Annals of Noninvasive Electrocardiology,
Journal Year:
2024,
Volume and Issue:
29(1)
Published: Jan. 1, 2024
Abstract
Objective
Patients
treated
with
preoperative
chemotherapy
and
immunotherapy
for
bladder
cancer
may
be
at
increased
risk
of
cardiotoxicity
electrophysiological
abnormalities.
This
study
aimed
to
analyze
their
electrocardiographic
(ECG)
alterations.
Methods
who
were
hospitalized
receiving
tislelizumab
plus
nab‐paclitaxel
(TnP)
enrolled
prospectively.
ECG,
cardiac
biomarkers,
echocardiography
performed
baseline
the
end
TnP.
Results
A
total
60
patients
(76.7%
males),
including
30
muscle‐invasive
non‐muscle‐invasive
cancer,
received
three
or
four
cycles
TnP,
respectively.
Hypertension
was
commonest
comorbidity
(41.7%),
25
(41.7%)
prescribed
cardiovascular
drugs.
In
comparison
characteristics,
troponin
I
(cTnI)
N‐terminal
pro‐brain
natriuretic
peptide
(NT‐proBNP)
within
normal
ranges
after
However,
echocardiographic
parameter
left
ventricular
ejection
fraction
slightly
decreased
TnP
(62.81
±
3.81%
61.10
4.37%,
p
=
.011).
The
incidence
abnormal
ECG
from
65.0%
76.7%,
which
only
a
higher
prevalence
fragmented
QRS
(fQRS)
observed
(33.3%
50.0%,
.013;
mainly
in
inferior
leads).
parameters
QT
dispersion
(QTd)
prolonged
significantly
regimen
(39.50
11.37
44.20
15.85
ms,
.019).
Conclusion
combined
immunotherapy,
main
abnormality
fQRS
QTd,
relatively
biomarkers
parameters.
Regular
screening
should
carried
out
carefully
detect
potential
long‐term
follow‐up.
Frontiers in Cardiovascular Medicine,
Journal Year:
2022,
Volume and Issue:
9
Published: March 17, 2022
Cardiovascular
disease
(CVD)
and
cancer
are
the
leading
causes
of
death
worldwide.
With
an
increasing
number
elderly
population,
early
screening
treatment,
cancers
cases
rising,
while
mortality
rate
is
decreasing.
However,
survivors
yearly.
prolonged
life
span
patients,
adverse
effects
anti-tumor
therapy,
especially
CVD,
have
gained
enormous
attention.
The
incidence
cardiovascular
events
such
as
cardiac
injury
or
toxicity
higher
than
malignant
tumors'
recurrence
rate.
Numerous
clinical
studies
also
shifted
their
focus
from
study
a
single
to
interdisciplinary
oncology
cardiology.
Previous
confirmed
that
therapy
can
cause
CVD.
Additionally,
treatment
CVD
related
tumors
incidence.
It
well
established
increased
in
patients
probably
due
unmodified
unhealthy
lifestyle
among
cardiotoxicity
caused
by
anti-cancer
therapy.
Nevertheless,
some
with
relatively
risk
because
highly
overlapping
factors,
including
gender,
age,
hypertension,
diabetes,
hyperlipidemia,
inflammation,
obesity.
advancements
diagnosis
many
simultaneously
suffer
cancer,
most
them
poor
prognosis.
Therefore,
clinicians
should
understand
relationship
between
tumors,
effectively
identify
primary
secondary
prevention
for
these
diseases,
follow
proper
methods.
Cells,
Journal Year:
2023,
Volume and Issue:
12(7), P. 986 - 986
Published: March 23, 2023
Continuous
monitoring
of
the
population’s
health
is
main
method
learning
about
disease
prevalence.
National
and
international
data
draw
attention
to
persistently
high
rates
cancer
incidence.
This
necessitates
intensification
efforts
aimed
at
developing
new,
more
effective
chemotherapeutic
chemopreventive
drugs.
Plants
represent
an
invaluable
source
natural
substances
with
versatile
medicinal
properties.
Multidirectional
activities
exhibited
by
their
ability
modulate
key
signaling
pathways,
mainly
related
cell
death,
make
these
important
research
direction.
review
summarizes
information
regarding
plant-derived
drugs,
including
mechanisms
action,
a
special
focus
on
selected
anti-cancer
drugs
(paclitaxel,
irinotecan)
approved
in
clinical
practice.
It
also
presents
promising
plant-based
drug
candidates
currently
being
tested
preclinical
trials
(betulinic
acid,
resveratrol,
roburic
acid).
Current Drug Targets,
Journal Year:
2023,
Volume and Issue:
24(11), P. 889 - 918
Published: July 31, 2023
Microtubules
are
a
well-known
target
in
cancer
chemotherapy
because
of
their
critical
role
cell
division.
Chromosome
segregation
during
mitosis
depends
on
the
establishment
mitotic
spindle
apparatus
through
microtubule
dynamics.
The
disruption
dynamics
stabilization
or
destabilization
microtubules
results
arrest
cells.
Microtubule-targeted
drugs,
which
interfere
with
dynamics,
inhibit
growth
cells
at
phase
and
induce
apoptotic
death.
principle
microtubule-targeted
drugs
is
to
reduce
disease
unchecked
proliferation.
Many
anti-microtubule
agents
produce
significant
inhibition
widely
used
as
chemotherapeutic
for
treatment
cancer.
that
interact
generally
bind
one
three
sites
vinblastine
site,
taxol
colchicine
site.
Colchicine
binds
interface
tubulin
heterodimer
induces
depolymerization
microtubules.
binding
site
much
sought-after
history
drug
discovery.
colchicine-binding
inhibitors
have
been
discovered,
but
use
limited
due
dose-limiting
toxicity
resistance
humans.
Combination
therapy
can
be
new
strategy
overcome
these
drawbacks
currently
available
anticancer
drugs.
This
review
discusses
significance
potential
pharmacological
stresses
necessity
finding
fight
disease.
Materials & Design,
Journal Year:
2024,
Volume and Issue:
240, P. 112817 - 112817
Published: Feb. 29, 2024
Oral
diseases
include
oral
cancer,
periodontitis,
endodontium
infection,
and
caries.
The
cavity
is
prone
to
the
proliferation
of
pathogenic
bacteria
infectious
owing
its
unique
environment.
During
drug-based
treatment
diseases,
saliva
can
dilute
drug
formulation,
reduce
interaction
between
site
action,
weaken
efficacy.
Therefore,
searching
an
effective
delivery
approach
extremely
critical
urgent.
Stimuli
responsive
hydrogels
respond
altered
environmental
conditions
under
disease
states,
allowing
specific
delivery.
Accordingly,
smart
systems
prolong
duration
adverse
reactions,
decrease
frequency
administration,
improve
patient
compliance,
thereby
accelerating
recovery.
In
this
review,
we
discuss
different
types
stimuli
for
delivery,
focusing
on
their
application
in
management.
Further,
provide
suggestions
future
research
treatment.
Gels,
Journal Year:
2024,
Volume and Issue:
10(7), P. 478 - 478
Published: July 18, 2024
Oral
diseases
encompassing
conditions
such
as
oral
cancer,
periodontitis,
and
endodontic
infections
pose
significant
challenges
due
to
the
cavity's
susceptibility
pathogenic
bacteria
infectious
agents.
Saliva,
a
key
component
of
environment,
can
compromise
drug
efficacy
during
disease
treatment
by
diluting
formulations
reducing
drug-site
interactions.
Thus,
it
is
imperative
develop
effective
delivery
methods.
Stimuli-responsive
nanocomposite
hydrogels
offer
promising
solution
adapting
changes
in
environmental
states,
thereby
enabling
targeted
delivery.
These
smart
systems
have
potential
enhance
efficacy,
minimize
adverse
reactions,
reduce
administration
frequency,
improve
patient
compliance,
thus
facilitating
faster
recovery.
This
review
explores
various
types
stimuli-responsive
tailored
for
delivery,
with
specific
focus
on
their
applications
managing
diseases.
International Journal of Molecular Sciences,
Journal Year:
2022,
Volume and Issue:
23(24), P. 15619 - 15619
Published: Dec. 9, 2022
Biologically
active
taxanes,
present
in
small-
to
medium-sized
evergreen
conifers
of
various
Taxus
species,
are
widely
used
for
their
antioxidant,
antimicrobial
and
anti-inflammatory
effects,
but
mostly
antitumour
effects
the
treatment
solid
tumours
breast,
ovary,
lung,
bladder,
prostate,
oesophagus
melanoma.
More
substances
found
plant
extracts
have
medical
potential.
Therefore,
at
beginning
this
review,
we
describe
methods
isolation,
identification
determination
taxanes
different
parts.
One
most
important
is
paclitaxel,
which
summarize
pharmacokinetic
parameters
its
formulations.
We
also
toxicological
risks
during
clinical
therapy
such
as
hypersensitivity,
neurotoxicity,
gastrointestinal,
cardiovascular,
haematological,
skin
renal
toxicity
respiratory
system.
Since
effect
drug-form
PTX
enhanced
by
spp.
extracts,
published
intoxications
all
fatal
poisonings
baccata
plant.
This
showed
that,
despite
significant
use
anticancer
treatment,
attention
should
be
focused
on
risk
intoxication
due
ingestion
from
these
plants,
commonly
our
surroundings.
