Polymers,
Journal Year:
2024,
Volume and Issue:
16(2), P. 206 - 206
Published: Jan. 10, 2024
Degradable
polymers
(both
biomacromolecules
and
several
synthetic
polymers)
for
biomedical
applications
have
been
promising
very
much
in
the
recent
past
due
to
their
low
cost,
biocompatibility,
flexibility,
minimal
side
effects.
Here,
we
present
an
overview
with
updated
information
on
natural
degradable
where
a
brief
account
different
polysaccharides,
proteins,
viz.
polyesters/polyamino
acids/polyanhydrides/polyphosphazenes/polyurethanes
relevant
has
provided.
The
various
approaches
transformation
of
these
by
physical/chemical
means
cross-linking,
as
polyblends,
nanocomposites/hybrid
composites,
interpenetrating
complexes,
interpolymer/polyion
functionalization,
polymer
conjugates,
block
graft
copolymers,
are
described.
degradation
mechanism,
drug
loading
profiles,
toxicological
aspects
polymeric
nanoparticles
formed
also
defined.
Biomedical
polymer-based
biomaterials
wound
dressing/healing,
biosensors,
delivery
systems,
tissue
engineering,
regenerative
medicine,
etc.,
highlighted.
In
addition,
use
such
nano
systems
solve
current
problems
is
briefly
reviewed.
Materials Today Bio,
Journal Year:
2023,
Volume and Issue:
23, P. 100837 - 100837
Published: Oct. 21, 2023
The
advent
of
nanotechnology
has
led
to
an
increased
interest
in
nanocarriers
as
a
drug
delivery
system
that
is
efficient
and
safe.
There
have
been
many
studies
addressing
nano-scale
vesicular
systems
such
liposomes
niosome
newer
generation
nanocarriers.
niosomes
provide
multilamellar
carrier
for
lipophilic
hydrophilic
bioactive
substances
the
self-assembled
vesicle,
which
are
composed
non-ionic
surfactants
conjunction
with
cholesterol
or
other
amphiphilic
molecules.
These
surfactant
vesicles,
simply
known
niosomes,
can
be
utilized
wide
variety
technological
applications.
As
alternative
liposomes,
considered
more
chemically
physically
stable.
methods
preparing
economic.
Many
reports
discussed
terms
their
physicochemical
properties
applications
systems.
carriers,
nano-sized
expand
horizons
pharmacokinetics,
decreasing
toxicity,
enhancing
solvability
bioavailability.
In
this
review,
we
review
components
fabrication
well
functionalization,
characterization,
administration
routes,
cancer
gene
delivery,
natural
product
delivery.
We
also
discuss
limitations
challenges
development
future
perspective
niosomes.
RSC Advances,
Journal Year:
2023,
Volume and Issue:
13(31), P. 21365 - 21382
Published: Jan. 1, 2023
This
review
focuses
on
the
research
progress
of
various
receptors
overexpressed
surface
cancer
cells
and
different
nano-delivery
systems
anticancer
drugs
targeted
cells.
Cancer Medicine,
Journal Year:
2024,
Volume and Issue:
13(5)
Published: March 1, 2024
Cancer
remains
a
leading
cause
of
death
worldwide,
necessitating
the
development
innovative
and
more
effective
treatment
strategies.
Conventional
cancer
treatments
often
suffer
from
limitations
such
as
systemic
toxicity,
poor
pharmacokinetics,
drug
resistance.
Recently,
there
has
been
growing
attention
to
utilizing
natural
compounds
derived
various
sources
possible
therapeutics.
Natural
have
demonstrated
diverse
bioactive
properties,
including
antioxidant,
anti-inflammatory,
antitumor
effects,
making
them
attractive
candidates
for
treatment.
However,
their
limited
solubility
bioavailability
present
challenges
delivery
cells.
To
overcome
these
limitations,
researchers
turned
nanotechnology-based
systems.
Nanoparticles,
with
small
size
unique
can
encapsulate
therapeutic
agents
offer
benefits
improved
solubility,
prolonged
release,
enhanced
cellular
uptake,
targeted
delivery.
Functionalizing
nanoparticles
specific
ligands
further
enhances
precision
in
recognizing
binding
Combining
nanotechnology
holds
great
promise
achieving
efficient
safe
by
enhancing
bioavailability,
selectivity
toward
This
review
article
provides
an
overview
advancements
substances
systems
It
discusses
drawbacks
types
nanoparticles,
well
characteristics
that
make
appealing
therapy.
Additionally,
current
research
on
preclinical
clinical
settings
is
highlighted.
Finally,
future
perspectives
developing
compound-nanoparticle-based
therapies
are
discussed.
Pharmaceutics,
Journal Year:
2024,
Volume and Issue:
16(2), P. 248 - 248
Published: Feb. 7, 2024
Traditional
tumor
treatments
have
the
drawback
of
harming
both
cells
and
normal
cells,
leading
to
significant
systemic
toxic
side
effects.
As
a
result,
there
is
pressing
need
for
targeted
drug
delivery
methods
that
can
specifically
target
or
tissues.
Currently,
researchers
made
progress
in
developing
systems
therapy
using
various
targeting
ligands.
This
review
aims
summarize
recent
advancements
therapy,
focusing
on
different
ligands
such
as
folic
acid,
carbohydrates,
peptides,
aptamers,
antibodies.
The
also
discusses
advantages,
challenges,
future
prospects
these
systems.
Pharmaceutics,
Journal Year:
2025,
Volume and Issue:
17(1), P. 114 - 114
Published: Jan. 15, 2025
Curcumin,
a
bioactive
compound
derived
from
the
rhizome
of
Curcuma
longa
L.,
has
garnered
significant
attention
for
its
potent
anticancer
properties.
Despite
promising
therapeutic
potential,
poor
bioavailability,
rapid
metabolism,
and
low
water
solubility
hinder
curcumin’s
clinical
application.
Nanotechnology
offers
viable
solution
to
these
challenges
by
enabling
development
curcumin-based
nanoparticles
(CNPs)
that
enhance
bioavailability
efficacy.
This
review
provides
comprehensive
overview
recent
advancements
in
design
synthesis
CNPs
cancer
therapy.
We
discuss
various
NP
formulations,
including
polymeric,
lipid-based,
inorganic
nanoparticles,
highlighting
their
role
improving
pharmacokinetic
pharmacodynamic
profiles.
The
mechanisms
which
exert
effects,
such
as
inducing
apoptosis,
inhibiting
cell
proliferation,
modulating
signaling
pathways,
are
explored
details.
Furthermore,
we
examine
preclinical
studies
have
demonstrated
efficacy
treating
different
types
tumors,
breast,
colorectal,
pancreatic
cancers.
Finally,
addresses
current
future
perspectives
translation
CNPs,
emphasizing
need
further
research
optimize
targeted
delivery
outcomes.
By
synthesizing
latest
research,
this
underscores
potential
avenue
advancing
