Advanced Healthcare Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 17, 2025
Abstract
In
this
study,
YIGSR‐functionalized
exosomes
(Exo)
are
engineered
and
hybridized
with
lipid
polymeric
nanoparticles
(LPNPs)
followed
by
loading
of
chemotherapy
Dasatinib
(DST)
to
spatially
target
laminin
receptors
on
tumors.
Exo
derived
from
differentiated
macrophages
YIGSR
targeting
peptides.These
YIGSR‐Exo
subsequently
fused
LPNPs
membranes
using
the
freeze‐thaw
method,
resulting
in
hybrid
YIGSR‐Exo,
which
then
loaded
DST,
creating
DST‐FuNP@YIGSR‐Exo
targeted
breast
cancer
(BC),
leading
enhanced
mitochondrial
membrane
potential
(54.50
±5.0%),
increased
reactive
oxygen
species
(59.50
±
6.0%),
apoptosis
(63
6.5%),
ultimately
inducing
cell
death.
Further,
cellular
uptake
receptor
blocking
studies
confirm
binding
affinity
interaction
receptors,
Intravenous
pharmacokinetic
analysis
reveals
a
significant
improvement
AUC0‐∞,
20.84‐fold
increase
compared
free
DST
1.61‐fold
enhancement
over
DST‐FuNP@Exo.
This
is
further
supported
vivo
imaging
demonstrated
improved
tumor
localization.
A
regression
study
shows
6.8‐fold
reduction
Tumor
tissue‐specific
IHC
for
Ki67
proliferative
marker
significantly
reduced
formulation.
The
as
an
effective
carrier
delivering
chemotherapeutic
drugs,
paving
path
advancement
biologically
obtained
nanocarriers
cancer.
Drug Discovery Today,
Journal Year:
2024,
Volume and Issue:
29(4), P. 103936 - 103936
Published: Feb. 29, 2024
This
review
highlights
the
transformative
impact
of
microfluidic
technology
on
personalized
drug
delivery.
Microfluidics
addresses
issues
in
traditional
synthesis,
providing
precise
control
and
scalability
nanoparticle
fabrication,
platforms
show
high
potential
for
versatility,
offering
patient-specific
dosing
real-time
monitoring
capabilities,
all
integrated
into
wearable
technology.
Covalent
conjugation
antibodies
to
nanoparticles
improves
bioactivity,
driving
innovations
targeting.
The
integration
microfluidics
with
sensor
technologies
artificial
intelligence
facilitates
feedback
autonomous
adaptation
delivery
systems.
Key
challenges,
such
as
droplet
polydispersity
fluidic
handling,
along
future
directions
focusing
reliability,
are
essential
considerations
advancing
Molecular Cancer,
Journal Year:
2025,
Volume and Issue:
24(1)
Published: Jan. 13, 2025
This
review
highlights
recent
progress
in
exosome-based
drug
delivery
for
cancer
therapy,
covering
exosome
biogenesis,
cargo
selection
mechanisms,
and
their
application
across
multiple
types.
As
small
extracellular
vesicles,
exosomes
exhibit
high
biocompatibility
low
immunogenicity,
making
them
ideal
vehicles
capable
of
efficiently
targeting
cells,
minimizing
off-target
damage
side
effects.
aims
to
explore
the
potential
with
a
focus
on
applications
chemotherapy,
gene
immunomodulation.
Additionally,
challenges
related
production
standardization
are
analyzed,
highlighting
importance
addressing
these
issues
clinical
application.
In
conclusion,
systems
offer
promising
future
therapies.
Further
research
should
aim
enhance
efficiency
facilitate
translation,
paving
way
innovative
treatment
strategies.
Medicine in Drug Discovery,
Journal Year:
2024,
Volume and Issue:
22, P. 100183 - 100183
Published: March 8, 2024
Psoriasis
is
a
chronic
autoimmune
disorder
that
has
major
effect
on
the
quality
of
life
for
millions
people
throughout
world.
The
pathogenesis
psoriasis
revealed
intricate
molecular
networks
and
signaling
pathways,
opening
new
avenues
precision
medicine.
treatments
include
topical
therapy,
phototherapy,
systemic
therapies,
biologics,
but
achieving
optimal
outcomes
difficult.
Despite
advancements
in
understanding
causes
development
various
treatments,
optimizing
therapeutic
remains
challenging.
Managing
poses
challenges
terms
drug
delivery
evaluation
models.
Novel
systems
capable
navigating
complex
skin
barriers
delivering
therapeutics
precisely
to
target
cells
are
crucial
advancing
treatment
options.
This
article
provides
an
inclusive
overview
psoriasis,
highlighting
recent
discoveries
potential
targets.
emphasizes
importance
combining
different
modalities,
such
as
synthetic
herbal
agents,
with
biologics
improve
efficacy.
Nanocarriers
show
promise
targeted
they
can
encapsulate
antipsoriatic
drugs,
gene
providing
enhanced
stability,
improved
tissue
penetration,
precise
cellular
targeting.
These
have
revolutionize
by
maximizing
efficacy
while
minimizing
side
effects.
also
discusses
commercial
formulations,
including
patents
related
ongoing
clinical
trials,
which
provide
valuable
insights
into
evolving
landscape
therapeutics.
provided
contribute
field
offer
hope
patients
suffering
from
psoriasis.
