Circ_0007534 as new emerging target in cancer: Biological functions and molecular interactions DOI Creative Commons
Bowen Liu,

Chengbin Dong,

Quan Chen

et al.

Frontiers in Oncology, Journal Year: 2022, Volume and Issue: 12

Published: Nov. 24, 2022

Circular RNA (circRNAs), an important member of the non-coding (ncRNA) family, are widely expressed in a variety biological cells. Owing to their stable structures, sequence conservations, and cell- or tissue-specific expressions, these have become popular subject scientific research. With development sequencing methods, it has been revealed that circRNAs exert function by sponging microRNAs (miRNAs), regulating transcription, binding proteins. Humans historically significantly impacted various types cancer. Studies shown abnormally cancers involved occurrence malignant tumors, such as tumor cell proliferation, migration, invasion. As one its star molecules, circ_0007534 is upregulated colorectal, cervical, pancreatic cancers; closely related occurrence, development, prognosis tumors; expected novel marker therapeutic target. This article briefly reviews expression mechanism tumors based on domestic foreign literature.

Language: Английский

Metabolic activation and hepatic cytotoxicity of osthole mediated by cytochrome P450 enzymes DOI
Siyu Liu,

Guode Zhao,

Yang Xu

et al.

Toxicology Letters, Journal Year: 2025, Volume and Issue: 404, P. 1 - 8

Published: Jan. 8, 2025

Language: Английский

Citations

2
Coumarins as versatile therapeutic phytomolecules: A systematic review DOI
Mohd Kamil Hussain,

Shahnaaz Khatoon,

Mohammad Faheem Khan

et al.

Phytomedicine, Journal Year: 2024, Volume and Issue: 134, P. 155972 - 155972

Published: Aug. 30, 2024

Language: Английский

Citations

14
Exploring the Anticancer Potential and Mechanisms of Action of Natural Coumarins and Isocoumarins DOI

Mohd Aqib,

Shahnaaz Khatoon,

Mujahid Ali

et al.

European Journal of Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 282, P. 117088 - 117088

Published: Nov. 22, 2024

Language: Английский

Citations

8
Role of non-coding RNAs and exosomal non-coding RNAs in retinoblastoma progression DOI Creative Commons

Nasrin Ahangar Davoodi,

Sajad Najafi,

Zari Naderi Ghale-Noie

et al.

Frontiers in Cell and Developmental Biology, Journal Year: 2022, Volume and Issue: 10

Published: Dec. 23, 2022

Retinoblastoma (RB) is a rare aggressive intraocular malignancy of childhood that has the potential to affect vision, and can even be fatal in some children. While tumor controlled efficiently at early stages, metastatic tumors lead high mortality. Non-coding RNAs (ncRNAs) are implicated number physiological cellular process, including differentiation, proliferation, migration, invasion, The deregulation ncRNAs correlated with several diseases, particularly cancer. categorized into two main groups based on their length, i.e. short long ncRNAs. Moreover, ncRNA been demonstrated play role pathogenesis development RB. Several ncRNAs, such as miR-491-3p, miR-613,and SUSD2 have found act suppressor genes RB, but other circ-E2F3, NEAT1, TUG1 promoter genes. Understanding regulatory mechanisms provide new opportunities for RB therapy. In present review, we discuss functional roles most important interaction responsible initiation progression, possible future clinical applications diagnostic prognostic tools or therapeutic targets.

Language: Английский

Citations

24
Osthole: An up-to-date review of its anticancer potential and mechanisms of action DOI Creative Commons
Shaojie Yang,

Wanlin Dai,

Jingnan Wang

et al.

Frontiers in Pharmacology, Journal Year: 2022, Volume and Issue: 13

Published: Sept. 7, 2022

With its high incidence and mortality rates, cancer is one of the largest health problems worldwide. Investigating various treatment options has been focus many domestic international researchers, significant progress made in study anticancer effects traditional Chinese medicines. Osthole, a coumarin compound extracted from Cnidium monnieri (L.) Cuss ., become new research hotspot. There have reports on effects, recent studies elucidated that underlying mechanism action mainly involves inhibiting cell proliferation, inducing apoptosis, invasion migration cells, angiogenesis, increasing sensitivity to chemotherapy drugs, reversing multidrug resistance cells. This mini-review summarizes osthole years.

Language: Английский

Citations

20
Circ_0007534 promotes cholangiocarcinoma stemness and resistance to anoikis through DDX3X-mediated positive feedback regulation of parental gene DDX42 DOI
Sidi Liu, Canghai Guan,

Xiangjun Sha

et al.

Cellular Signalling, Journal Year: 2024, Volume and Issue: 118, P. 111141 - 111141

Published: March 16, 2024

Language: Английский

Citations

4
Coumarins in Anticancer Therapy: Mechanisms of Action, Potential Applications and Research Perspectives DOI Creative Commons
Tomasz Kubrak, Anna Makuch‐Kocka, David Aebisher

et al.

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(5), P. 595 - 595

Published: May 1, 2025

Coumarins are natural organic compounds widely found in plants that show promising anticancer properties. This article reviews the current research on mechanisms of action coumarins cancer therapy, including induction apoptosis, inhibition tumor cell proliferation, modulation oxidative stress, and angiogenesis metastasis. Examples with demonstrated activity, such as scopoletin, umbeliferon, esculetin their synthetic derivatives, also presented. The results preclinical studies, potential use stand-alone drugs role combination therapy chemotherapy discussed. In addition, challenges related to bioavailability, safety interactions other highlighted. review concludes by pointing out future directions, design new coumarin analogs nanotechnology enhance efficacy treatment.

Language: Английский

Citations

0
Osthole, a Coumarin from Cnidium monnieri: A Review on Its Pharmacology, Pharmacokinetics, Safety, and Innovative Drug Delivery Platforms DOI

Hao Tzu Lin,

Qiang You, Xing Wei

et al.

The American Journal of Chinese Medicine, Journal Year: 2024, Volume and Issue: 52(05), P. 1397 - 1425

Published: Jan. 1, 2024

Osthole, a coumarin compound mainly derived from Cnidium monnieri (L.), has attracted much interest the scientific community owing to its multiple therapeutic properties. However, pharmacological mechanism, pharmacokinetics, and toxicological effects are far clear. Furthermore, potential drug delivery platforms of osthole remain be comprehensively delineated. The present review aimed systematically summarize most up-to-date information related pharmacology, safety issues osthole, discuss investigations novel platforms. herein discussed was retrieved authoritative databases, including PubMed, Web Science, Google Scholar, Chinese National Knowledge Infrastructure (CNKI) so on, reviewing published up until February 2024. New evidence shows that induces sequence actions moderate absorption rate rapid metabolic characteristics. In addition, this phytoconstituent possesses hepatotoxicity, caution should exercised against risk combination. given needy solubility in aqueous medium non-organizational targeting, methods have been designed overcome these shortcomings. Given properties benefits ought elucidated greater array comprehensive research studies, molecular mechanisms underlying explored.

Language: Английский

Citations

2
CTSB Nuclear Translocation Facilitates DNA Damage and Lysosomal Stress to Promote Retinoblastoma Cell Death DOI Creative Commons
Cairui Li, Shuguang Sun,

Yanmei Zhuang

et al.

Molecular Biotechnology, Journal Year: 2023, Volume and Issue: 66(9), P. 2583 - 2594

Published: Dec. 30, 2023

Abstract Retinoblastoma (RB) is a pernicious tumor originating from photoreceptor precursor cells that often endangers the lives of children. The purpose our study was to further investigate influence cathepsin B (CTSB) nuclear translocation on RB cell death. Y79 were injected into vitreous cavity nude mice at dose 4 µL/mouse establish an animal model RB. Real-time quantitative polymerase chain reaction (RT–qPCR), Western blot analysis, comet assay, Cell Counting Kit-8 (CCK-8) assay and flow cytometry used measure levels interrelated genes proteins evaluate alterations in autophagy, apoptosis, proliferation, DNA damage cycle arrest. CTSB found be expressed low samples lines. Functionally, promoted damage, arrest, ferroptosis autophagy inhibited their proliferation. Downstream mechanistic studies showed facilitates arrest by inhibiting breast cancer 1 protein (BRCA1) expression also activates signal transducer activator transcription 3/stimulator interferon response cGAMP interactor (STAT3/STING1) pathway induce lysosomal stress, leading alleviating Nuclear BRCA1 activating STAT3/STING1 induces which eventually leads mitigates

Language: Английский

Citations

5
Osthole mitigates the myofibroblast properties in oral submucous fibrosis by suppressing the TGF-β/smad2 signaling pathway and NCK-AS1 expression DOI Creative Commons

Po-Yu Yang,

Pei‐Ling Hsieh,

Jung‐Chun Yeh

et al.

Journal of Dental Sciences, Journal Year: 2024, Volume and Issue: 20(2), P. 911 - 918

Published: Sept. 8, 2024

Natural products are gaining increasing recognition as an alternative source for alleviating fibrosis they can regulate various mediators or pathways against by targeting non-coding RNAs. In the current study, we aimed to investigate therapeutic effects of osthole in oral submucous (OSF), a precancerous condition cavity. The cytotoxicity normal and fibrotic buccal mucosal fibroblasts (fBMFs) derived from OSF tissues was assessed using MTT assay. Collagen gel contraction transwell migration assays were conducted examine myofibroblast activities. Besides, expression TGF-β/Smad2 signaling well α-SMA type I collagen measured. Additionally, RNA sequencing used identify potential target involved anti-fibrotic effect osthole. Osthole exhibited higher cytotoxic on fBMFs compared BMFs dose-dependently reduced several activities, including contractility ability. addition, pathway inhibited along with lower osthole-receiving cells. Moreover, administration downregulated NCK1-AS1 fBMFs, which proven mediate anti-fibrosis property Our results indicate that may be promising compound inhibit progression OSF.

Language: Английский

Citations

1