Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 307 - 327
Published: Jan. 1, 2024
Language: Английский
Journal of Molecular Liquids, Journal Year: 2023, Volume and Issue: 390, P. 123037 - 123037
Published: Sept. 9, 2023
Language: Английский
Citations
37
Coordination Chemistry Reviews, Journal Year: 2023, Volume and Issue: 491, P. 215251 - 215251
Published: May 29, 2023
Language: Английский
Citations
30
International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(7), P. 6106 - 6106
Published: March 24, 2023
Human diseases are characterized by the perpetuation of an inflammatory condition in which levels Reactive Oxygen Species (ROS) quite high. Excessive ROS production leads to DNA damage, protein carbonylation and lipid peroxidation, conditions that lead a worsening disorders. In particular, compromised mitochondria sustain stressful cell, such mitochondrial dysfunctions become pathogenic, causing human disorders related reactions. Indeed, triggered inflammation loses its beneficial properties turns harmful if dysregulation not addressed. Thus, reducing oxidative stress with scavenger compounds has proven be successful approach inflammation. Among these, natural compounds, polyphenols, alkaloids coenzyme Q
Language: Английский
Citations
25
Chinese Herbal Medicines, Journal Year: 2023, Volume and Issue: 15(4), P. 485 - 495
Published: Sept. 4, 2023
Prostate cancer remains the second most common malignancy in men worldwide, is a global health issue, and poses huge burden. Precision medicine provides more treatment options for prostate patients, but its popularity, drug resistance, adverse reactions still need to be focused on. Chinese herbal medicines (CHMs) have been widely accepted as an alternative therapy cancer, with advantages of multiple targets, pathways, low toxicity. We searched experimental research clinical practice CHMs published PubMed, Embase, Web Science last five years. found CHM formulas six single extracts well 12 CHM-derived compounds, which showed induction apoptosis, autophagy, cell cycle arrest, suppression angiogenesis, proliferation, migration cells, reversal enhancement anti-tumor immunity. The mechanisms action include PI3K/Akt/mTOR, AR, EGFR Wnt/β-catenin signaling are commonly implicated development cancer. also summarized patients hormone-sensitive castration-resistant provided ideas their further design application.
Language: Английский
Citations
23
Life Sciences, Journal Year: 2022, Volume and Issue: 309, P. 120984 - 120984
Published: Sept. 20, 2022
Language: Английский
Citations
29
Phytomedicine Plus, Journal Year: 2024, Volume and Issue: 4(2), P. 100540 - 100540
Published: Feb. 21, 2024
cancer is one of the foremost life-threatening diseases and managed by various strategies like surgery, radiotherapy, chemotherapy. Among all, chemotherapy most preferential strategy for management but faces certain limitations. Phytochemicals (PCs) have been considered potential chemotherapeutics chemopreventive agents their clinical application can be questionable because poor bioavailability stability. phytosomes are promising carriers to deliver anticancer PCs target site with improved stability owing unique properties. This comprehensive review discusses recent advances in loaded (covering period 2013-December 2023) overcome limitations PCs. initially, this covers that under trials along FDA-approved (especially management). Here, we excluded a) an experimental/preclinical or investigational stage; b) possess activity other than anticancer; c) exhibit combination drugs; d) PC-based drugs anticancer. Further, article mainly emphasizes Additionally, cancer, challenges, future directions also discussed. versatile alternatives boost PCs' therapeutic efficacy, bioavailability, specific targeting distinctive structural composition, which similar composition cell membranes enabling them close physiological systems. Moreover, these vesicular systems increase oral polar PCs, protect from physical chemical degradation, facilitate efficiency through stimuli-responsive sustained release Therefore, will help researchers develop a phytochemical-based drug delivery system successful cancer.
Language: Английский
Citations
6
Drug Delivery, Journal Year: 2023, Volume and Issue: 30(1)
Published: Feb. 10, 2023
Andrographolide (AG), a major active constituent of Andrographis paniculata, is known to hinder proliferation several types cancer cells. However, its poor solubility and cellular permeability restrict use in clinical applications. In this study, AG-loaded phytosomes (AG-PTMs) were formulated optimized with respect particle size using l-α-phosphatidylcholine (PC):AG ratio sonication time (ST) as independent variables. The formula was prepared at 1:2.7 for AG:PC molar 4.9 min ST exhibited 243.7 ± 7.3 nm, polydispersity index (PDI) 0.310 entrapment efficiency 72.20 4.53. Also, the showed slow release AG over 24-h period. antiproliferative activity AG-PTMs investigated against liver cell line HepG2. significantly repressed growth HepG2 cells an IC50 value 4.02 0.14 µM. uptake by enhanced incubations containing formula. also caused G2-M cycle phase arrest increased fraction apoptotic pre-G1 phase. These effects associated induction oxidative stress mitochondrial dysfunction. addition, upregulated mRNA expression BAX downregulated that BCL2. Furthermore, concentration caspase-3 comparison raw AG. data indicate phytosomal delivery inhibited through uptake, arresting inducing mitochondrial-dependent apoptosis.
Language: Английский
Citations
16
International Journal of Food Properties, Journal Year: 2023, Volume and Issue: 26(1), P. 2476 - 2492
Published: Aug. 29, 2023
The target delivery of sensitive components to get the intended benefits is a challenge for global food industry. One principal strategies used boost individualized absorptivity, nutrient stability, and enhanced quality application liposomal systems in industry, which allows controlled release bioactive compounds. Lipid-oriented encapsulation such as liposomes are superior encapsulating components, increasing product solubility bioavailability, accurately targeting encapsulated content nutraceutical production. In this review, nature, composition, different methodologies preparation liposomes, Bangham Method, ethanol injection method, microfluidic channel freeze-drying method summarized. Moreover, crucial role delivering compounds cure health maladies has been emphasized.
Language: Английский
Citations
16
Biomaterials Advances, Journal Year: 2024, Volume and Issue: 162, P. 213903 - 213903
Published: May 24, 2024
Language: Английский
Citations
6
International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: 667, P. 124919 - 124919
Published: Nov. 7, 2024
Language: Английский
Citations
5