Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15
Published: Dec. 9, 2024
Nephrotic syndrome has a significant impact on global health, often leading to cardiovascular disease and high mortality due limited effective treatments. This study investigates the efficacy of Shensu IV in puromycin aminonucleoside (PAN)-induced rat model nephropathy.
Language: Английский
Antioxidants, Journal Year: 2024, Volume and Issue: 13(6), P. 687 - 687
Published: June 3, 2024
Affecting millions of people worldwide, chronic kidney disease is a serious medical problem. It results in decrease glomerular filtration rate below 60 mL/min/1.73 m, albuminuria, abnormalities urine sediment and pathologies detected by imaging studies lasting minimum 3 months. Patients with CKD develop uremia, as result the accumulation uremic toxins body, patients can be expected to suffer from number consequences such progression renal fibrosis, development atherosclerosis or increased incidence cardiovascular events. Another key element pathogenesis oxidative stress, resulting an imbalance between production antioxidants reactive oxygen species. Oxidative stress contributes damage cellular proteins, lipids DNA increases inflammation, perpetuating dysfunction. Additionally, fibrogenesis involving fibrous tissue kidneys occurs. In our review, we also included examples forms therapy for CKD. To improve condition patients, pharmacotherapy used, described review. Among drugs that prognosis CKD, include: GLP-1 analogues, SGLT2 inhibitors, Finerenone monoclonal antibody—Canakinumab Sacubitril/Valsartan.
Language: Английский
Citations
11
Nutrients, Journal Year: 2025, Volume and Issue: 17(3), P. 492 - 492
Published: Jan. 29, 2025
Objectives: This study aimed to investigate the relationship between triglyceride–glucose (TyG) index, its combination with body roundness index (BRI), and chronic kidney disease (CKD) in patients type 2 diabetes mellitus (T2DM) based on a cross-sectional analysis conducted Eastern China. Methods: The research originates from performed Zhejiang Province, China, March November 2018. TyG-BRI was calculated triglyceride, fasting blood glucose, BRI. correlation risk of CKD assessed using restricted cubic spline model. A multivariate logistic regression model used association CKD. Receiver operating characteristic (ROC) analyses evaluate optimal cut-off value for predicting Results: total 1756 T2DM participants were enrolled this study. significantly higher than those without In fully adjusted model, odds ratios second, third, fourth quartiles 0.93 (95% CI: 0.65–1.33), 1.33 0.94–1.88), 1.57 1.10–2.25), respectively, compared first quartile. RCS confirmed linear dose–response (all p nonlinearity > 0.05). ROC curve revealed that had moderate predictive CKD, an area under 0.626 0.597–0.656, < 0.001). 42.46, sensitivity 68.2% specificity 52.2%. Conclusions: positively associated population, demonstrating value. It may serve as valuable tool identifying high-risk individuals informing targeted interventions prevent or delay progression population.
Language: Английский
Citations
1
Food Bioscience, Journal Year: 2024, Volume and Issue: 59, P. 103904 - 103904
Published: March 14, 2024
Language: Английский
Citations
6
Biomedicines, Journal Year: 2025, Volume and Issue: 13(3), P. 728 - 728
Published: March 17, 2025
Atherosclerosis is a closely related complication of diabetes mellitus (DM), driven by endothelial dysfunction, inflammation, and oxidative stress. The progression atherosclerosis accelerated hyperglycemia, insulin resistance, hyperlipidemia. Novel antidiabetic agents, SGLT2 inhibitors, GLP-1 agonists improve glycemic control offer cardiovascular protection, reducing the risk major adverse events (MACEs) heart failure hospitalization. These along with nonsteroidal mineralocorticoid receptor antagonists (nsMRAs), promise to mitigate metabolic disorders their impact on function, stress, inflammation. This review explores potential molecular mechanisms through which these drugs may prevent development disease (CVD), supported summary preclinical clinical evidence.
Language: Английский
Citations
0
Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15
Published: July 4, 2024
Objectives To evaluate the efficacy and safety of non-steroid mineralocorticoid receptor antagonists (ns-MRAs) sodium-glucose cotransporter 2 inhibitors (SGLT2is) in patients with diabetic kidney disease (DKD). Methods Systematic literature searches were performed using PubMed, Embase Web Science encompassing inception until January 20, 2024. Randomized control trials (RCTs) comparing ns-MRAs SGLT2is DKD selected. The outcomes interest included kidney-specific composite outcome, cardiovascular (CV)-specific end-stage (ESKD), overall mortality. We also investigated outcomes, including acute injury (AKI) hyperkalemia. Results A total 10 randomized clinical 35,786 applying various treatments included. (SUCRA 99.84%) have potential superiority protection. (RR 1.41, 95%CI 1.26 to 1.57) 1.17, 95% CI 1.08 1.27) associated significantly lower outcome than placebo. Regarding reduction CV-specific ESKD, 91.61%; 91.38%) playing cardiorenal Concerning 1.27, 1.09 1.43) ESKD 1.43, 1.20 1.72), reduced risks compared mortality, 83.03%) postponing comparable effects placebo reduce risk mortality For AKI reduction, 63.58%) superiority. 1.24, 1.05 1.46) AKI. hyperkalemia 93.12%) nsMRAs 1.24 0.39 3.72) 1.01 0.40 3.02) did not show significant benefit Conclusion may be recommended as a treatment regimen for maximizing protection, minimal DKD. review registration https://www.crd.york.ac.uk/prospero/ , identifier CRD42023458613.
Language: Английский
Citations
3
Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: 335, P. 118679 - 118679
Published: Aug. 8, 2024
Sanqi oral solution (SQ) is a traditional Chinese patent medicine, widely used to treat chronic kidney diseases (CKD) in the clinic China. Previous studies have confirmed its anti-renal fibrosis effect, but specific pharmacological mechanism still unclear.
Language: Английский
Citations
3
Journal of Personalized Medicine, Journal Year: 2024, Volume and Issue: 14(12), P. 1157 - 1157
Published: Dec. 19, 2024
Chronic kidney disease (CKD) is a major worldwide health concern because of its progressive nature and complex biology. Traditional diagnostic therapeutic approaches usually fail to account for heterogeneity, resulting in low efficacy. Precision medicine offers novel approach studying by combining omics technologies such as genomics, transcriptomics, proteomics, metabolomics, epigenomics. By identifying discrete subtypes, molecular biomarkers, targets, these pave the way personalized treatment approaches. Multi-omics integration has enhanced our understanding CKD revealing intricate linkages pathways that contribute resistance progression. While pharmacogenomics insights into expected responses treatments, single-cell spatial transcriptomics can be utilized investigate biological heterogeneity. Despite significant development, challenges persist, including data concerns, high costs, ethical quandaries. Standardized protocols, collaborative data-sharing frameworks, advanced computational tools machine learning causal inference models are required address challenges. With advancement technology, nephrology may benefit from improved accuracy, risk assessment, care. overcoming barriers, precision potential develop techniques improving patient outcomes treatment.
Language: Английский
Citations
2
Biomolecules, Journal Year: 2024, Volume and Issue: 14(8), P. 973 - 973
Published: Aug. 9, 2024
The kidney performs fundamental functions by eliminating metabolic waste and reabsorbing essential nutrients electrolytes such as glucose, proteins, ions, anions [...].
Language: Английский
Citations
1
Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: 335, P. 118693 - 118693
Published: Aug. 12, 2024
Language: Английский
Citations
1
Cellular Signalling, Journal Year: 2024, Volume and Issue: 122, P. 111347 - 111347
Published: Aug. 13, 2024
Language: Английский
Citations
1