Frontiers in Immunology,
Journal Year:
2021,
Volume and Issue:
12
Published: Nov. 3, 2021
The
prevalence
of
inflammatory
bowel
disease
(IBD)
is
increasing
worldwide
and
correlates
with
dysregulated
immune
response
because
gut
microbiota
dysbiosis.
Some
adverse
early
life
events
influence
the
establishment
act
as
risk
factors
for
IBD.
Prenatal
maternal
stress
(PNMS)
induces
dysbiosis
perturbs
neuroimmune
network
offspring.
In
this
study,
we
aimed
to
investigate
whether
PNMS
increases
susceptibility
offspring
colitis
in
adulthood.
related
index
was
assessed
during
weaning
period
We
found
that
impaired
intestinal
epithelial
cell
proliferation,
goblet
Paneth
differentiation,
mucosal
barrier
function
3-week-old
induced
low-grade
inflammation,
but
no
signs
microscopic
changes
were
observed.
Although
there
pronounced
difference
between
control
terms
their
overall
measures
alpha
diversity
microbiota,
distinct
microbial
community
characterized
by
Desulfovibrio
,
Streptococcus
Enterococcus
decreases
Bifidobacterium
Blautia
Notably,
overgrowth
persisted
from
adulthood,
consistent
results
observed
using
fluorescence
situ
hybridization
colon
mucosa.
Mechanistically,
fecal
transplantation
experiment
showed
group
inflammation.
bacterial
solution
more
potent
than
inducing
inflammation
disruption
CaCo-2
cells.
After
treatment
a
TNF-α
inhibitor
(adalimumab),
statistical
indicators
two
groups.
Finally,
exposure
remarkably
increased
values
histopathological
parameters
cytokine
production
mouse
model
experimental
These
findings
suggest
can
inhibit
development,
impair
function,
cause
persistent
offspring,
resulting
exacerbated
Oxford University Press eBooks,
Journal Year:
2023,
Volume and Issue:
unknown
Published: Nov. 23, 2023
Abstract
The
2001
(first)
edition
of
this
Handbook
was
a
comprehensive
review
history,
research,
and
discussions
on
religion
health
through
the
year
2000.
Appendix
listed
1,200
separate
quantitative
studies
each
rated
in
quality
0–10
scale,
followed
by
about
2,000
references
an
extensive
index
for
rapid
topic
identification.
2012
(second)
systematically
updated
research
from
2000
to
2010,
with
number
then
reaching
thousands.
This
2023
(third)
is
most
scientifically
rigorous
date,
covering
best
published
2021
emphasis
prospective
randomized
controlled
trials.
Beginning
Foreword
Dr.
Howard
K.
Koh,
former
US
Assistant
Secretary
Health
Department
Human
Services,
nearly
600,000-word
volume
examines
almost
every
aspect
health,
reviewing
past
more
recent
relationship
between
outcomes.
Furthermore,
all
its
34
chapters
conclude
clinical
community
applications,
making
text
relevant
both
healthcare
professionals
(physicians,
nurses,
social
workers,
rehabilitation
therapists,
counselors,
psychologists,
sociologists,
etc.)
clergy
(community
clergy,
chaplains,
pastoral
etc.).
book’s
focuses
studies,
describing
study
single
line,
allowing
researchers
quickly
locate
existing
research.
It
should
not
be
surprising
that
two
decades
has
been
cited
health.
International Journal of Environmental Research and Public Health,
Journal Year:
2021,
Volume and Issue:
18(7), P. 3782 - 3782
Published: April 5, 2021
The
COVID
19
pandemic
represents
a
major
stress
factor
for
non-infected
pregnant
women.
Although
maternal
during
pregnancy
increases
the
risk
of
preterm
birth
and
intrauterine
growth
restriction,
an
increasing
number
studies
yielded
no
negative
effects
lockdowns
on
outcome.
present
study
focused
outcome
first
lockdown
phase
in
Austria.
In
particular,
it
was
hypothesized
that
national
had
weight,
low
weight
rate
rate.
retrospective
medical
record-based
single
center
study,
669
singleton
live
births
Vienna
Austria
between
March
July
2020
compared
with
277
at
same
hospital
pre-lockdown
months
January
February
and,
addition,
28,807
2005
2019.
very
gestational
age
significantly
lower
than
phase.
age,
however,
slightly
higher
Mean
phase;
rates
extremely
were
contrast,
gain
stressful
seems
to
have
affect
length
newborn
among
mothers.
JAMA Pediatrics,
Journal Year:
2024,
Volume and Issue:
178(5), P. 465 - 465
Published: March 18, 2024
Importance
Defining
basic
psychosocial
resources
to
facilitate
thriving
in
the
first
year
of
life
could
tangibly
inform
policy
and
enhance
child
development
worldwide.
Objective
To
determine
if
key
environmental
supports
measured
as
a
thrive
factor
(T-factor)
positively
impact
brain,
cognitive,
socioemotional
outcomes
through
age
3.
Design,
Setting,
Participants
This
prospective
longitudinal
cohort
study
took
place
at
Midwestern
academic
medical
center
from
2017
2022.
included
singleton
offspring
oversampled
for
those
facing
poverty,
without
birth
complications,
congenital
anomalies,
or
utero
substance
exposures
(except
cigarettes
marijuana)
ascertained
prenatally
followed
up
prospectively
3
years
life.
Data
were
analyzed
March
9,
2023,
January
3,
2024.
Exposures
Varying
levels
prenatal
social
disadvantage
advantage
T-factor
composed
stimulation,
nutrition,
neighborhood
safety,
positive
caregiving,
sleep.
Main
&
measures
Gray
white
matter
brain
volumes
cortical
folding
ages
2
years,
cognitive
language
abilities
by
Bayley-III,
internalizing
externalizing
symptoms
Infant-Toddler
Social
Emotional
Assessment.
Results
The
was
associated
with
(β
=
0.33;
95%
CI,
0.14-0.52),
controlling
variables
including
(PSD)
maternal
abilities.
0.36;
0.24-0.49),
but
not
after
covarying
PSD.
association
moderated
PSD
−0.32;
−0.48
−0.15
β
−0.36;
−0.52
−0.20,
respectively).
Increases
these
outcomes,
only
children
mean
1
SD
below
negatively
over
above
other
covariates
−0.30;
−0.08
−0.55
−0.09,
Increasing
scores
decreases
symptoms,
mean.
gray
0.29;
0.04-0.54),
no
interaction
between
T-factor.
Conclusions
Relevance
Findings
this
suggest
that
aspects
environment
critical
developmental
years.
suggests
enhancement
may
every
infant’s
ability
thrive,
setting
stage
more
trajectory.
Biological Psychiatry,
Journal Year:
2021,
Volume and Issue:
91(3), P. 303 - 312
Published: Aug. 19, 2021
The
fetal
origins
of
mental
health
is
a
well-established
framework
that
currently
lacks
robust
index
the
biological
embedding
prenatal
adversity.
Pediatric-Buccal-Epigenetic
(PedBE)
clock
novel
epigenetic
tool
associates
with
aspects
environment,
but
additional
validation
in
longitudinal
datasets
required.
Likewise,
relationship
between
maternal
and
PedBE
has
not
been
described.Longitudinal
cohorts
from
Netherlands
(Basal
Influences
on
Baby
Development
[BIBO]
n
=
165)
Singapore
(Growing
Up
Towards
Healthy
Outcomes
[GUSTO]
340)
provided
data
anxiety
assessments
buccal
cell-derived
genome-wide
DNA
methylation
assessed
at
6
10
years
age
BIBO,
3,
9,
48
months
GUSTO.
Measures
acceleration
were
calculated
using
benchmarked
against
an
established
multi-tissue
predictor.Prenatal
predicted
child
both
cohorts,
effects
largely
restricted
to
males
females.
These
results
independent
obstetric,
socioeconomic,
genetic
risk
factors,
larger
effect
size
for
than
depression.
increased
externalizing
symptoms
mid-
late
childhood
BIBO
cohort
only.These
findings
point
reveal
sensitivity
males.
Convergent
evidence
underscores
societal
importance
providing
timely
effective
support
pregnant
individuals,
which
may
have
lasting
consequences
mother
child.
In
one
of
my
first
acts
as
Governor,
I
established
the
role
California
Surgeon
General.Among
all
myriad
challenges
facing
our
administration
on
day,
addressing
persistent
to
health
and
welfare
people
state-especially
that
youngest
Californians-was
an
essential
priority.We
led
with
overwhelming
scientific
consensus
upstream
factors,
including
toxic
stress
social
determinants
health,
are
root
causes
many
most
harmful
challenges,
from
heart
disease
homelessness.An
issue
so
critical
40
million
Californians
deserved
nothing
less
than
a
world-renowned
expert
advocate.Appointed
in
2019
be
firstever
General,
Dr.
Nadine
Burke
Harris
brought
groundbreaking
research
expertise
childhood
trauma
adversity
State's
efforts.In
this
new
role,
set
three
key
priorities
-early
childhood,
equity
Adverse
Childhood
Experiences
(ACEs)
-and
is
working
across
give
voice
science
evidence-based
practices
foundational
success
work
state.The
Office
General
has
already
strong
programs,
first-in-the-nation
ACEs
Aware
initiative,
partnership
Department
Health
Care
Services
(DHCS),
taking
systematic
science-based
approach
by
training
healthcare
providers
screen
for
children
adults.We
have
also
matched
resolve
funding.Through
Initiative
Advance
Precision
Medicine,
we
invested
$9
demonstration
projects
address
impacts
using
precision
medicine
approaches.California
leading
way
public
crisis
because
it
one.This
preventive
measure
improve
societal
outcomes
state's
residents
generations
come.As
collectively
face
unprecedented
confluence
challenges-the
COVID-19
pandemic,
ensuing
economic
recession,
ongoing
national
reckoning
racial
injustice,
devastating
wildfires
exacerbated
climate
change-our
state
communities
grateful
Harris'
leadership
respond
waves
upon
us.It
responsibility
meet
moment.This
report
provides
roadmap
systemic
equitable
forward,
based
cross-sector
partnerships.We
must
listen
advised
evidence
clearly
tells
us
cumulative
adversity,
particularly
when
experienced
early
life,
cause
some
detrimental,
longest
lasting
costly
nation.This
highlights
how
stress,
if
unaddressed,
will
cost
over
trillion
dollars
next
10
years
due
costs
direct
care
life
lost
poor
disability
or
death.It
clear
me
implementing
type
evidence-based,
responses
necessary
decrease
burden
not
only
ethical
moral
imperative,
but
vitality.This
General's
Report
offers
insights
policymakers,
scientists,
providers,
educators,
advocates,
advances
solutions
approaches
better
safety
Golden
now
future.Furthermore,
exceptional
blueprint
can
truly
stage
well-being
countless
here
elsewhere
nation
world.