Frontiers in Microbiology,
Journal Year:
2023,
Volume and Issue:
14
Published: Feb. 20, 2023
Intestinal
absorption
of
food
is
one
the
sources
glucose.
Insulin
resistance
and
impaired
glucose
tolerance
caused
by
lifestyle
diet
are
precursors
type
2
diabetes.
Patients
with
diabetes
have
trouble
controlling
their
blood
sugar
levels.
For
long-term
health,
strict
glycemic
management
necessary.
Although
it
thought
to
be
well
correlated
metabolic
diseases
like
obesity,
insulin
resistance,
diabetes,
its
molecular
mechanism
still
not
completely
understood.
Disturbed
microbiota
triggers
gut
immune
response
reshape
homeostasis.
This
interaction
only
maintains
dynamic
changes
intestinal
flora,
but
also
preserves
integrity
barrier.
Meanwhile,
establishes
a
systemic
multiorgan
dialog
on
gut-brain
gut-liver
axes,
high-fat
affects
host’s
feeding
preference
metabolism.
Intervention
in
can
combat
decreased
sensitivity
linked
both
centrally
peripherally.
Moreover,
pharmacokinetics
oral
hypoglycemic
medications
influenced
microbiota.
The
accumulation
drugs
drug
efficacy,
composition
function
them,
thus
may
help
explain
individual
therapeutic
variances
pharmacological
efficacy.
Regulating
through
healthy
dietary
patterns
or
supplementing
pro/prebiotics
provide
guidance
for
interventions
people
poor
control.
Traditional
Chinese
medicine
used
as
complementary
effectively
regulate
becoming
new
target
against
diseases,
so
more
evidence
needed
elucidate
intricate
microbiota-immune-host
relationship,
explore
potential
targeting
Nutrition Reviews,
Journal Year:
2021,
Volume and Issue:
80(6), P. 1648 - 1663
Published: Sept. 8, 2021
Cereal
grains
are
the
main
dietary
source
of
energy,
carbohydrates,
and
plant
proteins
world-wide.
Currently,
only
41%
used
for
human
consumption,
up
to
35%
animal
feed.
Cereals
have
been
overlooked
as
a
environmentally
sustainable
healthy
could
play
major
role
in
transitioning
towards
more
food
system
diets.
good
nutritional
quality,
but
lysine
is
often
limiting
amino
acid.
When
consumed
whole
grains,
cereals
provide
health-protecting
components
such
fiber
phytochemicals.
Shifting
grain
use
from
feed
traditional
foods
conceptually
new
ingredients
improve
protein
security
alleviate
climate
change.
Rapid
development
grain-based
contexts,
dairy
replacements
meat
analogues,
accelerate
transition.
This
review
discusses
recent
developments
outlines
future
perspectives
cereal
use.
Mediators of Inflammation,
Journal Year:
2021,
Volume and Issue:
2021, P. 1 - 12
Published: Aug. 17, 2021
Gut
microbiota
has
attracted
widespread
attention
due
to
its
crucial
role
in
disease
pathophysiology,
including
type
2
diabetes
mellitus
(T2DM).
Metabolites
and
bacterial
components
of
gut
affect
the
initiation
progression
T2DM
by
regulating
inflammation,
immunity,
metabolism.
Short-chain
fatty
acids,
secondary
bile
acid,
imidazole
propionate,
branched-chain
amino
lipopolysaccharide
are
main
molecules
related
T2DM.
Many
studies
have
investigated
T2DM,
particularly
those
butyrate-producing
bacteria.
Increasing
evidence
demonstrated
that
fecal
transplantation
probiotic
capsules
useful
strategies
preventing
diabetes.
In
this
review,
we
aim
elucidate
complex
association
between
metabolism,
immune
disorders,
underlying
mechanisms,
translational
applications
microbiota.
This
review
will
provide
novel
insight
into
developing
individualized
therapy
for
patients
based
on
immunometabolism.
Science,
Journal Year:
2020,
Volume and Issue:
370(6514), P. 314 - 321
Published: Aug. 27, 2020
The
gut
microbiota
affects
tissue
physiology,
metabolism,
and
function
of
both
the
immune
nervous
systems.
We
found
that
intrinsic
enteric-associated
neurons
(iEANs)
in
mice
are
functionally
adapted
to
intestinal
segment
they
occupy;
ileal
colonic
more
responsive
microbial
colonization
than
duodenal
neurons.
Specifically,
a
microbially
subset
viscerofugal
CART
BMC Genomics,
Journal Year:
2021,
Volume and Issue:
22(1)
Published: July 10, 2021
Abstract
Background
16S
rRNA
gene
amplicon
sequencing
(16S
analysis)
is
widely
used
to
analyze
microbiota
with
next-generation
technologies.
Here,
we
compared
fecal
analysis
data
from
192
Japanese
volunteers
using
the
modified
V1–V2
(V12)
and
standard
V3–V4
primer
(V34)
sets
optimize
gut
protocol.
Results
QIIME1
QIIME2
revealed
a
higher
number
of
unclassified
representative
sequences
in
V34
than
V12
data.
The
comparison
bacterial
composition
demonstrated
that
at
phylum
level,
Actinobacteria
Verrucomicrobia
were
detected
levels
V12.
Among
these
phyla,
observed
relative
compositions
Bifidobacterium
Akkermansia
V34.
To
estimate
actual
abundance,
performed
quantitative
real-time
polymerase
chain
reaction
(qPCR)
assays
for
.
We
found
abundance
as
by
qPCR
was
close
data,
but
markedly
lower
Conclusions
These
results
indicate
derived
region
might
differ
specific
bacteria.
conclude
use
set
more
desirable
microbiota.
Molecular Biomedicine,
Journal Year:
2022,
Volume and Issue:
3(1)
Published: Oct. 11, 2022
Abstract
The
gut
microbiota
is
critical
to
human
health,
such
as
digesting
nutrients,
forming
the
intestinal
epithelial
barrier,
regulating
immune
function,
producing
vitamins
and
hormones,
metabolites
interact
with
host.
Meanwhile,
increasing
evidence
indicates
that
has
a
strong
correlation
occurrence,
progression
treatment
of
cardiovascular
diseases
(CVDs).
In
patients
CVDs
corresponding
risk
factors,
composition
ratio
have
significant
differences
compared
their
healthy
counterparts.
Therefore,
dysbiosis,
microbiota-generated
metabolites,
related
signaling
pathway
may
serve
explanations
for
some
mechanisms
about
occurrence
development
CVDs.
Several
studies
also
demonstrated
many
traditional
latest
therapeutic
treatments
are
associated
its
generated
pathways.
Given
information,
we
summarized
advances
in
current
research
regarding
effect
on
main
CVDs,
highlighted
roles
several
introduced
promising
microbiota.
this
review
mainly
focuses
exploring
role
potential
which
eventually
provide
better
solutions
well
prevention
International Journal of Molecular Sciences,
Journal Year:
2021,
Volume and Issue:
22(19), P. 10235 - 10235
Published: Sept. 23, 2021
Irritable
bowel
syndrome
(IBS)
is
a
chronic
functional
disorder
that
affects
the
gastrointestinal
tract.
Details
regarding
pathogenesis
of
IBS
remain
largely
unknown,
though
dysfunction
brain-gut-microbiome
(BGM)
axis
major
etiological
factor,
in
which
neurotransmitters
serve
as
key
communication
tool
between
enteric
microbiota
and
brain.
One
most
important
pathology
serotonin
(5-HT),
it
influences
motility,
pain
sensation,
mucosal
inflammation,
immune
responses,
brain
activity,
all
shape
features.
Genome-wide
association
studies
discovered
susceptible
genes
for
serotonergic
signaling
pathways.
In
clinical
practice,
treatment
strategies
targeting
5-HT
were
effective
certain
portion
cases.
The
synthesis
intestinal
enterochromaffin
cells
host
regulated
by
resident
microbiota.
Dysbiosis
can
trigger
development,
potentially
through
aberrant
BGM
axis;
thus,
manipulation
gut
may
be
an
alternative
strategy.
However,
precise
information
mechanisms
underlying
microbiota-mediated
pathway
related
to
remains
unclear.
present
review
summarizes
current
knowledge
recent
progress
understanding
microbiome-serotonin
interaction