Journal of Complementary and Integrative Medicine,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 26, 2024
Abstract
Background
Drug-induced
hepatotoxicity,
particularly
from
ethanol
and
acetaminophen
(APAP),
is
a
pressing
global
health
challenge.
This
damage
arises
oxidative
stress
inflammation,
manifesting
as
elevated
liver
enzymes
structural
alterations.
Resveratrol
silymarin,
recognized
for
their
antioxidant
anti-inflammatory
properties,
offer
potential
hepatoprotective
benefits.
Methods
study
investigated
the
efficacy
of
resveratrol
alone
in
combination,
rat
model
ethanol-
APAP-induced
injury.
Thirty
Wistar
rats
were
divided
into
five
groups:
control,
ethanol-APAP,
ethanol-APAP-resveratrol,
ethanol-APAP-silymarin,
ethanol-APAP-resveratrol-silymarin.
Treatments
administered
orally
10
days.
Serum
ALT
AST
levels
assessed,
tissues
underwent
histological
evaluation.
Results
Ethanol
APAP
administration
significantly
levels,
alongside
severe
disruptions.
Treatment
with
or
silymarin
normalized
enzyme
improved
histology.
Notably,
combined
resveratrol-silymarin
treatment
exhibited
greater
reductions
superior
restoration
architecture
compared
to
either
alone,
indicating
synergistic
effect.
Conclusions
effectively
counteract
hepatotoxicity
by
mitigating
inflammation.
Their
use
demonstrates
benefit,
evidenced
enhanced
biochemical
improvements.
These
findings
support
therapeutic
role
these
natural
agents
managing
drug-induced
Deleted Journal,
Journal Year:
2024,
Volume and Issue:
1(1)
Published: Dec. 31, 2024
Medicinal
plants
are
generally
important
for
the
therapeutically
active
materials
that
can
be
obtained
from
them.
Authenticating
herbal
products
these
medicinal
and
separating
adulterants
genuine
therapeutic
in
order
to
protect
health
of
public
guarantee
reproducible
quality
medicines
is
however
a
vital
necessity
both
manufacturers
regulatory
organisations
have
roles
ensuring
medicines.
Phytopharmaceuticals
or
drugs
defined
as
having
good
standards
when
their
identity,
purity,
composition,
other
physical,
chemical,
biological
characteristics,
well
manufacturing
processes
meet
certain
established
criteria.
Herbal
introduced
into
market
often
substandard
fail
criteria
quality,
safety,
even
legality,
regulations
thus
put
place
by
relevant
bodies
different
countries
regulate
beginning
raw
way
through
whole
process.
Moreover,
choice
an
appropriate
analytical
method
numerous
available
(microscopy,
spectrometry,
spectroscopy,
chromatography,
etc.)
ensure
before
consumption.
This
review
seeks
present
variety
evaluation
required
they
may
market.
