Mass Spectrometry Reviews, Journal Year: 2025, Volume and Issue: unknown
Published: April 23, 2025
ABSTRACT Cancer is the leading cause of death worldwide characterized by patient heterogeneity and complex tumor microenvironment. While genomics‐based testing has transformed modern medicine, challenge diverse clinical outcomes highlights unmet needs for precision oncology. As functional molecules regulating cellular processes, proteins hold great promise as biomarkers drug targets. Mass spectrometry (MS)‐based proteomics illuminated molecular features cancers facilitated discovery or therapeutic targets, paving way innovative strategies that enhance personalized treatment. In this article, we introduced tools current achievements MS‐based proteomics, choice targeted MS from to validation phases, profiling sensitivity bulk samples single‐cell level tissue liquid biopsy specimens, regulatory landscape protein laboratory‐developed tests (LDTs). The challenges, success future perspectives in translating research assay into applications are also discussed. With well‐designed studies demonstrate benefits meet requirements both analytical performance, assays promising with numerous opportunities improve cancer diagnosis, treatment, monitoring.
Language: Английский
Citations
0A review: early detection of oral cancer biomarkers using microfluidic colorimetric point-of-care devices
Analytical Methods, Journal Year: 2024, Volume and Issue: 16(36), P. 6098 - 6118
Published: Jan. 1, 2024
A comprehensive salivary biomarker study for oral cancer identification is carried out. Lateral flow assays (LFAs) and paper-based devices, low-resource settings, have been extensively examined.
Language: Английский
Citations
3Exploring Salivary Biomarkers for Tumor Diagnosis: A Narrative Review
Cureus, Journal Year: 2024, Volume and Issue: unknown
Published: July 30, 2024
A promising method for non-invasive cancer diagnosis and prognosis is through salivary biomarkers. By utilizing the distinct characteristics of saliva progress made in biomarker studies, these markers provide more accurate diagnoses a wider range malignancies. An attempt was to thoroughly investigate field biomarkers tumor diagnosis, with an emphasis on their use various forms. Predetermined search criteria were utilized systematic across numerous databases peer-reviewed papers from 2009 2021. Studies concentrating detection, validation, clinical different types cancers included inclusion criteria. Initially, 238 articles found, which 15 relevant satisfied requirements. Information study aims, methodology, findings, conclusions gathered data extraction. We identified recurrent themes, patterns, contradictions by thematic analysis. also assessed state-of-the-art prognosis. One major finding identification biomolecules linked several forms, including pancreatic, oral, breast, lung, stomach cancers. There increasing amount evidence demonstrating value saliva-based diagnostics oncology. This due new detection methods developments proteomics genomics. Identification exosomes microvesicles as profiles offered molecular understandings etiology evolution cancer, thereby opening avenues treatment. Salivary are approach early prediction thanks unique properties advancements research. potential revolution could enhance patient outcomes reduce cancer-related deaths.
Language: Английский
Citations
2Salivary 8-hydroxy-2′-deoxyguanosine levels in patients with oral cancer: a systematic review and meta-analysis
BMC Cancer, Journal Year: 2024, Volume and Issue: 24(1)
Published: Aug. 6, 2024
DNA is an important target for oxidative attack and its modification may increase the risk of mutagenesis. The aim this study was to evaluate compare salivary levels stress biomarker 8-hydroxy-2′-deoxyguanosine (8-OHdG) in patients with oral cancer (OC) compared control group by a comprehensive search available literature. present systematic review meta-analysis followed Preferred Reporting Items Systematic Reviews Meta-Analysis (PRISMA) guidelines registered Open Science Framework (OSF): https://doi.org/10.17605/OSF.IO/X3YMR. Four electronic databases were used identify studies review: PubMed, Scopus, ScienceDirect, Web from January 15, 2005, April 2021. Joanna Briggs Institute (JBI) tool assess article quality. Of 166 articles identified, 130 excluded on basis title abstract screening (duplicates, reviews, etc.). Thirty-six evaluated at full text 7 met inclusion criteria. these, only 5 had compatible data quantitative analysis. An 8-OHdG found OC healthy subjects, but without statistical significance. 8-OHdG: SMD = 2,72 (95%CI= -0.25–5.70); *p 0.07. This suggests clear trend increased saliva group. However, further are required clarify understand altered marker.
Language: Английский
Citations
2Salivary Diagnostics in Oral and Systemic Diseases - A Review
International Journal of Innovative Science and Research Technology (IJISRT), Journal Year: 2024, Volume and Issue: unknown, P. 2083 - 2087
Published: July 9, 2024
Salivary diagnostics, an emerging field in medical research, leverages the analysis of saliva for non- invasive detection, monitoring, and management various diseases. This abstract explores potential as a diagnostic fluid, highlighting its advantages such ease collection, cost-effectiveness, patient acceptability compared to traditional blood or tissue sampling. Key biomarkers identified include proteins, nucleic acids, metabolites that reflect systemic health conditions, oral diseases, infectious agents, even diseases like cancer diabetes. Advances technology, biosensors genomic analysis, enhance sensitivity specificity salivary paving way personalized medicine early intervention strategies. Challenges including standardization, variability composition, regulatory approval are also discussed, underscoring need further research clinical validation. diagnostics holds promise valuable tool future healthcare, potentially transforming how diagnosed managed globally.
Language: Английский
Citations
1The clinical potential of 1,5-anhydroglucitol as biomarker in diabetes mellitus
Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15
Published: Oct. 31, 2024
A crucial measure of diabetes management is to monitor blood glucose, which often requires continuous collection, leading economic burden and discomfort. Blood glucose glycated hemoglobin A1c serve as traditional indicators monitoring. But now albumin, fructosamine, 1,5-anhydroglucitol (1,5-AG) have been gaining more attention. 1,5-AG a chemically stable monosaccharide that exists in the human body. Its serum concentration remains when levels are normal. However, it decreases exceeds renal threshold. Studies shown 1.5-AG reflects changes 1 2 weeks; therefore, decreased can clinical indicator short-term disturbances. Recent studies be used not only for screening managing but also predicting diabetes-related adverse events islet β cell function prediabetic patients. In addition, saliva demonstrates potential value diagnosis diabetes. This review focuses on biological characteristics, detection methods, application promote understanding applicable research future.
Language: Английский
Citations
1Salivaomics: A Revolutionary Non-invasive Approach for Oral Cancer Detection
Cureus, Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 25, 2024
Salivaomics has emerged as a ground-breaking field in the detection and management of oral cancer (OC), offering non-invasive, efficient, patient-friendly alternative to traditional diagnostic methods. This innovative approach leverages comprehensive molecular insights provided by genomics, transcriptomics, proteomics, metabolomics, microbiomics. The potential salivaomics lies its ability enable early detection, predict malignant transformation, monitor treatment outcomes disease recurrence. Advancing salivary diagnostics necessitates standardization saliva collection processing protocols, identification validation robust biomarkers, development cutting-edge technologies. A single biomarker is unlikely fulfill all requirements; thus, research should focus on developing panel biomolecules enhance accuracy OC. stands at forefront non-invasive methods, with promise revolutionize Future directions emphasize integration multi-omics data for superior discovery, portable cost-effective point-of-care devices, fostering interdisciplinary collaborations drive innovation. Overcoming these challenges will facilitate translation into routine clinical practice, significantly improving diagnosis, treatment, prognosis review provides overview salivaomics, detailing use fluid. It covers collection, preparation, transportation, storage various analytical techniques. Additionally, discusses current future this transformative technology, emphasizing
Language: Английский
Citations
0Role of Peptides in Oral Cancer
Published: Jan. 1, 2024
Language: Английский
Citations
0