3 Biotech, Journal Year: 2023, Volume and Issue: 13(9)
Published: Aug. 24, 2023
Language: Английский
Environmental Chemistry Letters, Journal Year: 2024, Volume and Issue: 22(2), P. 841 - 887
Published: Jan. 20, 2024
Language: Английский
Citations
174
Bone Research, Journal Year: 2024, Volume and Issue: 12(1)
Published: Feb. 29, 2024
Abstract Diabetic osteoporosis (DOP) is a significant complication that poses continuous threat to the bone health of patients with diabetes; however, currently, there are no effective treatment strategies. In diabetes, increased levels ferroptosis affect osteogenic commitment and differentiation mesenchymal stem cells (BMSCs), leading skeletal changes. To address this issue, we aimed target propose novel therapeutic approach for DOP. We synthesized ferroptosis-suppressing nanoparticles, which could deliver curcumin, natural compound, marrow using tetrahedral framework nucleic acid (tFNA). This delivery system demonstrated excellent curcumin bioavailability stability, as well synergistic properties tFNA. Both in vitro vivo experiments revealed nanoparticles enhance mitochondrial function by activating nuclear factor E2-related 2 (NRF2)/glutathione peroxidase 4 (GPX4) pathway, inhibiting ferroptosis, promoting BMSCs diabetic microenvironment, reducing trabecular loss, increasing formation. These findings suggest curcumin-containing DNA tetrahedron-based have promising potential DOP other ferroptosis-related diseases.
Language: Английский
Citations
74
Advanced Healthcare Materials, Journal Year: 2023, Volume and Issue: 13(4)
Published: Nov. 9, 2023
Diabetic wounds are more likely to develop into complex and severe chronic wounds. The objective of this study is assess a reactive oxygen species (ROS)-responsive multifunctional injectable hydrogel for the purpose diabetic wound healing. A (HA@Cur@Ag) successfully synthesized with dual antioxidant, antibacterial, anti-inflammatory properties by crosslinking thiol hyaluronic acid (SH-HA) disulfide-bonded hyperbranched polyethylene glycol (HB-PBHE) through Michael addition; while, incorporating curcumin liposomes silver nanoparticles (AgNPs). HA@Cur@Ag exhibits favorable biocompatibility, degradability, injectivity. outcomes in vitro vivo experiments demonstrate that can effectively be loaded release liposomes, as well ions, thereby facilitating healing multiple mechanisms, including ROS scavenging, bactericidal activity, effects, promotion angiogenesis. Transcriptome sequencing reveals suppresses activation tumour necrosis factor (TNF)/nuclear κB (NF-κB) pathway ameliorate oxidative stress inflammation These findings suggest ROS-responsive hydrogel, which possesses ability precisely coordinate integrate intricate biological molecular processes involved healing, notable potential expediting
Language: Английский
Citations
50
Nanomaterials, Journal Year: 2024, Volume and Issue: 14(8), P. 672 - 672
Published: April 12, 2024
Curcumin, an organic phenolic molecule that is extracted from the rhizomes of Curcuma longa Linn, has undergone extensive evaluation for its diverse biological activities in both animals and humans. Despite favorable characteristics, curcumin encounters various formulation challenges stability issues can be effectively addressed through application nanotechnology. Nano-based techniques specifically focused on enhancing solubility, bioavailability, therapeutic efficacy while mitigating toxicity, have been explored curcumin. This review systematically presents information improvement curcumin’s beneficial properties when incorporated, either individually or conjunction with other drugs, into nanosystems such as liposomes, nanoemulsions, polymeric micelles, dendrimers, nanoparticles, solid-lipid nanostructured lipid carriers. Additionally, examines ongoing clinical trials recently granted patents, offering a thorough overview dynamic landscape delivery. Researchers are currently exploring nanocarriers crucial features surface modification, substantial loading capacity, biodegradability, compatibility, autonomous targeting specificity selectivity. Nevertheless, utilization delivery still initial phases, regulatory approval pending persistent safety concerns surrounding their use.
Language: Английский
Citations
24
International Journal of Nanomedicine, Journal Year: 2023, Volume and Issue: Volume 18, P. 4275 - 4311
Published: July 1, 2023
Abstract: Breast cancer (BC) is the most prevalent type of in world and main reason women die from cancer. Due to significant side effects conventional treatments such as chemotherapy radiotherapy, search for supplemental alternative natural drugs with lower toxicity interest researchers. Curcumin (CUR) a polyphenol extracted turmeric. Numerous studies have demonstrated that CUR an effective anticancer drug works by modifying different intracellular signaling pathways. CUR's therapeutic utility severely constrained its short half-life vivo, low water solubility, poor stability, quick metabolism, oral bioavailability, potential gastrointestinal discomfort high doses. One practical solutions aforementioned issues development targeted delivery systems (TDDSs) based on nanomaterials. To improve targeting efficacy serve reference use TDDSs clinical setting, this review describes physicochemical properties bioavailability mechanism action BC, emphasis recent BC combination CUR, including passive TDDSs, active TDDSs. Keywords: breast cancer, curcumin, system, targeting,
Language: Английский
Citations
40
International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 2441 - 2467
Published: March 1, 2024
Abstract: New nanotechnology strategies for enhancing drug delivery in brain disorders have recently received increasing attention from designers. The treatment of neurological conditions, including tumors, stroke, Parkinson's Disease (PD), and Alzheimer's disease (AD), may be greatly influenced by nanotechnology. Numerous studies on neurodegeneration demonstrated the effective application nanomaterials illnesses. Nanocarriers (NCs) made it easier to deliver drugs precisely where they are needed. Thus, most use is various diseases, as this amplifies overall impact medication emphasizes significance nanotherapeutics through gene therapy, enzyme replacement blood-barrier mechanisms. Recent advances led development multifunctional nanotherapeutic agents, a promising disorders. This novel method reduces side effects improves outcomes. review critically assesses efficient nano-based systems light obstacles outstanding achievements. that transfer medications across blood-brain barrier nano-assisted therapies, nano-immunotherapy, nano-gene nano scaffolds, 3D 6D printing, been widely explored study aimed evaluate existing literature regarding can penetrate (BBB) therapeutic agents treat Keywords: delivery, nanomedicine, nano-therapeutics, nanocarriers,
Language: Английский
Citations
13
Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 180, P. 117404 - 117404
Published: Sept. 21, 2024
Language: Английский
Citations
13
International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 275, P. 133551 - 133551
Published: Aug. 1, 2024
Language: Английский
Citations
12
Foods, Journal Year: 2024, Volume and Issue: 13(11), P. 1610 - 1610
Published: May 22, 2024
The global population surge presents a dual challenge and opportunity in the realms of food consumption, safety, mental well-being. This necessitates projected 70% increase production to meet growing demands. Amid this backdrop, ongoing COVID-19 pandemic exacerbates these issues, underscoring need for deeper understanding intricate interplay between consumption patterns health dynamics during crisis. Mitigating spread hinges upon rigorous adherence personal hygiene practices heightened disease awareness. Furthermore, maintaining stringent quality safety standards across both public private sectors is imperative safeguarding containing viral transmission. Drawing existing research, study delves into pandemic’s impact on health, habits, protocols. Through comprehensive analysis, it aims elucidate nuanced relationship among food, well-being amid pandemic, highlighting synergistic effects that underpin holistic human welfare. Our offers novel approach by integrating psychological wellness with security safety. In conceiving review, we aimed comprehensively explore security, backdrop pandemic. review structured encompass thorough examination synthesizing insights multifaceted relationships patterns, dynamics, protocols findings provide valuable practical recommendations enhancing well-being, thus supporting academic research real-world applications crisis management policy development.
Language: Английский
Citations
8
Food Hydrocolloids, Journal Year: 2023, Volume and Issue: 146, P. 109311 - 109311
Published: Sept. 19, 2023
Language: Английский
Citations
16