BMC Microbiology,
Journal Year:
2024,
Volume and Issue:
24(1)
Published: Sept. 9, 2024
The
quest
for
candidate
probiotics
and
prebiotics
to
develop
novel
synbiotics
sustainable
profitable
fish
farming
remains
a
major
focus
various
stakeholders.
In
this
study,
we
examined
the
effects
of
combining
two
fungal
probiotics,
Saccharomyces
cerevisiae
Aspergillus
niger
with
extracts
Jerusalem
artichoke
white
button
mushroom
synbiotic
formulation
improve
growth
health
status
zebrafish
(Danio
rerio).
An
initial
in
vitro
study
determined
most
effective
combination,
which
was
then
tested
60-day
vivo
nutritional
trial
using
(80
±
1.0
mg)
as
model
animal.
Four
experimental
diets
were
prepared:
control
diet
(basal
diet),
prebiotic
100%
selected
extract,
probiotic
10
Bioactives
of
natural
origin
have
recently
gained
a
lot
ground
in
drug
discovery
due
to
their
enormous
structural
diversity,
diverse
pharmacological
activities,
safety,
and
inherent
binding
capacity
with
other
biomolecules.
However,
the
high
demand
for
new
agents
prevention
therapy
inflammation-related
chronic
disorders
has
not
yet
been
sufficiently
addressed
by
process.
This
gap
highlights
relevance
intensifying
studies
reach
sustainable
employment
huge
world
biodiversity,
such
as
microorganisms,
including
fungi
biotechnological
agro-food
medical
interest
that
can
be
easily
cultured/engineered
sources
bioactives
development.
Thus,
are
important
bioactive
compounds
studied
applied
different
purposes,
specifically,
pharmaceutical
area,
development
antibiotics,
immunomodulators,
immunosuppressants,
enzyme
inhibitors,
antiviral,
hypercholesteremic,
antineoplastic/antitumor,
anti-inflammatory
agents.
Within
this
chapter,
several
examples
metabolites
produced
species
proven
effects
beneficial
antithrombotic
potential
thoroughly
reviewed.
After
recent
updates
field
"omics"
"one
strain
many
compounds"
(OSMAC)
approaches,
within
chapter
emerging
use
fungal
endophytes
strong
unconventional
biologically
active
producing
pharmacologically
valuable
specific
plant-derived
products
is
also
presented.
Overall,
explores
current
future
perspectives
potent
properties
subsequent
health
benefits
applications
supplements
and/or
drugs.
Chemistry & Biodiversity,
Journal Year:
2024,
Volume and Issue:
21(12)
Published: Aug. 23, 2024
Abstract
Edible
Astraeus
mushrooms
are
known
for
their
nutritional
and
culinary
benefits
potential
therapeutic
properties.
However,
more
investigation
discussion
still
needed
to
understand
mechanisms
of
action
regarding
observed
biological
activities
thorough
chemical
analysis
bioactive
compounds.
This
review
provides
a
comprehensive
summary
the
properties
mode
extracts
isolated
It
covers
reported
antioxidant,
anti‐inflammatory,
antidiabetic,
anticancer,
anti‐tuberculosis,
antimalarial,
antiviral
antileishmanial
activities,
as
well
on
metabolic
cardiovascular
health
immune
function.
The
highlights
significance
compounds,
such
sugar
alcohols,
polysaccharides,
steroids,
lanostane
triterpenoids.
Moreover,
identifies
under‐researched
areas,
species,
which
holds
immense
research
potential.
Ultimately,
aims
inspire
further
nutraceuticals
or
therapeutics
these
mushrooms.
Foods,
Journal Year:
2023,
Volume and Issue:
12(13), P. 2576 - 2576
Published: July 1, 2023
Lipid
molecules,
such
as
policosanol,
ergosterol,
sphingomyelin,
omega
3
rich
phosphatidylcholine,
α-tocopherol,
and
sodium
butyrate,
have
emerged
novel
additions
to
the
portfolio
of
bioactive
lipids.
In
this
state-of-the-art
review,
we
discuss
these
lipids,
their
activity
against
obesity
mental
or
neurological
disorders,
with
a
focus
on
proposed
cellular
targets
ways
in
which
they
produce
beneficial
effects.
Furthermore,
available
information
is
compared
that
provided
by
silico
Absorption,
Distribution,
Metabolism,
Excretion,
Toxicity
(ADMET)
models
order
understand
usefulness
tools
for
discovery
new
compounds.
Accordingly,
it
was
possible
highlight
how
lipids
interact
various
related
molecule
transportation
absorption
(e.g.,
α-tocopherol
transfer
protein
α-Tocopherol,
ATP-binding
cassette
ABC
transporters
Apolipoprotein
E
sphingomyelins
phospholipids)
other
processes,
regulation
gene
expression
(involving
Sterol
Regulatory
Element-Binding
Proteins
ergosterol
Peroxisome
Proliferator-Activated
Receptors
case
policosanol)
inflammation
(the
interleukins
butyrate).
When
comparing
literature
Quantitative
Structure–Activity
Relationship
(QSAR)
models,
observed
although
are
useful
selecting
molecules
when
batch,
provide
does
not
coincide
assessed
individually.
Our
review
highlights
importance
considering
broad
range
potential
bioactives
need
accurate
prediction
ADMET
parameters
biomolecules.
The
presented
here
provides
resource
researchers
interested
developing
strategies
treatment
disorders.
Journal of Cleaner Production,
Journal Year:
2024,
Volume and Issue:
440, P. 140898 - 140898
Published: Jan. 27, 2024
Fungal
fermentation
is
a
promising
strategy
to
secure
affordable,
nutritious
and
sustainable
food.
Encouraging
engagement
with
fungi-based
food
crucial
contribute
social,
economic,
environmental
sustainability.
Reflections
can
trigger
sense
of
meaning
in
engaging
activities
resources.
The
aim
this
mixed
methods
study
was
explore
perceptions
whether
participants
think
their
own
consequential.
To
do
so,
the
explored
ecoethical
reflections
relating
thought
beneficial
or
not
for
environment.
This
also
glocal
kind
ways
that
extend
people
around
them
(i.e.,
local
population)
other
parts
world
global
population).
N
=
160
completed
questionnaires.
Most
expressed
positive
outlook,
believing
embracing
could
promote
increased
sustainability
overall
well-being
humans
environment
numerous
different
ways.
shared
affect
conscious
locally
awareness
its
impact
which,
turn,
individuals
population
level
thereby
efforts
at
archiving
development.
Nevertheless,
findings
highlight
necessity
more
information
enable
engage
knowledgeable
and,
ultimately,
act
upon
values
what
meaningful
them.
results
are
important
future
development
conceptualization
only
but
expected
Current Research in Food Science,
Journal Year:
2024,
Volume and Issue:
9, P. 100829 - 100829
Published: Jan. 1, 2024
This
study
investigated
the
development
of
hybrid
cheese
analogues
(HCA)
made
with
fermented
brewery
side-stream
ingredients
(spent
yeast
and
malt
rootlets)
dairy
milk.
Different
percentages
flours
(3.5%,
5%,
7.5%)
were
mixed
pasteurized
milk,
developed
HCA
evaluated
for
their
biochemical
textural
properties.
The
addition
a
fermentation
step
improved
nutrient
availability
led
to
pH
(range
4.79-5.60)
moisture
content
45.86%-61.29%)
similar
traditional
animal-based
fresh
cheeses
(control).
inclusion
coagulation,
even
without
rennet
addition.
higher
concentration
flour
used,
faster
coagulation
time,
suggesting
synergistic
effect
between
enzymes
present
in
flours.
Nevertheless,
properties
inferior
compared
control.
Selected
formulations
added
3.5%
exhibited
increased
counts
enterococci
enterobacteria
cell
densities,
ranging
from
7.28
±
0.03
7.72
0.09
log
CFU/g
4.90
0.16
5.41
0.01
CFU/g,
respectively.
Compared
control
sample,
concentrations
organic
acids,
peptides,
free
amino
acids
(FAAs).
Lactic
acid
reached
up
23.78
0.94
g/kg
dry
matter
(DM),
while
peptide
area
22918.50
2370.93
mL⋅AU.
Additionally,
total
individual
FAAs
2809.74
104.85
mg/kg
DM,
contrasted
control,
which
resulted
lower
(847.65
0.02
DM).
overall
findings
suggested
that
despite
challenges
microbiological
quality
properties,
produced
could
be
sustainable
solution
produce
nutritious
alternatives.
