Prenatal Maternal Stress Exacerbates Experimental Colitis of Offspring in Adulthood DOI Creative Commons
Yue Sun,

Runxiang Xie,

Li Lü

et al.

Frontiers in Immunology, Journal Year: 2021, Volume and Issue: 12

Published: Nov. 3, 2021

The prevalence of inflammatory bowel disease (IBD) is increasing worldwide and correlates with dysregulated immune response because gut microbiota dysbiosis. Some adverse early life events influence the establishment act as risk factors for IBD. Prenatal maternal stress (PNMS) induces dysbiosis perturbs neuroimmune network offspring. In this study, we aimed to investigate whether PNMS increases susceptibility offspring colitis in adulthood. related index was assessed during weaning period We found that impaired intestinal epithelial cell proliferation, goblet Paneth differentiation, mucosal barrier function 3-week-old induced low-grade inflammation, but no signs microscopic changes were observed. Although there pronounced difference between control terms their overall measures alpha diversity microbiota, distinct microbial community characterized by Desulfovibrio , Streptococcus Enterococcus decreases Bifidobacterium Blautia Notably, overgrowth persisted from adulthood, consistent results observed using fluorescence situ hybridization colon mucosa. Mechanistically, fecal transplantation experiment showed group inflammation. bacterial solution more potent than inducing inflammation disruption CaCo-2 cells. After treatment a TNF-α inhibitor (adalimumab), statistical indicators two groups. Finally, exposure remarkably increased values histopathological parameters cytokine production mouse model experimental These findings suggest can inhibit development, impair function, cause persistent offspring, resulting exacerbated

Language: Английский

Handbook of Religion and Health DOI
Harold G. Koenig, Tyler J. VanderWeele, John R. Peteet

et al.

Oxford University Press eBooks, Journal Year: 2023, Volume and Issue: unknown

Published: Nov. 23, 2023

Abstract The 2001 (first) edition of this Handbook was a comprehensive review history, research, and discussions on religion health through the year 2000. Appendix listed 1,200 separate quantitative studies each rated in quality 0–10 scale, followed by about 2,000 references an extensive index for rapid topic identification. 2012 (second) systematically updated research from 2000 to 2010, with number then reaching thousands. This 2023 (third) is most scientifically rigorous date, covering best published 2021 emphasis prospective randomized controlled trials. Beginning Foreword Dr. Howard K. Koh, former US Assistant Secretary Health Department Human Services, nearly 600,000-word volume examines almost every aspect health, reviewing past more recent relationship between outcomes. Furthermore, all its 34 chapters conclude clinical community applications, making text relevant both healthcare professionals (physicians, nurses, social workers, rehabilitation therapists, counselors, psychologists, sociologists, etc.) clergy (community clergy, chaplains, pastoral etc.). book’s focuses studies, describing study single line, allowing researchers quickly locate existing research. It should not be surprising that two decades has been cited health.

Language: Английский

Citations

1074

Prenatal stress: Effects on fetal and child brain development DOI
Alexandra Lautarescu, Michael Craig, Vivette Glover

et al.

International review of neurobiology, Journal Year: 2019, Volume and Issue: unknown, P. 17 - 40

Published: Dec. 14, 2019

Language: Английский

Citations

244

Maternal anxiety, depression and stress affects offspring gut microbiome diversity and bifidobacterial abundances DOI Creative Commons
Jeffrey D. Galley, Lauren Mashburn‐Warren,

Lexie C. Blalock

et al.

Brain Behavior and Immunity, Journal Year: 2022, Volume and Issue: 107, P. 253 - 264

Published: Oct. 12, 2022

Language: Английский

Citations

84

Effectiveness of cognitive behavioral therapy for perinatal maternal depression, anxiety and stress: A systematic review and meta-analysis of randomized controlled trials DOI
Xinyuan Li, David P. Laplante, Vincent Paquin

et al.

Clinical Psychology Review, Journal Year: 2022, Volume and Issue: 92, P. 102129 - 102129

Published: Jan. 25, 2022

Language: Английский

Citations

73

Pregnancy Outcome during the First COVID 19 Lockdown in Vienna, Austria DOI Open Access
Sylvia Kirchengast, Beda Hartmann

International Journal of Environmental Research and Public Health, Journal Year: 2021, Volume and Issue: 18(7), P. 3782 - 3782

Published: April 5, 2021

The COVID 19 pandemic represents a major stress factor for non-infected pregnant women. Although maternal during pregnancy increases the risk of preterm birth and intrauterine growth restriction, an increasing number studies yielded no negative effects lockdowns on outcome. present study focused outcome first lockdown phase in Austria. In particular, it was hypothesized that national had weight, low weight rate rate. retrospective medical record-based single center study, 669 singleton live births Vienna Austria between March July 2020 compared with 277 at same hospital pre-lockdown months January February and, addition, 28,807 2005 2019. very gestational age significantly lower than phase. age, however, slightly higher Mean phase; rates extremely were contrast, gain stressful seems to have affect length newborn among mothers.

Language: Английский

Citations

66

Prenatal Stress and the Developing Brain: Postnatal Environments Promoting Resilience DOI Creative Commons
Saara Nolvi, Emily C. Merz, Eeva‐Leena Kataja

et al.

Biological Psychiatry, Journal Year: 2022, Volume and Issue: 93(10), P. 942 - 952

Published: Dec. 24, 2022

Language: Английский

Citations

58

Basic Environmental Supports for Positive Brain and Cognitive Development in the First Year of Life DOI
Joan L. Luby, Max P. Herzberg, Caroline P. Hoyniak

et al.

JAMA Pediatrics, Journal Year: 2024, Volume and Issue: 178(5), P. 465 - 465

Published: March 18, 2024

Importance Defining basic psychosocial resources to facilitate thriving in the first year of life could tangibly inform policy and enhance child development worldwide. Objective To determine if key environmental supports measured as a thrive factor (T-factor) positively impact brain, cognitive, socioemotional outcomes through age 3. Design, Setting, Participants This prospective longitudinal cohort study took place at Midwestern academic medical center from 2017 2022. included singleton offspring oversampled for those facing poverty, without birth complications, congenital anomalies, or utero substance exposures (except cigarettes marijuana) ascertained prenatally followed up prospectively 3 years life. Data were analyzed March 9, 2023, January 3, 2024. Exposures Varying levels prenatal social disadvantage advantage T-factor composed stimulation, nutrition, neighborhood safety, positive caregiving, sleep. Main & measures Gray white matter brain volumes cortical folding ages 2 years, cognitive language abilities by Bayley-III, internalizing externalizing symptoms Infant-Toddler Social Emotional Assessment. Results The was associated with (β = 0.33; 95% CI, 0.14-0.52), controlling variables including (PSD) maternal abilities. 0.36; 0.24-0.49), but not after covarying PSD. association moderated PSD −0.32; −0.48 −0.15 β −0.36; −0.52 −0.20, respectively). Increases these outcomes, only children mean 1 SD below negatively over above other covariates −0.30; −0.08 −0.55 −0.09, Increasing scores decreases symptoms, mean. gray 0.29; 0.04-0.54), no interaction between T-factor. Conclusions Relevance Findings this suggest that aspects environment critical developmental years. suggests enhancement may every infant’s ability thrive, setting stage more trajectory.

Language: Английский

Citations

13

Maternal Prenatal Anxiety and the Fetal Origins of Epigenetic Aging DOI Creative Commons

Megan McGill,

Irina Pokhvisneva,

Andrew Clappison

et al.

Biological Psychiatry, Journal Year: 2021, Volume and Issue: 91(3), P. 303 - 312

Published: Aug. 19, 2021

The fetal origins of mental health is a well-established framework that currently lacks robust index the biological embedding prenatal adversity. Pediatric-Buccal-Epigenetic (PedBE) clock novel epigenetic tool associates with aspects environment, but additional validation in longitudinal datasets required. Likewise, relationship between maternal and PedBE has not been described.Longitudinal cohorts from Netherlands (Basal Influences on Baby Development [BIBO] n = 165) Singapore (Growing Up Towards Healthy Outcomes [GUSTO] 340) provided data anxiety assessments buccal cell-derived genome-wide DNA methylation assessed at 6 10 years age BIBO, 3, 9, 48 months GUSTO. Measures acceleration were calculated using benchmarked against an established multi-tissue predictor.Prenatal predicted child both cohorts, effects largely restricted to males females. These results independent obstetric, socioeconomic, genetic risk factors, larger effect size for than depression. increased externalizing symptoms mid- late childhood BIBO cohort only.These findings point reveal sensitivity males. Convergent evidence underscores societal importance providing timely effective support pregnant individuals, which may have lasting consequences mother child.

Language: Английский

Citations

55

The Roadmap for Resilience: The California Surgeon General's Report on Adverse Childhood Experiences, Toxic Stress, and Health DOI Open Access
Devika Bhushan, Krista Kotz,

Julianne McCall

et al.

Published: Dec. 9, 2020

In one of my first acts as Governor, I established the role California Surgeon General.Among all myriad challenges facing our administration on day, addressing persistent to health and welfare people state-especially that youngest Californians-was an essential priority.We led with overwhelming scientific consensus upstream factors, including toxic stress social determinants health, are root causes many most harmful challenges, from heart disease homelessness.An issue so critical 40 million Californians deserved nothing less than a world-renowned expert advocate.Appointed in 2019 be firstever General, Dr. Nadine Burke Harris brought groundbreaking research expertise childhood trauma adversity State's efforts.In this new role, set three key priorities -early childhood, equity Adverse Childhood Experiences (ACEs) -and is working across give voice science evidence-based practices foundational success work state.The Office General has already strong programs, first-in-the-nation ACEs Aware initiative, partnership Department Health Care Services (DHCS), taking systematic science-based approach by training healthcare providers screen for children adults.We have also matched resolve funding.Through Initiative Advance Precision Medicine, we invested $9 demonstration projects address impacts using precision medicine approaches.California leading way public crisis because it one.This preventive measure improve societal outcomes state's residents generations come.As collectively face unprecedented confluence challenges-the COVID-19 pandemic, ensuing economic recession, ongoing national reckoning racial injustice, devastating wildfires exacerbated climate change-our state communities grateful Harris' leadership respond waves upon us.It responsibility meet moment.This report provides roadmap systemic equitable forward, based cross-sector partnerships.We must listen advised evidence clearly tells us cumulative adversity, particularly when experienced early life, cause some detrimental, longest lasting costly nation.This highlights how stress, if unaddressed, will cost over trillion dollars next 10 years due costs direct care life lost poor disability or death.It clear me implementing type evidence-based, responses necessary decrease burden not only ethical moral imperative, but vitality.This General's Report offers insights policymakers, scientists, providers, educators, advocates, advances solutions approaches better safety Golden now future.Furthermore, exceptional blueprint can truly stage well-being countless here elsewhere nation world.

Language: Английский

Citations

54

Data-Driven Modeling of Pregnancy-Related Complications DOI Creative Commons
Camilo Espinosa, Martin Becker, Ivana Marić

et al.

Trends in Molecular Medicine, Journal Year: 2021, Volume and Issue: 27(8), P. 762 - 776

Published: Feb. 9, 2021

A multitude of clinical, biological, environmental, and demographic factors influence the trajectory a pregnancy. Maternal genetics, environment, stress, nutrition, medical history, socioeconomic status, racial ethnic background all play role in determining success pregnancy.Diverse data sources are available for study pregnancy prediction adverse outcomes, including electronic health records (EHRs) administrative claims data, high-throughput multiomics characterizing biological systems, more complex like time series, imaging video text.Recent advances multiview, multitask, deep learning allow joint modeling across as well outcomes demonstrate vast potential such integrated approaches. healthy depends on interrelated adaptations involving placentation, maternal immune responses, hormonal homeostasis. Recent technologies have provided access to that, combined with clinical social can provide deeper understanding normal abnormal pregnancies. Integration these heterogeneous datasets using state-of-the-art machine-learning methods enable short- long-term trajectories mother offspring development treatments prevent or minimize complications. We review advanced that could: insights into not yet unveiled by current methodologies; clarify etiologies heterogeneity pathologies affect pregnancy; suggest best approaches address disparities affecting vulnerable populations. Pregnancy is process which each stage – implantation, decidualization, organogenesis, establishment maternal–fetal interface, fetal growth, and, finally, parturition successful completion previous [1.Cha J. et al.Mechanisms implantation: strategies pregnancy.Nat. Med. 2012; 18: 1754-1767Crossref PubMed Scopus (603) Google Scholar]. The exact most remain unknown, challenging therapeutic interventions. Preterm birth (PTB), defined before 37 weeks gestation, leading cause global infant morbidity mortality. Spontaneous PTB (sPTB) has many antecedents been attributed various pathological mechanisms intra-amniotic infection, disruption tolerance, vascular disorders, myometrial stretching, cervical incompetence, thus appearing be syndrome causes [2.Romero R. al.Preterm labor: one syndrome, causes.Science. 2014; 345: 760-765Crossref (865) Moreover, definition sPTB, based solely gestational age (GA) less than weeks, insufficient precisely identify neonates who will develop outcomes. Further this inability accurately estimate GA low- middle-income countries (LMICs) [3.Rosenberg R.E. al.Determining low-resource setting: validity last menstrual period.J. Health Popul. Nutr. 2009; 27: 332-338PubMed Similarly, there growing evidence two main types preeclampsia early versus late onset addition having different risk pathophysiologies [4.Tarca A.L. al.The preeclampsia: results from longitudinal proteomics study.PLoS One. 2019; 14e0217273Crossref (27) Various growth restriction (FGR), PTB, preterm premature rupture membranes (PPROM), spontaneous abortion, placental abruption associated common culprit: an placenta [5.Ilekis J.V. al.Placental origins outcomes: molecular targets: Executive Workshop Summary Eunice Kennedy Shriver National Institute Child Human Development.Am. Obstet. Gynecol. 2016; 215: S1-S46Abstract Full Text PDF (128) Scholar,6.Khalil A. al.Change incidence stillbirth delivery during COVID-19 pandemic.JAMA. 2020; 324: 705-706Crossref (81) These findings point complexity itself. 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Unfortunately, irrespective etiology, extremely difficult predict, partly because multifactorial clinicians lack necessary tools prior symptoms. PTL tocolytics, antibiotics, other measures benefit delaying once begun [21.American College Obstetricians Gynecologists' Committee Practice Bulletins Obstetrics bulletin no. 171: management labor.Obstet. 128: e155-e164Crossref Preeclampsia multiorgan disorder complicating 2–8% pregnancies [22.American Gestational hypertension ACOG practice bulletin, number 222.Obstet. 135: e237-e260Crossref hallmarks new-onset proteinuria, variety organs central nervous lungs, liver, kidneys, heart, mediated via generalized vasoconstriction may early- late-onset early-onset form indicative increased rates complications [23.Wójtowicz al.Early- cohort laboratory according ISHHP Criteria.Int. Hypertens. 20194108271Crossref (10) manifestations it hypothesized pathophysiology begins first trimester. 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Total Environ. 725138418Crossref 64.Zheng exposures trajectories.Ann. 82: 41-99Crossref 65.Patel occupational polycyclic aromatic hydrocarbons isolated offspring.Environ. 186109550Crossref 66.Choi outdoor limb deficiencies Birth Prevention Study.Environ. 179108716Crossref 67.Stingone nitrogen dioxide, methyl nutrients, offspring.Am. 186: 719-729Crossref (16) Machine model yields promising dependent enhance ability predict they shown

Language: Английский

Citations

47