Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: 104, P. 106466 - 106466
Published: Nov. 30, 2024
Language: Английский
Inorganic Chemistry Communications, Journal Year: 2025, Volume and Issue: unknown, P. 113904 - 113904
Published: Jan. 1, 2025
Language: Английский
Citations
2
Journal of Molecular Structure, Journal Year: 2024, Volume and Issue: 1313, P. 138665 - 138665
Published: May 16, 2024
Language: Английский
Citations
5
Odontology, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 17, 2025
Abstract Dental composite resins often face challenges related to secondary caries, polymerization shrinkage and fracture failure. This study aimed synthesize an experimental resin modified with grapefruit seed extract-mediated titanium dioxide nanoparticles (GSE-TiO₂NPs) evaluate its antibacterial activity mechanical physical properties. Green synthesis of TiO₂ was conducted utilizing GSE. The chemical profile GSE identified through gas chromatography-mass spectrometry. as-prepared were incorporated into composites at concentrations 10 wt.% (10 GSE-TiO₂NPs group) 20 (20 group), unmodified as the control group. Scanning electron microscopy (SEM) transmission (TEM) confirmed morphology size synthesized nanoparticles, SEM revealing uniform particle distribution in composite. Antibacterial against Streptococcus mutans assessed using agar disc diffusion method. Mechanical properties, including flexural strength (FS) modulus (FM), evaluated according ISO 4049 standards. Microhardness tested American Society for Testing Materials (ASTM E-384:1999) criteria. Polymerization measured strain gauge Modified exhibited significantly greater S. compared ( p < 0.001 ). group demonstrated increased FS FM values 0.05 All groups surpassed clinically acceptable microhardness threshold without significant differences = 0.588 reduced 0.01 ), showing lowest value (13.06 ± 0.92%). Incorporating enhances activity, improves reduces shrinkage, suggesting a promising approach developing advanced dental materials integrated natural bioactive components. Graphical abstract
Language: Английский
Citations
0
Journal of Materials Science Materials in Electronics, Journal Year: 2025, Volume and Issue: 36(13)
Published: May 1, 2025
Language: Английский
Citations
0
Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2024, Volume and Issue: 398(1), P. 933 - 950
Published: Aug. 2, 2024
In acute renal failure (ARF), the glomerular filtration rate is reduced, and nitrogenous waste products accumulate persistently, which can last anywhere from a few hours to several days. There hope for reversal of rapid loss function caused by this condition. This study, with gentamicin-induced ARF as prospective setting, sets out examine reno-protective benefits virgin coconut oil (VCO) GSH. Furthermore, study evaluated effect medication nanoparticle compositions on kidney markers. The induction achieved intraperitoneal injection gentamicin. To assess function, rats underwent 24 h dehydration hunger before their deaths. examined various aspects, including tests, markers oxidative stress, histology tissue, inflammatory cytokines, immunohistochemistry expression nuclear factor-kappa B (NF-κB), specific biomarkers tissue damage, such injury molecule-1 (KIM-1) neutrophil gelatinase-associated lipocalin (NGAL). results our indicated that combination VCO GSH, using both regular formulations, had better protective impact kidneys compared either drug alone. recovery serum markers, are symptomatic organ indicates improvement. was also demonstrated reduction in tubular TNF-α, IL-1β, KIM-1, NGAL. immunohistochemical studies showed therapy, especially nanoforms, greatly improved damaged cellular changes kidneys, shown higher levels NF-κB. shows when administered individually or combined, significantly improve rat model, highlighting potential therapeutic implications. Notably, combined nanoparticulate formulations exhibit substantial effectiveness.
Language: Английский
Citations
3
BioNanoScience, Journal Year: 2024, Volume and Issue: 14(5), P. 5080 - 5093
Published: Aug. 8, 2024
This study aimed to explore the effects of heat stress and black sand acute exposure on erythron profile, hematological antioxidant parameters, as well histological histochemical indices. Catfish were subjected nanoparticles (6.4 g per kg diet), thermal (32 °C), a combined treatment involving both stressors over period 15 days. exposed singly and/or in combination showed significantly lower red blood cells (RBCs) count, hemoglobin (Hb), platelets, white (WBCs) large lymphocytes, small monocytes. Antioxidant indices decreased NPs compared other groups. Notably, led substantial increase percentages RBCs alterations nuclear abnormalities. Histological examinations liver revealed various features, including intracellular bleeding, cytoplasmic vacuolation, tissue deterioration, hepatocyte pyknotic nuclei, displacement, shrinkage, accumulation melanomacrophage cells. In conclusion, underscores that indices, become more pronounced under elevated temperatures indicating potential for synergistic between pollution climate change. holistic approach is crucial developing accurate forecasts complex interactions environmental their implications aquatic ecosystems.
Language: Английский
Citations
3
Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)
Published: Sept. 23, 2024
Language: Английский
Citations
3
Pharmaceutical Development and Technology, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 25
Published: Sept. 12, 2024
The low and erratic oral absorption of sulpiride (SUL) a dopaminergic receptor antagonist, its P-glycoprotein efflux in the gastrointestinal tract restricted route for central nervous system disorders. An intranasal formulation was formulated based on nanostructured lipid carrier to tackle these obstacles deliver SUL directly brain. Sulipride-loaded (SUL-NLC) prepared using compritol®888 ATO different types liquid lipids emulsifiers. SUL-NLCs were characterized their particle size, charge, encapsulation efficiency. Morphology compatibility with other NLC excipients also studied. Moreover, vitro release, nanodispersion stability, vivo performance pharmacokinetics investigated. Results delineates that SUL-NLC have size ranging from 366.2 ± 62.1 640.4 50.2 nm efficiency 75.5 1.5%. showed sustained release pattern over 24 h maintained physical stability three months. Intranasal significantly (p < 0.01) higher brain concentration than found plasma after administration commercial product 4.47-fold increase relative bioavailability. as nose approach is promising enhancing bioavailability efficient management neurological
Language: Английский
Citations
2
Journal of Cluster Science, Journal Year: 2024, Volume and Issue: unknown
Published: Oct. 5, 2024
Language: Английский
Citations
2
Drug Development and Industrial Pharmacy, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 33
Published: Dec. 4, 2024
Recent developments in nanotechnology have regained the hope enabling eradication of lung cancer, while overcoming drawbacks classic therapeutics. Nevertheless, there are still formidable obstacles that hinder translation such platforms from bench into clinic. Herein, we shed light on clinical potential these formulations and discuss their future directions.
Language: Английский
Citations
2