Cell Host & Microbe, Journal Year: 2022, Volume and Issue: 30(10), P. 1464 - 1480.e6
Published: Sept. 12, 2022
Language: Английский
Archives of Biochemistry and Biophysics, Journal Year: 2024, Volume and Issue: 761, P. 110172 - 110172
Published: Oct. 4, 2024
Language: Английский
Citations
7
Frontiers in Science, Journal Year: 2024, Volume and Issue: 2
Published: May 23, 2024
The COVID-19 pandemic accelerated research and innovation across numerous fields of medicine. It emphasized how disease concepts must reflect dynamic heterogeneous interrelationships between physical characteristics, genetics, co-morbidities, environmental exposures, socioeconomic determinants health throughout life. This article explores scientists other stakeholders collaborate in novel, interdisciplinary ways at these new frontiers medicine, focusing on communicable diseases, precision/personalized systems data science. highlighted the critical protective role vaccines against current emerging threats. Radical efficiency gains vaccine development (through mRNA technologies, public private investment, regulatory measures) be leveraged future together with continued area monoclonal antibodies, novel antimicrobials, multisectoral, international action diseases. Inter-individual heterogeneity pathophysiology prompted targeted therapeutics. Beyond COVID-19, medicine will become increasingly personalized via advanced omics-based technologies biology—for example targeting gut microbiome specific mechanisms underlying immunoinflammatory diseases genetic conditions. Modeling proved to strengthening risk assessment supporting decision-making. Advanced computational analytics artificial intelligence (AI) may help integrate epidemic modeling, clinical features, genomics, immune factors, data, anthropometric measures into a “systems medicine” approach. also digital giving telehealth therapeutics roles system resilience patient care. New methods employed during including decentralized trials, could benefit evidence generation decision-making more widely. In conclusion, shaped by multistakeholder collaborations that address complex molecular, clinical, social interrelationships, fostering precision while improving health. Open science, innovative partnerships, patient-centricity key success.
Language: Английский
Citations
6
The World Journal of Men s Health, Journal Year: 2022, Volume and Issue: 40(3), P. 517 - 517
Published: Jan. 1, 2022
In males, testosterone levels have been implicated in various diseases. Recently, the influence of gut microbial-derived compounds on host metabolism has become evident, and it suggested that some bacteria may be involved metabolism. present study, we examined relationship between microbiota elderly Japanese men.
Language: Английский
Citations
28
Acta Biochimica et Biophysica Sinica, Journal Year: 2022, Volume and Issue: 54(10), P. 1406 - 1420
Published: Sept. 21, 2022
The role of gut-kidney crosstalk in the progression diabetic nephropathy (DN) is receiving increasing concern. On one hand, decline renal function increases circulating uremic toxins and affects composition gut microbiota. other intestinal dysbiosis destroys epithelial barrier, leading to increased exposure endotoxins, thereby exacerbating kidney damage by inducing systemic inflammation. Dietary inventions, such as higher fiber intake, prebiotics, probiotics, postbiotics, fecal microbial transplantation (FMT), engineering bacteria phages, are potential microbiota-based therapies for DN. Furthermore, novel agents, glucagon-like peptide-1 (GLP-1) receptor agonists, dipeptidyl peptidase-4 (DPP-4) inhibitors, sodium-dependent glucose transporter-2 (SGLT-2) may affect DN partly through In current review, we mainly summarize evidence concerning axis advancement discuss targeting microbiota, expecting provide new insight into clinical treatment
Language: Английский
Citations
27
Cell Host & Microbe, Journal Year: 2022, Volume and Issue: 30(10), P. 1464 - 1480.e6
Published: Sept. 12, 2022
Language: Английский
Citations
25