From Localized Mild Hyperthermia to Improved Tumor Oxygenation: Physiological Mechanisms Critically Involved in Oncologic Thermo-Radio-Immunotherapy

Cancers, Journal Year: 2023, Volume and Issue: 15(5), P. 1394 - 1394

Published: Feb. 22, 2023

(1) Background: Mild hyperthermia (mHT, 39-42 °C) is a potent cancer treatment modality when delivered in conjunction with radiotherapy. mHT triggers series of therapeutically relevant biological mechanisms, e.g., it can act as radiosensitizer by improving tumor oxygenation, the latter generally believed to be commensurate result increased blood flow, and positively modulate protective anticancer immune responses. However, extent kinetics flow (TBF) changes oxygenation are variable during after application mHT. The interpretation these spatiotemporal heterogeneities currently not yet fully clarified. (2) Aim methods: We have undertaken systematic literature review herein provide comprehensive insight into potential impact on clinical benefits therapeutic modalities such radio- immuno-therapy. (3) Results: mHT-induced increases TBF multifactorial differ both spatially time. In

Language: Английский

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A translational review of hyperthermia biology

International Journal of Hyperthermia, Journal Year: 2025, Volume and Issue: 42(1)

Published: Jan. 12, 2025

This review was written to be included in the Special Collection 'Therapy Ultrasound: Medicine's Swiss Army Knife?' The purpose of this is provide basic presentation and interpretation fundamentals hyperthermia biology, as it pertains uses therapeutic ultrasound. are presented but setting a translational view toward future. Subjects that require future research development highlighted. effects time temperature dependent. Because intra-tumoral temperatures non-uniform tumors, one has account for differential biologic different parts tumor occur simultaneously during after hyperthermia.

Language: Английский

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Radiosensitization by Hyperthermia Critically Depends on the Time Interval

International Journal of Radiation Oncology*Biology*Physics, Journal Year: 2023, Volume and Issue: 118(3), P. 817 - 828

Published: Oct. 10, 2023

Language: Английский

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Development of Cationic Lipid LAH4-L1 siRNA Complexes for Focused Ultrasound Enhanced Tumor Uptake

Molecular Pharmaceutics, Journal Year: 2023, Volume and Issue: 20(5), P. 2341 - 2351

Published: March 29, 2023

RNAi has considerable potential as a cancer therapeutic approach, but effective and efficient delivery of short interfering RNA (siRNA) to tumors remains major hurdle. It challenge prepare functional siRNA complex, target enough dose the tumor, stimulate its internalization into tumor cells release cytoplasm. Here, we show how these key barriers can be overcome with complex─comprising siRNA, cationic lipids, pH-responsive peptides─that is suited uptake enhancement via focused ultrasound (FUS). The complex provides nucleic acid encapsulation, nuclease protection, endosomal escape such that gene silencing in substantially more than obtained either equivalent lipoplexes or commercial reagents. In mice bearing MDA-MB-231 breast xenografts, both lipid ternary, lipid:peptide:siRNA complexes, prepared near-infrared fluorescently labeled accumulate following FUS treatments. Therefore, combining well-designed treatments promising route achieve robust vivo delivery.

Language: Английский

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Biological treatment evaluation in thermoradiotherapy: application in cervical cancer patients

Strahlentherapie und Onkologie, Journal Year: 2024, Volume and Issue: 200(6), P. 512 - 522

Published: Jan. 4, 2024

Abstract Background Hyperthermia treatment quality is usually evaluated by thermal (dose) parameters, though hyperthermic radiosensitization effects are also influenced the time interval between two modalities. This work applies biological modelling for clinical evaluation of cervical cancer patients treated with radiotherapy plus hyperthermia calculating equivalent radiation dose (EQD RT , i.e., needed same effect alone). Subsequent analyses evaluate impact logistics. Methods Biological was performed 58 23–28 fractions 1.8–2 Gy 4–5 weekly sessions. Measured temperatures (T50) and recorded intervals sessions were used to calculate EQD using an extended linear quadratic (LQ) model LQ parameters based on extensive experimental data. Next, a 30-min (optimized logistics) as well 4‑h (suboptimal evaluated. Results Median average measured T50 41.2 °C (range 39.7–42.5 °C) 79 min 34–125 min), respectively, resulting in median total enhancement (D50) 5.5 (interquartile range [IQR] 4.0–6.6 Gy). For intervals, would increase ~30% 7.1 (IQR 5.5–8.1 Gy; p < 0.001). In case ~ 40% decrease could be expected: 3.2 2.3–3.8 Normal tissue negligible (< 0.3 Gy), even short intervals. Conclusion useful addition standard treatments. Optimizing logistics shorten seems worthwhile improve efficacy.

Language: Английский

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Viability control of chemo-immunotherapy and radiotherapy by set-valued analysis

International Journal of Informatics and Applied Mathematics, Journal Year: 2023, Volume and Issue: unknown

Published: April 23, 2023

In this paper we set-valued analyze the problem of asymptotic stabilizing tumor size. A mathematical model exponential growing caused by carcinogenic substance is considered, with chemotherapy, immunotherapy, and radiotherapy effects. We control to be viable in therapeutic domains, reverse The obtained controls derive from derivative cone domains as solution minimizing problem.

Language: Английский

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A Numerical Study of the RF Hyperthermia Treatment of Brain Tumors Using Novel SPIO-Micelles

Published: July 8, 2024

Language: Английский

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Design and Validation of Experimental Setup for Cell Spheroid Radiofrequency-Induced Heating

Sensors, Journal Year: 2023, Volume and Issue: 23(9), P. 4514 - 4514

Published: May 5, 2023

While hyperthermia has been shown to induce a variety of cytotoxic and sensitizing effects on cancer tissues, the thermal dose-effect relationship is still not well quantified, it unclear how can be optimally combined with other treatment modalities. Additionally, speculated that different methods applying hyperthermia, such as water bath heating or electromagnetic energy, may have an effect resulting biological mechanisms involved in cell death tumor cells oncological treatments. In order further quantify characterize treatments cellular level, vitro experiments shifted towards use 3D spheroids. These are fact considered more representative model environment when compared 2D cultures. perform radiofrequency (RF)-induced vitro, we recently developed dedicated field applicator. this study, using applicator, designed validated experimental setup which heat spheroids conical polypropylene vial, thus providing reliable instrument for investigating at scale.

Language: Английский

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Application of an artificial intelligence segmentation for deep hyperthermia treatment planning in the pelvic region

Acta Polytechnica, Journal Year: 2023, Volume and Issue: 63(6)

Published: Dec. 31, 2023

During a microwave hyperthermia oncology treatment, the target region temperature is elevated to temperatures of 40–44 °C, which improves therapeutic effect standard radiotherapy and/or chemotherapy treatments. Amplitudes and phases antenna input signals in phased array setup surrounding 3D patient model are optimised with respect maximise energy deposition region. In this study, we successfully integrated an automatic artificial intelligence segmentation routine, used for patient-specific generation, into treatment planning process. This allows us apply more realistic online guidance including detailed retrospective analyses overall quality, possibly leading widespread clinical use planning.

Language: Английский

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Introduction to computational modeling in hyperthermia

International Journal of Hyperthermia, Journal Year: 2022, Volume and Issue: 39(1), P. 1358 - 1359

Published: Oct. 18, 2022

Language: Английский

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