Journal of Neural Transmission,
Journal Year:
2024,
Volume and Issue:
131(10), P. 1159 - 1186
Published: July 8, 2024
Abstract
The
ability
to
perform
activities
of
daily
living
(ADL)
function
is
a
multifaceted
construct
that
reflects
functionality
in
different
life
situations.
loss
ADL
due
cognitive
impairment
the
core
feature
for
diagnosis
Parkinson’s
disease
dementia
(PDD).
In
contrast
Alzheimer’s
disease,
PD
can
be
compromised
by
various
factors,
including
motor
and
non-motor
aspects.
This
narrative
review
summarizes
current
state
knowledge
on
association
cognition
people
with
introduces
concept
“cognitive
ADL”
those
problems
everyday
are
associated
deterioration
as
their
primary
cause.
Assessment
challenging
because
self-ratings,
informant-ratings,
performance-based
assessments
seldomly
differentiate
between
“cognitive”
“motor”
aspects
ADL.
related
multiple
domains,
attention,
executive
function,
memory
being
particularly
relevant.
Cognitive
characterized
behavioral
anomalies
such
trial-and-error
behavior
or
task
step
omissions,
lower
engagement
behaviors,
suggested
physical
activity
levels
prolonged
sedentary
behavior.
First
evidence
shows
multi-domain
interventions
may
improve
general,
but
confounded
Large
multicenter
randomized
controlled
trials
outcome
needed
investigate
which
pharmacological
non-pharmacological
effectively
prevent
delay
ultimately
progression
conversion
PDD.
Journal of Alzheimer s Disease Reports,
Journal Year:
2023,
Volume and Issue:
7(1), P. 699 - 714
Published: June 13, 2023
Social
concepts
such
as
loneliness
and
social
isolation
are
fairly
new
factors
that
have
been
recently
gaining
attention
to
their
involvement
in
changes
cognitive
function
association
with
dementia.
The
primary
aim
of
this
narrative
review
was
describe
the
current
understanding
how
influence
aging
they
linked
Studies
shown
there
is
an
between
loneliness,
isolation,
reduced
function,
older
adults,
across
multiple
domains,
well
a
heightened
risk
Numerous
underlying
neural
biomechanisms
including
cortisol
secretion
brain
volume
alterations
(e.g.,
white/grey
matter,
hippocampus)
may
contribute
these
relationships.
However,
due
poor
quality
research,
mixed
inconclusive
findings,
issues
accurately
defining
measuring
more
consistent
high-quality
interventions
needed
determine
whether
studies
addressing
can
impact
longer
term
This
especially
important
given
long-term
COVID-19
pandemic
on
people
yet
be
fully
understood.
The Lancet Healthy Longevity,
Journal Year:
2023,
Volume and Issue:
4(11), P. e591 - e599
Published: Nov. 1, 2023
BackgroundAlthough
the
long-term
health
effects
of
COVID-19
are
increasingly
recognised,
societal
restrictions
during
pandemic
hold
potential
for
considerable
detriment
to
cognitive
and
mental
health,
particularly
because
major
dementia
risk
factors—such
as
those
related
exercise
dietary
habits—were
affected
this
period.
We
used
longitudinal
data
from
PROTECT
study
evaluate
effect
on
cognition
in
older
adults
UK.MethodsFor
analysis,
we
computerised
neuropsychology
individuals
aged
50
years
participating
UK.
Data
were
collected
same
participants
before
(March
1,
2019–Feb
29,
2020)
its
first
2020–Feb
28,
2021)
second
2021–Feb
2022)
years.
compared
across
three
time
periods
using
a
linear
mixed-effects
model.
Subgroup
analyses
conducted
people
with
mild
impairment
who
reported
history
COVID-19,
an
exploratory
regression
analysis
identified
factors
associated
changes
trajectory.FindingsPre-pandemic
included
3142
participants,
whom
1696
(54·0%)
women
1446
(46·0%)
men,
mean
age
67·5
(SD
9·6,
range
50–96).
Significant
worsening
executive
function
working
memory
was
observed
year
whole
cohort
(effect
size
0·15
[95%
CI
0·12–0·17]
0·51
[0·49–0·53]
memory),
(0·13
[0·07–0·20]
0·40
[0·36–0·47]),
(0·24
[0·16–0·31]
0·46
[0·39–0·53]).
Worsening
sustained
(0·47;
0·44–0·49).
Regression
indicated
that
decline
significantly
reduced
(p=0·0049;
function)
increased
alcohol
use
(p=0·049;
memory)
cohort,
well
depression
(p=0·011;
loneliness
(p=0·0038;
impairment.
In
pandemic,
continued
affect
associations
between
(p=0·0040),
(p=0·042),
(p=0·014)
impairment,
(p=0·0029),
(p=0·031)
(p=0·036)
COVID-19.InterpretationThe
resulted
significant
adults,
known
factors.
The
highlights
need
public
interventions
mitigate
dementia—particularly
conversion
within
5
is
substantial
risk.
Long-term
intervention
should
be
considered
support
health.FundingNational
Institute
Health
Care
Research.
Appetite,
Journal Year:
2023,
Volume and Issue:
191, P. 107051 - 107051
Published: Oct. 5, 2023
Loneliness
or
social
isolation
and
food/eating
behaviours
have
important
health
consequences
there
are
rationales
for
why
they
could
interact.
dietary
recognised
as
determinants
targets
interventions
at
individual,
group
population
levels.
However,
currently
no
research
reviews
investigating
associations
between
these
areas.
This
scoping
review
synthesized
evidence
loneliness
in
people
aged
over
16
years
high-income
countries.
A
systematic
search
of
five
databases
from
2000
was
conducted
using
predetermined
terms.
Dissertation
database
backwards
citation
searches
were
also
conducted.
Full
text
screening
254
articles/theses
resulted
inclusion
three
qualitative
26
quantitative
studies,
with
eight
COVID-19
lockdowns.
Almost
all
studies
reported
a
relationship
loneliness/social
eating
usually
considered
harmful
such
low
fruit
vegetable
intake
lower
diet
quality.
Qualitative
supports
the
detrimental
influence
on
eating.
Study
quality
considered,
interpretation
comparison
results
complicated
by
use
varying
methods.
Better
awareness
understanding
complex
aspects
is
needed
to
inform
development
practice
nutrition
mental
practitioners,
policymakers,
researchers
end-users.
Ageing Research Reviews,
Journal Year:
2022,
Volume and Issue:
85, P. 101839 - 101839
Published: Dec. 31, 2022
We
aimed
to
estimate
the
impact
of
social
isolation
on
cognitive
function
and
mental
health
among
older
adults
during
two-year-and-a-half
COVID-19
period.
Pubmed
Central,
Medline,
CINAHL
Plus
PsychINFO
were
searched
between
March
1,
2020,
September
30,
2022.
included
all
studies
that
assessed
proportions
with
mean
or
median
a
minimum
age
above
60
reporting
worsening
health.
Thirty-two
from
18
countries
met
eligibility
criteria
for
meta-analyses.
found
dementia
who
experienced
impairment
exacerbation
new
onset
behavioral
psychological
symptoms
(BPSD)
approximately
twice
larger
than
HC
experiencing
SCD
Stage
dementia,
care
options,
severity
mobility
restriction
measures
did
not
yield
significant
differences
in
number
BPSD,
while
length
BPSD
but
impairment.
Our
study
highlights
adults.
Public
strategies
should
prioritize
efforts
promote
healthy
lifestyles
proactive
assessments.
Neuroscience & Biobehavioral Reviews,
Journal Year:
2024,
Volume and Issue:
163, P. 105734 - 105734
Published: May 23, 2024
This
review
addresses
key
findings
on
loneliness
from
the
social,
neurobiological
and
clinical
fields.
From
a
translational
perspective,
results
studies
in
humans
animals
are
included,
with
focus
social
interaction,
mental
physical
illness
role
of
oxytocin
loneliness.
In
terms
interactions,
lonely
individuals
tend
to
exhibit
range
abnormal
behaviors
based
dysfunctional
cognitions
that
make
it
difficult
for
them
form
meaningful
relationships.
Neurobiologically,
link
has
been
established
between
hypothalamic
peptide
hormone
oxytocin.
Since
interactions
especially
touch
regulate
signaling,
may
have
an
imbalance,
which
turn
affects
their
health
well-being.
Clinically,
is
predictor
leads
increased
morbidity
mortality.
There
evidence
psychopathology
both
cause
consequence
The
final
section
this
summarizes
perspectives
present
new
model
complex
construct
Frontiers in Public Health,
Journal Year:
2023,
Volume and Issue:
11
Published: March 27, 2023
Purpose:
To
investigate
the
cross-sectional
and
longitudinal
associations
between
sensory
impairments
including
single
vision
impairment
(SVI),
hearing
(SHI)
dual
(DSI)
with
social
isolation
in
middle-aged
older
Chinese
population.
Methods:
Data
was
obtained
from
China
Health
Retirement
Longitudinal
Survey
(CHARLS).
In
total,
11,674
adults
aging
over
45
were
included
at
baseline
2011,
6,859
participants
who
accomplished
all
4
interviews
2011
to
2018
adapted
for
analyses.
Sensory
status
measurements
disconnectedness
self-perceived
loneliness
collected.
Assessment
of
number
types
activities
which
they
participated
frequency
such
participation.
Loneliness
referred
subjective
perception
loneliness.
Other
covariates
socio-demographic
characteristics,
medical
condition
lifestyle-related
factors.
The
impacts
on
assessed
using
univariate
multivariate
generalized
linear
models.
A
model
estimation
equations
(GEE)
used
assess
association
time-varying
statuses
or
8
years
after
being
adjusted
multi-confounding
Results:
Participants
SIs
had
significantly
higher
levels
loneliness,
compared
those
free
SI.
All
kinds
associated
according
both
data.
correlations
DSI
also
noticed.
SHI
found
be
data,
activity
participation
analysis.
SVI
only
(all
p<0.05)
Conclusion:
impairments,
especially
have
explicitly
detrimental
effects
onset
progression
among
Over
time,
specifically
jeopardizes
their
rather
than
BMC Geriatrics,
Journal Year:
2025,
Volume and Issue:
25(1)
Published: Jan. 30, 2025
Loneliness
and
social
isolation
can
occur
at
any
stage
of
life,
but
some
predictors
may
be
more
common
among
older
adults.
Due
to
growing
population
ageing,
loneliness
are
relevant
issues.
Many
studies
apply
the
main
definitions
offered
by
literature
without
considering
how
individual
representations,
socio-cultural
context
culture
care
influence
their
perception.
This
study
wishes
fill
in
these
gaps
analysing
empirical
arising
from
a
mixed-gender
randomized
sample
Italian
oldest
old
people.
Between
January
March
2019,
132
people,
most
aged
80+,
living
northern
town,
were
asked
answer
questionnaire
semi-structured
interview.
According
mixed-method
analysis
analysed
respondents'
gender,
arrangement
(e.g.,
alone
or
with
partners
other
people),
years
education
find
possible
associations
meanings
attributed
two
concepts.
The
was
gender-balanced
mid-low
educated;
than
one
fourth
respondents
lived
alone.
results
underline
closer
each
academic
ones.
concepts
often
perceived
participants
as
distinct,
they
strongly
interconnected
so
that
used
interchangeably
themes
identified
"death"
"guilt".
In
opinion,
driver
is
loss
loved,
close
persons,
while
driven
disability.
Age,
educational
level,
arrangements
did
not
isolation.
On
contrary,
(P
=
0.002)
level
(p
0.023)
seem
loneliness.
knowledge
give
inspire
advanced
intervention
aimed
buffering
psychological
consequences
population.