Published: Jan. 1, 2024
Language: Английский
European Journal of Medicinal Chemistry, Journal Year: 2023, Volume and Issue: 260, P. 115758 - 115758
Published: Aug. 24, 2023
Language: Английский
Citations
47
Advanced Drug Delivery Reviews, Journal Year: 2023, Volume and Issue: 200, P. 115009 - 115009
Published: July 12, 2023
Adherence to daily oral antiretroviral therapy (ART) is a barrier both treatment and prevention of human immunodeficiency virus (HIV) infection. To overcome limitations life-long regimen adherence, long-acting (LA) injectable (ARV) drugs, nanoformulations, implants, vaginal rings, microarray patches, ultra-long-acting (ULA) prodrugs are now available or in development. These medicines enable persons who at risk for HIV infection be treated with simplified ART regimens. First-generation LA cabotegravir, rilpivirine, lenacapavir injectables dapivirine ring use. However, each remains limited by existing dosing intervals, ease administration, difficulties finding drug partners. ULA regimens provide an answer, but date, such next-generation formulations remain Establishing the niche will require affirmation extended dosing, improved access, reduced injection volumes, pharmacokinetic profiles, selections combination treatments, synchronization healthcare support. Based on needs, this review highlights recent pharmacological advances future perspective. While first-generation ARTs care, they far from ideal meeting patient needs. medicines, advanced preclinical development, may close gaps toward broader usage options.
Language: Английский
Citations
25
Drug Delivery and Translational Research, Journal Year: 2024, Volume and Issue: 14(12), P. 3438 - 3451
Published: March 7, 2024
Abstract Nanocrystals and nanosuspensions have become realistic approaches to overcome the formulation challenges of poorly water-soluble drugs. They also represent a less-known but versatile platform for multiple therapeutic applications. can be integrated into broad spectrum drug delivery systems including tablets, hydrogels, microneedles, microparticles, or even functionalized liposomes. The recent progresses, challenges, opportunities in this field are gathered originally together with an informative case study concerning itraconazole nanosuspension-in-hydrogel formulation. translational aspects, historical current clinical perspectives critically reviewed here shed light on incoming generation nanocrystal formulations.
Language: Английский
Citations
14
Acta Pharmaceutica Sinica B, Journal Year: 2024, Volume and Issue: 14(11), P. 4683 - 4716
Published: Sept. 2, 2024
About 40% of approved drugs and nearly 90% drug candidates are poorly water-soluble drugs. Low solubility reduces the drugability. Effectively improving bioavailability is a critical issue that needs to be urgently addressed in development application. This review briefly introduces conventional solubilization techniques such as solubilizers, hydrotropes, cosolvents, prodrugs, salt modification, micronization, cyclodextrin inclusion, solid dispersions, details crystallization strategies, ionic liquids, polymer-based, lipid-based, inorganic-based carriers bioavailability. Some most commonly used carrier materials for presented. Several using summarized. Furthermore, this summarizes mechanism each technique, reviews latest research advances challenges, evaluates potential clinical translation. could guide selection approach, dosage form, administration route Moreover, we discuss several promising attracting increasing attention worldwide.
Language: Английский
Citations
14
Microchimica Acta, Journal Year: 2024, Volume and Issue: 191(3)
Published: Feb. 14, 2024
Language: Английский
Citations
8
Archives of Microbiology, Journal Year: 2024, Volume and Issue: 206(3)
Published: Feb. 28, 2024
Language: Английский
Citations
6
AIDS Care, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 10
Published: Feb. 17, 2025
The prevalence of HIV is higher in the transgender population than general population, and pre-exposure prophylaxis (PrEP) an effective biomedical prevention strategy for HIV. However, gender-expansive community faces several challenges to PrEP uptake adherence. This community-based participatory study was conducted understand preferences long-acting modalities better. Data were collected virtually with adapted version World Café Conversation method in-depth interviews. A total 33 gender-diverse individuals participated either a conversation or individual interview about PrEP. All qualitative data transcribed coded themes. Two themes emerged: (1) related (2) bundling gender-affirming hormone therapy. To improve access adherence, needs be included as part therapy align patients' health priorities.
Language: Английский
Citations
0
Open Forum Infectious Diseases, Journal Year: 2025, Volume and Issue: 12(4)
Published: March 27, 2025
Abstract Background The first long-acting injectable antiretroviral therapy (LAI ART) for HIV was approved commercial use in the United States January 2021. Assessment of clinic characteristics and their associations with implementation outcomes barriers is essential to developing strategies equitable access LAI ART. Methods Using validated measures—acceptability intervention measure (AIM), appropriateness (IAM), feasibility (FIM)—we conducted a cross-sectional survey Ryan White clinics States. Additionally, we gathered information on clinics’ population, ART status, implementation. Data were analyzed using STATA, version 17. Open-ended responses an inductive thematic approach. Results Forty-two completed survey, 73% urban setting. Most identified as either federally qualified health centers (39%) or academic medical (27%). mean (SD) each (maximum 20) reflected higher AIM (17.7 [2.3]) IAM (17.6 [2.4]) compared FIM (16.4 [3.0]). There positive correlation between percentage patients Medicaid summative scores. greatest prior authorizations, drug procurement, cost Conclusions Despite high acceptability appropriateness, perceived low. Barriers include nonstandardization obtaining medication, Clinics larger Medicaid-insured population reported ART, suggesting that public insurance might promote access. Interventions address structural are needed improve uptake.
Language: Английский
Citations
0
BMC Infectious Diseases, Journal Year: 2024, Volume and Issue: 24(1)
Published: Feb. 23, 2024
Abstract The Food and Drug Administration (FDA) has licensed many antiretroviral medications to treat human immunodeficiency virus type 1 (HIV-1), however, treatment options for people with multi-drug resistant HIV remain limited. Medication resistance, undesirable effects, prior tolerance, previous interlacement incapacity deliver new drug classes all lead the requirement medication combination therapy. Fostemsavir (FTR) is a CD-4 attachment inhibitor medicine that was recently authorized by United States FDA HIV-1. In individuals multidrug-resistant (MDR) HIV-1, FTR well tolerated virologically active. According recent investigations, therapy can positively affect MDR-HIV. mechanism of action, interaction, pharmacokinetics, pharmacodynamics, safety been highlighted in this review.
Language: Английский
Citations
3
Global Health & Medicine, Journal Year: 2024, Volume and Issue: unknown
Published: Jan. 1, 2024
Human immunodeficiency virus (HIV) impacts millions of individuals worldwide, and well over 2/3 those living with HIV are accessing antiviral therapies that successfully repressing viral replication. Most often, treatments prevention administered in the form daily pills as combinations multiple drugs. An emergent effective strategy for suppressing replication is application long-acting antiretroviral therapy (LAART), or antivirals require less-frequent, non-daily doses. Thus far, repertoire LAARTs includes widely used classes non-nucleoside reverse transcriptase inhibitors (NNRTIs) integrase strand transfer (INSTIs) has recently expanded to include a capsid-targeting antiviral. Possible future additions nucleoside (NRTIs) translocation (NRTTIs). Here, we discuss different strategies using compounds treat prevent HIV-1 infection by targeting transcriptase, integrase, capsid.
Language: Английский
Citations
3