Nucleases Acting at Stalled Forks: How to Reboot the Replication Program with a Few Shortcuts DOI Open Access
Philippe Pasero, Alessandro Vindigni

Annual Review of Genetics, Journal Year: 2017, Volume and Issue: 51(1), P. 477 - 499

Published: Nov. 27, 2017

In a lifetime, human being synthesizes approximately 2×10 16 meters of DNA, distance that corresponds to 130,000 times the between Earth and Sun. This daunting task is executed by thousands replication forks, which progress along chromosomes frequently stall when they encounter DNA lesions, unusual structures, RNA polymerases, or tightly-bound protein complexes. To complete synthesis before onset mitosis, eukaryotic cells have evolved complex mechanisms process restart arrested forks through coordinated action multiple nucleases, topoisomerases, helicases. this review, we discuss recent advances in understanding role regulation nucleases acting at stalled with focus on nucleolytic degradation nascent commonly referred as fork resection. We also effects deregulated resection genomic instability unscheduled activation interferon response under stress conditions.

Language: Английский

SAMHD1 acts at stalled replication forks to prevent interferon induction DOI
Flavie Coquel, Maria João Silva, Hervé Técher

et al.

Nature, Journal Year: 2018, Volume and Issue: 557(7703), P. 57 - 61

Published: April 16, 2018

Language: Английский

Citations

385
Phosphorylation of SAMHD1 by Cyclin A2/CDK1 Regulates Its Restriction Activity toward HIV-1 DOI Creative Commons

Alexandra Cribier,

Benjamin Descours,

Ana Luiza Chaves Valadão

et al.

Cell Reports, Journal Year: 2013, Volume and Issue: 3(4), P. 1036 - 1043

Published: April 1, 2013

SAMHD1 restricts HIV-1 replication in myeloid and quiescent CD4+ T cells. Here, we show that restriction activity is regulated by phosphorylation. interacts with cyclin A2/cdk1 only cycling Cyclin A2/CDK1 phosphorylates at the Threonine 592 residue both vitro vivo. Phosphorylation of Thr592 correlates loss its ability to restrict HIV-1. Indeed, while PMA treatment proliferating THP1 cells results reduced phosphorylation, activation resting peripheral blood mononuclear (PBMCs) purified increased phosphorylation Thr592. Interestingly, found type 1 interferon reinforcing link between antiviral activity. Unlike wild-type SAMHD1, a phosphorylation-defective mutant was able PMA-treated untreated Our uncover as key regulatory mechanism

Language: Английский

Citations

357
The Retroviral Restriction Ability of SAMHD1, but Not Its Deoxynucleotide Triphosphohydrolase Activity, Is Regulated by Phosphorylation DOI Creative Commons

Tommy E. White,

Alberto Brandariz-Núñez, José Carlos Valle‐Casuso

et al.

Cell Host & Microbe, Journal Year: 2013, Volume and Issue: 13(4), P. 441 - 451

Published: April 1, 2013

Language: Английский

Citations

300
The ribonuclease activity of SAMHD1 is required for HIV-1 restriction DOI
Jeongmin Ryoo, Jongsu Choi, Changhoon Oh

et al.

Nature Medicine, Journal Year: 2014, Volume and Issue: 20(8), P. 936 - 941

Published: July 16, 2014

Language: Английский

Citations

264
Intrinsic host restrictions to HIV-1 and mechanisms of viral escape DOI
Viviana Simon,

Nicolin Bloch,

Nathaniel R. Landau

et al.

Nature Immunology, Journal Year: 2015, Volume and Issue: 16(6), P. 546 - 553

Published: May 19, 2015

Language: Английский

Citations

250
Werner syndrome: Clinical features, pathogenesis and potential therapeutic interventions DOI
Junko Oshima, Julia M. Sidorova, Raymond J. Monnat

et al.

Ageing Research Reviews, Journal Year: 2016, Volume and Issue: 33, P. 105 - 114

Published: March 15, 2016

Language: Английский

Citations

247
Nucleic Acid Immunity DOI Open Access
Gunther Hartmann

Advances in immunology, Journal Year: 2016, Volume and Issue: unknown, P. 121 - 169

Published: Dec. 15, 2016

Language: Английский

Citations

247
SAMHD1 is mutated recurrently in chronic lymphocytic leukemia and is involved in response to DNA damage DOI Open Access
Ruth Clifford,

Tania Louis,

Pauline Robbe

et al.

Blood, Journal Year: 2013, Volume and Issue: 123(7), P. 1021 - 1031

Published: Dec. 13, 2013

Language: Английский

Citations

217
Immunogenetics of systemic lupus erythematosus: A comprehensive review DOI
Yogita Ghodke‐Puranik, Timothy B. Niewold

Journal of Autoimmunity, Journal Year: 2015, Volume and Issue: 64, P. 125 - 136

Published: Aug. 29, 2015

Language: Английский

Citations

203
Intracellular Nucleic Acid Detection in Autoimmunity DOI Open Access

John T. Crowl,

Elizabeth Gray, Kathleen Pestal

et al.

Annual Review of Immunology, Journal Year: 2017, Volume and Issue: 35(1), P. 313 - 336

Published: March 30, 2017

Protective immune responses to viral infection are initiated by innate sensors that survey extracellular and intracellular space for foreign nucleic acids. The existence of these raises fundamental questions about self/nonself discrimination because the abundance self-DNA self-RNA occupy same compartments. Recent advances have revealed enzymes metabolize or modify endogenous acids essential preventing inappropriate activation antiviral response. In this review, we discuss rare human diseases caused dysregulated acid sensing, focusing primarily on We summarize lessons learned from disorders, rationalize in context evolution, propose framework may also apply a number more common autoimmune which underlying genetics mechanisms not yet fully understood.

Language: Английский

Citations

200