Flavonoids: Overview of Biosynthesis, Biological Activity, and Current Extraction Techniques

Plants, Journal Year: 2023, Volume and Issue: 12(14), P. 2732 - 2732

Published: July 23, 2023

Recently, increased attention has been paid to natural sources as raw materials for the development of new added-value products. Flavonoids are a large family polyphenols which include several classes based on their basic structure: flavanones, flavones, isoflavones, flavonols, flavanols, and anthocyanins. They have multitude biological properties, such anti-inflammatory, antioxidant, antiviral, antimicrobial, anticancer, cardioprotective, neuroprotective effects. Current trends research flavonoids relate identification, extraction, isolation, physico-chemical characterization, applications health benefits. This review presents an up-to-date survey most recent developments in flavonoid classes, activity representative flavonoids, current extraction techniques, perspectives.

Language: Английский

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High Fischer ratio oligopeptides from hard-shelled mussel: Preparation and hepatoprotective effect against acetaminophen-induced liver injury in mice

Food Bioscience, Journal Year: 2023, Volume and Issue: 53, P. 102638 - 102638

Published: April 10, 2023

Language: Английский

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Anthocyanins from Lycium ruthenicum Murray Mitigate Cadmium-Induced Oxidative Stress and Testicular Toxicity by Activating the Keap1/Nrf2 Signaling Pathway

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(3), P. 322 - 322

Published: March 1, 2024

Cadmium (Cd) is a hazardous heavy metal environmental pollutant that has carcinogenic, teratogenic, and mutagenic properties. Excessive exposure to Cd can induce oxidative stress, which greatly harms the male reproductive system. Anthocyanins have remarkable antioxidative, anti-inflammatory, anti-stress In this study, we investigated effects of anthocyanins underlying mechanisms through mitigate Cd-induced damage. We isolated purified Lycium ruthenicum Murray anthocyanin extract (LAE) performed UHPLC-MS/MS identify 30 different anthocyanins. established an ICR mouse injury model by administering 5 mg/kg/day CdCl2 for 28 consecutive days. LAE at 500 effectively ameliorated testicular damage preserved spermatogenesis. The mice in LAE-treated group had elevated testosterone inhibin B levels. Additionally, treatment restored activity antioxidant enzymes, including T-SOD, CAT, GR, substantially increased levels non-enzymatic GSH. Research findings indicate activate SIRT1/Nrf2/Keap1 pathway. This activation achieved upregulation both SIRT1 gene protein levels, leading deacetylation Nrf2. Moreover, reduces expression Keap1, alleviating its inhibitory effect on This, turn, facilitates uncoupling process, promoting translocation Nrf2 nucleus, where it governs downstream expression, HO-1 GPX1. mitigated toxicity system associated with stress testes.

Language: Английский

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Hepatoprotective Effects of Flavonoids against Benzo[a]Pyrene-Induced Oxidative Liver Damage along Its Metabolic Pathways

Antioxidants, Journal Year: 2024, Volume and Issue: 13(2), P. 180 - 180

Published: Jan. 31, 2024

Benzo[a]pyrene (B[a]P), a highly carcinogenic polycyclic aromatic hydrocarbon primarily formed during incomplete organic matter combustion, undergoes series of hepatic metabolic reactions once absorbed into the body. B[a]P contributes to liver damage, ranging from molecular DNA damage onset and progression various diseases, including cancer. Specifically, induces oxidative stress via reactive oxygen species generation within cells. Consequently, more research has focused on exploring underlying mechanisms B[a]P-induced potential strategies counter its toxicity. Flavonoids, natural compounds abundant in plants renowned for their antioxidant properties, possess ability neutralize adverse effects free radicals effectively. Although extensive investigated flavonoids, limited delved regulating metabolism alleviate stress. This review aims consolidate current knowledge examines role flavonoids mitigating

Language: Английский

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Echinatin attenuates acute lung injury and inflammatory responses via TAK1-MAPK/NF-κB and Keap1-Nrf2-HO-1 signaling pathways in macrophages

PLoS ONE, Journal Year: 2024, Volume and Issue: 19(5), P. e0303556 - e0303556

Published: May 16, 2024

Echinatin is an active ingredient in licorice, a traditional Chinese medicine used the treatment of inflammatory disorders. However, protective effect and underlying mechanism echinatin against acute lung injury (ALI) still unclear. Herein, we aimed to explore echinatin-mediated anti-inflammatory effects on lipopolysaccharide (LPS)-stimulated ALI its molecular mechanisms macrophages. In vitro , markedly decreased levels nitric oxide (NO) prostaglandin E2 (PGE 2 ) LPS-stimulated murine MH-S alveolar macrophages RAW264.7 by suppressing inducible synthase cyclooxygenase-2 (COX-2) expression. Furthermore, reduced LPS-induced mRNA expression release interleukin-1β (IL-1β) IL-6 cells. Western blotting CETSA showed that repressed activation mitogen-activated protein kinase (MAPK) nuclear factor-kappa B (NF-κB) pathways through targeting transforming growth factor-beta-activated 1 (TAK1). directly interacted with Kelch-like ECH-associated (Keap1) activated factor erythroid 2-related (Nrf2) pathway enhance heme oxygenase-1 (HO-1) vivo ameliorated injury, production IL-1β IL-6. These findings demonstrated exerted via blocking TAK1-MAPK/NF-κB activating Keap1-Nrf2-HO-1 pathway.

Language: Английский

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Anti-inflammatory properties of polysaccharides from edible fungi on health-promotion: a review

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: July 26, 2024

Edible fungus polysaccharides have garnered significant attention from scholars due to their safety and potential anti-inflammatory activity. However, comprehensive summaries of properties are still rare. This paper provides a detailed overview the effects mechanisms these polysaccharides, as well impact on inflammation-related diseases. Additionally, relationship between structure activity is discussed. It believed that this review will greatly enhance understanding application edible in treatments, thereby significantly promoting development utilization fungi.

Language: Английский

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Effects of in vitro fecal fermentation on the metabolism and antioxidant properties of cyanidin-3-O-glucoside

Food Chemistry, Journal Year: 2023, Volume and Issue: 431, P. 137132 - 137132

Published: Aug. 18, 2023

Language: Английский

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Enhancing the anti-fatigue effect of ginsenoside extract by Bifidobacterium animalis subsp. lactis CCFM1274 fermentation through biotransformation of Rb1, Rb2 and Rc to Rd

Food Bioscience, Journal Year: 2024, Volume and Issue: unknown, P. 105251 - 105251

Published: Oct. 1, 2024

Language: Английский

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Network pharmacology and experimental validation reveal dexmedetomidine’s protective mechanisms against acute liver injury in mice

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: March 17, 2025

Language: Английский

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Progress on the Extraction, Separation, Biological Activity, and Delivery of Natural Plant Pigments

Molecules, Journal Year: 2023, Volume and Issue: 28(14), P. 5364 - 5364

Published: July 12, 2023

Natural plant pigments are safe and have low toxicity, with various nutrients biological activities. However, the extraction, preservation, application of limited due to instability natural pigments. Therefore, it is necessary examine extraction processes in detail. This review discusses classification, methods, activities, modification methods that could improve stability from plants, providing a reference for applying industry cosmetics, food, pharmaceutical industries.

Language: Английский

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