Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: 338, P. 119065 - 119065
Published: Nov. 8, 2024
Language: Английский
Cell Host & Microbe, Journal Year: 2023, Volume and Issue: 31(2), P. 173 - 186
Published: Feb. 1, 2023
Language: Английский
Citations
190
World Journal of Gastroenterology, Journal Year: 2022, Volume and Issue: 28(18), P. 1875 - 1901
Published: May 6, 2022
Gut microbiota has a significant role in gut development, maturation, and immune system differentiation. It exerts considerable effects on the child's physical mental development. The composition structure depend many host microbial factors. factors include age, genetic pool, general health, dietary factors, medication use, intestine's pH, peristalsis, transit time, mucus secretions, mucous immunoglobulin, tissue oxidation-reduction potentials. nutrient availability, bacterial cooperation or antagonism, adhesion. Each part of its due to specific characteristics. interacts with different body parts, affecting pathogenesis local systemic diseases. Dysbiosis is common finding childhood disorders such as autism, failure thrive, nutritional disorders, coeliac disease, Necrotizing Enterocolitis, helicobacter pylori infection, functional gastrointestinal childhood, inflammatory bowel diseases, other disorders. also observed allergic conditions like atopic dermatitis, rhinitis, asthma. can impact development progression cardiac including heart failure. Probiotic supplements could provide some help managing these However, we are still need more studies. In this narrative review, will shed light management
Language: Английский
Citations
77
International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 232, P. 123488 - 123488
Published: Jan. 31, 2023
Language: Английский
Citations
56
Microbiome, Journal Year: 2023, Volume and Issue: 11(1)
Published: Feb. 21, 2023
Gut homeostasis, including intestinal immunity and microbiome, is essential for cognitive function via the gut-brain axis. This axis altered in high-fat diet (HFD)-induced impairment closely associated with neurodegenerative diseases. Dimethyl itaconate (DI) an derivative has recently attracted extensive interest due to its anti-inflammatory effect. study investigated whether intraperitoneal administration of DI improves prevents deficits HF diet-fed mice.DI effectively attenuated HFD-induced decline behavioral tests object location, novel recognition, nesting building, concurrent improvement hippocampal RNA transcription profiles genes cognition synaptic plasticity. In agreement, reduced damage ultrastructure deficit proteins (BDNF, SYN, PSD95), microglial activation, neuroinflammation HFD-fed mice. colon, significantly lowered macrophage infiltration expression pro-inflammatory cytokines (TNF-α, IL-1β, IL-6) mice on diet, while upregulating immune homeostasis-related (IL-22, IL-23) antimicrobial peptide Reg3γ. Moreover, alleviated gut barrier impairments, elevation colonic mucus thickness tight junction (zonula occludens-1, occludin). Notably, microbiome alteration was improved by supplementation, characterized increase propionate- butyrate-producing bacteria. Correspondingly, increased levels propionate butyrate serum HFD Intriguingly, fecal transplantation from DI-treated facilitated variables compared mice, higher indexes behavior optimization ultrastructure. These results highlight microbiota necessary effects improving impairment.The present provides first evidence that brain significant beneficial axis, suggesting may serve as a drug treating obesity-associated Video Abstract.
Language: Английский
Citations
54
Microbiome, Journal Year: 2024, Volume and Issue: 12(1)
Published: Feb. 20, 2024
Abstract Background Remodeling eubiosis of the gut microenvironment may contribute to preventing occurrence and development depression. Mounting experimental evidence has shown that complement C3 signaling is associated with pathogenesis depression, disruption microbiota be an underlying cause system activation. However, mechanism by which participates in gut-brain crosstalk depression remains unknown. Results In present study, we found chronic unpredictable mild stress (CUMS)-induced mice exhibited obvious depression-like behavior as well cognitive impairment, was significant dysbiosis, especially enrichment Proteobacteria elevation microbiota-derived lipopolysaccharides (LPS). addition, peripheral central activation C3/CR3-mediated aberrant synaptic pruning microglia have also been observed. Transplantation from CUMS-induced model into specific pathogen-free germ-free induced concomitant impairment recipient mice, accompanied increased C3/CR3 pathway prefrontal cortex abnormalities microglia-mediated pruning. Conversely, antidepressants fecal transplantation antidepressant-treated donors improved behaviors restored microbiome disturbances depressed mice. Concurrently, inhibition pathway, amelioration abnormal pruning, expression synapsin postsynaptic density protein 95 were Collectively, our results revealed dysbiosis induces through synapse C3, key targeting microbes treat Conclusions Our findings provide novel insights involvement chemotactic
Language: Английский
Citations
31
Frontiers in Immunology, Journal Year: 2022, Volume and Issue: 13
Published: Nov. 17, 2022
Background Gastrectomy is the most effective treatment to improve clinical survival rate of patients with gastric cancer. However, pathophysiological changes caused by gastrectomy have seriously affected postoperative recovery. Methods In present trial, Ataining (containing C. butyricum , CGMCC0313.1) was applied in after investigate effect on early recovery monitoring inflammatory immune response blood indicators, detecting gut microbiota high-throughput sequencing, and analyzing short-chain fatty acids (SCFAs) targeted metabolomics. This study registered number ChiCTR2000040915. Results Our outcomes revealed that had significantly reduced Leucocyte ( P < 0.001), percentage Neutrophil expression IL-1β 0.01), IL-6 0.05), TNF-α while markedly enhanced immunity indexes (immunoglobulin lymphocyte) 0.05) nutrition (albumin total protein) 0.05). addition, use greatly enriched relative abundance beneficial bacteria Bacteroides Faecalibacterium Gemmiger pathogenic Streptococcus Desulfovibrio Actinomyces were decreased at genus level. We also observed significant up-regulation SCFAs, including acetic acid, propionic butyric acid isobutyric administration receiving gastrectomy. Conclusion Therefore, evidence supported oral can reduce inflammation, enhance ability, restore intestinal eubiosis, increase occurrence complications, ultimately promote patient. Clinical trial registration http://www.chictr.org.cn/ identifier (ChiCTR2000040915).
Language: Английский
Citations
46
Critical Reviews in Food Science and Nutrition, Journal Year: 2022, Volume and Issue: 63(26), P. 7945 - 7982
Published: March 30, 2022
Human milk is a highly complex liquid food tailor-made to match an infant's needs. Beyond documented positive effects of breastfeeding on infant and maternal health, there increasing evidence that constituents also impact child neurodevelopment. Non-nutrient bioactives would contribute the (long-term) development cognition behavior, process termed 'Lactocrine Programming'. In this review we discuss current state field human composition its links with cognitive behavioral development. To promote state-of-the-art methodologies designs facilitate data pooling meta-analytic endeavors, present detailed recommendations best practices for future studies. Finally, determine important scientific gaps need be filled advance field, innovative directions research. Unveiling mechanisms underlying between behavior will deepen our understanding broad functions food, as well provide necessary information designing interventions.
Language: Английский
Citations
42
Nutrients, Journal Year: 2023, Volume and Issue: 15(3), P. 782 - 782
Published: Feb. 3, 2023
The dysbiosis of intestinal microbiota and their metabolites is linked to the occurrence development metabolic syndrome. Although fructose has been proven be associated with worsened mucus in colon, its mechanism remains unclear. In this study, we evaluated relatively low intake sucrose experimental colitis Sprague Dawley rats by investigating microbiome metabolome. Results showed that significantly reduced body weight, colon length increased inflammation infiltration colon. Sucrose worsen functions inhibiting expression tight junction (TJ) protein ZO-1 increasing level lipopolysaccharide neoandrographolide (LPS) plasma, while was more significant. Furthermore, changed composition gut characterized decreasing Adlercreutzia, Leuconostoc, Lactococcus Oscillospira Allobaculum Holdemania along reducing histidine, phenylalanine, arginine, glycine, aspartic acid, serine, methionine valine, alanine, lysine, isoleucine, leucine, threonine, tryptophan, tyrosine, proline, citrulline, 4-hydroxyproline gamma amino butyric acid (GABA). Metabolome results may aggravate symptoms inducing metabolism These findings suggested manipulating crosstalk between metabolites.
Language: Английский
Citations
26
Frontiers in Aging Neuroscience, Journal Year: 2023, Volume and Issue: 15
Published: June 7, 2023
Gut-brain axis might play an important role in cognitive impairments by various diseases including Alzheimer's disease (AD).To investigate the differences gut microbial composition, intestinal barrier function, and systemic inflammation patients with AD or mild impairment (MCI), normal control (NC) cases.A total of 118 subjects (45 AD, 38 MCI, 35 NC) were recruited. Cognitive function was assessed using Mini-Mental State Examination (MMSE), Montreal Assessment Scale (MoCA). Functional ability Activity Daily Living (ADL). The composition microbiome examined 16S rRNA high-throughput sequencing. Phylogenetic Investigation Communities Reconstruction Unobserved States (PICRUSt) used to predict functional transfer microbiota. Gut dysfunction evaluated measuring levels diamine oxidase (DAO), D-lactic acid (DA), endotoxin (ET). serum high-sensitivity C-reactive protein (hs-CRP) level indicate inflammation.Compared controls, (AD MCI) had lower abundance Dorea higher DAO, DA, ET. Kyoto Encyclopedia Genes Genomes (KEGG) results showed that pathways related glycan biosynthesis metabolism increased MCI patients, while ones membrane transport decreased. Bacteroides Faecalibacterium negatively correlated content ET, positively scores MMSE MoCA. hs-CRP similar among three groups. A significant negative correlation observed between severity function.Cognitive be associated dysbiosis dysfunction.
Language: Английский
Citations
26
Gut Microbes, Journal Year: 2024, Volume and Issue: 16(1)
Published: Jan. 10, 2024
The gut microbiota is vital for human body development and function. Its in early life influenced by various environmental factors. In this randomized controlled trial, the was obtained as a secondary outcome measure study on effects of one hour daily skin-to-skin contact (SSC) five weeks healthy full-term infants. Specifically, we studied alpha/beta diversity, volatility, maturation, bacterial gut-brain-axis-related functional abundances assessed thrice first year. Pregnant Dutch women (n = 116) were randomly assigned to SSC or care-as-usual groups. group participants engaged from birth age. Stool samples collected at two, five, 52 V4 region sequenced. We observed significant differences composition, abundances, predicted pathways between exhibited lower volatility during infancy. Microbiota maturation slower year our results suggested that breastfeeding duration may have partially mediated relation. Our findings provide evidence postpartum influence development. Replication necessary validate generalize these results. Future studies should include direct stress measurements extend sampling beyond investigate mechanism research SSC's impact long-term trajectories.
Language: Английский
Citations
12