Frontiers in Microbiology, Journal Year: 2024, Volume and Issue: 15
Published: March 14, 2024
The gut-liver axis has emerged as a focal point in chronic liver disorders, prompting more research into the role of gut microbiota cirrhosis. In individuals with cirrhosis, changes structure and function are closely tied to clinical prognosis. However, there is scarcity bibliometric evaluations conducted this particular field.
Language: Английский
Trends in Microbiology, Journal Year: 2022, Volume and Issue: 31(1), P. 76 - 91
Published: Aug. 22, 2022
Language: Английский
Citations
108
Biomedicines, Journal Year: 2022, Volume and Issue: 10(3), P. 524 - 524
Published: Feb. 23, 2022
Nonalcoholic fatty liver disease (NAFLD) is considered as one of the most prevalent chronic diseases worldwide due to rapidly rising prevalence obesity and metabolic syndrome. As a hepatic manifestation disease, NAFLD begins with fat accumulation progresses inflammation, termed non-alcoholic steatohepatitis (NASH), fibrosis/cirrhosis, finally leading NAFLD-related hepatocellular carcinoma (NAFLD-HCC). Accumulating evidence showed that gut microbiome plays vital role in initiation progression through gut–liver axis. The axis mutual communication between comprising portal circulation, bile duct, systematic circulation. dysbiosis contributes development by dysregulating axis, increased intestinal permeability unrestrained transfer microbial metabolites into liver. In this review, we systematically summarized up-to-date information metabolomic changes along stages steatosis, NASH, fibrosis, NAFLD-HCC. components functions its association were then discussed. addition, highlighted current knowledge microbiome-based treatment strategies targeting for preventing associated HCC.
Language: Английский
Citations
88
Gut Microbes, Journal Year: 2022, Volume and Issue: 14(1)
Published: May 25, 2022
Despite a short history since its first isolation, Akkermansia muciniphila has been extensively studied in relation to effects on human metabolism. A recent intervention study also demonstrated that the bacterium is safe use for therapeutic purposes. The best-known of A. health and disease relate ability strengthen gut integrity, modulate insulin resistance, protect host from metabolic inflammation. further molecular mechanism, induction GLP-1 secretion through ICAM-2 receptor, was recently discovered with identification new bacterial protein produced by muciniphila. However, other studies have suggested detrimental role specific immune settings. Here, we evaluate molecular, mechanistic suggest some missing links be connected before organism should considered as next-generation biotherapeutic agent.
Language: Английский
Citations
81
Cell, Journal Year: 2024, Volume and Issue: 187(11), P. 2717 - 2734.e33
Published: April 22, 2024
The gut microbiota has been found to play an important role in the progression of metabolic dysfunction-associated steatohepatitis (MASH), but mechanisms have not established. Here, by developing a click-chemistry-based enrichment strategy, we identified several microbial-derived bile acids, including previously uncharacterized 3-succinylated cholic acid (3-sucCA), which is negatively correlated with liver damage patients liver-tissue-biopsy-proven fatty disease (MAFLD). By screening human bacterial isolates, Bacteroides uniformis strains as effective producers 3-sucCA both vitro and vivo. activity-based protein purification identification, enzyme annotated β-lactamase B. responsible for biosynthesis. Furthermore, that lumen-restricted metabolite alleviates MASH promoting growth Akkermansia muciniphila. Together, our data offer new insights into microbiota-liver axis may be leveraged augment management MASH.
Language: Английский
Citations
77
Microbiome, Journal Year: 2022, Volume and Issue: 10(1)
Published: Nov. 16, 2022
Abstract Background Vascular calcification is a major cause of the high morbidity and mortality cardiovascular diseases closely associated with intestinal microbiota. Short-chain fatty acids (SCFAs) are derived from microbiota can also regulate homeostasis. However, it remains unclear whether exogenous supplementation propionate, SCFA, ameliorate vascular by regulating This study was conducted to explore roles propionate in process calcification. Methods In total, 92 patients were enrolled consecutively as observational cohort analyse relationship between SCFAs both blood faecal samples. A rat model induced vitamin D3 nicotine (VDN) validate effect propionate. Differences analysed 16S ribosomal RNA gene sequencing. Faecal transplantation Akkermansia muciniphila experiments performed evaluate functions Results The results revealed that levels (particularly propionate) samples independently correlated negatively scores ( P < 0.01). To verify activities provided VDN-treated rats, oral or rectal delivery reshaped microbiota, resulted elevated SCFA production, improved barrier function alleviated inflammation, ultimately ameliorating Furthermore, we demonstrated propionate-modulated beneficial outcomes similar those administration. Interestingly, linear discriminant analysis (LDA) size (LEfSe) administration enriched primarily . Subsequently, could VDN-induced rats. Conclusions Propionate significantly this mediated remodelling. findings our indicate tract-vessel axis promising target for alleviating
Language: Английский
Citations
70
Journal of Advanced Research, Journal Year: 2023, Volume and Issue: 52, P. 59 - 72
Published: Jan. 11, 2023
Non-alcoholic fatty liver disease (NAFLD) with obesity seriously threats public health. Our previous studies showed that dark tea had more potential on regulating lipid metabolism than other teas, and theabrownin (TB) was considered to be a main contributor the bioactivity of tea.This in vivo study aims reveal effects molecular mechanisms TB NAFLD obesity, role gut-liver axis is explored.The histopathological examinations, biochemical tests, nuclear magnetic resonance were applied evaluate obesity. The untargeted metabolomics used find key molecule for further exploration mechanisms. 16S rRNA gene sequencing assess changes gut microbiota. antibiotic cocktail fecal microbiota transplant clarify microbiota.TB markedly reduced body weight gain (67.01%), fat rate (62.81%), hepatic TG level (51.35%) preventive experiment. Especially, decreased (32.16%), (42.56%), (42.86%) therapeutic action could improvement acid oxidation, lipolysis, oxidative stress via regulation serotonin-related signaling pathways. Also, increased abundance microbiota, such as Akkermansia, Bacteroides Parabacteroides. Antibiotics-induced bacterial dysbiosis disrupted pathways liver, whereas beneficial target proteins regained restoration microbiota.We has by serotonin related through Furthermore, co-contribute alleviating promising medicine
Language: Английский
Citations
56
Nutrients, Journal Year: 2023, Volume and Issue: 15(8), P. 1815 - 1815
Published: April 8, 2023
The gut microbiota plays a critical role in the modulation of host metabolism and immune response, its impairment has been implicated many gastrointestinal extraintestinal diseases. Current evidence shows well-documented A. muciniphila maintaining integrity intestinal barrier, modulating improving several metabolic pathways, making it key element pathogenesis human In this scenario, is most promising next-generation probiotic one first microbial species suitable for specific clinical use when compared with traditional probiotics. Further studies are needed to provide more accurate insight into mechanisms action better elucidate properties major areas, paving way integrated personalized therapeutic approach that finally makes our knowledge microbiota.
Language: Английский
Citations
43
Advanced Science, Journal Year: 2023, Volume and Issue: 10(29)
Published: Sept. 14, 2023
Abstract The combination of immunotherapy and molecular targeted therapy exhibits promising therapeutic efficacy in hepatocellular carcinoma (HCC), but the underlying mechanism is still unclear. Here, phosphoglycerate mutase 1 (PGAM1) identified as a novel immunometabolic target by using bioinformatic algorithm based on multiple HCC datasets. PGAM1 highly expressed associated with poor prognosis response to immunotherapy. In vitro vivo experiments indicate that targeting inhibited cell growth promoted infiltration CD8 + T‐cells due decreased enzymatic activity. Mechanistically, inhibition promotes ferroptosis downregulating Lipocalin (LCN2) inducing energy stress ROS‐dependent AKT inhibition, which can also downregulate Programmed death 1‐ligand (PD‐L1). Moreover, an allosteric inhibitor (KH3) good antitumor effects patient‐derived xenograft (PDX) models enhanced anti‐PD‐1 subcutaneous orthotopic models. Taken together, findings demonstrate exerts effect promoting T‐cell synergize HCC. Targeting be new strategy “killing two birds one stone” for treatment.
Language: Английский
Citations
43
Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15
Published: March 20, 2024
Metabolic diseases are comprehensive disease based on obesity. Numerous cumulative studies have shown a certain correlation between the fluctuating abundance of Akkermansia muciniphila and occurrence metabolic diseases. A. , potential probiotic candidate colonized in human intestinal mucus layer, its derivatives various physiological functions, including treating disorders maintaining health. This review systematically explicates change rules It also details high efficacy specific molecules mechanism obesity, type 2 diabetes mellitus, cardiovascular disease, non-alcoholic fatty liver disease.
Language: Английский
Citations
32
Hepatology Communications, Journal Year: 2024, Volume and Issue: 8(3)
Published: Feb. 26, 2024
Metabolic dysfunction-associated steatotic liver disease (MASLD), a replacement of the nomenclature employed for NAFLD, is most prevalent chronic worldwide. Despite its high global prevalence, NAFLD often under-recognized due to absence reliable noninvasive biomarkers diagnosis and staging. Growing evidence suggests that gut microbiome plays significant role in occurrence progression by causing immune dysregulation metabolic alterations dysbiosis. The rapid advancement sequencing tools metabolomics has enabled identification signatures microbiota-derived metabolite profiles numerous clinical studies related NAFLD. Overall, these have shown decrease α-diversity changes microbiota abundance, characterized increased levels Escherichia Prevotella, decreased Akkermansia muciniphila Faecalibacterium patients with Furthermore, bile acids, short-chain fatty trimethylamine N-oxide, tryptophan metabolites are believed be closely associated onset In this review, we provide novel insights into vital pathogenesis Specifically, summarize major classes thereby highlighting links between specific bacterial species certain
Language: Английский
Citations
21