Recent advances in nanoparticulate RNA delivery systems DOI Creative Commons
Jacob Witten, Yizong Hu, Róbert Langer

et al.

Proceedings of the National Academy of Sciences, Journal Year: 2024, Volume and Issue: 121(11)

Published: March 4, 2024

Nanoparticle-based RNA delivery has shown great progress in recent years with the approval of two mRNA vaccines for Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and a liver-targeted siRNA therapy. Here, we discuss preclinical clinical advancement new generations therapies along multiple axes. Improvements cargo design such as circularization data-driven untranslated region optimization can drive better expression. New materials discovery research driven improved to extrahepatic targets lung splenic immune cells, which could lead pulmonary gene therapy cancer vaccines, respectively. Other organs even specific cell types be targeted via conjugation small molecule ligands, antibodies, or peptides nanoparticles. Moreover, response any nanoparticle plays crucial role determining efficacy. Targeting increased immunogenicity without induction reactogenic side effects is while minimization important therapies. developments have addressed each these priorities. Last, range trials targeting diverse organs, types, diseases suggest some key advances that may play next wave

Language: Английский

mRNA-based cancer therapeutics DOI
Chuang LIU,

Qiangqiang Shi,

Xiangang Huang

et al.

Nature reviews. Cancer, Journal Year: 2023, Volume and Issue: 23(8), P. 526 - 543

Published: June 13, 2023

Language: Английский

Citations

219
Lipid Nanoparticle (LNP) Enables mRNA Delivery for Cancer Therapy DOI
Yan Zong, Yi Lin, Tuo Wei

et al.

Advanced Materials, Journal Year: 2023, Volume and Issue: 35(51)

Published: May 17, 2023

Abstract Messenger RNA (mRNA) has received great attention in the prevention and treatment of various diseases due to success coronavirus disease 2019 (COVID‐19) mRNA vaccines (Comirnaty Spikevax). To meet therapeutic purpose, it is required that must enter target cells express sufficient proteins. Therefore, development effective delivery systems necessary crucial. Lipid nanoparticle (LNP) represents a remarkable vehicle indeed accelerated applications humans, as several mRNA‐based therapies have already been approved or are clinical trials. In this review, focus on mRNA‐LNP‐mediated anticancer therapy. It summarizes main strategies mRNA‐LNP formulations, discusses representative approaches cancer, points out current challenges possible future directions research field. hoped these delivered messages can help further improve application technology cancer

Language: Английский

Citations

180
Targeting cancer with mRNA–lipid nanoparticles: key considerations and future prospects DOI Open Access
Edo Kon, Nitay Ad‐El, Inbal Hazan‐Halevy

et al.

Nature Reviews Clinical Oncology, Journal Year: 2023, Volume and Issue: 20(11), P. 739 - 754

Published: Aug. 16, 2023

Language: Английский

Citations

136
Nanomaterials in tumor immunotherapy: new strategies and challenges DOI Creative Commons
Xudong Zhu, Shenglong Li

Molecular Cancer, Journal Year: 2023, Volume and Issue: 22(1)

Published: June 13, 2023

Abstract Tumor immunotherapy exerts its anti-tumor effects by stimulating and enhancing immune responses of the body. It has become another important modality therapy with significant clinical efficacy advantages compared to chemotherapy, radiotherapy targeted therapy. Although various kinds tumor immunotherapeutic drugs have emerged, challenges faced in delivery these drugs, such as poor permeability low cell uptake rate, had prevented their widespread application. Recently, nanomaterials emerged a means for treatment different diseases due targeting properties, biocompatibility functionalities. Moreover, possess characteristics that overcome defects traditional immunotherapy, large drug loading capacity, precise easy modification, thus leading wide application immunotherapy. There are two main classes novel nanoparticles mentioned this review: organic (polymeric nanomaterials, liposomes lipid nanoparticles) inorganic (non-metallic metallic nanomaterials). Besides, fabrication method nanoparticles, Nanoemulsions, was also introduced. In summary, review article mainly discussed research progress based on past few years offers theoretical basis exploring strategies future.

Language: Английский

Citations

110
Managing the immune microenvironment of osteosarcoma: the outlook for osteosarcoma treatment DOI Creative Commons
Hailong Tian,

Jiangjun Cao,

Bowen Li

et al.

Bone Research, Journal Year: 2023, Volume and Issue: 11(1)

Published: Feb. 27, 2023

Osteosarcoma, with poor survival after metastasis, is considered the most common primary bone cancer in adolescents. Notwithstanding efforts of researchers, its five-year rate has only shown limited improvement, suggesting that existing therapeutic strategies are insufficient to meet clinical needs. Notably, immunotherapy certain advantages over traditional tumor treatments inhibiting metastasis. Therefore, managing immune microenvironment osteosarcoma can provide novel and valuable insight into multifaceted mechanisms underlying heterogeneity progression disease. Additionally, given advances nanomedicine, there exist many advanced nanoplatforms for enhanced satisfactory physiochemical characteristics. Here, we review classification, characteristics, functions key components osteosarcoma. This also emphasizes application, progress, prospects discusses several nanomedicine-based options enhance efficiency treatment. Furthermore, examine disadvantages standard present future perspectives immunotherapy.

Language: Английский

Citations

106
Circular RNA vaccine in disease prevention and treatment DOI Creative Commons
Dun Niu, Yaran Wu, Jiqin Lian

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2023, Volume and Issue: 8(1)

Published: Sept. 11, 2023

Abstract CircRNAs are a class of single-stranded RNAs with covalently linked head-to-tail topology. In the decades since its initial discovery, their biogenesis, regulation, and function have rapidly disclosed, permitting better understanding adoption them as new tools for medical applications. With development biotechnology molecular medicine, artificial circRNAs been engineered novel vaccines disease treatment prevention. Unlike linear mRNA vaccine which applications were limited by instability, inefficiency, innate immunogenicity, circRNA incorporate internal ribosome entry sites (IRESs) open reading frame (ORF) provides an improved approach to RNA-based vaccination safety, stability, simplicity manufacture, scalability. However, at early stage, optimization, delivery require further evaluation. this review, we comprehensively describe vaccine, including history superiority. We also summarize discuss current methodological research preparation, design, synthesis, purification. Finally, highlight options potential in diseases Considering unique high low protein/peptide-coding capacity special closed-loop construction, circRNA-based therapeutic platforms may superior application prospects broad range diseases.

Language: Английский

Citations

99
mRNA-based vaccines and therapeutics: an in-depth survey of current and upcoming clinical applications DOI Creative Commons
Yu‐Shiuan Wang,

Monika Kumari,

Guanhong Chen

et al.

Journal of Biomedical Science, Journal Year: 2023, Volume and Issue: 30(1)

Published: Oct. 7, 2023

mRNA-based drugs have tremendous potential as clinical treatments, however, a major challenge in realizing this drug class will promise to develop methods for safely delivering the bioactive agents with high efficiency and without activating immune system. With regard mRNA vaccines, researchers modified structure enhance its stability promote systemic tolerance of antigenic presentation non-inflammatory contexts. Still, delivery naked mRNAs is inefficient results low levels antigen protein production. As such, lipid nanoparticles been utilized improve protect cargo from extracellular degradation. This advance was milestone development vaccines dispelled skepticism about technology yield clinically approved medicines. Following resounding success COVID-19, many other proposed treatment variety diseases. review begins discussion modifications vehicles, well factors that influence administration routes. Then, we summarize applications discuss further key points pertaining preclinical targeting wide range Finally, latest market trends future drugs.

Language: Английский

Citations

74
Recent Advances in Nanomaterials-Based Targeted Drug Delivery for Preclinical Cancer Diagnosis and Therapeutics DOI Creative Commons
Harshita Tiwari, Nilesh Rai, Swati Singh

et al.

Bioengineering, Journal Year: 2023, Volume and Issue: 10(7), P. 760 - 760

Published: June 25, 2023

Nano-oncology is a branch of biomedical research and engineering that focuses on using nanotechnology in cancer diagnosis treatment. Nanomaterials are extensively employed the field oncology because their minute size ultra-specificity. A wide range nanocarriers, such as dendrimers, micelles, PEGylated liposomes, polymeric nanoparticles used to facilitate efficient transport anti-cancer drugs at target tumor site. Real-time labeling monitoring cells quantum dots essential for determining level therapy needed The drug targeted site either by passive or active means. Passive targeting makes use microenvironment enhanced permeability retention effect, while involves ligand-coated nanoparticles. Nanotechnology being diagnose early stage detecting cancer-specific biomarkers imaging. implication employs photoinduced nanosensitizers, reverse multidrug resistance, enabling delivery CRISPR/Cas9 RNA molecules therapeutic applications. However, despite recent advancements nano-oncology, there need delve deeper into domain designing applying improved diagnostics.

Language: Английский

Citations

69
Recent Advancement in mRNA Vaccine Development and Applications DOI Creative Commons

Nojoud AL Fayez,

Majed S. Nassar, Abdullah A. Alshehri

et al.

Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(7), P. 1972 - 1972

Published: July 18, 2023

Messenger RNA (mRNA) vaccine development for preventive and therapeutic applications has evolved rapidly over the last decade. The mRVNA proven efficacy in various applications, including infectious disease, immunotherapy, genetic disorders, regenerative medicine, cancer. Many mRNA vaccines have made it to clinical trials, a couple obtained FDA approval. This emerging approach several advantages conventional methods: safety; efficacy; adaptability; bulk production; cost-effectiveness. However, is worth mentioning that delivery target site vivo degradation thermal stability are boundaries can alter their outcomes. In this review, we shed light on different types of vaccines, mode action, process optimize overcome limitations. We also explored systems focusing nanoparticle-mediated vaccine. Generally, system plays vital role enhancing stability, biocompatibility, homing desired cells tissues. addition function as vehicle, they serve compartment shields protects molecules against physical, chemical, biological activities efficiency. Finally, focused future considerations should be attained safer more efficient application underlining disadvantages current vaccines.

Language: Английский

Citations

66
Recent advances in mRNA cancer vaccines: meeting challenges and embracing opportunities DOI Creative Commons
Bolin Wang,

Jinli Pei,

Shengnan Xu

et al.

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: Sept. 6, 2023

Since the successful application of messenger RNA (mRNA) vaccines in preventing COVID-19, researchers have been striving to develop mRNA for clinical use, including those exploited anti-tumor therapy. cancer emerged as a promising novel approach immunotherapy, offering high specificity, better efficacy, and fewer side effects compared traditional treatments. Multiple therapeutic are being evaluated preclinical trials, with early-phase results. However, development these faces various challenges, such tumor heterogeneity, an immunosuppressive microenvironment, practical obstacles like vaccine administration methods evaluation systems application. To address we highlight recent advances from studies trials that provide insight into identifying associated discuss potential strategies overcome them. In future, it is crucial caution diligence while promoting innovation existing barriers. A delicate balance between opportunities challenges will help guide progress this field towards its full potential.

Language: Английский

Citations

66