The Role of Curcumin in Cancer: A Focus on the PI3K/Akt Pathway

Cancers, Journal Year: 2024, Volume and Issue: 16(8), P. 1554 - 1554

Published: April 18, 2024

Cancer is a life-threatening disease and one of the leading causes death worldwide. Despite significant advancements in therapeutic options, most available anti-cancer agents have limited efficacy. In this context, natural compounds with diverse chemical structures been investigated for their multimodal properties. Curcumin polyphenol isolated from rhizomes Curcuma longa has widely studied its anti-inflammatory, anti-oxidant, effects. acts on regulation different aspects cancer development, including initiation, metastasis, angiogenesis, progression. The phosphatidylinositol-3-kinase (PI3K)/protein kinase B (AKT) pathway key target therapy, since it implicated proliferation, cell survival. found to inhibit PI3K/Akt tumor cells, primarily via mediators, growth factors, protein kinases, cytokines. This review presents potential curcumin malignancies, such as glioblastoma, prostate breast cancer, head neck cancers, through targeting signaling pathway.

Language: Английский

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Nano-Formulations for Pulmonary Delivery: Past, Present, and Future Perspectives

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(2), P. 161 - 161

Published: Jan. 24, 2024

With the development of nanotechnology and confronting problems traditional pharmaceutical formulations in treating lung diseases, inhalable nano-formulations have attracted interest. Inhalable for diseases allow precise pulmonary drug delivery, overcoming physiological barriers, improving aerosol deposition rates, increasing bioavailability. They are expected to solve difficulties faced diseases. However, limited success has been recorded industrialization translation nano-formulations. Only one relevant product approved by FDA date, suggesting that there still many issues be resolved clinical application These systems characterized a dependence on inhalation devices, while adaptability device formulation is inconclusive, which most important issue impeding translational research. In this review, we categorized various nano-formulations, summarized advantages over conventional formulations, listed undergoing studies. We focused influence devices analyzed their adaptability. After extensive analysis delivery mechanisms, technical processes, limitations different concluded vibrating mesh nebulizers might suitable delivering related examples were introduced validate our view. Finally, presented challenges outlook future development. anticipate providing an informative reference field.

Language: Английский

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Applications and advancements of nanoparticle-based drug delivery in alleviating lung cancer and chronic obstructive pulmonary disease

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2023, Volume and Issue: 397(5), P. 2793 - 2833

Published: Nov. 22, 2023

Language: Английский

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lncRNAs as prognostic markers and therapeutic targets in cuproptosis-mediated cancer

Clinical and Experimental Medicine, Journal Year: 2024, Volume and Issue: 24(1)

Published: Sept. 26, 2024

Abstract Long non-coding RNAs (lncRNAs) have emerged as crucial regulators in various cellular processes, including cancer progression and stress response. Recent studies demonstrated that copper accumulation induces a unique form of cell death known cuproptosis, with lncRNAs playing key role regulating cuproptosis-associated pathways. These may trigger cell-specific responses to stress, presenting new opportunities prognostic markers therapeutic targets. This paper delves into the cuproptosis-mediated cancer, underscoring their potential biomarkers targets for innovative strategies. A thorough review scientific literature was conducted, utilizing databases such PubMed, Google Scholar, ScienceDirect, search terms like 'lncRNAs,' 'cuproptosis,' 'cancer.' Studies were selected based on relevance lncRNA regulation cuproptosis pathways implications prognosis treatment. The highlights significant contribution cuproptosis-related genes pathways, impacting metabolism, mitochondrial responses, apoptotic signaling. Specific are breast, lung, liver, ovarian, pancreatic, gastric cancers. objective this article is explore cancers mediated by cuproptosis.

Language: Английский

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Bispecific Antibodies in Lung Cancer: A State-of-the-Art Review

Pharmaceuticals, Journal Year: 2023, Volume and Issue: 16(10), P. 1461 - 1461

Published: Oct. 14, 2023

Bispecific antibodies have emerged as a promising class of therapeutics in the field oncology, offering an innovative approach to target cancer cells while sparing healthy tissues. These are designed bind two different antigens, enabling them bridge immune with cells, resulting enhanced tumor cell killing and improved treatment responses. This review article summarizes current landscape bispecific lung cancer, including their mechanisms action, clinical development, potential applications other solid malignancies. Additionally, challenges opportunities associated use clinic discussed, along future directions for research development this exciting area immunotherapy.

Language: Английский

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The dual roles of circRNAs in Wnt/β-Catenin signaling and cancer progression

Pathology - Research and Practice, Journal Year: 2024, Volume and Issue: 255, P. 155132 - 155132

Published: Feb. 1, 2024

Language: Английский

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LncRNA-HOXC-AS2 regulates tumor-associated macrophage polarization through the STAT1/SOCS1 and STAT1/CIITA pathways to promote the progression of non-small cell lung cancer

Cellular Signalling, Journal Year: 2023, Volume and Issue: 115, P. 111031 - 111031

Published: Dec. 31, 2023

Language: Английский

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CRBN‐PROTACs in Cancer Therapy: From Mechanistic Insights to Clinical Applications

Chemical Biology & Drug Design, Journal Year: 2024, Volume and Issue: 104(5)

Published: Nov. 1, 2024

Cereblon (CRBN), a member of the E3 ubiquitin ligase complex, has gained significant attention as therapeutic target in cancer. CRBN regulates degradation various proteins cancer progression, including transcription factors and signaling molecules. PROTACs (proteolysis-targeting chimeras) are novel approach that uses cell's system to remove disease-causing selectively. CRBN-dependent work by tagging harmful for destruction through ubiquitin-proteasome system. This strategy offers several advantages over traditional protein inhibition methods, potential overcome drug resistance. Recent progress developing CRBN-based shown promising preclinical results both hematologic malignancies solid tumors. Additionally, have enhanced our understanding CRBN's role cancer, potentially serving biomarkers patient stratification predicting responses. In this review, we delineate mechanisms action (CRBN-PROTACs), summarize recent advances clinical applications, provide perspective on future development.

Language: Английский

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Integrated Network Pharmacology, Molecular Docking, Molecular Simulation, and In Vitro Validation Revealed the Bioactive Components in Soy-Fermented Food Products and the Underlying Mechanistic Pathways in Lung Cancer

Nutrients, Journal Year: 2023, Volume and Issue: 15(18), P. 3949 - 3949

Published: Sept. 12, 2023

Globally, lung cancer remains one of the leading causes cancer-related mortality, warranting exploration novel and effective therapeutic approaches. Soy-fermented food products have long been associated with potential health benefits, including anticancer properties. There is still a lack understanding active components these drugs as well their underlying mechanistic pathways responsible for anti-lung effects. In this study, we undertaken an integrated approach combining network pharmacology molecular docking to elucidate mechanism action soy-fermented against through simulation in vitro validation. Using pharmacology, constructed comprehensive interactions between identified isoflavones cancer-associated targets. Molecular was performed predict binding affinities compounds key proteins. Additionally, utilized investigate stability compound-target complexes over time, providing insights into dynamic interactions. Our results daidzein component high towards critical simulations confirmed daidzein-MMP9 daidzein-HSP90AA1 complexes, suggesting inhibitors. validation experiments demonstrated that treatment significantly inhibited cell proliferation suppressed migration invasion A549 cells. Consequently, estrogen signaling pathway recognized modulated by cancer. Overall, findings present study highlight provide valuable development targeted therapies using bioactive compounds. Further investigation clinical studies are warranted validate translate them applications improved management.

Language: Английский

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SNX30 inhibits lung adenocarcinoma cell proliferation and induces cell ferroptosis through regulating SETDB1

Journal of Cardiothoracic Surgery, Journal Year: 2025, Volume and Issue: 20(1)

Published: Jan. 9, 2025

Lung adenocarcinoma is the most common form of lung cancer and one life-threatening malignant tumors. Ferroptosis an iron-dependent regulatory cell death pathway that crucial for tumor growth. SNX30 a key factor in cardiac development; however, its mechanism role inducing ferroptosis remain unclear. This study aimed to elucidate functions specific mechanisms action adenocarcinomas. levels lines (A549 HCC827) were determined using reverse transcription quantitative real-time PCR (RT-qPCR) or western blotting. Cell proliferation apoptosis assessed by CCK8 flow cytometry, respectively. The intracellular total iron Fe2+ detected Iron Assay Kits. Reactive oxygen species (ROS) evaluated DCFH-DA probe cytometry. Cysteine (Cys), glutathione (GSH), peroxidase 4 (GPX4) measured detection assay kits. Other related markers, including Ptgs2, Chac1, SETDB1 cleaved-Caspase3, Caspase3 analyzed RT-qPCR downregulated lines. SNX30-plasmid depressed proliferation, accelerated apoptosis, enhanced cleaved-Caspase3 expression cleaved-Caspase3/Caspase3 ratio. Ferrostatin-1 significantly reversed effects on adenocarcinoma, as confirmed reduced ROS levels, inhibited decreased Ptgs2 Chac1 expression, increased Cys, GSH, GPX4 release. We observed level was lower group than control-plasmid group, whereas opposite results ferrostatin-1 treated cells. negatively regulates upregulation inhibits induces regulating expression.

Language: Английский

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