Recommendations for daytime, evening, and nighttime indoor light exposure to best support physiology, sleep, and wakefulness in healthy adults

PLoS Biology, Journal Year: 2022, Volume and Issue: 20(3), P. e3001571 - e3001571

Published: March 17, 2022

Ocular light exposure has important influences on human health and well-being through modulation of circadian rhythms sleep, as well neuroendocrine cognitive functions. Prevailing patterns do not optimally engage these actions for many individuals, but advances in our understanding the underpinning mechanisms emerging lighting technologies now present opportunities to adjust promote optimal physical mental performance. A newly developed, international standard provides a SI-compliant way quantifying influence intrinsically photosensitive, melanopsin-expressing, retinal neurons that mediate effects. The report recommendations lighting, based an expert scientific consensus expressed easily measured quantity (melanopic equivalent daylight illuminance (melaponic EDI)) defined within this standard. are supported by detailed analysis sensitivity circadian, neuroendocrine, alerting responses ocular provide straightforward framework inform design practice.

Language: Английский

---

A Review of Human Physiological Responses to Light: Implications for the Development of Integrative Lighting Solutions

LEUKOS The Journal of the Illuminating Engineering Society of North America, Journal Year: 2021, Volume and Issue: 18(3), P. 387 - 414

Published: March 26, 2021

Architectural lighting has potent biological effects but applied practices that capitalize on this potential have been limited. In review, we endeavor to consolidate and synthesize key references will be useful for professionals, with the goal of supporting knowledge translation into pragmatic strategies. Specifically, explain relevant terminology, outline basic concepts, identify references, provide a balanced overview current state knowledge, highlight important remaining questions. We summarize physiological light human health well-being, including description processes underlying photic regulation circadian, neuroendocrine, neurobehavioral functions. review seminal work elucidating elements mediating potency these responses, specific attention factors critical interpreting those findings. parallel, endorse melanopic Equivalent Daylight Illuminance (Ev,melD65) as preferred measure quantify light. Ultimately, while future studies are necessary further facilitate laboratory domestic workplace settings, immediate better support is clear. Aiming integrative solutions biologically high during day low night perhaps most improvement made in order applications humans.

Language: Английский

---

Reducing nighttime light exposure in the urban environment to benefit human health and society

Science, Journal Year: 2023, Volume and Issue: 380(6650), P. 1130 - 1135

Published: June 15, 2023

Nocturnal light pollution can have profound effects on humans and other organisms. Recent research indicates that nighttime outdoor lighting is increasing rapidly. Evidence from controlled laboratory studies demonstrates nocturnal exposure strain the visual system, disrupt circadian physiology, suppress melatonin secretion, impair sleep. There a growing body of work pointing to adverse human health, including risk chronic diseases, but this knowledge in more nascent stage. In Review, we synthesize recent context-specific factors physiology relevant relation health society, identify critical areas for future research, highlight policy steps recommendations mitigating urban environment.

Language: Английский

---

Wearables in Chronomedicine and Interpretation of Circadian Health

Diagnostics, Journal Year: 2025, Volume and Issue: 15(3), P. 327 - 327

Published: Jan. 30, 2025

Wearable devices have gained increasing attention for use in multifunctional applications related to health monitoring, particularly research of the circadian rhythms cognitive functions and metabolic processes. In this comprehensive review, we encompass how wearables can be used study disease. We highlight importance these as markers well-being potential predictors outcomes. focus on wearable technologies sleep research, medicine, chronomedicine beyond domain emphasize actigraphy a validated tool monitoring sleep, activity, light exposure. discuss various mathematical methods currently analyze actigraphic data, such parametric non-parametric approaches, linear, non-linear, neural network-based applied quantify non-circadian variability. also introduce novel actigraphy-derived markers, which personalized proxies status, assisting discriminating between disease, offering insights into neurobehavioral status. lifestyle factors physical activity exposure modulate brain health. establishing reference standards measures further refine data interpretation improve clinical The review calls existing tools methods, deepen our understanding health, develop healthcare strategies.

Language: Английский

---

Chrono‐nutrition: From molecular and neuronal mechanisms to human epidemiology and timed feeding patterns

Journal of Neurochemistry, Journal Year: 2020, Volume and Issue: 157(1), P. 53 - 72

Published: Nov. 22, 2020

Abstract The circadian timing system governs daily biological rhythms, synchronising physiology and behaviour to the temporal world. External time cues, including light‐dark cycle of food intake, provide signals for entrainment central, master clock in hypothalamic suprachiasmatic nuclei (SCN), metabolic rhythms peripheral tissues, respectively. Chrono‐nutrition is an emerging field building on relationship between eating patterns, health. Evidence from both animal human research demonstrates adverse consequences disruption. Conversely, a growing body evidence indicates that aligning intake periods day when processes are optimised nutrition may be effective improving Circadian glucose lipid homeostasis, insulin responsiveness sensitivity, energy expenditure, postprandial metabolism, favour patterns characterised by earlier distribution energy. This review details molecular basis clocks, regulation feeding behaviour, meal as entraining signal models. epidemiology humans examined, together with intervention studies investigating effects morning compared evening chrono‐nutrition interventions such time‐restricted feeding. have therapeutic application individuals at‐risk disease convey health benefits within general population. image

Language: Английский

---

Human-centric lighting: Myth, magic or metaphor?

Lighting Research & Technology, Journal Year: 2020, Volume and Issue: 53(2), P. 97 - 118

Published: Oct. 6, 2020

This paper discusses the rise of human-centric lighting and its current status in lighting. We summarise human benefits associated with light show that has sound motivations, despite being tainted by misleading marketing claims. The phrase integrative avoids hype encapsulates what aspires to be. Embodied these concepts are some things old new. is twofold. First, without diminishing value products, core ingredient for good outcomes design, driven a design team. Second, still vision, visibility, visual comfort amenity as important ever. Complementing new awareness responsibility how influence non-visual responses humans. Circadian, neuroendocrine neurobehavioural health should be considered on-par responses. leads toward solutions increased contrast between day night. parties responsible addressing evolving. Architects, professionals, equipment manufacturers, medical building owners individuals all have stake, but who drive decisions proportion?

Language: Английский

---

Intrinsically Photosensitive Retinal Ganglion Cells of the Human Retina

Frontiers in Neurology, Journal Year: 2021, Volume and Issue: 12

Published: March 25, 2021

Light profoundly affects our mental and physical health. In particular, light, when not delivered at the appropriate time, may have detrimental effects. mammals, light is perceived only by rods cones but also a subset of retinal ganglion cells that express photopigment melanopsin renders them intrinsically photosensitive (ipRGCs). ipRGCs participate in contrast detection play critical roles non-image-forming vision, set responses include circadian entrainment, pupillary reflex (PLR), modulation sleep/alertness, mood. are found human retina, their response to has been characterized indirectly through suppression nocturnal melatonin PLR. However, until recently, had rarely investigated directly. This gap progressively being filled as, over last years, an increasing number studies provided descriptions morphology, gene expression. Here, I review progress knowledge ipRGCs, different morphological functional subtypes described so far how they match murine subtypes. highlight questions remain be addressed. Investigating as these few major role well-being. Additionally, display increased vulnerability or resilience certain disorders compared conventional RGCs, deeper function could help identify therapeutic approaches develop diagnostic tools. Overall, better understanding eye will deliver precise usage recommendations implement light-based interventions improve cognitive performance, mood, life quality.

Language: Английский

---

Human-Centric Lighting: Foundational Considerations and a Five-Step Design Process

Frontiers in Neurology, Journal Year: 2021, Volume and Issue: 12

Published: Jan. 27, 2021

At its best, human-centric lighting considers the visual and non-visual effects of light in support positive human outcomes. worst, it is a marketing phrase used to healthwash products or design solutions. There no doubt that environmental contributes health, but how might one practice given both credible potential implausible hype? Marketing literature filled with promises. Technical societies have summarized science not yet offered guidance. Meanwhile, designers are middle, attempting distinguish knowledge from which dubious make decisions affect people directly. This article intended to: (1) empower reader fundamental understandings ways affects health; (2) provide process for can dovetail decision-making already part designer's workflow.

Language: Английский

---

Evening home lighting adversely impacts the circadian system and sleep

Scientific Reports, Journal Year: 2020, Volume and Issue: 10(1)

Published: Nov. 5, 2020

The regular rise and fall of the sun resulted in development 24-h rhythms virtually all organisms. In an evolutionary heartbeat, humans have taken control their light environment with electric light. Humans are highly sensitive to light, yet most people now use until bedtime. We evaluated impact modern home lighting environments relation sleep individual-level sensitivity using a new wearable spectrophotometer. found that nearly half homes had bright enough suppress melatonin by 50%, but wide range individual responses (0-87% suppression for average home). Greater evening relative individual's was associated increased wakefulness after Homes energy-efficient lights double melanopic illuminance incandescent lighting. These findings demonstrate significantly affects circadian system, specific is unpredictable.

Language: Английский

---

The Lighting Environment, Its Metrology, and Non-visual Responses

Frontiers in Neurology, Journal Year: 2021, Volume and Issue: 12

Published: March 4, 2021

International standard CIE S 026:2018 provides lighting professionals and field researchers in chronobiology with a method to characterize light exposures respect non-visual photoreception responses. This defines five spectral sensitivity functions that describe optical radiation for its ability stimulate each of the α-opic retinal photoreceptor classes contribute effects humans via intrinsically-photosensitive ganglion cells (ipRGCs). The also recently published an open-access toolbox calculates all quantities ratios metrology photometric, radiometric photon systems, based on either measured (user-defined) spectrum or selected illuminants (A, D65, E, FL11, LED-B3) built into toolbox. For wide variety ecologically-valid conditions, melanopsin-based ipRGCs has been shown account responses, from shifting timing nocturnal sleep melatonin secretion regulating steady-state pupil diameter. Recent findings continue confirm photopigment melanopsin plays role visual may have significant influence brightness perception aspects spatial vision. Although knowledge concerning extent which rods cones interact driving is still growing, position statement used melanopic equivalent daylight (D65) illuminance preliminary guidance applying “proper at proper time” manipulate Further this approach awaited participants 2nd Workshop Circadian Neurophysiological Photometry (in Manchester, August 2019). new 026 enables traceable measurements formal, quantitative specification personal exposures, photic interventions designs. Here, we apply everyday sources including natural time series, range LED products and, using toobox, smartphone display screen. collection examples suggests ways variations content over day can be adopted strategies use support human health well-being.

Language: Английский

---