The Science of The Total Environment, Journal Year: 2023, Volume and Issue: 904, P. 166889 - 166889
Published: Sept. 6, 2023
Language: Английский
International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(10), P. 9087 - 9087
Published: May 22, 2023
Several studies in recent years have demonstrated that gut microbiota-host interactions play an important role human health and disease, including inflammatory cardiovascular diseases. Dysbiosis has been linked to not only well-known diseases, such as bowel rheumatoid arthritis, systemic lupus erythematous, but also risk factors, atherosclerosis, hypertension, heart failure, chronic kidney obesity, type 2 diabetes mellitus. The ways the microbiota is involved modulating are multiple related mechanisms. Indeed, microbiome cooperate a metabolically active superorganism, this affects host physiology through metabolic pathways. In turn, congestion of splanchnic circulation associated with edema intestinal wall, altered function permeability barrier result translocation bacteria their products into circulation, further enhancing pro-inflammatory conditions underlying disorders. aim present review describe complex interplay between microbiota, its metabolites, development evolution We discuss possible interventions intended modulate reduce risk.
Language: Английский
Citations
79
JAMA Psychiatry, Journal Year: 2023, Volume and Issue: 80(6), P. 597 - 597
Published: April 19, 2023
Importance Metabolomics reflect the net effect of genetic and environmental influences thus provide a comprehensive approach to evaluating pathogenesis complex diseases, such as depression. Objective To identify metabolic signatures major depressive disorder (MDD), elucidate direction associations using mendelian randomization, evaluate interplay human gut microbiome metabolome in development MDD. Design, Setting Participants This cohort study used data from participants UK Biobank (n = 500 000; aged 37 73 years; recruited 2006 2010) whose blood was profiled for metabolomics. Replication sought PREDICT BBMRI-NL studies. Publicly available summary statistics 2019 genome-wide association depression were randomization (individuals with MDD 59 851; control individuals 113 154). Summary metabolites obtained OpenGWAS MRbase 118 000). depression, performed Dutch cohorts. Data analyzed March December 2021. Main Outcomes Measures lifetime recurrent MDD, 249 nuclear magnetic resonance spectroscopy Nightingale platform. Results The included 6811 compared 51 446 4370 62 508 individuals. Individuals younger (median [IQR] age, 56 [49-62] years vs 58 [51-64] years) more often female (4447 [65%] 2364 [35%]) than Metabolic consisted 124 spanning energy lipid metabolism pathways. Novel findings 49 metabolites, including those involved tricarboxylic acid cycle (ie, citrate pyruvate). Citrate significantly decreased (β [SE], −0.07 [0.02]; FDR 4 × 10 −04 ) pyruvate increased 0.04 0.02) Changes observed these particularly lipoproteins, consistent differential composition microbiota belonging order Clostridiales phyla Proteobacteria / Pseudomonadota Bacteroidetes Bacteroidota . Mendelian suggested that fatty acids intermediate very large density lipoproteins changed disease process but high-density did not. Conclusions Relevance showed disturbed may play role
Language: Английский
Citations
73
Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(3), P. 774 - 774
Published: Feb. 26, 2023
Nanomedicine is a branch of medicine using nanotechnology to prevent and treat diseases. Nanotechnology represents one the most effective approaches in elevating drug‘s treatment efficacy reducing toxicity by improving drug solubility, altering biodistribution, controlling release. The development materials has brought profound revolution medicine, significantly affecting various major diseases such as cancer, injection, cardiovascular experienced explosive growth past few years. Although clinical transition nanomedicine not very satisfactory, traditional drugs still occupy dominant position formulation development, but increasingly active have adopted nanoscale forms limit side effects improve efficacy. review summarized approved nanomedicine, its indications, properties commonly used nanocarriers nanotechnology.
Language: Английский
Citations
59
Frontiers in Microbiology, Journal Year: 2024, Volume and Issue: 14
Published: Jan. 5, 2024
The imbalance of microbial composition and diversity in favor pathogenic microorganisms combined with a loss beneficial gut microbiota taxa results from factors such as age, diet, antimicrobial administration for different infections, other underlying medical conditions, etc. Probiotics are known their capacity to improve health by stimulating the indigenous microbiota, enhancing host immunity resistance infection, helping digestion, carrying out various functions. Concurrently, metabolites produced these microorganisms, termed postbiotics, which include compounds like bacteriocins, lactic acid, hydrogen peroxide, contribute inhibiting wide range bacteria. This review presents an update on using probiotics managing treating human diseases, including complications that may emerge during or after COVID-19 infection.
Language: Английский
Citations
52
Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15
Published: Jan. 26, 2024
The gut microbiome is a heterogeneous population of microbes comprising viruses, bacteria, fungi, and protozoa. Such essential for sustaining host equilibrium, its impact on human health can be altered by variety factors such as external variables, social behavior, age, nutrition, genetics. Gut microbes’ imbalances are related to chronic diseases including cancer, obesity, digestive disorders. Globally, recent findings show that intestinal have significant role in the formation cardiovascular disease (CVD), which still primary cause fatalities. Atherosclerosis, hypertension, diabetes, inflammation, some inherited variables all risk variables. However, studies found correlations between metabolism, flora, dietary intake. Variations diversity changes their activity thought influence CVD etiology. Furthermore, microbiota acts an endocrine organ, producing bioactive metabolites TMA (trimethylamine)/TMAO (trimethylamine N-oxide), SCFA (short-chain fatty acids), bile acids, substantial wellness multiple mechanisms. purpose this overview compile current evidence highlighting intricate links microbiota, metabolites, development CVD. It focuses how dysbiosis promotes heart failure, atherosclerosis. This review explores normal physiology potential techniques targeting bacteria treatment using various microbial metabolites. also examines significance treatment, supplements, prebiotics, probiotics, antibiotic therapies, fecal transplantation, innovative approach management As result, metabolic pathways become increasingly attractive targets intervention.
Language: Английский
Citations
42
Molecular and Cellular Biochemistry, Journal Year: 2024, Volume and Issue: unknown
Published: July 26, 2024
Language: Английский
Citations
19
Carbohydrate Polymers, Journal Year: 2023, Volume and Issue: 323, P. 121414 - 121414
Published: Sept. 19, 2023
Language: Английский
Citations
32
Microorganisms, Journal Year: 2023, Volume and Issue: 11(7), P. 1714 - 1714
Published: June 30, 2023
Recently, probiotics are increasingly being used for human health. So far, only lactic acid bacteria isolated from the gastrointestinal tract were recommended use as probiotics. However, more authors suggest that can be also unconventional sources, such fermented food products of animal and plant origin. Traditional a rich source microorganisms, some which may have probiotic properties. A novel category recently microorganisms with great potential health benefits next-generation (NGPs). In this review, general information "beneficial microbes", including NGPs acetic bacteria, presented well essential mechanisms microbe host interactions. Many reports showed NGP selected strains sources exhibit positive properties when it comes to (i.e., they effect on metabolic, gastrointestinal, neurological, cardiovascular, immune system diseases). Here we briefly present current regulatory framework requirements should followed introduce new use. The term "probiotic" herein is not limited conventional Innovation will undoubtedly result in isolation fascinating advantages hitherto unforeseen functionalities.
Language: Английский
Citations
26
Molecular Neurobiology, Journal Year: 2023, Volume and Issue: 60(8), P. 4618 - 4640
Published: May 1, 2023
Language: Английский
Citations
24
Journal of Colloid and Interface Science, Journal Year: 2023, Volume and Issue: 653, P. 540 - 550
Published: Sept. 17, 2023
Language: Английский
Citations
23