Exercise triggers fat breakdown at some times of day and not others DOI

Nature, Journal Year: 2023, Volume and Issue: 614(7949), P. 596 - 596

Published: Feb. 13, 2023

Language: Английский

Organism-wide, cell-type-specific secretome mapping of exercise training in mice DOI Creative Commons
Wei Wei, Nicholas M. Riley,

Xuchao Lyu

et al.

Cell Metabolism, Journal Year: 2023, Volume and Issue: 35(7), P. 1261 - 1279.e11

Published: May 3, 2023

Language: Английский

Citations

46
Effects of exercise on circadian rhythms in humans DOI Creative Commons
Bingyi Shen, Changxiao Ma, Guanlin Wu

et al.

Frontiers in Pharmacology, Journal Year: 2023, Volume and Issue: 14

Published: Oct. 11, 2023

The biological clock system is an intrinsic timekeeping device that integrates internal physiology and external cues. Maintaining a healthy crucial for life. Disruptions to the body’s can lead disturbances in sleep-wake cycle abnormalities hormone regulation, blood pressure, heart rate, other vital processes. Long-term have been linked development of various common major diseases, including cardiovascular metabolic disorders, tumors, neuropsychiatric conditions, so on. External factors, such as diurnal rhythm light, significant impact on clock. Additionally, important non-photic zeitgeber, exercise regulate rhythms certain extent, making it possible become non-drug intervention preventing treating circadian disorders. This comprehensive review encompasses behavioral, physiological, molecular perspectives provide deeper understanding how influences its association with related diseases.

Language: Английский

Citations

27
Circadian Rhythms in Cardiovascular Metabolism DOI Open Access
Hind Lal, Suresh K Verma, Yajing Wang

et al.

Circulation Research, Journal Year: 2024, Volume and Issue: 134(6), P. 635 - 658

Published: March 14, 2024

Energetic demand and nutrient supply fluctuate as a function of time-of-day, in alignment with sleep-wake fasting-feeding cycles. These daily rhythms are mirrored by 24-hour oscillations numerous cardiovascular functional parameters, including blood pressure, heart rate, myocardial contractility. It is, therefore, not surprising that metabolic processes also over the course day, to ensure temporal needs for ATP, building blocks, metabolism-based signaling molecules met. What has become increasingly clear is addition classic signal-response coupling (termed reactionary mechanisms), cardiovascular-relevant cells use autonomous circadian clocks temporally orchestrate pathways preparation predicted stimuli/stresses anticipatory mechanisms). Here, we review current knowledge regarding regulation metabolism, how synchronized function, whether misalignment/disruption contribute toward pathogenesis disease.

Language: Английский

Citations

11
Metabolic plasticity and obesity-associated changes in diurnal postexercise metabolism in mice DOI

Logan A. Pendergrast,

Stephen P. Ashcroft, Amy M. Ehrlich

et al.

Metabolism, Journal Year: 2024, Volume and Issue: 155, P. 155834 - 155834

Published: March 11, 2024

Language: Английский

Citations

5
Nutrition and exercise: Cornerstones of health with emphasis on obesity and type 2 diabetes management—A narrative review DOI Creative Commons
H. Kim, Oran Kwon

Obesity Reviews, Journal Year: 2024, Volume and Issue: 25(8)

Published: May 7, 2024

Summary While a broad consensus exists that integrated nutrition and regular exercise are foundational for health maintenance serve as robust non‐pharmacological strategy against cardiometabolic diseases, the nuanced interplay between these elements remains incompletely understood. Through multifaceted interactions, factors profoundly influence primary metabolic organs, notably skeletal muscle adipose tissue. Despite critical nature of this interactivity, holistic understanding combined effects physical activity dietary practices is still emerging. This narrative review aims to elucidate intertwined roles exercise. It provides comprehensive overview their synergistic dynamics emphasizes importance dual‐focus approach in mitigating managing disorders, predominantly obesity type 2 diabetes.

Language: Английский

Citations

5
Mitochondrial UCP1: Potential thermogenic mechanistic switch for the treatment of obesity and neurodegenerative diseases using natural and epigenetic drug candidates DOI
Md. Reyad‐ul‐Ferdous, Ijaz Gul,

Muhammad Akmal Raheem

et al.

Phytomedicine, Journal Year: 2024, Volume and Issue: 130, P. 155672 - 155672

Published: May 4, 2024

Language: Английский

Citations

4
Effects of time-of-day on the noradrenaline, adrenaline, cortisol and blood lipidome response to an ice bath DOI Creative Commons

Alexander Braunsperger,

Maximilian Bauer,

Chaima Ben Brahim

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Jan. 8, 2025

Abstract While the effect of time-of-day (morning versus evening) on hormones, lipids and lipolysis has been studied in relation to meals exercise, there are no studies that have investigated effects ice bath induced hormone lipidome responses. In this crossover-designed study, a group six women men, 26 ± 5 years old, 176 7 cm tall, weighing 75 10 kg, BMI 23 2 kg/m had an (8–12 °C for min) both morning evening separate days. Absence from intense physical nutrient intake meal order was standardized 24 h prior baths account confounders such as diet or exercise. We collected venous blood samples before after (5 min 30 measure hormones (noradrenaline, adrenaline, cortisol) lipid levels plasma via liquid chromatography mass spectrometry shotgun lipidomics. found increase fatty acids more than evening. Overall composition significantly differed in-between evening, only bathing is accompanied by increased 5.1 2.2% 6.0 2.4% ( P = 0.029) 6.3 3.1% 0.008) after. Noradrenaline not affected immediately 127 2% (pre: 395 158 pg/ml, post min: 896 562 0.025) 144 385 146 937 547 0.015). Cortisol generally higher 179 108 pg/ml 91 59 0.013; 222 96 101 52 0.001; 190 98 54 0.009). There difference hormonal response between men. The main finding study noradrenaline, cortisol responses similar However,

Language: Английский

Citations

0
Accelerometer‐measured physical activity timing with incident dementia DOI Creative Commons
Yuye Ning, Meiling Chen, Hao Yang

et al.

Alzheimer s & Dementia, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 27, 2025

Abstract INTRODUCTION Moderate to vigorous physical activity (MVPA) is linked lower dementia risk, though the optimal timing remains unclear. METHODS Using accelerometer‐measured MVPA data from 90,329 dementia‐free UK Biobank participants with at least 2 years of follow‐up, we assessed associations between patterns (morning, afternoon, evening, mixed, inactive) and risk via multivariable‐adjusted Cox proportional hazards models. RESULTS Compared inactive group, a tendency morning had all‐cause (hazard ratio [HR]: 0.60, 95% confidence interval [CI]: 0.40–0.90) Alzheimer's disease (AD) (HR: 0.44, CI: 0.22–0.86). No association other time point was observed. Additionally, incidence vascular (VD) did not exhibit significant relationship among all groups. DISCUSSION Morning associated AD, while any showed no VD. Highlights Few studies have examined moderate incident dementia. Participants disease. found risk. Findings suggest timing‐specific interventions for prevention.

Language: Английский

Citations

0
Objectively-Determined Chronoactivity and Type 2 Diabetes Risk: A Prospective Study in UK Biobank Participants DOI
Qiuyu Feng, Gali Albalak, Ko Willems van Dijk

et al.

Published: Jan. 1, 2025

Language: Английский

Citations

0
Dietary timing enhances exercise by modulating fat-muscle crosstalk via adipocyte AMPKα2 signaling DOI

Jianghui Chen,

Jing Xiang, Meiyu Zhou

et al.

Cell Metabolism, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

Citations

0