Exploring and disentangling the production of potentially bioactive phenolic catabolites from dietary (poly)phenols, phenylalanine, tyrosine and catecholamines

Redox Biology, Journal Year: 2024, Volume and Issue: 71, P. 103068 - 103068

Published: Feb. 13, 2024

Following ingestion of fruits, vegetables and derived products, (poly)phenols that are not absorbed in the upper gastrointestinal tract pass to colon, where they undergo microbiota-mediated ring fission resulting production a diversity low molecular weight phenolic catabolites, which appear circulatory system excreted urine along with their phase II metabolites. There is increasing interest these catabolites because potential bioactivity use as biomarkers (poly)phenol intake. Investigating fate dietary (poly)phenolics colon has become confounded result recent realisation many phenolics appearing biofluids can also be from aromatic amino acids, l-phenylalanine l-tyrosine, lesser extent catecholamines, reactions catalysed by both colonic microbiota endogenous mammalian enzymes. The available evidence, albeit currently rather limited, indicates substantial amounts originate phenylalanine tyrosine, while somewhat smaller quantities produced (poly)phenols. This review outlines information on this topic assesses procedures used help distinguish between originating (poly)phenols, two acids catecholamines.

Language: Английский

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A critical examination of human data for the biological activity of quercetin and its phase-2 conjugates

Critical Reviews in Food Science and Nutrition, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 37

Published: Jan. 8, 2024

This critical review examines evidence for beneficial effects of quercetin phase-2 conjugates from clinical intervention studies, volunteer feeding trials, and in vitro work. Plasma concentrations quercetin-3-

Language: Английский

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A critical examination of human data for the biological activity of phenolic acids and their phase-2 conjugates derived from dietary (poly)phenols, phenylalanine, tyrosine and catecholamines

Critical Reviews in Food Science and Nutrition, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 60

Published: Oct. 9, 2024

Free or conjugated aromatic/phenolic acids arise from the diet, endogenous metabolism of catecholamines (adrenaline, noradrenaline, dopamine), protein (phenylalanine, tyrosine), pharmaceuticals (aspirin, metaprolol) plus gut microbiota dietary (poly)phenols and undigested protein. Quantitative data obtained with authentic calibrants for 112 including phase-2 conjugates in human plasma, urine, ileal fluid, feces tissues have been collated mean/median values compared

Language: Английский

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Transformations of phenolic compounds in cocoa shell during in vitro colonic fermentation

Current Research in Food Science, Journal Year: 2024, Volume and Issue: 9, P. 100930 - 100930

Published: Jan. 1, 2024

Language: Английский

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Microbially-Mediated Phenolic Catabolites Exert Differential Geno-Protective Activities in Normal and Adenocarcinoma Cell Lines

Published: Aug. 9, 2023

Ageing is associated with a decline in both Nrf2 activity and DNA repair efficiency, leading to the accumulation of damage an increased risk cancer. Understanding mechanisms behind level damaged during ageing crucial for developing interventions mitigate age-related cancer improve overall health older individuals. (Poly)phenols are plant-derived bioactive compounds that undergo metabolism into simpler phenolic catabolites following ingestion. While these have been various benefits, further analysis their bioavailable necessary. To this end, four derived from colonic microbiota were investigated ability reduce response oxidative challenge modulate Nrf2-Antixoidant Response Element pathway. Normal adenocarcinoma colonocyte cell lines (CCD 841 CoN, & HT29 respectively) exposed sub cytotoxic concentrations (>10 µM,) hydroxylated (4-hydroxybenzoic acid, 3-(3’-hydroxyphenyl) propionic acid) non-hydroxylated (benzoic acid or 3-phenylpropionic acids. Using COMET assay, each catabolite demonstrated significant (p<0.001) geno-protective activity, albeit varying potency. They also significantly modulated expression key genes Nrf2-ARE pathway, including Nrf2, Heme oxygenase-1 (HO-1), NAD(P)H dehydrogenase quinone 1 (NQO1). Hydroxylation acids appeared limited effect respect bioactivity. Overall, colon metabolites, when assessed at physiologically relevant concentrations, reduced normal cells challenge, mediated – least part via upregulation

Language: Английский

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Chronic consumption of a bergamot-based beverage does not affect glucose, lipid and inflammatory biomarkers of cardiometabolic risk in healthy subjects: a randomised controlled intervention study

Food & Function, Journal Year: 2024, Volume and Issue: 15(11), P. 5842 - 5854

Published: Jan. 1, 2024

Background: Pure bergamot juice exerts lipid lowering effects in dyslipidemic subjects. It is unknown whether bergamot-based beverages exert similar healthy Aim: To assess the effects, if any, of a beverage (BBB, ≤25%) on lipid, metabolic and inflammatory biomarkers. Methods: Forty-five subjects were randomised 1 : to BBB intake (400 mL day-1) (55.5%) or control (44.5%) for 12 weeks. Anthropometric (waist circumference, body mass index (BMI)) clinical (blood pressure) parameters, blood samples (glucose, glycated haemoglobin, insulinemia, profile, liver renal function, biomarkers) 24-h urine analysis (poly)phenol metabolites collected at baseline Intakes energy, nutrients food groups assessed by 7-day dietary record. Results: Both exhibited time-related significant decrease total cholesterol (p = 0.02), fasting plasma glucose 0.016), insulin 0.034), BMI < 0.001) waist circumference 0.04), but with no between-arm difference. The urinary profile from BBB-derived (poly)phenols well discriminated two study groups, documenting good compliance intervention arm. Notably, 3-hydroxy-3-methylglutaryl (HMG) -containing flavanones derived HMG-containing not detectable. was tolerated adverse events recorded. Conclusion: This first randomized controlled trial consumption showed cardiometabolic risk profile. safe nutritional adjunct context balanced diet.

Language: Английский

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Bioavailability of Mango (Poly)Phenols: An Evaluation of the Impact of the Colon, and Phenylalanine and Tyrosine on the Production of Phenolic Catabolites

Published: Jan. 1, 2024

Language: Английский

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Microbially mediated phenolic catabolites exert differential genoprotective activities in normal and adenocarcinoma cell lines

International Journal of Food Sciences and Nutrition, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 14

Published: Sept. 11, 2024

Age-associated decline of nuclear factor erythroid 2-related 2 (Nrf2) activity and DNA repair efficiency leads to the accumulation damage increased risk cancer. Understanding mechanisms behind levels damaged is crucial for developing interventions mitigate age-related cancer risk. Associated with various health benefits, (poly)phenols their microbially mediated phenolic catabolites represent a potential means reduce damage. Four colonic-microbiota-derived were investigated ability H

Language: Английский

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Bioavailability of mango (poly)phenols: an evaluation of the impact of the colon, and phenylalanine and tyrosine on the production of phenolic catabolites

Free Radical Biology and Medicine, Journal Year: 2024, Volume and Issue: 225, P. 605 - 616

Published: Oct. 18, 2024

Language: Английский

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