Human autoantibodies neutralizing type I IFNs: From 1981 to 2023 DOI Creative Commons
Paul Bastard, Adrian Gervais, Tom Le Voyer

et al.

Immunological Reviews, Journal Year: 2024, Volume and Issue: 322(1), P. 98 - 112

Published: Jan. 9, 2024

Summary Human autoantibodies (auto‐Abs) neutralizing type I IFNs were first discovered in a woman with disseminated shingles and described by Ion Gresser from 1981 to 1984. They have since been found patients diverse conditions are even used as diagnostic criterion autoimmune polyendocrinopathy syndrome 1 (APS‐1). However, their apparent lack of association viral diseases, including shingles, led wide acceptance the conclusion that they had no pathological consequences. This perception began change 2020, when underlie about 15% cases critical COVID‐19 pneumonia. shown other severe 5%, 20%, 40% influenza pneumonia, MERS West Nile virus encephalitis, respectively. also seem be associated various settings. These auto‐Abs present all age groups general population, but frequency increases reach at least 5% elderly. We estimate 100 million people worldwide carry IFNs. Here, we briefly review history study these auto‐Abs, focusing particularly on known causes

Language: Английский

The IL-1β, IL-6, and TNF cytokine triad is associated with post-acute sequelae of COVID-19 DOI
Christoph Schultheiß, Edith Willscher, Lisa Paschold

et al.

Cell Reports Medicine, Journal Year: 2022, Volume and Issue: 3(6), P. 100663 - 100663

Published: June 1, 2022

Language: Английский

Citations

322
The risk of COVID-19 death is much greater and age dependent with type I IFN autoantibodies DOI Creative Commons
Jérémy Manry, Paul Bastard, Adrian Gervais

et al.

Proceedings of the National Academy of Sciences, Journal Year: 2022, Volume and Issue: 119(21)

Published: May 16, 2022

Significance There is growing evidence that preexisting autoantibodies neutralizing type I interferons (IFNs) are strong determinants of life-threatening COVID-19 pneumonia. It important to estimate their quantitative impact on mortality upon SARS-CoV-2 infection, by age and sex, as both the prevalence these risk death increase with higher in men. Using an unvaccinated sample 1,261 deceased patients 34,159 individuals from general population, we found against IFNs strongly increased infection fatality rate at all ages, men women. Autoantibodies common predictors COVID-19. Testing for should be considered population.

Language: Английский

Citations

160
A Review on Chikungunya Virus Epidemiology, Pathogenesis and Current Vaccine Development DOI Creative Commons

Thaíse Yasmine Vasconcelos de Lima Cavalcanti,

Mylena Ribeiro Pereira,

Sérgio Oliveira de Paula

et al.

Viruses, Journal Year: 2022, Volume and Issue: 14(5), P. 969 - 969

Published: May 5, 2022

Chikungunya virus (CHIKV) is a mosquito-borne alphavirus that recently re-emerged in many parts of the world causing large-scale outbreaks. CHIKV infection presents as febrile illness known chikungunya fever (CHIKF). Infection self-limited and characterized mainly by severe joint pain myalgia can last for weeks or months; however, disease presentation also occur minor proportion infections. Among atypical manifestations have been described, arthralgia neurological complications, such encephalitis, meningitis, Guillain-Barré Syndrome, are now reported Moreover, death cases were reported, placing relevant public health disease. Virus evolution, globalization, climate change may contributed to spread. In addition this, lack preventive vaccines approved antiviral treatments turning into major global threat. this review, we discuss current knowledge about pathogenesis, with focus on manifestations, persistent neurologic presentation. We bring an up-to-date review vaccine development. Altogether, these topics highlight some most recent advances our understanding pathogenesis provide important insights development clinical trials potential candidates.

Language: Английский

Citations

156
T Cell Responses to SARS-CoV-2 DOI
Alessandro Sette, John Sidney, Shane Crotty

et al.

Annual Review of Immunology, Journal Year: 2023, Volume and Issue: 41(1), P. 343 - 373

Published: Feb. 8, 2023

A large body of evidence generated in the last two and a half years addresses roles T cells SARS-CoV-2 infection following vaccination. Infection or vaccination induces multi-epitope CD4 CD8 cell responses with polyfunctionality. Early have been associated mild COVID-19 outcomes. In concert animal model data, these results suggest that while antibody are key to prevent infection, may also play valuable reducing disease severity controlling infection. memory after is sustained for at least six months. While neutralizing impacted by variants, most preserved. This review highlights extensive progress made, data knowledge gaps remain, our understanding vaccines.

Language: Английский

Citations

126
COVID-19 2022 update: transition of the pandemic to the endemic phase DOI Creative Commons
Michela Biancolella, Vito Luigi Colona, Ruty Mehrian‐Shai

et al.

Human Genomics, Journal Year: 2022, Volume and Issue: 16(1)

Published: June 1, 2022

Abstract COVID-19, which is caused by the SARS-CoV-2, has ravaged world for past 2 years. Here, we review current state of research into disease with focus on its history, human genetics and genomics transition from pandemic to endemic phase. We are particularly concerned lack solid information initial phases that highlighted necessity better preparation face similar future threats. On other hand, gratified progress genetic susceptibility investigations believe now time explore The latter will require worldwide vigilance cooperation, especially in emerging countries. In phase, vaccination rates have lagged developed countries should assist, as warranted, bolstering worldwide. also discuss status vaccines outlook COVID-19.

Language: Английский

Citations

120
The human genetic epidemiology of COVID-19 DOI Open Access
Mari Niemi, Mark J. Daly, Andrea Ganna

et al.

Nature Reviews Genetics, Journal Year: 2022, Volume and Issue: 23(9), P. 533 - 546

Published: May 2, 2022

Language: Английский

Citations

119
Studying severe long COVID to understand post-infectious disorders beyond COVID-19 DOI Open Access
Petter Brodin, Giorgio Casari, Liam Townsend

et al.

Nature Medicine, Journal Year: 2022, Volume and Issue: 28(5), P. 879 - 882

Published: April 5, 2022

Language: Английский

Citations

118
From rare disorders of immunity to common determinants of infection: Following the mechanistic thread DOI Creative Commons
Jean‐Laurent Casanova, Laurent Abel

Cell, Journal Year: 2022, Volume and Issue: 185(17), P. 3086 - 3103

Published: Aug. 1, 2022

The immense interindividual clinical variability during any infection is a long-standing enigma. Inborn errors of IFN-γ and IFN-α/β immunity underlying rare infections with weakly virulent mycobacteria seasonal influenza virus have inspired studies two common infections: tuberculosis COVID-19. A TYK2 genotype impairing production accounts for about 1% cases, autoantibodies neutralizing account 15% critical COVID-19 cases. discovery inborn mechanisms drove the identification monogenic or autoimmune determinants related infections. This “rare-to-common” genetic mechanistic approach to infectious diseases may be heuristic value.

Language: Английский

Citations

106
Human autoantibodies underlying infectious diseases DOI Creative Commons
Anne Puel, Paul Bastard, Jacinta Bustamante

et al.

The Journal of Experimental Medicine, Journal Year: 2022, Volume and Issue: 219(4)

Published: March 23, 2022

The vast interindividual clinical variability observed in any microbial infection—ranging from silent infection to lethal disease—is increasingly being explained by human genetic and immunological determinants. Autoantibodies neutralizing specific cytokines underlie the same infectious diseases as inborn errors of corresponding cytokine or response pathway. against type I IFNs COVID-19 pneumonia adverse reactions live attenuated yellow fever virus vaccine. II IFN severe disease caused environmental tuberculous mycobacteria, other intra-macrophagic microbes. IL-17A/F IL-6 are less common mucocutaneous candidiasis staphylococcal diseases, respectively. Inborn autoantibodies GM-CSF pulmonary alveolar proteinosis; associated infections well characterized. In individual patients, preexist with pathogen concerned disease. Human antibody-driven autoimmunity can interfere that essential for protective immunity agents but otherwise redundant, thereby underlying diseases.

Language: Английский

Citations

97
Recessive inborn errors of type I IFN immunity in children with COVID-19 pneumonia DOI Creative Commons
Qian Zhang, Daniela Matuozzo, Jérémie Le Pen

et al.

The Journal of Experimental Medicine, Journal Year: 2022, Volume and Issue: 219(8)

Published: June 16, 2022

Recessive or dominant inborn errors of type I interferon (IFN) immunity can underlie critical COVID-19 pneumonia in unvaccinated adults. The risk children, which is much lower than adults, remains unexplained. In an international cohort 112 children (<16 yr old) hospitalized for pneumonia, we report 12 (10.7%) aged 1.5–13 with (7 children), severe (3), and moderate (2) 4 the 15 known clinically recessive biochemically complete IFN immunity: X-linked TLR7 deficiency children) autosomal IFNAR1 (1), STAT2 TYK2 (3) deficiencies. Fibroblasts deficient IFNAR1, STAT2, are highly vulnerable to SARS-CoV-2. These deficiencies were not found 1,224 adults benign SARS-CoV-2 infection without (P = 1.2 × 10−11) overlapping age, sex, consanguinity, ethnicity characteristics. may ∼10% hospitalizations children.

Language: Английский

Citations

92