian rhythms and disorders of the timing of sleep DOI
Nicholas Meyer, Allison G. Harvey, Steven W. Lockley

et al.

The Lancet, Journal Year: 2022, Volume and Issue: 400(10357), P. 1061 - 1078

Published: Sept. 1, 2022

Language: Английский

Citations

172
Circadian rhythm sleep–wake disturbances and depression in young people: implications for prevention and early intervention DOI
Jacob J. Crouse, Joanne S. Carpenter, Yun Ju Christine Song

et al.

The Lancet Psychiatry, Journal Year: 2021, Volume and Issue: 8(9), P. 813 - 823

Published: Aug. 19, 2021

Language: Английский

Citations

154
A Review of Human Physiological Responses to Light: Implications for the Development of Integrative Lighting Solutions DOI Creative Commons
Céline Vetter, P. Morgan Pattison, Kevin W. Houser

et al.

LEUKOS The Journal of the Illuminating Engineering Society of North America, Journal Year: 2021, Volume and Issue: 18(3), P. 387 - 414

Published: March 26, 2021

Architectural lighting has potent biological effects but applied practices that capitalize on this potential have been limited. In review, we endeavor to consolidate and synthesize key references will be useful for professionals, with the goal of supporting knowledge translation into pragmatic strategies. Specifically, explain relevant terminology, outline basic concepts, identify references, provide a balanced overview current state knowledge, highlight important remaining questions. We summarize physiological light human health well-being, including description processes underlying photic regulation circadian, neuroendocrine, neurobehavioral functions. review seminal work elucidating elements mediating potency these responses, specific attention factors critical interpreting those findings. parallel, endorse melanopic Equivalent Daylight Illuminance (Ev,melD65) as preferred measure quantify light. Ultimately, while future studies are necessary further facilitate laboratory domestic workplace settings, immediate better support is clear. Aiming integrative solutions biologically high during day low night perhaps most improvement made in order applications humans.

Language: Английский

Citations

140
The translational neuroscience of sleep: A contextual framework DOI
Michael A. Grandner, Fabian‐Xosé Fernandez

Science, Journal Year: 2021, Volume and Issue: 374(6567), P. 568 - 573

Published: Oct. 28, 2021

Sleep is entwined across many physiologic processes in the brain and periphery, thereby exerting tremendous influence on our well-being. Yet sleep exists a social-environmental context. Contextualizing health with respect to its determinants—from individual- societal-level factors—would enable neuroscientists more effectively translate into clinical practice. Key challenges opportunities pertain (i) recognizing exploring sleep’s functional roles, (ii) clarifying causal mechanisms relation key outcomes, (iii) developing richer model systems, (iv) linking models known contextual factors, (v) leveraging advances multisensory technology. Meeting these would help transcend disciplinary boundaries such that considerations related become an ever-greater presence clinic.

Language: Английский

Citations

114
Light exposure during sleep impairs cardiometabolic function DOI Creative Commons
Ivy C. Mason, Daniela Grimaldi, Kathryn J. Reid

et al.

Proceedings of the National Academy of Sciences, Journal Year: 2022, Volume and Issue: 119(12)

Published: March 14, 2022

SignificanceAmbient nighttime light exposure is implicated as a risk factor for adverse health outcomes, including cardiometabolic disease. However, the effects of during sleep on outcomes and related mechanisms are unclear. This laboratory study shows that, in healthy adults, one night moderate (100 lx) increases heart rate, decreases rate variability (higher sympathovagal balance), next-morning insulin resistance when compared to dimly lit (<3 environment. Moreover, positive relationship between higher balance levels suggests that sympathetic activation may play role observed light-induced changes sensitivity.

Language: Английский

Citations

92
Reducing nighttime light exposure in the urban environment to benefit human health and society DOI
Karolina M. Zielińska-Dąbkowska, Eva Schernhammer, John P. Hanifin

et al.

Science, Journal Year: 2023, Volume and Issue: 380(6650), P. 1130 - 1135

Published: June 15, 2023

Nocturnal light pollution can have profound effects on humans and other organisms. Recent research indicates that nighttime outdoor lighting is increasing rapidly. Evidence from controlled laboratory studies demonstrates nocturnal exposure strain the visual system, disrupt circadian physiology, suppress melatonin secretion, impair sleep. There a growing body of work pointing to adverse human health, including risk chronic diseases, but this knowledge in more nascent stage. In Review, we synthesize recent context-specific factors physiology relevant relation health society, identify critical areas for future research, highlight policy steps recommendations mitigating urban environment.

Language: Английский

Citations

57