Global Prevalence of Post-Coronavirus Disease 2019 (COVID-19) Condition or Long COVID: A Meta-Analysis and Systematic Review

The Journal of Infectious Diseases, Journal Year: 2022, Volume and Issue: 226(9), P. 1593 - 1607

Published: April 14, 2022

Abstract Background This study aims to examine the worldwide prevalence of post-coronavirus disease 2019 (COVID-19) condition, through a systematic review and meta-analysis. Methods PubMed, Embase, iSearch were searched on July 5, 2021 with verification extending March 13, 2022. Using random-effects framework DerSimonian-Laird estimator, we meta-analyzed post-COVID-19 condition at 28+ days from infection. Results Fifty studies included, 41 meta-analyzed. Global estimated pooled was 0.43 (95% confidence interval [CI], .39–.46). Hospitalized nonhospitalized patients had estimates 0.54 CI, .44–.63) 0.34 .25–.46), respectively. Regional Asia (0.51; 95% .37–.65), Europe (0.44; .32–.56), United States America (0.31; .21–.43). for 30, 60, 90, 120 after infection be 0.37 .26–.49), 0.25 .15–.38), 0.32 .14–.57), 0.49 .40–.59), Fatigue most common symptom reported 0.23 .17–.30), followed by memory problems (0.14; .10–.19). Conclusions finds is substantial; health effects COVID-19 seem prolonged can exert stress healthcare system.

Language: Английский

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Human genetic and immunological determinants of critical COVID-19 pneumonia

Nature, Journal Year: 2022, Volume and Issue: 603(7902), P. 587 - 598

Published: Jan. 28, 2022

Language: Английский

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Post-acute sequelae of covid-19 six to 12 months after infection: population based study

BMJ, Journal Year: 2022, Volume and Issue: unknown, P. e071050 - e071050

Published: Oct. 13, 2022

Abstract Objectives To describe symptoms and symptom clusters of post-covid syndrome six to 12 months after acute infection, risk factors, examine the association with general health working capacity. Design Population based, cross sectional study Setting Adults aged 18-65 years confirmed SARS-CoV-2 infection between October 2020 March 2021 notified authorities in four geographically defined regions southern Germany. Participants 50 457 patients were invited participate study, whom 053 (24%) responded 11 710 (58.8% (n=6881) female; mean age 44.1 years; 3.6% (412/11 602) previously admitted covid-19; follow-up time 8.5 months) could be included analyses. Main outcome measures Symptom frequencies (six versus before infection), severity clustering, associations recovery Results The fatigue (37.2% (4213/11 312), 95% confidence interval 36.4% 38.1%) neurocognitive impairment (31.3% (3561/11 361), 30.5% 32.2%) contributed most reduced capacity, but chest symptoms, anxiety/depression, headache/dizziness, pain syndromes also prevalent relevant for some differences according sex age. Considering new at least moderate daily life ≤80% recovered or overall estimate was 28.5% (3289/11 536, 27.7% 29.3%) among participants 6.5% (3289/50 457) infected adult population (assuming that all non-responders had completely recovered). true value is likely these estimates. Conclusions Despite limitation a low response rate possible selection recall biases, this suggests considerable burden self-reported post-acute sequelae, notably impairment, even young middle adults mild substantial impact on Trial registration German registry clinical studies DRKS 00027012.

Language: Английский

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An analysis of 45 large-scale wastewater sites in England to estimate SARS-CoV-2 community prevalence

Nature Communications, Journal Year: 2022, Volume and Issue: 13(1)

Published: July 25, 2022

Accurate surveillance of the COVID-19 pandemic can be weakened by under-reporting cases, particularly due to asymptomatic or pre-symptomatic infections, resulting in bias. Quantification SARS-CoV-2 RNA wastewater used infer infection prevalence, but uncertainty sensitivity and considerable variability has meant that accurate measurement remains elusive. Here, we use data from 45 sewage sites England, covering 31% population, estimate prevalence within 1.1% estimates representative surveys (with 95% confidence). Using machine learning phenomenological models, show differences between sampled sites, flow rate, influence estimation require careful interpretation. We find signals appear 4-5 days earlier comparison clinical testing are coincident with suggesting a leading indicator for symptomatic viral infections. Surveillance viruses complements strengthens surveillance, significant implications public health.

Language: Английский

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Global SARS-CoV-2 genomic surveillance: What we have learned (so far)

Infection Genetics and Evolution, Journal Year: 2023, Volume and Issue: 108, P. 105405 - 105405

Published: Jan. 18, 2023

The COVID-19 pandemic has brought significant challenges for genomic surveillance strategies in public health systems worldwide. During the past thirty-four months, many countries faced several epidemic waves of SARS-CoV-2 infections, driven mainly by emergence and spread novel variants. In that line, been a crucial toolkit to study real-time evolution, assessment optimization diagnostic assays, improve efficacy existing vaccines. pandemic, identification emerging lineages carrying lineage-specific mutations (particularly those Receptor Binding domain) showed how these might significantly impact viral transmissibility, protection from reinfection vaccination. So far, an unprecedented number genomes released databases (i.e., GISAID, NCBI), achieving 14 million genome sequences available as early-November 2022. present review, we summarise global landscape during first months circulation evolution. It demonstrates urgency importance sustained investment timely identify any potential pathogen or associated variants, which turn is key preparedness.

Language: Английский

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Wastewater-based prediction of COVID-19 cases using a highly sensitive SARS-CoV-2 RNA detection method combined with mathematical modeling

Environment International, Journal Year: 2023, Volume and Issue: 173, P. 107743 - 107743

Published: Jan. 7, 2023

Wastewater-based epidemiology (WBE) has the potential to predict COVID-19 cases; however, reliable methods for tracking SARS-CoV-2 RNA concentrations (C

Language: Английский

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The immunology of asymptomatic SARS-CoV-2 infection: what are the key questions?

Nature reviews. Immunology, Journal Year: 2021, Volume and Issue: 21(12), P. 762 - 768

Published: Oct. 19, 2021

An important challenge during the COVID-19 pandemic has been to understand asymptomatic disease and extent which this may be a source of transmission. As is by definition hard screen for, there lack clarity about aspect spectrum. Studies have considered whether prevalence determined differences in age, demographics, viral load, duration shedding, magnitude or durability immunity. It clear that adaptive immunity strongly activated infection, but some features T cell antibody response differ from those symptomatic disease. Areas need greater include leads persistent symptoms (long COVID), quality, quantity immune priming required confer subsequent protection. Individuals with can transmit virus at risk long-term In Progress article, Boyton Altman present current insights into responses SARS-CoV-2 infection discuss relevance for public health strategies.

Language: Английский

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SARS-CoV-2 RNA is enriched by orders of magnitude in primary settled solids relative to liquid wastewater at publicly owned treatment works

Environmental Science Water Research & Technology, Journal Year: 2022, Volume and Issue: 8(4), P. 757 - 770

Published: Jan. 1, 2022

We compared SARS-CoV-2 RNA concentrations in primary settled solids and raw wastewater samples matched date to investigate the relationship between two matrices.

Language: Английский

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Potential Autoimmunity Resulting from Molecular Mimicry between SARS-CoV-2 Spike and Human Proteins

Viruses, Journal Year: 2022, Volume and Issue: 14(7), P. 1415 - 1415

Published: June 28, 2022

Molecular mimicry between viral antigens and host proteins can produce cross-reacting antibodies leading to autoimmunity. The coronavirus SARS-CoV-2 causes COVID-19, a disease curiously resulting in varied symptoms outcomes, ranging from asymptomatic fatal. Autoimmunity due molecular may provide an explanation. Thus, we computationally investigated Spike known epitopes. We discovered hotspots highlight two examples with tentative high autoimmune potential implications for understanding COVID-19 complications. show that TQLPP motif thrombopoietin shares similar antibody binding properties. Antibodies induce thrombocytopenia, condition observed patients. Another motif, ELDKY, is shared multiple human proteins, such as PRKG1 involved platelet activation calcium regulation, tropomyosin, which linked cardiac disease. tropomyosin cause complications blood-clotting disorders disease, respectively. Our findings illuminate pathogenesis the importance of considering when developing therapeutic interventions reduce adverse reactions.

Language: Английский

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Occurrence and transmission potential of asymptomatic and presymptomatic SARS-CoV-2 infections: Update of a living systematic review and meta-analysis

PLoS Medicine, Journal Year: 2022, Volume and Issue: 19(5), P. e1003987 - e1003987

Published: May 26, 2022

Debate about the level of asymptomatic Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection continues. The amount evidence is increasing and study designs have changed over time. We updated a living systematic review to address 3 questions: (1) Among people who become infected with SARS-CoV-2, what proportion does not experience symptoms at all during their infection? (2) What infectiousness presymptomatic, compared symptomatic, SARS-CoV-2 (3) transmission in population accounted for by are or presymptomatic?

Language: Английский

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