Cognition and Activity of Daily Living Function in people with Parkinson’s disease DOI Creative Commons
Merle Bode, Elke Kalbe, Inga Liepelt‐Scarfone

et al.

Journal of Neural Transmission, Journal Year: 2024, Volume and Issue: 131(10), P. 1159 - 1186

Published: July 8, 2024

Abstract The ability to perform activities of daily living (ADL) function is a multifaceted construct that reflects functionality in different life situations. loss ADL due cognitive impairment the core feature for diagnosis Parkinson’s disease dementia (PDD). In contrast Alzheimer’s disease, PD can be compromised by various factors, including motor and non-motor aspects. This narrative review summarizes current state knowledge on association cognition people with introduces concept “cognitive ADL” those problems everyday are associated deterioration as their primary cause. Assessment challenging because self-ratings, informant-ratings, performance-based assessments seldomly differentiate between “cognitive” “motor” aspects ADL. related multiple domains, attention, executive function, memory being particularly relevant. Cognitive characterized behavioral anomalies such trial-and-error behavior or task step omissions, lower engagement behaviors, suggested physical activity levels prolonged sedentary behavior. First evidence shows multi-domain interventions may improve general, but confounded Large multicenter randomized controlled trials outcome needed investigate which pharmacological non-pharmacological effectively prevent delay ultimately progression conversion PDD.

Language: Английский

The Impact of Loneliness and Social Isolation on Cognitive Aging: A Narrative Review DOI Creative Commons

Jade Guarnera,

Eva Yuen, Helen Macpherson

et al.

Journal of Alzheimer s Disease Reports, Journal Year: 2023, Volume and Issue: 7(1), P. 699 - 714

Published: June 13, 2023

Social concepts such as loneliness and social isolation are fairly new factors that have been recently gaining attention to their involvement in changes cognitive function association with dementia. The primary aim of this narrative review was describe the current understanding how influence aging they linked Studies shown there is an between loneliness, isolation, reduced function, older adults, across multiple domains, well a heightened risk Numerous underlying neural biomechanisms including cortisol secretion brain volume alterations (e.g., white/grey matter, hippocampus) may contribute these relationships. However, due poor quality research, mixed inconclusive findings, issues accurately defining measuring more consistent high-quality interventions needed determine whether studies addressing can impact longer term This especially important given long-term COVID-19 pandemic on people yet be fully understood.

Language: Английский

Citations

38

Cognitive decline in older adults in the UK during and after the COVID-19 pandemic: a longitudinal analysis of PROTECT study data DOI Creative Commons
Anne Corbett, Gareth Williams, Byron Creese

et al.

The Lancet Healthy Longevity, Journal Year: 2023, Volume and Issue: 4(11), P. e591 - e599

Published: Nov. 1, 2023

BackgroundAlthough the long-term health effects of COVID-19 are increasingly recognised, societal restrictions during pandemic hold potential for considerable detriment to cognitive and mental health, particularly because major dementia risk factors—such as those related exercise dietary habits—were affected this period. We used longitudinal data from PROTECT study evaluate effect on cognition in older adults UK.MethodsFor analysis, we computerised neuropsychology individuals aged 50 years participating UK. Data were collected same participants before (March 1, 2019–Feb 29, 2020) its first 2020–Feb 28, 2021) second 2021–Feb 2022) years. compared across three time periods using a linear mixed-effects model. Subgroup analyses conducted people with mild impairment who reported history COVID-19, an exploratory regression analysis identified factors associated changes trajectory.FindingsPre-pandemic included 3142 participants, whom 1696 (54·0%) women 1446 (46·0%) men, mean age 67·5 (SD 9·6, range 50–96). Significant worsening executive function working memory was observed year whole cohort (effect size 0·15 [95% CI 0·12–0·17] 0·51 [0·49–0·53] memory), (0·13 [0·07–0·20] 0·40 [0·36–0·47]), (0·24 [0·16–0·31] 0·46 [0·39–0·53]). Worsening sustained (0·47; 0·44–0·49). Regression indicated that decline significantly reduced (p=0·0049; function) increased alcohol use (p=0·049; memory) cohort, well depression (p=0·011; loneliness (p=0·0038; impairment. In pandemic, continued affect associations between (p=0·0040), (p=0·042), (p=0·014) impairment, (p=0·0029), (p=0·031) (p=0·036) COVID-19.InterpretationThe resulted significant adults, known factors. The highlights need public interventions mitigate dementia—particularly conversion within 5 is substantial risk. Long-term intervention should be considered support health.FundingNational Institute Health Care Research.

Language: Английский

Citations

32

The association between loneliness or social isolation and food and eating behaviours: A scoping review DOI Creative Commons
Katherine Hanna,

Jenna Cross,

A.C. Nicholls

et al.

Appetite, Journal Year: 2023, Volume and Issue: 191, P. 107051 - 107051

Published: Oct. 5, 2023

Loneliness or social isolation and food/eating behaviours have important health consequences there are rationales for why they could interact. dietary recognised as determinants targets interventions at individual, group population levels. However, currently no research reviews investigating associations between these areas. This scoping review synthesized evidence loneliness in people aged over 16 years high-income countries. A systematic search of five databases from 2000 was conducted using predetermined terms. Dissertation database backwards citation searches were also conducted. Full text screening 254 articles/theses resulted inclusion three qualitative 26 quantitative studies, with eight COVID-19 lockdowns. Almost all studies reported a relationship loneliness/social eating usually considered harmful such low fruit vegetable intake lower diet quality. Qualitative supports the detrimental influence on eating. Study quality considered, interpretation comparison results complicated by use varying methods. Better awareness understanding complex aspects is needed to inform development practice nutrition mental practitioners, policymakers, researchers end-users.

Language: Английский

Citations

26

Nurses’ perception towards care robots and their work experience with socially assistive technology during COVID-19: A qualitative study DOI Open Access
Hee Sun Kang, In Soon Koh,

Kiyoko Makimoto

et al.

Geriatric Nursing, Journal Year: 2023, Volume and Issue: 50, P. 234 - 239

Published: Feb. 6, 2023

Language: Английский

Citations

23

The impact of social isolation from COVID-19-related public health measures on cognitive function and mental health among older adults: A systematic review and meta-analysis DOI Creative Commons
Prapichaya Prommas,

Kaung Suu Lwin,

Yi Chi Chen

et al.

Ageing Research Reviews, Journal Year: 2022, Volume and Issue: 85, P. 101839 - 101839

Published: Dec. 31, 2022

We aimed to estimate the impact of social isolation on cognitive function and mental health among older adults during two-year-and-a-half COVID-19 period. Pubmed Central, Medline, CINAHL Plus PsychINFO were searched between March 1, 2020, September 30, 2022. included all studies that assessed proportions with mean or median a minimum age above 60 reporting worsening health. Thirty-two from 18 countries met eligibility criteria for meta-analyses. found dementia who experienced impairment exacerbation new onset behavioral psychological symptoms (BPSD) approximately twice larger than HC experiencing SCD Stage dementia, care options, severity mobility restriction measures did not yield significant differences in number BPSD, while length BPSD but impairment. Our study highlights adults. Public strategies should prioritize efforts promote healthy lifestyles proactive assessments.

Language: Английский

Citations

30

Do social media influencers influence the vaccination drive? An application of source credibility theory and uses and gratification theory DOI
Faizan Alam, Tao Meng,

Rashmi Rastogi

et al.

Technological Forecasting and Social Change, Journal Year: 2023, Volume and Issue: 198, P. 122973 - 122973

Published: Nov. 24, 2023

Language: Английский

Citations

21

A translational neuroscience perspective on loneliness: Narrative review focusing on social interaction, illness and oxytocin DOI Creative Commons
Simon Barton,

Ana Zovko,

Christina Müller

et al.

Neuroscience & Biobehavioral Reviews, Journal Year: 2024, Volume and Issue: 163, P. 105734 - 105734

Published: May 23, 2024

This review addresses key findings on loneliness from the social, neurobiological and clinical fields. From a translational perspective, results studies in humans animals are included, with focus social interaction, mental physical illness role of oxytocin loneliness. In terms interactions, lonely individuals tend to exhibit range abnormal behaviors based dysfunctional cognitions that make it difficult for them form meaningful relationships. Neurobiologically, link has been established between hypothalamic peptide hormone oxytocin. Since interactions especially touch regulate signaling, may have an imbalance, which turn affects their health well-being. Clinically, is predictor leads increased morbidity mortality. There evidence psychopathology both cause consequence The final section this summarizes perspectives present new model complex construct

Language: Английский

Citations

6

A meta-analysis of loneliness and risk of dementia using longitudinal data from >600,000 individuals DOI
Martina Luchetti, Damaris Aschwanden,

Amanda A. Sesker

et al.

Nature Mental Health, Journal Year: 2024, Volume and Issue: 2(11), P. 1350 - 1361

Published: Oct. 9, 2024

Language: Английский

Citations

5

Is there a correlation between sensory impairments and social isolation in middle-aged and older Chinese population? Cross-sectional and longitudinal evidence from a nationally representative survey DOI Creative Commons
Ye Liu,

Qinglei Sun,

KaiweiSa Abuduxukuer

et al.

Frontiers in Public Health, Journal Year: 2023, Volume and Issue: 11

Published: March 27, 2023

Purpose: To investigate the cross-sectional and longitudinal associations between sensory impairments including single vision impairment (SVI), hearing (SHI) dual (DSI) with social isolation in middle-aged older Chinese population. Methods: Data was obtained from China Health Retirement Longitudinal Survey (CHARLS). In total, 11,674 adults aging over 45 were included at baseline 2011, 6,859 participants who accomplished all 4 interviews 2011 to 2018 adapted for analyses. Sensory status measurements disconnectedness self-perceived loneliness collected. Assessment of number types activities which they participated frequency such participation. Loneliness referred subjective perception loneliness. Other covariates socio-demographic characteristics, medical condition lifestyle-related factors. The impacts on assessed using univariate multivariate generalized linear models. A model estimation equations (GEE) used assess association time-varying statuses or 8 years after being adjusted multi-confounding Results: Participants SIs had significantly higher levels loneliness, compared those free SI. All kinds associated according both data. correlations DSI also noticed. SHI found be data, activity participation analysis. SVI only (all p<0.05) Conclusion: impairments, especially have explicitly detrimental effects onset progression among Over time, specifically jeopardizes their rather than

Language: Английский

Citations

12

“Loneliness is a sad disease”: oldest old adults’ empirical definition of loneliness and social isolation from a mixed-method study in Northern Italy DOI Creative Commons
Sara Santini, M. Colombo, Antonio Guaita

et al.

BMC Geriatrics, Journal Year: 2025, Volume and Issue: 25(1)

Published: Jan. 30, 2025

Loneliness and social isolation can occur at any stage of life, but some predictors may be more common among older adults. Due to growing population ageing, loneliness are relevant issues. Many studies apply the main definitions offered by literature without considering how individual representations, socio-cultural context culture care influence their perception. This study wishes fill in these gaps analysing empirical arising from a mixed-gender randomized sample Italian oldest old people. Between January March 2019, 132 people, most aged 80+, living northern town, were asked answer questionnaire semi-structured interview. According mixed-method analysis analysed respondents' gender, arrangement (e.g., alone or with partners other people), years education find possible associations meanings attributed two concepts. The was gender-balanced mid-low educated; than one fourth respondents lived alone. results underline closer each academic ones. concepts often perceived participants as distinct, they strongly interconnected so that used interchangeably themes identified "death" "guilt". In opinion, driver is loss loved, close persons, while driven disability. Age, educational level, arrangements did not isolation. On contrary, (P = 0.002) level (p 0.023) seem loneliness. knowledge give inspire advanced intervention aimed buffering psychological consequences population.

Language: Английский

Citations

0