Long-term cardiovascular outcomes of COVID-19

Nature Medicine, Journal Year: 2022, Volume and Issue: 28(3), P. 583 - 590

Published: Feb. 7, 2022

Abstract The cardiovascular complications of acute coronavirus disease 2019 (COVID-19) are well described, but the post-acute manifestations COVID-19 have not yet been comprehensively characterized. Here we used national healthcare databases from US Department Veterans Affairs to build a cohort 153,760 individuals with COVID-19, as two sets control cohorts 5,637,647 (contemporary controls) and 5,859,411 (historical individuals, estimate risks 1-year burdens set pre-specified incident outcomes. We show that, beyond first 30 d after infection, at increased risk spanning several categories, including cerebrovascular disorders, dysrhythmias, ischemic non-ischemic heart disease, pericarditis, myocarditis, failure thromboembolic disease. These were evident even among who hospitalized during phase infection in graded fashion according care setting (non-hospitalized, admitted intensive care). Our results provide evidence that burden survivors substantial. Care pathways those surviving episode should include attention health

Language: Английский

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Long-term neurologic outcomes of COVID-19

Nature Medicine, Journal Year: 2022, Volume and Issue: 28(11), P. 2406 - 2415

Published: Sept. 22, 2022

Abstract The neurologic manifestations of acute COVID-19 are well characterized, but a comprehensive evaluation postacute sequelae at 1 year has not been undertaken. Here we use the national healthcare databases US Department Veterans Affairs to build cohort 154,068 individuals with COVID-19, 5,638,795 contemporary controls and 5,859,621 historical controls; inverse probability weighting balance cohorts, estimate risks burdens incident disorders 12 months following SARS-CoV-2 infection. Our results show that in phase there was increased risk an array including ischemic hemorrhagic stroke, cognition memory disorders, peripheral nervous system episodic (for example, migraine seizures), extrapyramidal movement mental health musculoskeletal sensory Guillain–Barré syndrome, encephalitis or encephalopathy. We estimated hazard ratio any sequela 1.42 (95% confidence intervals 1.38, 1.47) burden 70.69 63.54, 78.01) per 1,000 persons months. were elevated even people who did require hospitalization during COVID-19. Limitations include comprising mostly White males. Taken together, our provide evidence long-term had

Language: Английский

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The landscape of mRNA nanomedicine

Nature Medicine, Journal Year: 2022, Volume and Issue: 28(11), P. 2273 - 2287

Published: Nov. 1, 2022

Language: Английский

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Unraveling the Mystery Surrounding Post-Acute Sequelae of COVID-19

Frontiers in Immunology, Journal Year: 2021, Volume and Issue: 12

Published: June 30, 2021

More than one year since its emergence, corona virus disease 2019 (COVID-19) is still looming large with a paucity of treatment options. To add to this burden, sizeable subset patients who have recovered from acute COVID-19 infection reported lingering symptoms, leading significant disability and impairment their daily life activities. These are considered suffer what has been termed as “chronic” or “long” form post-acute sequelae COVID-19, experiencing syndrome long-haulers. Despite recovery infection, the persistence atypical chronic including extreme fatigue, shortness breath, joint pains, brain fogs, anxiety depression, that could last for months implies an underlying pathology persist beyond presentation disease. As opposed direct effects itself, immune response severe respiratory coronavirus 2 (SARS-CoV-2) believed be largely responsible appearance these lasting possibly through facilitating ongoing inflammatory process. In review, we hypothesize potential immunological mechanisms persistent prolonged effects, describe multi-organ long-term manifestations COVID-19.

Language: Английский

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Long COVID following Mild SARS-CoV-2 Infection: Characteristic T Cell Alterations and Response to Antihistamines

Journal of Investigative Medicine, Journal Year: 2021, Volume and Issue: 70(1), P. 61 - 67

Published: Oct. 5, 2021

Long COVID is characterized by the emergence of multiple debilitating symptoms following SARS-CoV-2 infection. Its etiology unclear and it often follows a mild acute illness. Anecdotal reports gradual clinical responses to histamine receptor antagonists (HRAs) suggest histamine-dependent mechanism that distinct from anaphylaxis, possibly mediated T cells, which are also regulated histamine. cell perturbations have been previously reported in post-viral syndromes, but landscape patients who recovered COVID-19 its relationship both long any symptomatic response HRA remain underexplored. We addressed these questions an observational study 65 individuals had COVID-19. Participants were surveyed between 87 408 days after onset symptoms; none required hospitalization, 16 uneventfully, 49 developed COVID. Symptoms quantified using structured questionnaire subsets enumerated standard diagnostic assay. Patients with long-COVID reduced CD4+ CD8+ effector memory (EM) numbers increased PD-1 (programmed death protein 1) expression on central (CM) whereas asymptomatic participants EM cells only CD28 CM cells. 72% received improvement, although profiling did not clearly distinguish those responded HRA. This demonstrates persist for several months associated symptoms.

Language: Английский

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Intracellular Reverse Transcription of Pfizer BioNTech COVID-19 mRNA Vaccine BNT162b2 In Vitro in Human Liver Cell Line

Current Issues in Molecular Biology, Journal Year: 2022, Volume and Issue: 44(3), P. 1115 - 1126

Published: Feb. 25, 2022

Preclinical studies of COVID-19 mRNA vaccine BNT162b2, developed by Pfizer and BioNTech, showed reversible hepatic effects in animals that received the BNT162b2 injection. Furthermore, a recent study SARS-CoV-2 RNA can be reverse-transcribed integrated into genome human cells. In this study, we investigated effect on liver cell line Huh7 vitro. cells were exposed to quantitative PCR was performed extracted from We detected high levels changes gene expression long interspersed nuclear element-1 (LINE-1), which is an endogenous reverse transcriptase. Immunohistochemistry using antibody binding LINE-1 open reading frame-1 RNA-binding protein (ORFp1) treated with indicated increased nucleus distribution LINE-1. genomic DNA amplified sequence unique BNT162b2. Our results indicate fast up-take Huh7, leading distribution. also show transcribed intracellularly as 6 h upon exposure.

Language: Английский

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COVID-19 and its long-term sequelae: what do we know in 2023?

Polskie Archiwum Medycyny Wewnętrznej, Journal Year: 2023, Volume and Issue: unknown

Published: Jan. 9, 2023

Post‑viral syndrome is a well‑known medical condition characterized by different levels of physical, cognitive, and emotional impairment that may persist with fluctuating severity after recovering from an acute viral infection. Unsurprisingly, COVID‑19 also be accompanied medium- long‑term clinical sequelae SARS‑CoV‑2 Although many definitions have been provided, "long‑COVID" can defined as occurring in patients history infection, developing 3 months the symptoms onset, persisting for at least 2 months, not explained alternative diagnoses. According to recent global analyses, cumulative prevalence long‑COVID seems range between 9% 63%, up 6‑fold higher than similar postviral infection conditions. Long‑COVID primarily encompasses presence 1 symptom, such fatigue, dyspnea, cognitive / brain fog, postexertional malaise, memory issues, musculoskeletal pain spasms, cough, sleep disturbances, tachycardia palpitations, altered smell taste perception, headache, chest pain, depression. The most important demographic predictors date are female sex, older age, cigarette smoking, pre‑existing conditions, lack vaccination, pre‑Omicron variants, number phase symptoms, load, severe critical illness, well invasive mechanical ventilation. Concerning care patients, greatest challenge fact this cannot considered single entity, thus it needs integrated multidisciplinary management, specifically tailored type symptoms.

Language: Английский

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A split prime editor with untethered reverse transcriptase and circular RNA template

Nature Biotechnology, Journal Year: 2022, Volume and Issue: 40(9), P. 1388 - 1393

Published: April 4, 2022

Language: Английский

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Persistent post–COVID-19 smell loss is associated with immune cell infiltration and altered gene expression in olfactory epithelium

Science Translational Medicine, Journal Year: 2022, Volume and Issue: 14(676)

Published: Dec. 21, 2022

SARS-CoV-2 causes profound changes in the sense of smell, including total smell loss. Although these alterations are often transient, many patients with COVID-19 exhibit olfactory dysfunction that lasts months to years. animal and human autopsy studies have suggested mechanisms driving acute anosmia, it remains unclear how persistent loss a subset patients. To address this question, we analyzed epithelial samples collected from 24 biopsies, nine objectively quantified long-term after COVID-19. This biopsy-based approach revealed diffuse infiltrate T cells expressing interferon-γ shift myeloid cell population composition, enrichment CD207+ dendritic depletion anti-inflammatory M2 macrophages. Despite absence detectable RNA or protein, gene expression barrier supporting epithelium, termed sustentacular cells, appeared reflect response ongoing inflammatory signaling, which was accompanied by reduction number sensory neurons relative cells. These findings indicate cell-mediated inflammation persists epithelium long has been eliminated tissue, suggesting mechanism for post-COVID-19

Language: Английский

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Long Covid: where we stand and challenges ahead

Cell Death and Differentiation, Journal Year: 2022, Volume and Issue: unknown

Published: Sept. 7, 2022

Abstract Post-acute sequelae of SARS-CoV-2 (PASC), also known as Post-Covid Syndrome, and colloquially Long Covid, has been defined a constellation signs symptoms which persist for weeks or months after the initial infection. PASC affects wide range diverse organs systems, with manifestations involving lungs, brain, cardiovascular system other such kidney neuromuscular system. The pathogenesis is complex multifactorial. Evidence suggests that seeding persistence in different organs, reactivation, response to unrelated viruses EBV, autoimmunity, uncontrolled inflammation are major drivers PASC. relative importance pathogenetic pathways may differ tissue organ contexts. vaccination, addition protecting against disease, reduces breakthrough infection although its actual impact remains be defined. represents formidable challenge health care systems dissecting mechanisms pave way targeted preventive therapeutic approaches.

Language: Английский

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