Cell Cycle,
Journal Year:
2023,
Volume and Issue:
22(9), P. 1074 - 1076
Published: Feb. 14, 2023
Selective
autophagy
specifically
eliminates
certain
intracellular
substrates
through
the
pathway.
Organelles
and
aggregation-prone
proteins
can
be
degraded
receptor
protein
SQSTM1/p62,
which
renders
them
a
promising
therapeutic
approach
against
infertility.
He
et
al.
demonstrate
that
blocking
of
in
cumulus
granulosa
cells
directly
attenuate
citrate
levels
turn
affect
oocyte
maturation
quality.
Further
findings
show
SQSTM1
connects
K63-polyubiquitinated
ACLY
(ATP
lyase)
during
process
selective
autophagic
degradation,
further
compromises
homeostasis
citrate.
Therefore,
quality
meiotic
evaluated
by
cells.
Nature Communications,
Journal Year:
2025,
Volume and Issue:
16(1)
Published: Jan. 8, 2025
Ferroptosis
is
a
newly
identified
programmed
cell
death
induced
by
iron-driven
lipid
peroxidation
and
implicated
as
potential
approach
for
tumor
treatment.
However,
emerging
evidence
indicates
that
hepatocellular
carcinoma
(HCC)
cells
are
generally
resistant
to
ferroptosis
the
underlying
molecular
mechanism
poorly
understood.
Here,
our
study
confirms
S100
calcium
binding
protein
P
(S100P),
which
significantly
up-regulated
in
ferroptosis-resistant
HCC
cells,
efficiently
inhibits
ferroptosis.
Mechanistically,
S100P
facilitates
lysosomal
degradation
of
acetyl-CoA
carboxylase
alpha
(ACC1),
indispensable
de
novo
biosynthesis
lipids.
Loss
elevates
expression
ACC1
promotes
ferroptotic
sensitivity
cells.
S100P-mediated
relies
on
RAB5C,
directs
lysosome
via
P62-dependent
selective
autophagy.
Knockdown
RAB5C
or
P62
abrogates
S100P-induced
restores
resistance
Our
work
reveals
an
alternative
anti-ferroptosis
pathway
suggests
promising
druggable
target
ferroptosis-related
therapy
HCC.
Resistance
remains
be
authors
identify
(S100P)
suppressor
(ACC1)
downregulate
biosynthesis.
Journal of Ovarian Research,
Journal Year:
2024,
Volume and Issue:
17(1)
Published: May 31, 2024
Abstract
In
women
who
are
getting
older,
the
quantity
and
quality
of
their
follicles
or
oocytes
decline.
This
is
characterized
by
decreased
ovarian
reserve
function
(DOR),
fewer
remaining
oocytes,
lower
oocytes.
As
more
choose
to
delay
childbirth,
decline
in
fertility
associated
with
age
has
become
a
significant
concern
for
modern
women.
The
oocyte
key
indicator
aging.
Many
studies
suggest
that
age-related
changes
energy
metabolism
may
impact
quality.
Changes
affect
adenosine
5'-triphosphate
(ATP)
production,
but
how
related
products
proteins
influence
remains
largely
unknown.
review
focuses
on
aging
its
potential
quality,
as
well
therapeutic
strategies
partially
metabolism.
research
aims
enhance
our
understanding
metabolism,
identification
biomarkers
treatment
methods.
Journal of Nanobiotechnology,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: Aug. 1, 2024
Nanoplastics
(NPs)
are
emerging
pollutants
that
pose
risks
to
living
organisms.
Recent
findings
have
unveiled
the
reproductive
harm
caused
by
polystyrene
nanoparticles
(PS-NPs)
in
female
animals,
yet
intricate
mechanism
remains
incompletely
understood.
Under
this
research,
we
investigated
whether
sustained
exposure
PS-NPs
at
certain
concentrations
vivo
can
enter
oocytes
through
zona
pellucida
or
other
routes
affect
reproduction.
We
show
disrupted
ovarian
functions
and
decreased
oocyte
quality,
which
may
be
a
contributing
factor
lower
fertility
mice.
RNA
sequencing
of
mouse
ovaries
illustrated
PI3K-AKT
signaling
pathway
emerged
as
predominant
environmental
information
processing
responding
PS-NPs.
Western
blotting
results
cells
vitro
showed
deactivated
down-regulating
expression
PI3K
reducing
AKT
phosphorylation
protein
level,
was
accompanied
activation
autophagy
apoptosis
disruption
steroidogenesis
granulosa
cells.
Since
penetrate
but
not
oocytes,
examined
indirectly
quality
using
cell–oocyte
coculture
system.
Preincubation
with
causes
cell
dysfunction,
resulting
decrease
cocultured
reversed
addition
17β-estradiol.
This
study
provides
on
how
impact
function
include
transcriptome
analysis
tissue.
The
demonstrates
impair
altering
functioning
Therefore,
it
is
necessary
focus
research
effects
reproduction
related
methods
mitigate
their
toxicity.
reduced
inhibited
ovary
viability
inducing
autophagy.
suppressed
causing
dysfunction.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(23), P. 13144 - 13144
Published: Dec. 6, 2024
The
efficacy
of
assisted
reproductive
technologies
(ARTs)
in
older
women
remains
constrained,
largely
due
to
an
incomplete
understanding
the
underlying
pathophysiology.
This
review
aims
consolidate
current
knowledge
on
age-associated
mitochondrial
alterations
and
their
implications
for
ovarian
aging,
with
emphasis
causes
DNA
(mtDNA)
mutations,
repair
mechanisms,
future
therapeutic
directions.
Relevant
articles
published
up
30
September
2024
were
identified
through
a
systematic
search
electronic
databases.
free
radical
theory
proposes
that
reactive
oxygen
species
(ROS)
inflict
damage
mtDNA
impair
function
essential
ATP
generation
oocytes.
Oocytes
face
prolonged
pressure
persisting
five
decades.
MtDNA
exhibits
limited
capacity
double-strand
break
repair,
heavily
depending
poly
ADP-ribose
polymerase
1
(PARP1)-mediated
single-strand
breaks.
process
depletes
nicotinamide
adenine
dinucleotide
(NAD⁺)
ATP,
creating
detrimental
cycle
where
continued
further
compromises
oocyte
functionality.
Interventions
interrupt
this
destructive
may
offer
preventive
benefits.
In
conclusion,
cumulative
burden
mutations
demands
can
lead
depletion
elevate
risk
aneuploidy,
ultimately
contributing
ART
failure
women.
Cell Death and Disease,
Journal Year:
2024,
Volume and Issue:
15(7)
Published: July 31, 2024
Abstract
Chemotherapeutic
efficacy
is
seriously
impeded
by
chemoresistance
in
more
than
half
of
hepatocellular
carcinoma
(HCC)
patients.
However,
the
mechanisms
involved
chemotherapy-induced
upregulation
chemoresistant
genes
are
not
fully
understood.
Here,
this
study
unravels
a
novel
mechanism
controlling
nuclear
acetyl-CoA
production
to
activate
transcription
HCC.
NAT10
upregulated
HCC
tissues
and
its
correlated
with
poor
prognosis
also
cells.
Targeting
increases
cytotoxicity
chemotherapy
cells
mouse
xenografts.
Upon
chemotherapy,
translocates
from
nucleolus
nucleus
CYP2C9
PIK3R1
.
Additionally,
specifically
NAT10.
Mechanistically,
binds
ACLY
acetylates
at
K468
counteract
SQSTM1-mediated
degradation
upon
chemotherapy.
K468-Ac
accumulates
through
enhancing
H3K27ac.
Importantly,
required
for
localization
ACLY.
Significantly,
tissues,
ablation
sensitizes
xenografts
Collectively,
these
findings
identify
as
driver
blockage
NAT10-mediated
possesses
potential
attenuate
chemoresistance.
Cells,
Journal Year:
2024,
Volume and Issue:
13(16), P. 1354 - 1354
Published: Aug. 14, 2024
Autophagy,
an
evolutionarily
conserved
cellular
mechanism
essential
for
maintaining
internal
stability,
plays
a
crucial
function
in
female
reproductive
ability.
In
this
review,
we
discuss
the
complex
interplay
between
autophagy
and
several
facets
of
health,
encompassing
pregnancy,
ovarian
functions,
gynecologic
malignancies,
endometriosis,
infertility.
Existing
research
emphasizes
significance
embryo
implantation,
specifically
endometrium,
highlighting
its
necessity
ensuring
proper
fetal
development.
Although
some
knowledge
has
been
gained,
there
is
still
lack
on
specific
molecular
impacts
quality
oocytes,
growth
follicles,
general
health.
Autophagy
role
maturation,
quality,
development
oocytes.
It
also
involved
aging,
contributing
to
reductions
that
occur
with
age.
This
review
explores
physiological
functions
system,
participation
toxicity,
important
connections
endometrium
embryo.
addition,
study
investigates
possibility
emerging
treatment
approaches
aim
modify
autophagy,
using
both
natural
substances
synthetic
molecules,
improve
fertility
outcomes.
Additionally,
intends
inspire
future
exploration
into
intricate
health
by
reviewing
recent
studies
pinpointing
areas
where
current
lacking.
Subsequent
investigations
should
prioritize
conversion
these
discoveries
practical
uses
medical
field,
which
could
potentially
result
groundbreaking
therapies
infertility
other
difficulties
related
reproduction.
Therefore,
gaining
comprehensive
understanding
many
effects
would
not
only
further
field
biology
but
open
new
possibilities
diagnostic
methods.
Aging Cell,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 15, 2024
Abstract
The
versatile
epigenetic
modification
known
as
N6‐methyladenosine
(m
6
A)
has
been
demonstrated
to
be
pivotal
in
numerous
physiological
and
pathological
contexts.
Nonetheless,
the
precise
regulatory
mechanisms
linking
m
A
histone
modifications
involvement
of
transposable
elements
(TEs)
ovarian
development
aging
are
still
not
completely
understood.
First,
we
discovered
that
highly
expressed
during
(OA),
with
significant
contributions
from
decreased
demethylase
FTO
overexpressed
methyltransferase
METTL16.
Then,
using
knockout
mouse
model
KGN
cell
line,
also
observed
deletion
METTL16
overexpression
significantly
increased
levels.
This
led
downregulation
SUV39H1,
resulting
reduced
H3K9me3
expression.
SUV39H1
primarily
activated
LTR7
LTR12,
subsequently
activating
ERV1.
resulted
a
decrease
proliferation,
while
levels
apoptosis,
cellular
markers,
autophagy
markers
OA.
In
summary,
our
study
offers
intriguing
insights
into
role
regulating
DNA
epigenetics,
including
TEs,
well
autophagy,
thereby
accelerating
