Public human microbiome data are dominated by highly developed countries

PLoS Biology, Journal Year: 2022, Volume and Issue: 20(2), P. e3001536 - e3001536

Published: Feb. 15, 2022

The importance of sampling from globally representative populations has been well established in human genomics. In microbiome research, however, we lack a full understanding the global distribution research studies. This information is crucial to better understand patterns microbiome-associated diseases and extend health benefits this all populations. Here, analyze country origin 444,829 samples that are available world's 3 largest genomic data repositories, including Sequence Read Archive (SRA). 2,592 studies 19 body sites, 220,017 gut microbiome. We show more than 71% with known come Europe, United States, Canada, 46.8% US alone, despite representing only 4.3% population. also find central southern Asia most underrepresented region: Countries such as India, Pakistan, Bangladesh account for quarter world population but make up 1.8% samples. These results demonstrate critical need ensure representation participants

Language: Английский

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The global human gut microbiome: genes, lifestyles, and diet

Trends in Molecular Medicine, Journal Year: 2023, Volume and Issue: 29(10), P. 789 - 801

Published: July 27, 2023

Language: Английский

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Microbial transmission in the social microbiome and host health and disease

Cell, Journal Year: 2024, Volume and Issue: 187(1), P. 17 - 43

Published: Jan. 1, 2024

Language: Английский

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Microbiome Dynamics: A Paradigm Shift in Combatting Infectious Diseases

Journal of Personalized Medicine, Journal Year: 2024, Volume and Issue: 14(2), P. 217 - 217

Published: Feb. 18, 2024

Infectious diseases have long posed a significant threat to global health and require constant innovation in treatment approaches. However, recent groundbreaking research has shed light on previously overlooked player the pathogenesis of disease-the human microbiome. This review article addresses intricate relationship between microbiome infectious unravels its role as crucial mediator host-pathogen interactions. We explore remarkable potential harnessing this dynamic ecosystem develop innovative strategies that could revolutionize management diseases. By exploring latest advances emerging trends, aims provide new perspective combating by targeting

Language: Английский

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Examining the healthy human microbiome concept

Nature Reviews Microbiology, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 23, 2024

Language: Английский

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Integration of 168,000 samples reveals global patterns of the human gut microbiome

Cell, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

The factors shaping human microbiome variation are a major focus of biomedical research. While other fields have used large sequencing compendia to extract insights requiring otherwise impractical sample sizes, the field has lacked comparably sized resource for 16S rRNA gene amplicon commonly quantify composition. To address this gap, we processed 168,464 publicly available gut samples with uniform pipeline. We use compendium evaluate geographic and technical effects on variation. find that regions such as Central Southern Asia differ significantly from more thoroughly characterized microbiomes Europe Northern America composition alone can be predict sample's region origin. also strong associations between primers DNA extraction. anticipate growing work, Human Microbiome Compendium, will enable advanced applied methodological

Language: Английский

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Enteric Microbiota-Mediated Serotonergic Signaling in Pathogenesis of Irritable Bowel Syndrome

International Journal of Molecular Sciences, Journal Year: 2021, Volume and Issue: 22(19), P. 10235 - 10235

Published: Sept. 23, 2021

Irritable bowel syndrome (IBS) is a chronic functional disorder that affects the gastrointestinal tract. Details regarding pathogenesis of IBS remain largely unknown, though dysfunction brain-gut-microbiome (BGM) axis major etiological factor, in which neurotransmitters serve as key communication tool between enteric microbiota and brain. One most important pathology serotonin (5-HT), it influences motility, pain sensation, mucosal inflammation, immune responses, brain activity, all shape features. Genome-wide association studies discovered susceptible genes for serotonergic signaling pathways. In clinical practice, treatment strategies targeting 5-HT were effective certain portion cases. The synthesis intestinal enterochromaffin cells host regulated by resident microbiota. Dysbiosis can trigger development, potentially through aberrant BGM axis; thus, manipulation gut may be an alternative strategy. However, precise information mechanisms underlying microbiota-mediated pathway related to remains unclear. present review summarizes current knowledge recent progress understanding microbiome-serotonin interaction

Language: Английский

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Exiting the Anthropocene: Achieving personal and planetary health in the 21st century

Allergy, Journal Year: 2022, Volume and Issue: 77(12), P. 3498 - 3512

Published: June 24, 2022

Planetary health provides a perspective of ecological interdependence that connects the and vitality individuals, communities, Earth's natural systems. It includes social, political, economic ecosystems influence both individuals whole societies. In an era interconnected grand challenges threatening all systems at scales, planetary framework for cross-sectoral collaboration unified approaches to solutions. The field allergy is forefront these efforts. Allergic conditions are sentinel measure environmental impact on human in early life-illuminating how changes affect immune development predispose wider range inflammatory noncommunicable diseases (NCDs). This shows adverse macroscale ecology Anthropocene penetrates molecular level personal microscale ecology, including microbial foundations ecosystems. basis more integrated efforts address widespread degradation effects maladaptive urbanization, food systems, lifestyle behaviors, socioeconomic disadvantage. Nature-based solutions improve nature-relatedness crucial restoring symbiosis, balance, mutualism every sense, recognizing choices collective structural actions needed tandem. Ultimately, meaningful will depend placing greater emphasis psychological cultural dimensions such as mindfulness, values, moral wisdom ensure sustainable resilient future.

Language: Английский

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Research gaps and opportunities in precision nutrition: an NIH workshop report

American Journal of Clinical Nutrition, Journal Year: 2022, Volume and Issue: 116(6), P. 1877 - 1900

Published: Aug. 30, 2022

Language: Английский

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Human microbiome variation associated with race and ethnicity emerges as early as 3 months of age

PLoS Biology, Journal Year: 2023, Volume and Issue: 21(8), P. e3002230 - e3002230

Published: Aug. 17, 2023

Human microbiome variation is linked to the incidence, prevalence, and mortality of many diseases associates with race ethnicity in United States. However, age at which variability emerges between these groups remains a central gap knowledge. Here, we identify that gut associated arises after 3 months persists through childhood. One-third bacterial taxa vary across caregiver-identified racial categories children are reported also adults. Machine learning modeling childhood microbiomes from 8 cohort studies (2,756 samples 729 children) distinguishes ethnic 87% accuracy. Importantly, predictive genera among top 30 most important when used predict adult self-identified ethnicity. Our results highlight critical developmental window or shortly social environmental factors drive ethnicity-associated may contribute health disparities.

Language: Английский

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