International Journal of Infectious Diseases, Journal Year: 2023, Volume and Issue: 130, P. 108 - 125
Published: Feb. 1, 2023
Herpesviruses are ubiquitous and after primary infection they establish lifelong latency. The impairment of maintaining latency with short-term or long-term consequences could be triggered by other infection. Therefore, reactivation herpesviruses in COVID-19 patients represents an emerging issue.
Language: Английский
Cell, Journal Year: 2022, Volume and Issue: 185(5), P. 881 - 895.e20
Published: Jan. 25, 2022
Post-acute sequelae of COVID-19 (PASC) represent an emerging global crisis. However, quantifiable risk factors for PASC and their biological associations are poorly resolved. We executed a deep multi-omic, longitudinal investigation 309 patients from initial diagnosis to convalescence (2-3 months later), integrated with clinical data patient-reported symptoms. resolved four PASC-anticipating at the time diagnosis: type 2 diabetes, SARS-CoV-2 RNAemia, Epstein-Barr virus viremia, specific auto-antibodies. In gastrointestinal PASC, SARS-CoV-2-specific CMV-specific CD8+ T cells exhibited unique dynamics during recovery COVID-19. Analysis symptom-associated immunological signatures revealed coordinated immunity polarization into endotypes, exhibiting divergent acute severity PASC. find that between diminish over time, leading distinct convalescent immune states. Detectability most emphasizes importance early disease measurements understanding emergent chronic conditions suggests treatment strategies.
Language: Английский
Citations
911
Clinical Microbiology and Infection, Journal Year: 2022, Volume and Issue: 28(5), P. 657 - 666
Published: Feb. 3, 2022
Language: Английский
Citations
445
Med, Journal Year: 2022, Volume and Issue: 3(6), P. 371 - 387.e9
Published: April 13, 2022
Language: Английский
Citations
336
Therapeutic Advances in Chronic Disease, Journal Year: 2022, Volume and Issue: 13
Published: Jan. 1, 2022
Accumulating evidence points toward a very high prevalence of prolonged neurological symptoms among coronavirus disease 2019 (COVID-19) survivors. To date, there are no solidified criteria for 'long-COVID' diagnosis. Nevertheless, is conceptualized as multi-organ disorder with wide spectrum clinical manifestations that may be indicative underlying pulmonary, cardiovascular, endocrine, hematologic, renal, gastrointestinal, dermatologic, immunological, psychiatric, or disease. Involvement the central peripheral nervous system noted in more than one-third patients antecedent severe acute respiratory syndrome 2 (SARS-CoV-2) infection, while an approximately threefold higher incidence recorded observational studies including patient-reported data. The most frequent encompass fatigue; 'brain fog'; headache; cognitive impairment; sleep, mood, smell, taste disorders; myalgias; sensorimotor deficits; and dysautonomia. Although limited exists to date on pathophysiological mechanisms implicated manifestation 'long-COVID', neuroinflammatory oxidative stress processes thought prevail propagating sequelae. In this narrative review, we sought present comprehensive overview our current understanding features, risk factors, Moreover, propose diagnostic therapeutic algorithms aid prompt recognition management causes persist beyond resolution COVID-19. Furthermore, causal treatments currently unavailable, approaches symptom-oriented symptoms. addition, emphasize collaborative research initiatives urgently needed expedite development preventive strategies
Language: Английский
Citations
222
The Lancet Diabetes & Endocrinology, Journal Year: 2021, Volume and Issue: 9(11), P. 786 - 798
Published: Oct. 6, 2021
Language: Английский
Citations
211
Cell Death and Differentiation, Journal Year: 2022, Volume and Issue: unknown
Published: Sept. 7, 2022
Abstract Post-acute sequelae of SARS-CoV-2 (PASC), also known as Post-Covid Syndrome, and colloquially Long Covid, has been defined a constellation signs symptoms which persist for weeks or months after the initial infection. PASC affects wide range diverse organs systems, with manifestations involving lungs, brain, cardiovascular system other such kidney neuromuscular system. The pathogenesis is complex multifactorial. Evidence suggests that seeding persistence in different organs, reactivation, response to unrelated viruses EBV, autoimmunity, uncontrolled inflammation are major drivers PASC. relative importance pathogenetic pathways may differ tissue organ contexts. vaccination, addition protecting against disease, reduces breakthrough infection although its actual impact remains be defined. represents formidable challenge health care systems dissecting mechanisms pave way targeted preventive therapeutic approaches.
Language: Английский
Citations
100
Virology Journal, Journal Year: 2022, Volume and Issue: 19(1)
Published: Oct. 9, 2022
Most COVID-19 patients recovered with low mortality; however, some experienced long-term symptoms described as "long-COVID" or "Post-COVID syndrome" (PCS). Patients may have persisting for weeks after acute SARS-CoV-2 infection, including dyspnea, fatigue, myalgia, insomnia, cognitive and olfactory disorders. These last months in patients. PCS progress association the development of mast cell activation syndrome (MCAS), which is a distinct kind disorder, characterized by hyper-activation cells inappropriate excessive release chemical mediators. survivors, mainly women, persistent severe fatigue 10 recovery history neuropsychiatric disorders are more prone to develop PCS. High D-dimer levels blood urea nitrogen were observed be risk factors associated pulmonary dysfunction survivors 3 post-hospital discharge has systemic manifestations that resolve time no further complications. However, final outcomes chiefly unknown. Persistence inflammatory reactions, autoimmune mimicry, reactivation pathogens together host microbiome alterations contribute The deregulated mediators MCAS produces extraordinary during course infection correlated severity Therefore, treated antihistamines, inhibition synthesis mediators, mediator release, degranulation cells.
Language: Английский
Citations
96
PLoS Biology, Journal Year: 2022, Volume and Issue: 20(6), P. e3001687 - e3001687
Published: June 1, 2022
DNA viruses often persist in the body of their host, becoming latent and recurring many months or years later. By contrast, most RNA cause acute infections that are cleared from host as they lack mechanisms to persist. However, it is clear viral can after clinical recovery elimination detectable infectious virus. This persistence either be asymptomatic associated with late progressive disease nonspecific lingering symptoms, such may case following infection Ebola Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Why does sometimes an infection? Where come from? And what consequences?
Language: Английский
Citations
80
JAMA Network Open, Journal Year: 2023, Volume and Issue: 6(1), P. e2251360 - e2251360
Published: Jan. 18, 2023
Importance Understanding the factors associated with post-COVID conditions is important for prevention. Objective To identify characteristics persistent post–COVID-19 symptoms and to describe medical encounters. Design, Setting, Participants This cohort study used data from Epidemiology, Immunology, Clinical Characteristics of Emerging Infectious Diseases With Pandemic Potential (EPICC) implemented in US military health system (MHS); MHS beneficiaries aged 18 years or older who tested positive SARS-CoV-2 February 28, 2020, through December 31, 2021, were analyzed, 1-year follow-up. Exposures infection. Main Outcomes Measures The outcomes analyzed included survey-reported 6 months after infection International Statistical Classification Related Health Problems, Tenth Revision diagnosis categories reported records following vs 3 before Results More than half 1832 participants these analyses 44 (1226 [66.9%]; mean [SD] age, 40.5 [13.7] years), male (1118 [61.0%]), unvaccinated at time their (1413 [77.1%]), had no comorbidities (1290 [70.4%]). A total 728 (39.7%) illness that lasted 28 days longer (28-89 days: 364 [19.9%]; ≥90 [19.9%]). prior (risk ratio [RR], 1.39; 95% CI, 1.04-1.85), moderate (RR, 1.80; 1.47-2.22) severe 2.25; 1.80-2.81) initial illnesses, more hospitalized (RR per each day hospitalization, 1.02; 1.00-1.03), a Charlson Comorbidity Index score 5 greater 1.55; 1.01-2.37) likely report symptoms. Among participants, postinfection vaccination was 41% lower risk reporting 0.59; 0.40-0.89). higher pulmonary 2.00; 1.40-2.84), diabetes 1.46; 1.00-2.13), neurological 1.29; 1.02-1.64), mental health–related encounters 1.28; 1.01-1.62) symptom onset baseline (before infection). Conclusions Relevance In this study, acute illness, score, being COVID-19 lasting more. seek care diabetes, pulmonary, neurological, least compared pre-COVID use patterns. These findings may inform risk-benefit policy.
Language: Английский
Citations
65
Multiple Sclerosis and Related Disorders, Journal Year: 2021, Volume and Issue: 55, P. 103268 - 103268
Published: Sept. 17, 2021
SARS-COV- 2 is now recognized to be responsible not only for a lung condition but multi-organ syndrome (Ramakrishnan et al., 2021). After the initial acute infection, like many other viral disorders, multitude of long-lasting symptoms have been described. Although widely discussed in social media evidence around this new scarce. A provisional definition would persistent and potential sequelae beyond four weeks from onset, which main features are breathlessness, cognitive impairment, fatigue, anxiety depression
Language: Английский
Citations
97