Axon arrival times and physical occupancy establish visual projection neuron integration on developing dendrites in the Drosophila optic glomeruli DOI Open Access
Brennan W. McFarland, HyoJong Jang, Natalie Smolin

et al.

Published: May 9, 2024

Behaviorally relevant, higher order representations of an animal’s environment are built from the convergence visual features encoded in early stages processing. Although developmental mechanisms that generate feature encoding channels circuits have been uncovered, relatively little is known about direct to enable appropriate integration into downstream circuits. Here we explore development a collision detection sensorimotor circuit Drosophila melanogaster , projection neurons (VPNs) onto dendrites large descending neuron, giant fiber (GF). We find VPNs different establish their respective territories on GF through sequential axon arrival during development. Physical occupancy, but not activity, important maintain territories. Ablation one VPN results expansion remaining and functional compensation enables retain responses ethologically relevant stimuli. observed using pupal electrophysiology preparation, appears after established, likely contributes later synapse assembly refinement. Our data highlight temporal for promote optic glomeruli, where connectivity resides, as powerful model investigating complex wiring programs plasticity.

Language: Английский

The language network as a natural kind within the broader landscape of the human brain DOI
Evelina Fedorenko, Anna A. Ivanova, Tamar I. Regev

et al.

Nature reviews. Neuroscience, Journal Year: 2024, Volume and Issue: 25(5), P. 289 - 312

Published: April 12, 2024

Language: Английский

Citations

75
Against cortical reorganisation DOI Creative Commons
Tamar R. Makin, John W. Krakauer

eLife, Journal Year: 2023, Volume and Issue: 12

Published: Nov. 21, 2023

Neurological insults, such as congenital blindness, deafness, amputation, and stroke, often result in surprising impressive behavioural changes. Cortical reorganisation, which refers to preserved brain tissue taking on a new functional role, is invoked account for these Here, we revisit many of the classical animal patient cortical remapping studies that spawned this notion reorganisation. We highlight empirical, methodological, conceptual problems call into doubt. argue appeal idea reorganisation attributable part way maps are empirically derived. Specifically, defined based oversimplified assumptions 'winner-takes-all', turn leads an erroneous interpretation what it means when appear change. Conceptually, interpreted circuit receiving novel input processing unrelated its original function. This implies neurons either pluripotent enough change they tuned or can computes. Instead more likely occur due potentiation pre-existing architecture already has requisite representational computational capacity pre-injury. be facilitated via Hebbian homeostatic plasticity mechanisms. Crucially, our revised framework proposes opportunities constrained throughout lifespan by underlying structural 'blueprint'. At no period, including early development, does cortex offer pluripotency. conclude distinct form plasticity, ubiquitously evoked with words 'take-over'' 'rewiring', not exist.

Language: Английский

Citations

63
A seat at the (language) table: incorporating the cerebellum into frameworks for language processing DOI Creative Commons
Amanda LeBel, Anila M. D’Mello

Current Opinion in Behavioral Sciences, Journal Year: 2023, Volume and Issue: 53, P. 101310 - 101310

Published: Sept. 15, 2023

Language: Английский

Citations

25
Visual word processing engages a hierarchical, distributed, and bilateral cortical network DOI Creative Commons
Raina Vin, Nicholas M. Blauch, David C. Plaut

et al.

iScience, Journal Year: 2024, Volume and Issue: 27(2), P. 108809 - 108809

Published: Jan. 6, 2024

Highlights•The visual word processing network is modulated bilaterally by textual stimulus type•The composed of three clusters arrayed on the posterior-anterior brain axis•VWFA emerges as a mediator between early vision and language clusters•Region-level stimulus-mediated modulation, but network-level stability, observedSummaryAlthough Visual Word Form Area (VWFA) in left temporal cortex considered pre-eminent region processing, other regions are also implicated. We examined entire text-selective circuit, using functional MRI. Ten interest (ROIs) per hemisphere were defined, which, based clustering, grouped into vision, high-level clusters. analyzed responses ROIs to words, inverted consonant strings univariate, multivariate, connectivity measures. Bilateral modulation condition was evident, with stronger effect regions. Last, graph theory, we observed that VWFA equivalently connected both hemispheres, reflecting its role circuit. Although individual flexibly altered nature input, stability held at level global circuit connectivity, complex hierarchical distributed system serving text perception.Graphical abstract

Language: Английский

Citations

8
Ignoring the cerebellum is hindering progress in neuroscience DOI
Bangjie Wang, Amanda LeBel, Anila M. D’Mello

et al.

Trends in Cognitive Sciences, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

Citations

1
Functional and structural brain asymmetries in language processing DOI
Patrick C. Trettenbrein, Angela D. Friederici

Handbook of clinical neurology, Journal Year: 2025, Volume and Issue: unknown, P. 269 - 287

Published: Jan. 1, 2025

Language: Английский

Citations

1
Precision fMRI reveals that the language network exhibits adult-like left-hemispheric lateralization by 4 years of age DOI Creative Commons
Ola Ozernov‐Palchik, Amanda O’Brien,

Elizabeth Jiachen Lee

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: May 15, 2024

Abstract Left hemisphere damage in adulthood often leads to linguistic deficits, but many cases of early leave processing preserved, and a functional language system can develop the right hemisphere. To explain this apparent equipotentiality two hemispheres for language, some have proposed that is bilateral during development only becomes left-lateralized with age. We examined lateralization using magnetic resonance imaging large pediatric cohorts (total n=273 children ages 4-16; n=107 adults). Strong, adult-level left-hemispheric (in activation volume response magnitude) was evident by age 4. Thus, although take over function brain damage, features do show protracted (magnitude strength inter-regional correlations network), left-hemisphere bias robustly present 4 years These results call alternative accounts language. Significance Statement Language most canonical shows strong hemispheric asymmetry adult brains. However, whether already lateralized left has long been debated, given leaves unimpaired. developmental trajectory large-scale datasets robust individual-subject fMRI approaches. found exhibits adult-like 4, other aspects neural infrastructure clear change between late childhood. findings challengethe claim

Language: Английский

Citations

5
A Weak Shadow of Early Life Language Processing Persists in the Right Hemisphere of the Mature Brain DOI Creative Commons
K. Martin, Anna Seydell‐Greenwald, Madison M. Berl

et al.

Neurobiology of Language, Journal Year: 2022, Volume and Issue: 3(3), P. 364 - 385

Published: Jan. 1, 2022

Studies of language organization show a striking change in cerebral dominance for over development: We begin life with left hemisphere (LH) bias processing, which is weaker than that adults and can be overcome if there LH injury. Over development this becomes stronger no longer reversed. Prior work has shown results from significant reduction the magnitude activation right (RH) regions compared to children. Here we investigate whether

Language: Английский

Citations

18
One right can make a left: sentence processing in the right hemisphere after perinatal stroke DOI
K. Martin, Anna Seydell‐Greenwald, Peter E. Turkeltaub

et al.

Cerebral Cortex, Journal Year: 2023, Volume and Issue: 33(23), P. 11257 - 11268

Published: Oct. 19, 2023

Abstract When brain regions that are critical for a cognitive function in adulthood irreversibly damaged at birth, what patterns of plasticity support the successful development an alternative location? Here we investigate consistency language organization right hemisphere (RH) after left (LH) perinatal stroke. We analyzed fMRI data collected during auditory sentence comprehension task on 14 people with large cortical LH arterial ischemic strokes (left stroke (LHPS) participants) and 11 healthy sibling controls using “top voxel” approach allowed us to compare same number active voxels across each participant controls. found (1) LHPS participants consistently recruited RH areas were mirror-image typical areas, (2) aligned better strongly activated typically developed brains control (when flipped images compared) than weakly areas. Our findings suggest processing may part depend recruiting arrangement frontotemporal reflective dominant LH.

Language: Английский

Citations

9
Insights on cognitive reorganization after hemispherectomy in Rasmussen’s encephalitis. A narrative review DOI

Anna Borne,

Marcela Perrone‐Bertolotti, Sarah Ferrand‐Sorbets

et al.

Reviews in the Neurosciences, Journal Year: 2024, Volume and Issue: 35(7), P. 747 - 774

Published: May 16, 2024

Rasmussen's encephalitis is a rare neurological pathology affecting one cerebral hemisphere, therefore, posing unique challenges. Patients may undergo hemispherectomy, surgical procedure after which cognitive development occurs in the isolated contralateral hemisphere. This situation provides an excellent opportunity to evaluate brain plasticity and recovery at hemispheric level. literature review synthesizes existing body of research on following hemispherectomy Rasmussen patients, considering domains modulatory factors that influence outcomes. While language function has traditionally been focus postoperative assessments, there growing acknowledgment need broaden scope investigation interaction with other consider scaffolding recovery. By synthesizing findings reported literature, we delineate how functions find support from right hemisphere left but also how, beyond language, global functioning affected. We highlight critical several outcomes, including timing baseline preoperative status, pointing early intervention as predictive better However, further specific studies are needed confirm this correlation. aims emphasize understanding mechanisms underlying specialization humans, particularly important for both clinical advancements. narrative underscores integrative approach based provide comprehensive reorganization patients hemispherectomy.

Language: Английский

Citations

3