ChemistrySelect,
Journal Year:
2024,
Volume and Issue:
9(27)
Published: July 12, 2024
Abstract
This
study
presents
the
synthesis
and
characterization
of
a
new,
recyclable,
thermally
stable
heterogeneous
catalyst
for
efficient
polyhydroquinoline
chromene
derivatives.
The
was
characterized
using
various
techniques,
including
UV
spectroscopy,
FT‐IR,
TGA,
DTG,
SEM,
XRD,
ICP
Spectroscopy,
CHN
analysis.
successfully
designed
phthalocyanine
incorporates
both
Brønsted
Lewis
acid
functionality,
along
with
zwitterionic
properties.
It
effectively
utilized
in
methodology
offers
several
advantages,
such
as
simple
procedure,
excellent
yields,
short
reaction
time.
findings
from
this
research
provide
valuable
insights
into
formulating
advancing
new
catalysts
significant
organic
reactions.
ChemistrySelect,
Journal Year:
2025,
Volume and Issue:
10(14)
Published: April 1, 2025
Abstract
In
this
research,
we
explore
the
synthesis
and
in
vitro
antibacterial
activity
of
hydrazone
Schiff
base
derivatives
bearing
ibuprofen
nucleus.
These
were
synthesized
by
treating
with
hydrazine
hydrate
presence
1,1‐carbonyldiimidazole
(CDI)
tetrahydrofuran
(THF).
The
obtained
hydrazide
was
further
treated
various
benzaldehydes
ethanol
solvent
containing
acetic
acid
as
a
catalyst
to
get
desired
bases
good
yields.
Structures
these
have
been
structurally
deduced
means
modern
spectroscopic
techniques
(FT‐IR,
mass,
1
H‐NMR,
13
C‐NMR)
screened
against
Gram‐positive
andGram‐negative
strains
(ATCC)
including
Escherichia
coli
(ATCC
25922),
Klebsiella
pneumoniae
BAA‐1705),
Staphylococos
aureus
33862),
Pseudomonas
aeruginosa
15442)
quiet
diverse
results
observed.
All
compounds
series
presented
significant
levels
inhibition
all
tested
(MIC
range
0.019
1.25
mg/mL).
Most
active
reported
2a
0.78
mg/mL)
2d
(0.019
g/mL).
Molecular
docking
investigation
performed
know
binding
interactions
targeted
enzyme's
site.
The Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
89(15), P. 10773 - 10784
Published: July 17, 2024
This
study
showcases
successfully
switchable
approaches
to
accomplish
the
C3-aryl
methylation
and
C3-
amino
of
privileged
nitrogen-containing
pharmaceutical
compounds
"imidazopyridines"
with
distinct
amines,
which
surmounts
long-standing
requirement
for
a
superfluous
directing
group.
These
two
transformations
manifest
pronounced
regio-
chemo-divergent
behavior,
demonstrating
unprecedented
multicomponent
"abnormal
Mannich
Mannich-type"
reactions.
The
remarkable
environmentally
benign
protocol
has
been
efficiently
extended
concise
synthesis
late-stage
derivatization.
