Talanta, Journal Year: 2024, Volume and Issue: unknown, P. 126886 - 126886
Published: Sept. 1, 2024
Language: Английский
Chemical Reviews, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 27, 2025
Nanozymes have shown significant potential in cancer catalytic therapy by strategically catalyzing tumor-associated substances and metabolites into toxic reactive oxygen species (ROS) situ, thereby inducing oxidative stress promoting cell death. However, within the complex tumor microenvironment (TME), rational design of nanozymes factors like activity, reaction substrates, TME itself significantly influence efficiency ROS generation. To address these limitations, recent research has focused on exploring that affect activity developing nanozyme-based cascade systems, which can trigger two or more processes tumors, producing therapeutic achieving efficient stable with minimal side effects. This area remarkable progress. Perspective provides a comprehensive overview nanozymes, covering their classification fundamentals. The regulation nanozyme strategies are discussed detail. Furthermore, representative paradigms for successful construction systems treatment summarized focus revealing underlying mechanisms. Finally, we current challenges future prospects development biomedical applications.
Language: Английский
Citations
3
Small Methods, Journal Year: 2024, Volume and Issue: unknown
Published: March 13, 2024
Abstract Cascade reactions are described as efficient and versatile tools, organized catalytic cascades can significantly improve the efficiency of chemical interworking between nanozymes. They have attracted great interest in many fields such chromogenic detection, biosensing, tumor diagnosis, therapy. However, how to selectively kill cells by enzymatic without harming normal cells, well exploring two or more enzyme‐engineered nanoreactors for cascading reactions, remain challenges field targeted specific cancer diagnostics The latest research advances nanozyme‐catalyzed cascade processes diagnosis therapy this article. Here, various sensing strategies summarized, tumor‐specific diagnostics. Targeting mechanisms treatment using nanozymes classified analyzed, “elements” “dimensions” nanozymes, types, designs structure, assembly modes highly active a variety new targeting based on reaction Finally, integrated application systems tumor‐targeted diagnostic is which will lay foundation design rational, efficient, therapeutic modalities future.
Language: Английский
Citations
15
Small, Journal Year: 2024, Volume and Issue: 20(44)
Published: July 6, 2024
Abstract Sonodynamic therapy (SDT), featuring noninvasive, deeper penetration, low cost, and repeatability, is a promising approach for deep‐seated tumors. However, the general or only utilization of SDT shows efficiency unsatisfactory treatment outcomes due to complicated tumor microenvironment (TME) process. To circumvent issues, three feasible approaches enhancing SDT‐based therapeutic effects, including sonosensitizer optimization, strategies conquering hypoxia TME, combinational are summarized, with particular focus on combination other modalities, chemodynamic therapy, photodynamic photothermal chemotherapy, starvation gas immunotherapy. In end, current challenges in tumors discussed enhanced effects provided. It envisioned that this review will provide new insight into strategic design high‐efficiency sonosensitizer‐derived nanotheranostics, thereby augmenting accelerating potential clinical transformation.
Language: Английский
Citations
12
Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)
Published: March 30, 2024
Language: Английский
Citations
10
Journal of Colloid and Interface Science, Journal Year: 2024, Volume and Issue: 675, P. 746 - 760
Published: July 9, 2024
Language: Английский
Citations
9
Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)
Published: Feb. 20, 2025
The advent of nanozymes has revolutionized approaches to cancer diagnosis and therapy, introducing innovative strategies that address the limitations conventional treatments. Nanozyme nanostructures with enzyme-mimicking catalytic abilities exhibit exceptional stability, biocompatibility, customizable functions, positioning them as promising tools for theranostics. By emulating natural enzyme reactions, can selectively target eradicate cells, minimizing harm adjacent healthy tissues. Nanozymes also be functionalized specific targeting ligands, allowing precise delivery regulated release therapeutic agents, improving treatment effectiveness reducing adverse effects. However, issues such selectivity, regulatory compliance remain critical challenges clinical application nanozymes. This review provides an overview nanozymes, highlighting their unique properties, various classifications, activities, diverse applications in strategic oncological deployment could profoundly impact future advancements personalized medicine, recent progress prospective directions enzyme-mimetic treatment. summarizes
Language: Английский
Citations
1
Journal of Materials Chemistry B, Journal Year: 2023, Volume and Issue: 12(1), P. 39 - 63
Published: Nov. 27, 2023
Cyclodextrin (CD)-based supramolecular hydrogels are polymer network systems with the ability to rapidly form reversible three-dimensional porous structures through multiple cross-linking methods, offering potential applications in drug delivery. Although CD-based have been increasingly used a wide range of recent years, comprehensive description their structure, mechanical property modulation, loading, delivery, and biomedical fields from perspective is lacking. To provide overview hydrogels, this review systematically describes design, regulation properties, modes loading release, roles various fields, particularly oncology, wound dressing, bone repair, myocardial tissue engineering. Additionally, provides rational discussion on current challenges prospects which can ideas for rapid development foster translation laboratory clinical medicine.
Language: Английский
Citations
17
Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(5), P. 603 - 603
Published: April 29, 2024
Sonodynamic therapy (SDT) has attracted significant attention in recent years as it is an innovative approach to tumor treatment. It involves the utilization of sound waves or ultrasound (US) activate acoustic sensitizers, enabling targeted drug release for precise This review aims provide a comprehensive overview SDT, encompassing its underlying principles and therapeutic mechanisms, applications nanomaterials, potential synergies with combination therapies. The begins by introducing fundamental principle SDT delving into intricate mechanisms through which facilitates A detailed analysis presented, outlining how effectively destroys cells modulating mechanisms. Subsequently, this explores diverse range nanomaterials utilized highlights their specific contributions enhancing treatment outcomes. Furthermore, combine other modalities such photothermal (PTT) chemotherapy discussed. These combined approaches aim synergistically improve efficacy while mitigating side effects. In conclusion, emerges promising frontier that offers personalized effective options revolutionize patient care. As research progresses, poised play pivotal role shaping future landscape oncology providing patients broader spectrum efficacious tailored options.
Language: Английский
Citations
7
Nano Today, Journal Year: 2024, Volume and Issue: 57, P. 102386 - 102386
Published: July 13, 2024
Language: Английский
Citations
6
International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 268, P. 131736 - 131736
Published: April 21, 2024
Language: Английский
Citations
5