International Journal of Pharmaceutics, Journal Year: 2025, Volume and Issue: unknown, P. 125592 - 125592
Published: April 1, 2025
Language: Английский
Environmental Chemistry Letters, Journal Year: 2022, Volume and Issue: 21(1), P. 97 - 152
Published: Oct. 8, 2022
Abstract The development and recycling of biomass production can partly solve issues energy, climate change, population growth, food feed shortages, environmental pollution. For instance, the use seaweeds as feedstocks reduce our reliance on fossil fuel resources, ensure synthesis cost-effective eco-friendly products biofuels, develop sustainable biorefinery processes. Nonetheless, in several biorefineries is still infancy stage compared to terrestrial plants-based lignocellulosic biomass. Therefore, here we review seaweed with focus production, economical benefits, feedstock for anaerobic digestion, biochar, bioplastics, crop health, food, livestock feed, pharmaceuticals cosmetics. Globally, could sequester between 61 268 megatonnes carbon per year, an average 173 megatonnes. Nearly 90% sequestered by exporting deep water, while remaining 10% buried coastal sediments. 500 gigatonnes replace nearly 40% current soy protein production. Seaweeds contain valuable bioactive molecules that be applied antimicrobial, antioxidant, antiviral, antifungal, anticancer, contraceptive, anti-inflammatory, anti-coagulants, other cosmetics skincare products.
Language: Английский
Citations
140
Antibiotics, Journal Year: 2025, Volume and Issue: 14(2), P. 134 - 134
Published: Jan. 30, 2025
Antimicrobial resistance (AMR) poses a critical global health threat, necessitating innovative approaches in antimicrobial stewardship (AMS). Artificial intelligence (AI) and machine learning (ML) have emerged as transformative tools this domain, enabling data-driven interventions to optimize antibiotic use combat resistance. This comprehensive review explores the multifaceted role of AI ML models enhancing efforts across healthcare systems. AI-powered predictive analytics can identify patterns resistance, forecast outbreaks, guide personalized therapies by leveraging large-scale clinical epidemiological data. algorithms facilitate rapid pathogen identification, profiling, real-time monitoring, precise decision making. These technologies also support development advanced diagnostic tools, reducing reliance on broad-spectrum antibiotics fostering timely, targeted treatments. In public health, AI-driven surveillance systems improve detection AMR trends enhance monitoring capabilities. By integrating diverse data sources—such electronic records, laboratory results, environmental data—ML provide actionable insights policymakers, providers, officials. Additionally, applications programs (ASPs) promote adherence prescribing guidelines, evaluate intervention outcomes, resource allocation. Despite these advancements, challenges such quality, algorithm transparency, ethical considerations must be addressed maximize potential field. Future research should focus developing interpretable interdisciplinary collaborations ensure equitable sustainable integration into initiatives.
Language: Английский
Citations
3
ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: 17(9), P. 13646 - 13659
Published: Feb. 18, 2025
Antimicrobial peptides (AMPs) represent a promising strategy for combating antibiotic-resistant bacterial infections; however, their therapeutic application remains limited by high toxicity and poor stability. In this study, we designed class of core-shell nanoparticles through the self-assembly an imperfectly amphipathic peptide, with fatty acids varying chain lengths acting as stabilizing agents. The lead nanoparticle, designated GV2, demonstrated superior antibacterial efficacy, safety, stability compared to its nonassembled peptide form. GV2 exhibited rapid bactericidal effect potent activity against both planktonic biofilm-associated bacteria, no observed development resistance. Mechanistic investigations revealed that permeabilized ruptured membranes targeting three major components in membrane including lipopolysaccharide (LPS), lipoteichoic acid (LTA), phosphatidylglycerol (PG). Notably, effectively protected skin wound infections context, highlighting clinical potential. This study not only presents antimicrobial candidate but also provides strategic framework rational design stable safe AMPs.
Language: Английский
Citations
2
International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(9), P. 7808 - 7808
Published: April 25, 2023
Biomaterial-based therapies have been receiving attention for treating microbial infections mainly to overcome the increasing number of drug-resistant bacterial strains and off-target impacts therapeutic agents by conventional strategies. A fibrous, non-soluble protein, collagen, is one most studied biopolymers development antimicrobial biomaterials owing its superior physicochemical, biomechanical, biological properties. In this study, we reviewed different approaches used develop collagen-based devices, such as non-pharmacological, antibiotic, metal oxide, peptide, herbal extract-based, combination approaches, with a particular focus on preclinical studies that published in last decade.
Language: Английский
Citations
23
Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2024, Volume and Issue: 397(12), P. 9603 - 9615
Published: July 25, 2024
Language: Английский
Citations
10
Materials Today Bio, Journal Year: 2024, Volume and Issue: 26, P. 101069 - 101069
Published: April 27, 2024
The urgency to address skeletal abnormalities and diseases through innovative approaches has led a significant interdisciplinary convergence of engineering, 3D printing, design in developing individualised bioceramic bioscaffolds. This review explores into the recent advancements future trajectory non-antibiotic antibacterial bioceramics bone tissue an importance given escalating challenges orthopaedic infections, antibiotic resistance, emergent pathogens. Initially, provides in-depth exploration complex interactions among bacteria, immune cells, clinical contexts, highlighting multifaceted nature infection dynamics, including protein adsorption, immunological responses, bacterial adherence, endotoxin release. Then, focus on next-generation designed offer multifunctionality, especially delivering properties independent traditional antibiotics. A key highlight this study is smart bioceramics, marking revolutionary stride medical implant technology. also aims guide ongoing development adoption materials, focusing their dual capabilities promoting regeneration exhibiting properties. These represent paradigm shift technology, offering multifunctional benefits that transcend approaches.
Language: Английский
Citations
9
The Microbe, Journal Year: 2025, Volume and Issue: unknown, P. 100281 - 100281
Published: Feb. 1, 2025
Language: Английский
Citations
1
Microbial Pathogenesis, Journal Year: 2024, Volume and Issue: 189, P. 106574 - 106574
Published: Feb. 13, 2024
Language: Английский
Citations
8
Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15
Published: Feb. 14, 2024
Once hailed as miraculous solutions, antibiotics no longer hold that status. The excessive use of across human healthcare, agriculture, and animal husbandry has given rise to a broad array multidrug-resistant (MDR) pathogens, posing formidable treatment challenges. Antimicrobial resistance (AMR) evolved into pressing global health crisis, linked elevated mortality rates in the modern medical era. Additionally, absence effective introduces substantial risks surgical procedures. dwindling interest pharmaceutical industries developing new against MDR pathogens aggravated scarcity issue, resulting an exceedingly limited pipeline antibiotics. Given these circumstances, imperative devise novel strategies combat perilous become paramount. Contemporary research unveiled several promising avenues for addressing this challenge. article provides comprehensive overview innovative therapeutic approaches, highlighting their mechanisms action, benefits, drawbacks.
Language: Английский
Citations
8
Nano Convergence, Journal Year: 2024, Volume and Issue: 11(1)
Published: July 11, 2024
Abstract Bacteria extracellular vesicles (BEVs), characterized as the lipid bilayer membrane-surrounded nanoparticles filled with molecular cargo from parent cells, play fundamental roles in bacteria growth and pathogenesis, well facilitating essential interaction between host systems. Notably, benefiting their unique biological functions, BEVs hold great promise novel nanopharmaceuticals for diverse biomedical potential, attracting significant interest both industry academia. Typically, are evaluated promising drug delivery platforms, on account of intrinsic cell-targeting capability, ease versatile engineering, capability to penetrate physiological barriers. Moreover, attributing considerable immunogenicity, able interact immune system boost immunotherapy nanovaccine against a wide range diseases. Towards these directions, this review, we elucidate nature role activating response better understanding BEV-based nanopharmaceuticals’ development. Additionally, also systematically summarize recent advances achieving target genetic material, therapeutic agents, functional materials. Furthermore, vaccination strategies using carefully covered, illustrating flexible potential combating bacterial infections, viral cancer. Finally, current hurdles further outlook will be provided. Graphical
Language: Английский
Citations
7