NF-κB in biology and targeted therapy: new insights and translational implications

Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)

Published: March 4, 2024

Abstract NF-κB signaling has been discovered for nearly 40 years. Initially, was identified as a pivotal pathway in mediating inflammatory responses. However, with extensive and in-depth investigations, researchers have that its role can be expanded to variety of mechanisms, biological processes, human diseases, treatment options. In this review, we first scrutinize the research process signaling, summarize composition, activation, regulatory mechanism signaling. We investigate interaction other important pathways, including PI3K/AKT, MAPK, JAK-STAT, TGF-β, Wnt, Notch, Hedgehog, TLR The physiological pathological states well intricate involvement inflammation, immune regulation, tumor microenvironment, are also explicated. Additionally, illustrate how is involved cancers, autoimmune cardiovascular metabolic neurological COVID-19. Further, discuss therapeutic approaches targeting IKK inhibitors, monoclonal antibodies, proteasome nuclear translocation DNA binding TKIs, non-coding RNAs, immunotherapy, CAR-T. Finally, provide an outlook field hope present stereoscopic, comprehensive will inform future clinical practice.

Language: Английский

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Antioxidant, Anti-Inflammatory, Anti-Menopausal, and Anti-Cancer Effects of Lignans and Their Metabolites

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(24), P. 15482 - 15482

Published: Dec. 7, 2022

Since chronic inflammation can be seen in severe, long-lasting diseases such as cancer, there is a high demand for effective methods to modulate inflammatory responses. Among many therapeutic candidates, lignans, absorbed from various plant sources, represent type of phytoestrogen classified into secoisolariciresionol (Seco), pinoresinol (Pino), matairesinol (Mat), medioresinol (Med), sesamin (Ses), syringaresinol (Syr), and lariciresinol (Lari). Lignans consumed by humans further modified END or ENL the activities gut microbiota. are known exert antioxidant anti-inflammatory activities, together with activity estrogen receptor-dependent pathways. may have potential postmenopausal symptoms, including cardiovascular disease, osteoporosis, psychological disorders. Moreover, antitumor efficacy lignans has been demonstrated cancer cell lines, hormone-dependent breast prostate well colorectal cancer. Interestingly, molecular mechanisms these involve inhibition signals, nuclear factor (NF)-κB pathway. Therefore, we summarize recent vitro vivo studies evaluating biological effects focusing on their values agents.

Language: Английский

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Plant-Derived Bioactive Compounds and Potential Health Benefits: Involvement of the Gut Microbiota and Its Metabolic Activity

Biomolecules, Journal Year: 2022, Volume and Issue: 12(12), P. 1871 - 1871

Published: Dec. 13, 2022

The misuse and abuse of antibiotics in livestock poultry seriously endanger both human health the continuously healthy development breeding industry. Plant-derived bioactive compounds (curcumin, capsaicin, quercetin, resveratrol, catechin, lignans, etc.) have been widely studied recent years, due to their extensive pharmacological functions biological activities, such as anti-inflammatory, antioxidant, antistress, antitumor, antiviral, lowering blood glucose lipids, improving insulin sensitivity. Numerous studies demonstrated that plant-derived are able enhance host’s ability resist or diminish diseases by regulating abundance its gut microbiota, achieving great potential a substitute for antibiotics. Recent developments humans animals also highlighted major contribution microbiota nutrition, metabolism, immunity, neurological functions. Changes composition closely related obesity can lead numerous metabolic diseases. Mounting evidence has compounds, especially curcumin, improve intestinal barrier function flora. Furthermore, constituents be directly metabolized flora further produce metabolites interaction between host This largely enhances protective effect on whole body health, indicating bidirectional regulation application maintaining preventing treating various review mainly summarizes latest research progress bioregulation together with animals, so provide theoretical support new feed additives substitutes Overall, based this review, it concluded modulating hold promise toward animal husbandry.

Language: Английский

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Interplay between Lignans and Gut Microbiota: Nutritional, Functional and Methodological Aspects

Molecules, Journal Year: 2023, Volume and Issue: 28(1), P. 343 - 343

Published: Jan. 1, 2023

Lignans are non-flavonoid polyphenols present in a wide range of foods frequently consumed the Western world, such as seeds, vegetables and fruits, beverages coffee, tea wine. In particular, human gut microbiota (GM) can convert dietary lignans into biologically active compounds, especially enterolignans (i.e., enterolactone enterodiol), which play anti-inflammatory anti-oxidant roles, act estrogen receptor activators modulate gene expression and/or enzyme activity. Interestingly, recent evidence documenting those interventions involving enriched have shown beneficial protective effects on various pathologies, including colorectal breast cancer cardiovascular diseases. However, considering that more factors (e.g., diet, food transit time intestinal redox state) bioactivation by GM, there usually remarkable inter-individual differences urine, fecal blood concentrations enterolignans; hence, precise validated analytical methods, gas/liquid chromatography coupled to mass spectrometry, needed for their accurate quantification. Therefore, this review aims summarize roles enterolignans, interaction with GM new methodological approaches developed evaluation different biological samples, since they could be considered future promising nutraceuticals prevention chronic disorders.

Language: Английский

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Impact of Olive Oil Components on the Expression of Genes Related to Type 2 Diabetes Mellitus

Nutrients, Journal Year: 2025, Volume and Issue: 17(3), P. 570 - 570

Published: Feb. 3, 2025

Type 2 diabetes mellitus (T2DM) is a multifactorial metabolic disorder characterized by insulin resistance and beta cell dysfunction, resulting in hyperglycemia. Olive oil, cornerstone of the Mediterranean diet, has attracted considerable attention due to its potential health benefits, including reducing risk developing T2DM. This literature review aims critically examine synthesize existing research regarding impact olive oil on expression genes relevant paper also seeks provide an immunological genetic perspective signaling pathways main components extra virgin oil. Key bioactive such as oleic acid phenolic compounds, were identified modulators signaling. These compounds enhanced pathway, improved lipid metabolism, reduced oxidative stress decreasing reactive oxygen species (ROS) production. Additionally, they shown alleviate inflammation inhibiting NF-κB pathway downregulating pro-inflammatory cytokines enzymes. Furthermore, these observed mitigate endoplasmic reticulum (ER) markers, thereby protecting cells from apoptosis preserving their function. In summary, particularly constituents, been demonstrated enhance sensitivity, protect function, reduce modulating key involved processes. findings underscore oil’s therapeutic managing However, further research, well-designed human clinical trials, required fully elucidate role personalized nutrition strategies for prevention treatment

Language: Английский

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Ferroptosis meets inflammation: a new frontier in cancer therapy

Cancer Letters, Journal Year: 2025, Volume and Issue: unknown, P. 217696 - 217696

Published: April 1, 2025

Language: Английский

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Targeting gut-liver axis by dietary lignans ameliorate obesity: evidences and mechanisms

Critical Reviews in Food Science and Nutrition, Journal Year: 2023, Volume and Issue: unknown, P. 1 - 22

Published: Oct. 23, 2023

An imbalance between energy consumption and expenditure causes obesity. It is characterized by increased adipose accumulation accompanied chronic low-grade inflammation. Many studies have suggested that the gut microbiota of host mediates relationship high-fat diet development Diet nutrition body are heavily influenced microbiota. The alterations in may effects on homeostasis host's levels, systemic inflammation, lipid metabolism, insulin sensitivity. liver an important organ for fat metabolism gut-liver axis play role metabolism. Gut-liver a bidirectional its liver. As essential plant components, lignans been shown to different biological functions. Accumulating evidences lipid-lowering properties. Lignans can regulate level their metabolites host, thereby affecting signaling pathways related synthesis These make difference inhibiting accumulation, accelerating appetite, will provide groundwork future impact creation functional meals based those findings.

Language: Английский

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Bound Polyphenols of Oat Bran Released by Gut Microbiota Mitigate High Fat Diet-Induced Oxidative Stress and Strengthen the Gut Barrier via the Colonic ROS/Akt/Nrf2 Pathway

Journal of Agricultural and Food Chemistry, Journal Year: 2024, Volume and Issue: 72(23), P. 13099 - 13110

Published: May 28, 2024

Whole-grain foods are rich in bound polyphenols (BPs) whose health benefits were largely underestimated compared with free polyphenols. We first found that DFBP (dietary fiber BPs from oat bran) exhibited stronger colonic antioxidant activities than DF. 16S rRNA sequencing showed selectively changed gut microbial composition, which reciprocally released DFBP. Released reduced excessive ROS and via the ROS/Akt/Nrf2 pathway revealed by transcriptome western blot analysis. Colonic of mediated microbiota next proven treating mice broad-spectrum antibiotics. Next,

Language: Английский

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Targeting Nrf2 by bioactive peptides alleviate inflammation: expanding the role of gut microbiota and metabolites

Critical Reviews in Food Science and Nutrition, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 20

Published: June 17, 2024

Inflammation is a complex process that usually refers to the general response of body harmful stimuli various pathogens, tissue damage, or exogenous pollutants. Nuclear factor erythroid 2-related 2 (Nrf2) transcription regulates cellular defense against oxidative damage and toxicity by expressing genes related stress drug detoxification. In addition its antioxidant properties, Nrf2 involved in many other important physiological processes, including inflammation metabolism. can bind promoters upregulates their expressions, which alleviate oxidation-induced inflammation. has been shown upregulate heme oxygenase-1 expression, promotes NF-κB activation closely with Nrf2, as key response, expressions pro-inflammatory factors, pathway cell Bioactive peptides come from wide range sources have biological functions. Increasing evidence indicates bioactive potential anti-inflammatory activities. This article summarized sources, absorption utilization role alleviating via pathway. also regulate gut microbiota alter metabolites, through novel supplement mechanisms peptides. review provides reference for further study on effect development functional foods.

Language: Английский

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The synergistic effects of polyphenols and intestinal microbiota on osteoporosis

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: Oct. 23, 2023

Osteoporosis is a common metabolic disease in middle-aged and elderly people. It characterized by reduction bone mass, compromised microstructure, heightened fragility, an increased susceptibility to fractures. The dynamic imbalance between osteoblast osteoclast populations decisive factor the occurrence of osteoporosis. With increase population society, incidence osteoporosis, disability, mortality have gradually increased. Polyphenols are fascinating class compounds that found both food medicine exhibit variety biological activities with significant health benefits. As component food, polyphenols not only provide color, flavor, aroma but also act as potent antioxidants, protecting our cells from oxidative stress reducing risk chronic disease. Moreover, these natural anti-inflammatory properties, which aid immune response regulation potentially alleviate symptoms diverse ailments. gut microbiota can degrade into more absorbable metabolites, thereby increasing their bioavailability. shape its abundance. Therefore, studying synergistic effect may help treatment prevention By delving how enhance bioavailability abundance, this review offers valuable information references for

Language: Английский

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