Phytomedicine, Journal Year: 2025, Volume and Issue: 139, P. 156446 - 156446
Published: Jan. 31, 2025
Language: Английский
Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 14
Published: Jan. 9, 2024
Diabetic peripheral neuropathy (DPN) refers to the development of nerve dysfunction in patients with diabetes when other causes are excluded. distal symmetric polyneuropathy (DSPN) is most representative form DPN. As one common complications diabetes, its prevalence increases duration diabetes. 10-15% newly diagnosed T2DM have DSPN, and can exceed 50% for more than 10 years. Bilateral limb pain, numbness, paresthesia clinical manifestations DPN, severe cases, foot ulcers occur, even leading amputation. The etiology pathogenesis diabetic not yet completely clarified, but hyperglycemia, disorders lipid metabolism, abnormalities insulin signaling pathways currently considered be initiating factors a range pathophysiological changes In presence abnormal metabolic factors, normal structure function entire nervous system disrupted, including myelinated unmyelinated axons, perikaryon, neurovascular, glial cells. addition, pathway will inhibit neural axon repair promote apoptosis damaged Here, we discuss recent advances study DPN mechanisms, oxidative stress pathways, mechanisms microvascular damage, damage receptor potential associated neuroinflammation, mitochondrial dysfunction, cellular damage. Identifying contributions from each associations between them may help us further explore targeted screening treatment interventions.
Language: Английский
Citations
68
International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(15), P. 12378 - 12378
Published: Aug. 3, 2023
Diabetes mellitus (DM) belongs to the category of socially significant diseases with epidemic rates increases in prevalence. Diabetic nephropathy (DN) is a specific kind kidney damage that occurs 40% patients DM and considered serious complication DM. Most modern methods for treatments aimed at slowing down progression DN have side effects do not produce unambiguous positive results long term. This fact has encouraged researchers search additional or alternative treatment methods. Hyperglycemia negative effect on renal structures due number factors, including activation polyol hexosamine glucose metabolism pathways, renin-angiotensin-aldosterone sympathetic nervous systems, accumulation advanced glycation end products insulin resistance endothelial dysfunction tissues. The above mechanisms cause development oxidative stress (OS) reactions mitochondrial dysfunction, which turn contribute DN. Modern antioxidant therapies involve various phytochemicals (food antioxidants, resveratrol, curcumin, alpha-lipoic acid preparations, etc.), are widely used only diabetes but also other systemic diseases. It been suggested therapeutic approaches target source reactive oxygen species may certain advantages terms nephroprotection from OS. review describes significance studies OS biomarkers pathogenesis analyzes reducing intensity prevention
Language: Английский
Citations
45
Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: 12(5), P. 1126 - 1148
Published: Jan. 1, 2024
This review highlights the latest progress of smart hydrogel dressings for bandaging, monitoring and therapy diabetic wounds.
Language: Английский
Citations
19
Cell Death and Disease, Journal Year: 2024, Volume and Issue: 15(6)
Published: June 24, 2024
Abstract Diabetic kidney disease, known as a glomerular arises from metabolic disorder impairing renal cell function. Mitochondria, crucial organelles, play key role in substance metabolism via oxidative phosphorylation to generate ATP. Cells undergo reprogramming compensatory mechanism fulfill energy needs for survival and growth, attracting scholarly attention recent years. Studies indicate that mitochondrial significantly influences the pathophysiological progression of DKD. Alterations lead abnormal expression signaling molecules activation pathways, inducing stress-related cellular damage, inflammatory responses, apoptosis, autophagy irregularities, culminating fibrosis insufficiency. This review delves into impact on DKD pathogenesis, emphasizing regulation regulators downstream pathways. Therapeutic interventions targeting can potentially delay progression. The findings underscore importance focusing develop safer more effective therapeutic approaches.
Language: Английский
Citations
18
Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 15
Published: Feb. 19, 2025
It has been regarded as an essential treatment option for diabetic nephropathy (DN) in Traditional Chinese medicine. Previous studies have demonstrated the anti-DN efficacy of Schisandra chinensis Fruit Mixture (SM); however, a comprehensive chemical fingerprint is still uncertain, and its mechanism action, especially potential therapeutic targets anti-DN, needs to be further elucidated. Potential mechanisms SM action on DN were explored through network pharmacology experimental validation. The composition was analyzed using UPLC-ESI-MS/MS technology. Active bioactive components identified TCMSP, SwissDrugDesign, SymMap platforms. Differentially expressed genes determined microarray gene data from GSE30528 dataset. Related obtained online databases, which include GeneCards, OMIM DisGeNET. PPI networks compound-target-pathway constructed Cytoscape. Functional annotation performed R software GO enrichment KEGG pathway analysis. model built validation high-sugar high-fat diet combined with STZ induction. Hub critical signaling pathways detected qPCR, Western blotting immunofluorescence. Utilizing coupling technique, analysis 1281 SM's ethanol extract, 349 these recognized compounds pharmacology. Through this analysis, 126 shared 15 HUB pinpointed. Of these, JAK2 most gene. Enrichment revealed that primarily operates within PI3K/AKT pathway. In vivo experiments confirmed improved pathological injury renal function rats while improving mitochondrial morphology modulating expression proteins linked apoptosis (cleaved-caspase-3, Bax, Bcl-2) pro-inflammatory factors (IL-6 TNF-α). Mechanistically, alleviates by suppressing PI3K/AKT/mTOR JAK2/STAT3 fulfill energy tissues. Furthermore, molecular docking provided direct findings. findings study offer initial indications active component robust anti-inflammatory anti-apoptotic characteristics mitigation DN, along capacity safeguard integrity functionality mitochondria. This research unequivocally validates favorable effects SM, indicating viable pharmaceutical agent management DN.
Language: Английский
Citations
2
Archives of Physiology and Biochemistry, Journal Year: 2023, Volume and Issue: 130(6), P. 616 - 641
Published: Aug. 11, 2023
Diabetes mellitus (DM) is a huge global health issue and one of the most studied diseases, with large prevalence. Oxidative stress cytotoxic consequence excessive development ROS suppression antioxidant defense system for elimination, which accelerates progression diabetes complications such as diabetic neuropathy, retinopathy, nephropathy. Hyperglycaemia induced oxidative causes activation seven major pathways implicated in pathogenesis complications. These increase production RNS, contributes to dysregulated autophagy, gene expression changes, numerous pro-inflammatory mediators may eventually lead This review will illustrate that plays vital role complications, use antioxidants help reduce thus alleviate
Language: Английский
Citations
27
Biomolecules, Journal Year: 2024, Volume and Issue: 14(1), P. 137 - 137
Published: Jan. 22, 2024
Kidney fibrosis, diffused into the interstitium, vessels, and glomerulus, is main pathologic feature associated with loss of renal function chronic kidney disease (CKD). Fibrosis may be triggered in diseases by different genetic molecular insults. However, several studies have shown that fibrosis can linked to oxidative stress mitochondrial dysfunction CKD. In this review, we will focus on three pathways link namely: (i) hyperglycemia energy imbalance, (ii) mineralocorticoid signaling pathway, (iii) hypoxia-inducible factor (HIF) pathway. We selected these because they are targeted available medications capable reducing such as sodium-glucose cotransporter-2 (SGLT2) inhibitors, non-steroidal receptor antagonists (MRAs), HIF-1alpha-prolyl hydroxylase inhibitors. These drugs a reduction reduced collagen deposition across CKD subtypes. there still long winding road clear understanding anti-fibrotic effects compounds humans, due inherent practical ethical difficulties obtaining sequential biopsies lack specific biomarkers measurable easily accessible matrices like urine. narrative describe pathways, their interconnections, activity fibrosis.
Language: Английский
Citations
16
Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 14
Published: Jan. 8, 2024
Rhodiola rosea is a valuable functional medicinal plant widely utilized in China and other Asian countries for its anti-fatigue, anti-aging, altitude sickness prevention properties. Salidroside, most active constituent derived from , exhibits potent antioxidative, hypoxia-resistant, anti-inflammatory, anticancer, anti-aging effects that have garnered significant attention. The appreciation of the pharmacological role salidroside has burgeoned over last decade, making it beneficial option treatment multiple diseases, including atherosclerosis, Alzheimer’s disease, Parkinson’s cardiovascular more. With renoprotective effects, parallel with inhibition oxidative stress inflammation, holds promise as potential therapeutic agent kidney damage. This article provides an overview microinflammatory state disease discuss current strategies, particular focus on highlighting recent advancements utilizing renal disease. mechanisms action are primarily associated regulation gene protein expression glomerular endothelial cells, podocytes, tubule mesangial cells cell carcinoma cell, TNF-α, TGF-β, IL-1β, IL-17A, IL-6, MCP-1, Bcl-2, VEGF, ECM protein, caspase-3, HIF-1α, BIM, well modulation AMPK/SIRT1, Nrf2/HO-1, Sirt1/PGC-1α, ROS/Src/Cav-1, Akt/GSK-3β, TXNIP-NLRP3, ERK1/2, TGF-β1/Smad2/3, PI3K/Akt, Wnt1/Wnt3a β-catenin, TLR4/NF-κB, MAPK, JAK2/STAT3, SIRT1/Nrf2 pathways. To best our knowledge, this review first to comprehensively cover protective diverse suggests great be developed drug metabolic syndrome, cerebrovascular diseases complications.
Language: Английский
Citations
14
Aquatic Toxicology, Journal Year: 2024, Volume and Issue: 267, P. 106839 - 106839
Published: Jan. 15, 2024
Language: Английский
Citations
10
Aggregate, Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 6, 2024
Abstract Diabetes significantly impairs the body's wound‐healing capabilities, leading to chronic, infection‐prone wounds. These wounds are characterized by hyperglycemia, inflammation, hypoxia, variable pH levels, increased matrix metalloproteinase activity, oxidative stress, and bacterial colonization. complex conditions complicate effective wound management, prompting development of advanced diabetic care strategies that exploit specific characteristics such as acidic pH, high glucose stress trigger controlled drug release, thereby enhancing therapeutic effects dressings. Among solutions, hydrogels emerge promising due their stimuli‐responsive nature, making them highly for managing these The latest advancements in mono/multi‐stimuli‐responsive smart showcase superiority potential healthcare materials, highlighted relevant case studies. However, traditional dressings fall short meeting nuanced needs wounds, adjustable adhesion, easy removal, real‐time status monitoring, dynamic release adjustment according wound's conditions. Responsive represent a significant leap forward proficient sensing responding environment, offering more targeted approach treatment. This review highlights recent dressing, delivery, emphasizing role improving healing. It addresses ongoing challenges future directions, aiming guide clinical adoption.
Language: Английский
Citations
9