Mechanisms of gut microbiota-immune-host interaction on glucose regulation in type 2 diabetes DOI Creative Commons

Yu-Dian Zhou,

Feng‐Xia Liang,

Hao-Ran Tian

et al.

Frontiers in Microbiology, Journal Year: 2023, Volume and Issue: 14

Published: Feb. 20, 2023

Intestinal absorption of food is one the sources glucose. Insulin resistance and impaired glucose tolerance caused by lifestyle diet are precursors type 2 diabetes. Patients with diabetes have trouble controlling their blood sugar levels. For long-term health, strict glycemic management necessary. Although it thought to be well correlated metabolic diseases like obesity, insulin resistance, diabetes, its molecular mechanism still not completely understood. Disturbed microbiota triggers gut immune response reshape homeostasis. This interaction only maintains dynamic changes intestinal flora, but also preserves integrity barrier. Meanwhile, establishes a systemic multiorgan dialog on gut-brain gut-liver axes, high-fat affects host’s feeding preference metabolism. Intervention in can combat decreased sensitivity linked both centrally peripherally. Moreover, pharmacokinetics oral hypoglycemic medications influenced microbiota. The accumulation drugs drug efficacy, composition function them, thus may help explain individual therapeutic variances pharmacological efficacy. Regulating through healthy dietary patterns or supplementing pro/prebiotics provide guidance for interventions people poor control. Traditional Chinese medicine used as complementary effectively regulate becoming new target against diseases, so more evidence needed elucidate intricate microbiota-immune-host relationship, explore potential targeting

Language: Английский

Grains – a major source of sustainable protein for health DOI Creative Commons
Kaisa Poutanen, Anna Kårlund, Carlos Gómez-Gallego

et al.

Nutrition Reviews, Journal Year: 2021, Volume and Issue: 80(6), P. 1648 - 1663

Published: Sept. 8, 2021

Cereal grains are the main dietary source of energy, carbohydrates, and plant proteins world-wide. Currently, only 41% used for human consumption, up to 35% animal feed. Cereals have been overlooked as a environmentally sustainable healthy could play major role in transitioning towards more food system diets. good nutritional quality, but lysine is often limiting amino acid. When consumed whole grains, cereals provide health-protecting components such fiber phytochemicals. Shifting grain use from feed traditional foods conceptually new ingredients improve protein security alleviate climate change. Rapid development grain-based contexts, dairy replacements meat analogues, accelerate transition. This review discusses recent developments outlines future perspectives cereal use.

Language: Английский

Citations

176
The ever-changing roles of serotonin DOI
Lauren A. Jones, Emily Sun, Alyce M. Martin

et al.

The International Journal of Biochemistry & Cell Biology, Journal Year: 2020, Volume and Issue: 125, P. 105776 - 105776

Published: May 29, 2020

Language: Английский

Citations

171
Gut Microbiota and Type 2 Diabetes Mellitus: Association, Mechanism, and Translational Applications DOI Creative Commons
Lili Zhang,

Jinjin Chu,

Wenhao Hao

et al.

Mediators of Inflammation, Journal Year: 2021, Volume and Issue: 2021, P. 1 - 12

Published: Aug. 17, 2021

Gut microbiota has attracted widespread attention due to its crucial role in disease pathophysiology, including type 2 diabetes mellitus (T2DM). Metabolites and bacterial components of gut affect the initiation progression T2DM by regulating inflammation, immunity, metabolism. Short-chain fatty acids, secondary bile acid, imidazole propionate, branched-chain amino lipopolysaccharide are main molecules related T2DM. Many studies have investigated T2DM, particularly those butyrate-producing bacteria. Increasing evidence demonstrated that fecal transplantation probiotic capsules useful strategies preventing diabetes. In this review, we aim elucidate complex association between metabolism, immune disorders, underlying mechanisms, translational applications microbiota. This review will provide novel insight into developing individualized therapy for patients based on immunometabolism.

Language: Английский

Citations

111
The gut microbiome and mental health: advances in research and emerging priorities DOI
Andrew Shoubridge, Jocelyn M. Choo, Alyce M. Martin

et al.

Molecular Psychiatry, Journal Year: 2022, Volume and Issue: 27(4), P. 1908 - 1919

Published: March 2, 2022

Language: Английский

Citations

82
Microbiota metabolism of intestinal amino acids impacts host nutrient homeostasis and physiology DOI
Tingting Li, Xi Chen, Da Huo

et al.

Cell Host & Microbe, Journal Year: 2024, Volume and Issue: 32(5), P. 661 - 675.e10

Published: April 23, 2024

Language: Английский

Citations

47
Microbiota-modulated CART + enteric neurons autonomously regulate blood glucose DOI Open Access
Paul Müller, Fanny Matheis, Marc Schneeberger

et al.

Science, Journal Year: 2020, Volume and Issue: 370(6514), P. 314 - 321

Published: Aug. 27, 2020

The gut microbiota affects tissue physiology, metabolism, and function of both the immune nervous systems. We found that intrinsic enteric-associated neurons (iEANs) in mice are functionally adapted to intestinal segment they occupy; ileal colonic more responsive microbial colonization than duodenal neurons. Specifically, a microbially subset viscerofugal CART

Language: Английский

Citations

125
Benchmark of 16S rRNA gene amplicon sequencing using Japanese gut microbiome data from the V1–V2 and V3–V4 primer sets DOI Creative Commons

Shoichiro Kameoka,

Daisuke Motooka, Satoshi Watanabe

et al.

BMC Genomics, Journal Year: 2021, Volume and Issue: 22(1)

Published: July 10, 2021

Abstract Background 16S rRNA gene amplicon sequencing (16S analysis) is widely used to analyze microbiota with next-generation technologies. Here, we compared fecal analysis data from 192 Japanese volunteers using the modified V1–V2 (V12) and standard V3–V4 primer (V34) sets optimize gut protocol. Results QIIME1 QIIME2 revealed a higher number of unclassified representative sequences in V34 than V12 data. The comparison bacterial composition demonstrated that at phylum level, Actinobacteria Verrucomicrobia were detected levels V12. Among these phyla, observed relative compositions Bifidobacterium Akkermansia V34. To estimate actual abundance, performed quantitative real-time polymerase chain reaction (qPCR) assays for . We found abundance as by qPCR was close data, but markedly lower Conclusions These results indicate derived region might differ specific bacteria. conclude use set more desirable microbiota.

Language: Английский

Citations

79
The role of the gut microbiota in health and cardiovascular diseases DOI Creative Commons
Lu Wang, Shiqi Wang, Qing Zhang

et al.

Molecular Biomedicine, Journal Year: 2022, Volume and Issue: 3(1)

Published: Oct. 11, 2022

Abstract The gut microbiota is critical to human health, such as digesting nutrients, forming the intestinal epithelial barrier, regulating immune function, producing vitamins and hormones, metabolites interact with host. Meanwhile, increasing evidence indicates that has a strong correlation occurrence, progression treatment of cardiovascular diseases (CVDs). In patients CVDs corresponding risk factors, composition ratio have significant differences compared their healthy counterparts. Therefore, dysbiosis, microbiota-generated metabolites, related signaling pathway may serve explanations for some mechanisms about occurrence development CVDs. Several studies also demonstrated many traditional latest therapeutic treatments are associated its generated pathways. Given information, we summarized advances in current research regarding effect on main CVDs, highlighted roles several introduced promising microbiota. this review mainly focuses exploring role potential which eventually provide better solutions well prevention

Language: Английский

Citations

70
Serotonin Deficiency Is Associated With Delayed Gastric Emptying DOI
Lai Wei, Rajan Singh, Se Eun Ha

et al.

Gastroenterology, Journal Year: 2021, Volume and Issue: 160(7), P. 2451 - 2466.e19

Published: March 2, 2021

Language: Английский

Citations

60
Enteric Microbiota-Mediated Serotonergic Signaling in Pathogenesis of Irritable Bowel Syndrome DOI Open Access
Yoshiyuki Mishima, Shunji Ishihara

International Journal of Molecular Sciences, Journal Year: 2021, Volume and Issue: 22(19), P. 10235 - 10235

Published: Sept. 23, 2021

Irritable bowel syndrome (IBS) is a chronic functional disorder that affects the gastrointestinal tract. Details regarding pathogenesis of IBS remain largely unknown, though dysfunction brain-gut-microbiome (BGM) axis major etiological factor, in which neurotransmitters serve as key communication tool between enteric microbiota and brain. One most important pathology serotonin (5-HT), it influences motility, pain sensation, mucosal inflammation, immune responses, brain activity, all shape features. Genome-wide association studies discovered susceptible genes for serotonergic signaling pathways. In clinical practice, treatment strategies targeting 5-HT were effective certain portion cases. The synthesis intestinal enterochromaffin cells host regulated by resident microbiota. Dysbiosis can trigger development, potentially through aberrant BGM axis; thus, manipulation gut may be an alternative strategy. However, precise information mechanisms underlying microbiota-mediated pathway related to remains unclear. present review summarizes current knowledge recent progress understanding microbiome-serotonin interaction

Language: Английский

Citations

58