Iron Oxide Nanoparticles in Cancer Treatment: Cell Responses and the Potency to Improve Radiosensitivity

Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(10), P. 2406 - 2406

Published: Sept. 30, 2023

The main concept of radiosensitization is making the tumor tissue more responsive to ionizing radiation, which leads an increase in potency radiation therapy and allows for decreasing dose concomitant side effects. Radiosensitization by metal oxide nanoparticles widely discussed, but range mechanisms studied not sufficiently codified often does reflect ability nanocarriers have a specific impact on cells. This review focused magnetic iron while they occupied special niche among prospective radiosensitizers due unique physicochemical characteristics reactivity. We collected data about possible molecular underlying radiosensitizing effects (IONPs) approaches their therapeutic efficacy variable modifications.

Language: Английский

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Hyperthermia in Combination with Emerging Targeted and Immunotherapies as a New Approach in Cancer Treatment

Cancers, Journal Year: 2024, Volume and Issue: 16(3), P. 505 - 505

Published: Jan. 24, 2024

Despite significant advancements in the development of novel therapies, cancer continues to stand as a prominent global cause death. In many cases, cornerstone standard-of-care therapy consists chemotherapy (CT), radiotherapy (RT), or combination both. Notably, hyperthermia (HT), which has been clinical use last four decades, proven enhance effectiveness CT and RT, owing its recognized potency sensitizer. Furthermore, HT exerts effects on all steps cancer–immunity cycle impact key oncogenic pathways. Most recently, there noticeable expansion research related treatment options involving immunotherapy (IT) targeted (TT), trend also visible pipelines pharmaceutical companies. However, potential results arising from these innovative therapeutic approaches with remain largely unexplored. Therefore, this review aims explore oncology major companies, primary objective identifying principal targets forthcoming therapies that have be advantageous for patients by specifically targeting molecular pathways involved HT. The ultimate goal is pave way future initiatives trials harness synergy between emerging IT TT medications when used conjunction

Language: Английский

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Box–Behnken design of thermo-responsive nano-liposomes loaded with a platinum(iv) anticancer complex: evaluation of cytotoxicity and apoptotic pathways in triple negative breast cancer cells

Nanoscale Advances, Journal Year: 2023, Volume and Issue: 5(19), P. 5399 - 5413

Published: Jan. 1, 2023

Herein, thermo-responsive liposomes (TLs) loaded with Asp (Asp/TLs) were produced by self-assembling DPPC, DSPE-PEG2000, and cholesterol. The preparation variables optimized using the Box-Behnken design (BBD). Asp/TLs exhibited an average particle size of 114.05 ± 1.56 nm, PDI 0.15 0.015, zeta potential -15.24 0.65 mV, entrapment efficiency (EE%) 84.08 2.75%. In addition, under physiological conditions, showed spherical shape, outstanding stability thermo-triggered release at 38 °C, reaching maximum 40 °C. MTT assay that optimal highest cytotoxic activity upon exposure to mild hyperthermia (40 °C) against invasive triple-negative breast cancer cell line (MDA-MB-231) when compared other preparations. IC50 was estimated 0.9 μg mL-1, while free 3.83 mL-1. As such, shown increase 4-fold hyperthermia. values without °C 6.6 mL-1 186 respectively. This indicated released only placed apoptosis revealed caused a remarkable in percentage population among both late necrosis quartiles, as well significant decline viable quartile (P ≤ 0.001) °C). could stimulate intrinsic pathway upregulating apoptotic genes Bak Bax, downregulating anti-apoptotic genes, BCL-xL BCL-2. increased gene expression Bax 4.4- 5.2-folds, reducing BCL-2 50% 73%, TLs manifested more potent effects demonstrated upregulation Bak, P53 5.6-, 7.2-, 1.3-folds, downregulation 70% 85%, treatment displayed most profile induced MDA-MB-231.

Language: Английский

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Targeting the heat shock response induced by modulated electro-hyperthermia (mEHT) in cancer

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Journal Year: 2024, Volume and Issue: 1879(2), P. 189069 - 189069

Published: Jan. 2, 2024

The Heat Shock Response (HSR) is a cellular stress reaction crucial for cell survival against stressors, including heat, in both healthy and cancer cells. Modulated electro-hyperthermia (mEHT) an emerging non-invasive therapy utilizing electromagnetic fields to selectively target cells via temperature-dependent independent mechanisms. However, mEHT triggers HSR treated Despite demonstrated efficacy treatment, understanding the underlying molecular mechanisms improved therapeutic outcomes remains focus. This review examines induced by cells, discussing potential strategies modulate it enhanced tumor-killing effects. Approaches such as HSF1 gene-knockdown small molecule inhibitors like KRIBB11 are explored downregulate augment tumor destruction. We emphasize impact of inhibition on viability, sensitivity, synergistic effects, addressing challenges future directions. offers opportunities optimizing treatment advancing precision medicine therapy.

Language: Английский

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Augmentation of the EPR effect by mild hyperthermia to improve nanoparticle delivery to the tumor

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Journal Year: 2024, Volume and Issue: 1879(4), P. 189109 - 189109

Published: May 14, 2024

The clinical translation of the nanoparticle (NP)-based anticancer therapies is still unsatisfactory due to heterogeneity enhanced permeability and retention (EPR) effect. Despite promising preclinical outcome pharmacological EPR enhancers, their systemic toxicity can limit application. Hyperthermia (HT) presents an efficient tool augment by improving tumor blood flow (TBF) vascular permeability, lowering interstitial fluid pressure (IFP), disrupting structure extracellular matrix (ECM). Furthermore, HT-triggered intravascular release approach overcome In contrast approaches, HT safe be focused cancer tissues. Moreover, conveys direct anti-cancer effects, which improve efficacy agents encapsulated in NPs. However, application challenging heterogeneous distribution temperature within tumor, length treatment complexity monitoring.

Language: Английский

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Harnessing Hyperthermia: Molecular, Cellular, and Immunological Insights for Enhanced Anticancer Therapies

Integrative Cancer Therapies, Journal Year: 2024, Volume and Issue: 23

Published: Jan. 1, 2024

Hyperthermia, the raising of tumor temperature (≥39°C), holds great promise as an adjuvant treatment for cancer therapy. This review focuses on 2 key aspects hyperthermia: its molecular and cellular effects impact immune system. Hyperthermia has profound critical biological processes. Increased temperatures inhibit DNA repair enzymes, making cells more sensitive to chemotherapy radiation. Elevated also induce cell cycle arrest trigger apoptotic pathways. Furthermore, hyperthermia modifies expression heat shock proteins, which play vital roles in therapy, including enhancing responses. Hyperthermic treatments have a significant body’s response against tumors, potentially improving efficacy checkpoint inhibitors. Mild systemic (39°C-41°C) mimics fever, activating metabolic rates. Intense above 50°C can release antigens, reactions. Using photothermal nanoparticles targeted heating drug delivery modulate response. emerges cost-effective well-tolerated therapy when integrated with immunotherapy. comprehensive serves valuable resource selection patient-specific guidance future experimental studies.

Language: Английский

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A translational review of hyperthermia biology

International Journal of Hyperthermia, Journal Year: 2025, Volume and Issue: 42(1)

Published: Jan. 12, 2025

This review was written to be included in the Special Collection 'Therapy Ultrasound: Medicine's Swiss Army Knife?' The purpose of this is provide basic presentation and interpretation fundamentals hyperthermia biology, as it pertains uses therapeutic ultrasound. are presented but setting a translational view toward future. Subjects that require future research development highlighted. effects time temperature dependent. Because intra-tumoral temperatures non-uniform tumors, one has account for differential biologic different parts tumor occur simultaneously during after hyperthermia.

Language: Английский

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Hyperthermia combined with opioid therapy: Enhancing cancer pain management and reducing surgical stress in gastrointestinal cancer patients

World Journal of Gastrointestinal Surgery, Journal Year: 2025, Volume and Issue: 17(3)

Published: Feb. 24, 2025

In this article, we evaluate the findings of study by Qian et al , which explores efficacy combining hyperthermia with opioid therapy for enhanced cancer pain management in patients middle and late-stage gastrointestinal tumors. The undertakes a retrospective analysis comparing traditional to an integrated approach opioids across 70 patients, highlighting significant benefits control, reduction dosage, minimization adverse reactions. our not only discuss these but also emphasize broader implications clinical practice, particularly enhancing patient outcomes through innovative strategies. We advocate further research establish more robust data supporting explore mechanistic insights that enable benefits. This discussion reflects on potential paradigm shift managing debilitating cancer-related pain, urging reevaluation current practices incorporate effectively.

Language: Английский

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Metabolic modulation of the biological effects of ionizing radiation and chemotherapy (review)

Russian Journal of Oncology, Journal Year: 2025, Volume and Issue: unknown

Published: March 5, 2025

The review presents general information about the tumor cell microenvironment, its role in development and progression of malignant process results antitumor therapy. analysis showed that methods for influencing key metabolic targets cells their microenvironment is a promising direction experimental clinical oncology. Some approaches to inducing modulation are considered: inhibitors cellular pumps, hyperglycemia hyperthermia. therapeutic effect first two induction options based on acid-base balance (pH) tumor. biological hyperthermia broader directly depends severity temperature-exposure mode heating. Ultimately, such changes lead an increase damaging ionizing radiation drugs Despite fact composition heterogeneous varies depending type tumor, some specific mediators present all types. Therefore, developed treatment can be universal most locations.

Language: Английский

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Advancements in tantalum based nanoparticles for integrated imaging and photothermal therapy in cancer management

RSC Advances, Journal Year: 2024, Volume and Issue: 14(46), P. 33681 - 33740

Published: Jan. 1, 2024

Tantalum-based nanoparticles (TaNPs) have emerged as promising tools in cancer management, owing to their unique properties that facilitate innovative imaging and photothermal therapy applications.

Language: Английский

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