CURRENT PERSPECTIVES ON THE EFFECTS OF MAIN TYPES OF CARRAGEENANS ON THE HUMAN BODY DOI Open Access

R. O. Bachynskyi,

Оксана Анатоліївна Наконечна, S. Stetsenko

et al.

Актуальні проблеми сучасної медицини Вісник Української медичної стоматологічної академії, Journal Year: 2024, Volume and Issue: 24(4), P. 309 - 314

Published: Dec. 26, 2024

The relevance of studying carrageenans (red seaweed extracts) stems from the need to address a medical and scientific issue concerning limited depth understanding regarding their effects on human body. purpose this study is analyze current literature primary types carrageenans—kappa, iota, lambda—and evaluate safety efficacy these food additives in industry. Results discussion. Due hydrocolloidal properties, contribute formation stable structures various matrices, making them key ingredient production dairy meat products, as well products made plant ingredients. On other hand, due structural functional diversity, are used cosmetics pharmaceutical industries. According modern research, external use biopolymers considered safe. Moreover, experimental studies have shown that antioxidant demonstrate wide range antiviral effects, effective against viruses, including SARS-CoV-2, dengue virus, herpes simplex cytomegalovirus, HIV, rabies papillomavirus, influenza rhinoviruses. It has been established different dietary undegraded can significantly affect gastrointestinal tract, namely, digestion processes - proteolysis. In vitro results demonstrated inhibit activity enzymes such gastric pepsin pancreatic trypsin. One potential toxic orally consuming E407 E407a disruption protein leading deficiency essential amino acids inhibition To gain deeper further in-depth needed explore biochemical mechanisms by which investigate dose-dependent nature changes.

Language: Английский

Erythronecroptosis: an overview of necroptosis or programmed necrosis in red blood cells DOI
Anton Tkachenko, Ondřej Havránek

Molecular and Cellular Biochemistry, Journal Year: 2024, Volume and Issue: 479(12), P. 3273 - 3291

Published: March 1, 2024

Language: Английский

Citations

10
Marine Polysaccharides Carrageenans Enhance Eryptosis and Alter Lipid Order of Cell Membranes in Erythrocytes DOI
Volodymyr Prokopіuk, Anatolii Onishchenko, Liliya Tryfonyuk

et al.

Cell Biochemistry and Biophysics, Journal Year: 2024, Volume and Issue: 82(2), P. 747 - 766

Published: Feb. 9, 2024

Language: Английский

Citations

6
Recent Advances in the Evaluation of the Toxicological and Ecotoxicological Risks of Polymer, Zinc Oxide, Titanium Dioxide and Graphene Oxide Nanoparticles DOI Creative Commons
M. Pilar Vinardell

Nanomaterials, Journal Year: 2025, Volume and Issue: 15(2), P. 97 - 97

Published: Jan. 9, 2025

Nanotechnology has substantial potential for advancements in the fields of biology and medicine [...]

Language: Английский

Citations

0
A bibliometric analysis of programmed cell death in oral cancer literature: research patterns and emerging trends (2000–2024) DOI Creative Commons

Wenli Gu

Discover Oncology, Journal Year: 2025, Volume and Issue: 16(1)

Published: April 22, 2025

Language: Английский

Citations

0
An Overview of Hexavalent Chromium-Induced Necroptosis, Pyroptosis, and Ferroptosis DOI

Saulesh Kurmangaliyeva,

Kristina Baktikulova,

Viktoriya Tkachenko

et al.

Biological Trace Element Research, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 17, 2024

Language: Английский

Citations

3
Hemocompatibility of dextran-graft-polyacrylamide/zinc oxide nanosystems: hemolysis or eryptosis? DOI
Anatolii Onishchenko, Volodymyr Prokopіuk, Vasyl Chumachenko

et al.

Nanotechnology, Journal Year: 2023, Volume and Issue: 35(3), P. 035102 - 035102

Published: Oct. 12, 2023

Aim. In this study, blood compatibility of ZnO nanoparticles-polymer nanocomplex (D-PAA/ZnONPs(SO42-)) synthesizedin situinto dextran-graft-polyacrylamide (D-PAA) using zinc sulphate as a precursor was tested hemolysis, osmotic fragility and eryptosis assays.Materials methods. Dose-dependent ability to induce assessed following 24 h incubation at concentrations 0-800 mg l-1analyzing hallmarks (cell shrinkage phosphatidylserine externalization), well reactive oxygen species generation. Hemolysis detected spectrophotometrically based on hemoglobin release exposure the D-PAA/ZnONPs(SO42-) nanocomplex. Osmotic test (OFT) involved detection hemolysis red cells exposed 0.2% saline solution with Additional in presence or absence either ascorbic acid EGTA used reveal implication oxidative stress- Ca2+-mediated mechanisms nanocomplex-induced erythrotoxicity.Results. Hemocompatibility assessment revealed that it induced reduced resistance erythrocytes stress above 400 200 l-1, respectively. Oxidative were not hemolysis. Strikingly, did promote cell membrane scrambling, direct for h. Thus, eryptosisin vitro. Eryptosis is generally considered occur earlier than response order prevent hemolytic death. Counterintuitively, our data suggest can be triggered by nanomaterials prior indicating assays should combination testing nanomaterials.Conclusions. The has good hemocompatibility profile low concentrations. nanotoxicology include both assays.

Language: Английский

Citations

8
Redox Status of Erythrocytes as an Important Factor in Eryptosis and Erythronecroptosis DOI Open Access
Anton Tkachenko, Ondřej Havránek

Folia Biologica, Journal Year: 2023, Volume and Issue: 69(4), P. 116 - 126

Published: Jan. 1, 2023

Overall, reactive oxygen species (ROS) signalling significantly contributes to initiation and mo­dulation of multiple regulated cell death (RCD) pathways. Lately, more information has become available about RCD modalities erythrocytes, including the role ROS. ROS accumulation therefore been increasingly recognized as a critical factor involved in eryptosis (apoptosis erythrocytes) erythro­necroptosis (necroptosis erythrocytes). Eryptosis is Ca 2+ -dependent apoptosis-like erythrocytes that occurs response oxidative stress, hyperosmolarity, ATP depletion, wide range xenobiotics. Moreover, seems be pathogenesis human diseases pathological processes. Several studies have reported can also undergo necroptosis, lytic RIPK1/RIPK3/MLKL-mediated RCD. As an example, erythronecroptosis occur CD59-specific pore-forming toxins. We systematically summarized regarding involvement stress these two distinct RCDs erythrocytes. focused specifically on cellular pathways ROS-mediated decisions Furthermore, we dysregulation related erythrocytic antioxidant defence systems. The general concept eryptotic necroptotic established. However, further are required uncover complex crosstalk interplay between survival

Language: Английский

Citations

7
Recent progress in biomaterials-driven ferroptosis for cancer therapy DOI

Nianting Xiao,

Xiong Su, Ziwei Zhou

et al.

Biomaterials Science, Journal Year: 2024, Volume and Issue: 12(2), P. 288 - 307

Published: Jan. 1, 2024

This paper summarizes the application of biomedical nanomaterials including hydrogels for ferroptosis driven tumours treatment, and various in was categorizes reviewed.

Language: Английский

Citations

2
Cancer-Associated Programmed Cell Death Mechanisms: Extended with Biochemical Markers and Experimental Approaches DOI
Goksemin Fatma Sengul,

Fatma Secer-Celik,

Gaye Pisiren

et al.

Interdisciplinary cancer research, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Language: Английский

Citations

1
Acute toxicity of zinc carbonate nanocrystals on white mice model DOI Creative Commons

V. І. Koshevoy,

S. V. Naumenko, О. Л. Оробченко

et al.

Scientific Messenger of LNU of Veterinary Medicine and Biotechnology, Journal Year: 2023, Volume and Issue: 25(112), P. 123 - 130

Published: Dec. 3, 2023

Zinc-based nanoparticles (NPs) are successfully used to meet the mineral needs of animals and poultry, capable increasing growth rate efficiency their use feed. Nanoparticles zinc oxide widely used, which superior conventional sources in terms pharmacological activity bioavailability, have a positive effect on productivity antioxidant protection, increase reproductive potential. However, detailed investigation toxicological parameters showed risks introduction into body, as result large number NPs were synthesized by methods “green chemistry”, main drawback is complex methodology high level costs. We investigated acute toxicity colloidal solution carbonate nanocrystals model white mice. The experiment was conducted 42 female non-linear mice, 3–4 months old, with live weight 21–23 g, kept under optimal vivarium conditions. According principle analogues, 6 experimental groups formed: mice injected doses (by absolute drug) 15,000.0; 20000.0; 25000.0; 30000; 35000.0 40000.0 mg/kg body based drug, according active substance (zinc nanoparticles) (37.5; 50.0; 62.5; 75.0; 87.5 100, 0 weight), orally using an esophageal-gastric tube. Mice control group distilled water volume 0.2 cm3 same protocol. clinical condition observed for 14 days, noting appearance development signs poisoning, time death or recovery physiological norm. After (diagnostic slaughter) animals, pathological autopsy performed. Clinical observations that single intragastric administration drug 1-6 did not cause poisoning. deaths all during 14-day observation period, LD50 indicator could be calculated. At time, maximum possible dose weight) 40,000.0 (100.0 substance), allows assigned VI class – substances relatively harmless (LD50 > 15000.0 degree danger up IV low-hazardous 5000.0 weight).

Language: Английский

Citations

2